发布求助
文献互助 智能选刊 最新文献

Journal of Pharmacology and Toxicology最新文献

筛选
英文 中文
Cytotoxic Evaluation Using Murine Fibroblasts (L-929) Three Dimensional Cell Culture Technique 利用小鼠成纤维细胞(L-929)三维细胞培养技术评价细胞毒性
Journal of Pharmacology and Toxicology Pub Date : 2018-12-15 DOI: 10.3923/JPT.2019.18.27
Pratyusha Ghanta, U. Bhatnagar, S. Pasumarthi, Sunil Kumar Chiliveri
{"title":"Cytotoxic Evaluation Using Murine Fibroblasts (L-929) Three Dimensional Cell Culture Technique","authors":"Pratyusha Ghanta, U. Bhatnagar, S. Pasumarthi, Sunil Kumar Chiliveri","doi":"10.3923/JPT.2019.18.27","DOIUrl":"https://doi.org/10.3923/JPT.2019.18.27","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88968792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-spasmolytic and Anti-diarrheal Activities of Newbouldia laevis, Cola nitida and Acanthus montanus Extracts on Gastrointestinal Muscles 山楂、可乐和棘豆提取物对胃肠道肌肉的抗痉挛和抗腹泻作用
Journal of Pharmacology and Toxicology Pub Date : 2018-12-15 DOI: 10.3923/JPT.2019.1.8
R. Ibeh, G. Ikechukwu, S. Ijioma, C. Nwankwo, Ashok K. Singh, M. Samani, S. Onoja, G. S. Aloh
{"title":"Anti-spasmolytic and Anti-diarrheal Activities of Newbouldia laevis, Cola nitida and Acanthus montanus Extracts on Gastrointestinal Muscles","authors":"R. Ibeh, G. Ikechukwu, S. Ijioma, C. Nwankwo, Ashok K. Singh, M. Samani, S. Onoja, G. S. Aloh","doi":"10.3923/JPT.2019.1.8","DOIUrl":"https://doi.org/10.3923/JPT.2019.1.8","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88820391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Ulcerogenic Potential of Eucalyptus globulus L. Leaf Extract in Wistar Albino Rats 蓝桉叶提取物对Wistar白化大鼠的致溃疡潜势
Journal of Pharmacology and Toxicology Pub Date : 2018-01-01 DOI: 10.3923/JPT.2018.45.51
S. Obakiro, L. Bunalema, J. Gakunga-Nd, E. Nyatia, J. P. Waako
{"title":"Ulcerogenic Potential of Eucalyptus globulus L. Leaf Extract in Wistar Albino Rats","authors":"S. Obakiro, L. Bunalema, J. Gakunga-Nd, E. Nyatia, J. P. Waako","doi":"10.3923/JPT.2018.45.51","DOIUrl":"https://doi.org/10.3923/JPT.2018.45.51","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"11 1","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85687914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Determination of Some Phyto-constituents Present in Terminalia catappa Endocarp Flour and Biochemical Evaluation of its Ethanolic Extract on Hepatic Indices in Male Wistar Rats 石麻内皮粉中部分植物成分的测定及其醇提物对雄性Wistar大鼠肝脏指标的生化评价
Journal of Pharmacology and Toxicology Pub Date : 2018-01-01 DOI: 10.3923/JPT.2018.27.36
C. AnuforoPhilemon, K. AchiNgozi, Anthony Cemaluk C. Egbuonu, Egu U. Elizabeth
{"title":"Determination of Some Phyto-constituents Present in Terminalia catappa Endocarp Flour and Biochemical Evaluation of its Ethanolic Extract on Hepatic Indices in Male Wistar Rats","authors":"C. AnuforoPhilemon, K. AchiNgozi, Anthony Cemaluk C. Egbuonu, Egu U. Elizabeth","doi":"10.3923/JPT.2018.27.36","DOIUrl":"https://doi.org/10.3923/JPT.2018.27.36","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"59 1","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90629990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Bersama engleriana (Melianthaceae) Extracts Alleviate Cypermethrin-induced Alteration of Haemato-biochemical Parameters in Male Guinea Pigs 菝葜提取物减轻氯氰菊酯诱导的雄性豚鼠血液生化参数的改变
Journal of Pharmacology and Toxicology Pub Date : 2018-01-01 DOI: 10.3923/JPT.2018.19.26
N. Edouard, V. Narcisse, Nelo Chancel Patrick, M. F. Pascal, Kenfack Augustave, N. Ferdinand, Teguia Alexis
{"title":"Bersama engleriana (Melianthaceae) Extracts Alleviate Cypermethrin-induced Alteration of Haemato-biochemical Parameters in Male Guinea Pigs","authors":"N. Edouard, V. Narcisse, Nelo Chancel Patrick, M. F. Pascal, Kenfack Augustave, N. Ferdinand, Teguia Alexis","doi":"10.3923/JPT.2018.19.26","DOIUrl":"https://doi.org/10.3923/JPT.2018.19.26","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"12 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82804201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics and Toxicity of Oily Delivery System of Ropivacaine via Subcutaneous Injection in Beagle Dogs 罗哌卡因油滴给药系统在比格犬皮下注射的药代动力学及毒性研究
Journal of Pharmacology and Toxicology Pub Date : 2018-01-01 DOI: 10.3923/JPT.2018.37.44
Yong-Xiao Cao, M. Hui, Lu Wudang, Wei-Ping Yu, Tao Chen, Jing-liang Gu
{"title":"Pharmacokinetics and Toxicity of Oily Delivery System of Ropivacaine via Subcutaneous Injection in Beagle Dogs","authors":"Yong-Xiao Cao, M. Hui, Lu Wudang, Wei-Ping Yu, Tao Chen, Jing-liang Gu","doi":"10.3923/JPT.2018.37.44","DOIUrl":"https://doi.org/10.3923/JPT.2018.37.44","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"2 1","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88251319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Ameliorating Effect of Zinc Against Oxidative Stress and Lipid Peroxidation Induced by Fipronil in Male Rats 锌对氟虫腈诱导的雄性大鼠氧化应激和脂质过氧化的改善作用
Journal of Pharmacology and Toxicology Pub Date : 2017-12-15 DOI: 10.3923/JPT.2017.24.32
E. S. Swelam, Ibrahim S. Abdallah, A. Mossa
{"title":"Ameliorating Effect of Zinc Against Oxidative Stress and Lipid Peroxidation Induced by Fipronil in Male Rats","authors":"E. S. Swelam, Ibrahim S. Abdallah, A. Mossa","doi":"10.3923/JPT.2017.24.32","DOIUrl":"https://doi.org/10.3923/JPT.2017.24.32","url":null,"abstract":"Objective: The present study was carried out to investigate the protective effect of zinc against oxidative damage induced by fipronil (FPN) in the liver and kidney of male rats. Methodology: Rats were assigned to four groups and received, water (control group), fipronil at concentration 10 mg LG1 (2.0 mg kgG1 b.wt.), zinc at concentration 227 mg LG1 and fipronil plus zinc group. All treatments were administered through drinking water for 45 days. The concentration used of fipronil in this study represents 2.0 mg kgG1 b.wt., based on average water consumptions and body weights of treated rats. Results: Results revealed that fipronil induced insignificant changes in body weight and significant increase in liver weight of treated rats. Also, significant activities of oxidative stress enzymes such as, superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GPx), catalase (CAT) and level of glutathione reduced (GSH) were obtained. The FPN caused a significant elevation in lipid peroxidation level. However, the adverse effects induced by FPN were mitigated when the rats were supplemented with zinc. Moreover, three new protein bands were detected only in the electrophoretic pattern of the FPN treated group and disappeared in the remaining three groups; control, zinc and fipronil plus zinc. Conclusion: The overall outcome suggested that FPN induced adverse effects on oxidant/antioxidant status in the liver and kidney of intoxicated rats and zinc has a role in attenuating these effects. These outcome show that administration of Zn may be useful, easy and economical to protect human against phenyl pyrazole insecticide toxic effects.","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"1 1","pages":"24-32"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84729650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
5-fluorouracil Synergized with Raloxifene and Cytosine β-D-arabinofuranoside to Combat Colorectal Cancers in vitro via Controlling Lipolysis 5-氟尿嘧啶与雷洛昔芬和胞嘧啶β- d -阿拉伯糖葡糖苷协同作用通过控制脂肪分解体外对抗结直肠癌
Journal of Pharmacology and Toxicology Pub Date : 2017-12-15 DOI: 10.3923/JPT.2017.14.23
Ahmed A. Abd-Rabou, M. Mwaheb, O. Sayed, Safaa H. Mohamed, Mohamed S. Kishta
{"title":"5-fluorouracil Synergized with Raloxifene and Cytosine β-D-arabinofuranoside to Combat Colorectal Cancers in vitro via Controlling Lipolysis","authors":"Ahmed A. Abd-Rabou, M. Mwaheb, O. Sayed, Safaa H. Mohamed, Mohamed S. Kishta","doi":"10.3923/JPT.2017.14.23","DOIUrl":"https://doi.org/10.3923/JPT.2017.14.23","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"26 1","pages":"14-23"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79115634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Evaluation of the Antidepressant Activity of Beta vulgaris Alone and in Combination with Fluoxetine in Mice 寻常β单用及联用氟西汀抗抑郁作用的小鼠评价
Journal of Pharmacology and Toxicology Pub Date : 2017-12-15 DOI: 10.3923/JPT.2017.33.41
Mihir Invally, Ginpreet Kaur, H. Buttar
{"title":"Evaluation of the Antidepressant Activity of Beta vulgaris Alone and in Combination with Fluoxetine in Mice","authors":"Mihir Invally, Ginpreet Kaur, H. Buttar","doi":"10.3923/JPT.2017.33.41","DOIUrl":"https://doi.org/10.3923/JPT.2017.33.41","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"1 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83053860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Combined Paracetamol and Ibuprofen for the Study of Analgesic Activity of Newly Formulated Dose in Prospective Pain Management in Bangladesh 对乙酰氨基酚和布洛芬联合应用于孟加拉国前瞻性疼痛治疗新配方剂量的镇痛活性研究
Journal of Pharmacology and Toxicology Pub Date : 2017-12-15 DOI: 10.3923/JPT.2017.1.13
A. Tabassum, R. R. Saha, Minhazur Rahman, M. A. Nure, Rubaba Karim, A. Imon, M. Maniruzzam, A. L. Kabir, A. Islam, J. F. Chaity, Bikash Chandra Adhikary, Abeer Sarwar, Tamanna Binte Huq, Mst. Marium Begum
{"title":"Combined Paracetamol and Ibuprofen for the Study of Analgesic Activity of Newly Formulated Dose in Prospective Pain Management in Bangladesh","authors":"A. Tabassum, R. R. Saha, Minhazur Rahman, M. A. Nure, Rubaba Karim, A. Imon, M. Maniruzzam, A. L. Kabir, A. Islam, J. F. Chaity, Bikash Chandra Adhikary, Abeer Sarwar, Tamanna Binte Huq, Mst. Marium Begum","doi":"10.3923/JPT.2017.1.13","DOIUrl":"https://doi.org/10.3923/JPT.2017.1.13","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"16 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85134979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信