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Anti-Inflammatory Activity of Extracts from Parkia biglobosa (Jacq.) R.Br. Ex G.Don. (Fabaceae-Mimosoideae) Trunk Bark 枇杷提取物的抗炎活性研究R.Br。G.Don交货。(蚕豆科-蚕豆科)树干树皮
Journal of Pharmacology and Toxicology Pub Date : 2020-12-15 DOI: 10.3923/JPT.2021.1.8
N. Ouedraogo, Constantin Boladé Atchadé, T TataKadiatou, B. Ouedraogo, Boly Abdoul Gilchrist Laurent, W.L.M. Esther Kab, Jules Yoda, F. Kini, M. Lompo, M. Ouédraogo, S. Ouédraogo
{"title":"Anti-Inflammatory Activity of Extracts from Parkia biglobosa (Jacq.) R.Br. Ex G.Don. (Fabaceae-Mimosoideae) Trunk Bark","authors":"N. Ouedraogo, Constantin Boladé Atchadé, T TataKadiatou, B. Ouedraogo, Boly Abdoul Gilchrist Laurent, W.L.M. Esther Kab, Jules Yoda, F. Kini, M. Lompo, M. Ouédraogo, S. Ouédraogo","doi":"10.3923/JPT.2021.1.8","DOIUrl":"https://doi.org/10.3923/JPT.2021.1.8","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82488122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Repetitive Exposure to Bacterial Endotoxin LPS Alters Synaptic Transmission 反复暴露于细菌内毒素LPS改变突触传递
Journal of Pharmacology and Toxicology Pub Date : 2020-06-15 DOI: 10.3923/jpt.2020.65.72
Oscar Istas, Abigail Greenhalgh, R. Cooper
{"title":"Repetitive Exposure to Bacterial Endotoxin LPS Alters Synaptic Transmission","authors":"Oscar Istas, Abigail Greenhalgh, R. Cooper","doi":"10.3923/jpt.2020.65.72","DOIUrl":"https://doi.org/10.3923/jpt.2020.65.72","url":null,"abstract":"Background and Objective: Gram-negative bacteria produce and release endotoxins in the form of lipopolysaccharides (LPS), which can have direct effects on neural synaptic communication. Since the effects of acute repetitive exposures of LPS have not been fully addressed previously, the objective of this study was to investigate the repetitive effects of acute applications of LPS on synaptic transmission. Materials and Methods: The membrane potential of cells and the amplitude of evoked synaptic responses were measured with intracellular recordings. The larval Drosophila neuromuscular junction was used as a glutamatergic synaptic model. Results: LPS depressed synaptic transmission in a dose-dependent manner. LPS blocked the glutamate receptors while hyperpolarizing the postsynaptic cell. LPS induced hyperpolarization desensitized the cell to the effects of subsequent exposures to LPS. The responses from repeating short one minute exposures to LPS with 5 min of removal and washing with saline were reproducible over three trials. Over twenty minutes of incubation with LPS, the muscle fibers depolarized and did not recover with the removal of LPS as well as the glutamatergic synaptic responses. Conclusion: LPS directly blocks glutamatergic synaptic transmission. Cells can recover from rapid exposures to LPS within 1 min. Longer than 5 min of LPS exposure produces long term irreversible effects. Additive effects with low to higher concentrations of LPS occur. The mechanism of LPS hyperpolarizing skeletal muscle is unknown but occurs in larval Drosophila muscle.","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"199 1","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2020-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75955920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Neuromodulatory Influences of Nutraceuticals on D-galactose Induced Hippocampal Neuronal Metabolic Dysfunction Model 营养药品对d -半乳糖诱导的海马神经元代谢功能障碍模型的神经调节作用
Journal of Pharmacology and Toxicology Pub Date : 2020-06-15 DOI: 10.3923/jpt.2020.44.57
Marwa A Masoud, Omar A. Ahmed-Fari, Hanan A. Rizk
{"title":"Neuromodulatory Influences of Nutraceuticals on D-galactose Induced Hippocampal Neuronal Metabolic Dysfunction Model","authors":"Marwa A Masoud, Omar A. Ahmed-Fari, Hanan A. Rizk","doi":"10.3923/jpt.2020.44.57","DOIUrl":"https://doi.org/10.3923/jpt.2020.44.57","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"1 1","pages":"44-57"},"PeriodicalIF":0.0,"publicationDate":"2020-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88844895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sedative and Anti-convulsant Effects of the Stem Bark Extract of Combretum hypopilinum in Laboratory Animals 矮蕨茎皮提取物对实验动物的镇静和抗惊厥作用
Journal of Pharmacology and Toxicology Pub Date : 2020-06-15 DOI: 10.3923/jpt.2020.58.64
A. Kabiru, U. Aminu, Y. Musa, M. Abubakaar, S. Hassan, A. Suleiman, Rabiu Tijani Gia, A. Tanko
{"title":"Sedative and Anti-convulsant Effects of the Stem Bark Extract of Combretum hypopilinum in Laboratory Animals","authors":"A. Kabiru, U. Aminu, Y. Musa, M. Abubakaar, S. Hassan, A. Suleiman, Rabiu Tijani Gia, A. Tanko","doi":"10.3923/jpt.2020.58.64","DOIUrl":"https://doi.org/10.3923/jpt.2020.58.64","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"6 1","pages":"58-64"},"PeriodicalIF":0.0,"publicationDate":"2020-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83566389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Comparison of Neutralization of Two Experimental Monovalent Antivenoms of Colombia's Bothrops asper from Different Localities 两种不同产地哥伦比亚Bothrops asper实验单价抗蛇毒血清的中和作用比较
Journal of Pharmacology and Toxicology Pub Date : 2020-01-30 DOI: 10.3923/jpt.2020.8.15
K. Sarmiento, IvonneTorres, C. Ríos, Julian Salazar, Andrea Baracaldo, Jorge Zambrano, German Ramírez-Forero, Diego Hernández, Luisa Pérez, Diana Castaño, H. Díez
{"title":"Comparison of Neutralization of Two Experimental Monovalent Antivenoms of Colombia's Bothrops asper from Different Localities","authors":"K. Sarmiento, IvonneTorres, C. Ríos, Julian Salazar, Andrea Baracaldo, Jorge Zambrano, German Ramírez-Forero, Diego Hernández, Luisa Pérez, Diana Castaño, H. Díez","doi":"10.3923/jpt.2020.8.15","DOIUrl":"https://doi.org/10.3923/jpt.2020.8.15","url":null,"abstract":"Background and Objectives: Colombia does not produce fabotherapic antivenoms, the aim of current study was comparison of the neutralization of Bothrops asper venom from Atlantic and Andean region with 2 experimental monovalent antivenoms. Materials and Methods: The protein of the venom and antivenoms was quantified by absorbance at 280 nm and characterized by SDS-PAGE. The protein profile venoms were performed by RT-HPLC. It was calculated LD50 for the venoms and ED50 for the antivenoms, using Prism-statMate. An immunization scheme of 3 months was conducted in equine using Andean venom. The complete IgG antivenom was produced with caprylic acid, while the fabotherapic F(ab’)2 antivenom with pepsin. Both antivenoms were tested with Andean venom and Atlantic venom. Electrophoresis was conducted to verify the antivenoms by weight. Results: The protein was 11.5 mg/mL to Andean venom and 13.4 mg/mL to Atlantic venom. The SDS-PAGE showed bands of 15-20 kDa for both venoms. The LD50 to Andean venom was 2.8 and 2.3 mg/kg to Atlantic venom. The RT-HPLC showed similar protein fractions at first 40 min in both venoms. The protein for IgG was 9.8 mg/mL, while for F(ab’)2 it was 11.2 mg/mL. The SDS-PAGE showed bands of 130-200 kDa for IgG whyle of 94-150 kDa for F(ab’)2. The ED50 with Atlantic venom was 1.4 mg/mL using IgG and 1.75 mg/mL using F(ab’)2. The ED50 with Andean venom was 1.6 mg/mL using IgG and 1.9 mg/mL using F(ab’)2. Conclusion: Both antivenoms were efficient to neutralize the venom of Andean and Atlantic venom, without significant differences.","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"68 1","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"2020-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85210520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Haematinic Effects of Ethanol Extract of Ficus sur Leaves on Diethylnitrosamine-induced Toxicity in Wistar Rats 无花果叶乙醇提取物对二乙基亚硝胺致Wistar大鼠血液学毒性的影响
Journal of Pharmacology and Toxicology Pub Date : 2020-01-30 DOI: 10.3923/jpt.2020.16.21
O. Yakubu, E. Ojogbane, Michael Sunday Abu, Christopher Shaibu, Winner Emmanuel Ayegba
{"title":"Haematinic Effects of Ethanol Extract of Ficus sur Leaves on Diethylnitrosamine-induced Toxicity in Wistar Rats","authors":"O. Yakubu, E. Ojogbane, Michael Sunday Abu, Christopher Shaibu, Winner Emmanuel Ayegba","doi":"10.3923/jpt.2020.16.21","DOIUrl":"https://doi.org/10.3923/jpt.2020.16.21","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"46 1","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2020-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88824968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effects of Ethanolic Leaf and Stem-bark Extracts of Adansonia digitata in Alloxan-induced Diabetic Wistar Rats 荆芥叶和茎皮乙醇提取物对四氧嘧啶诱导的糖尿病大鼠的影响
Journal of Pharmacology and Toxicology Pub Date : 2020-01-16 DOI: 10.3923/jpt.2020.1.7
O. Yakubu, C. Imo, Christopher Shaibu, John Akighir, D. Ameh
{"title":"Effects of Ethanolic Leaf and Stem-bark Extracts of Adansonia digitata in Alloxan-induced Diabetic Wistar Rats","authors":"O. Yakubu, C. Imo, Christopher Shaibu, John Akighir, D. Ameh","doi":"10.3923/jpt.2020.1.7","DOIUrl":"https://doi.org/10.3923/jpt.2020.1.7","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"30 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88067475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Curative Effect of Terminalia superba Engl. and Diels (Combretaceae) Trunk Bark on Paracetamol-induced Hepatotoxicity in Rats 黄芩的疗效观察。对乙酰氨基酚对大鼠肝毒性的影响
Journal of Pharmacology and Toxicology Pub Date : 2020-01-15 DOI: 10.3923/jpt.2020.36.43
Goze Nomane Ber, N. Oussou, guessa, L KouakouKouakou, Koko Kouam eacu, Yapo Angou eacu
{"title":"Curative Effect of Terminalia superba Engl. and Diels (Combretaceae) Trunk Bark on Paracetamol-induced Hepatotoxicity in Rats","authors":"Goze Nomane Ber, N. Oussou, guessa, L KouakouKouakou, Koko Kouam eacu, Yapo Angou eacu","doi":"10.3923/jpt.2020.36.43","DOIUrl":"https://doi.org/10.3923/jpt.2020.36.43","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"8 1","pages":"36-43"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89971764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Intraperitoneal Acute Toxicity of Aluminum Hydroxide Nanoparticle as an Adjuvant Vaccine Candidate in Mice 氢氧化铝纳米颗粒作为佐剂候选疫苗在小鼠腹腔内的急性毒性
Journal of Pharmacology and Toxicology Pub Date : 2019-12-15 DOI: 10.3923/jpt.2020.22.35
Sjaikhurrizal El Muttaqi, E. Mardliyati, S. Rahmani, S. Pambudi, S. Maimunah, Ziah Izati Azki, Nurmeilis, A. Sulfianti, J. Efendi, Damai Ria Setyaw, Asutiati Nurhasanah, I. Faizal
{"title":"Intraperitoneal Acute Toxicity of Aluminum Hydroxide Nanoparticle as an Adjuvant Vaccine Candidate in Mice","authors":"Sjaikhurrizal El Muttaqi, E. Mardliyati, S. Rahmani, S. Pambudi, S. Maimunah, Ziah Izati Azki, Nurmeilis, A. Sulfianti, J. Efendi, Damai Ria Setyaw, Asutiati Nurhasanah, I. Faizal","doi":"10.3923/jpt.2020.22.35","DOIUrl":"https://doi.org/10.3923/jpt.2020.22.35","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"10 1","pages":"22-35"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72672462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Acute and Sub-acute Toxicity Studies of a Patented Anti-anxiety Poly Herbal Formulation 一种专利抗焦虑复方的急性和亚急性毒性研究
Journal of Pharmacology and Toxicology Pub Date : 2018-12-15 DOI: 10.3923/JPT.2019.9.17
C. Duraipandi, Settu Dinesh Kumar, M. Rajanandh
{"title":"Acute and Sub-acute Toxicity Studies of a Patented Anti-anxiety Poly Herbal Formulation","authors":"C. Duraipandi, Settu Dinesh Kumar, M. Rajanandh","doi":"10.3923/JPT.2019.9.17","DOIUrl":"https://doi.org/10.3923/JPT.2019.9.17","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77264591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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