Journal of Pharmacopolium最新文献_第4页

Formulasi Dan Evaluasi Sediaan Fisik Sediaan Serum Wajah Ekstrak Beras Merah (Oryza Nivara L.) 配方和评估白米饭萃取面血清(Oryza Nivara L)。

Journal of Pharmacopolium Pub Date : 2022-08-31 DOI: 10.36465/jop.v5i2.908

Siti Sarifah

引用次数: 0

KAJIAN FITOKIMIA PIGMEN WARNA UNGU DAN PROFIL ANTIOKSIDAN PADA EKSTRAK BUNGA HARENDONG (Melastoma malabatrichum L.)

Journal of Pharmacopolium Pub Date : 2022-08-31 DOI: 10.36465/jop.v5i2.919

Hendy Suhendy, Nita Astuti, Firman Gustaman

{"title":"KAJIAN FITOKIMIA PIGMEN WARNA UNGU DAN PROFIL ANTIOKSIDAN PADA EKSTRAK BUNGA HARENDONG (Melastoma malabatrichum L.)","authors":"Hendy Suhendy, Nita Astuti, Firman Gustaman","doi":"10.36465/jop.v5i2.919","DOIUrl":"https://doi.org/10.36465/jop.v5i2.919","url":null,"abstract":"Bunga harendong (Melastoma malabatrichum L.) merupakan salah satu tanaman sebagai sumber pigmen alami yang berkontribusi terhadap zat warna ungu. Pigmen warna ungu yang terdapat pada tanaman salah satunya bersumber dari antosianin dan diketahui bahwa secara farmakologis antosianin memberikan aktivitas antioksidan. Penelitian ini bertujuan untuk mengetahui pigmen warna ungu pada beberapa ekstrak dan menentukan aktivitas antioksidan secara kualitatif dan kuantitatif ekstrak terpilih. Serbuk simplisia bunga harendong diekstraksi dengan maserasi bertingkat menggunakan pelarut yang berbeda kepolaran dan ditambahkan dengan pelarut asam klorida 1%. Pengujian ekstrak dengan monitoring pigmen warna ungu dan memberikan aktivitas antioksidan secara kualitatif menggunakan kromatografi lapis tipis dan pengujian kuantitatif antioksidan menggunakan metode spektrofotometri UV-Vis dengan reagen DPPH. Data IC50 yang diperoleh dianalisis secara statistik menggunakan SPSS dengan metode independent T-Test. Pigmen warna ungu sebagai flavonoid yang memberikan aktivitas antioksidan secara kualitatif hanya terdapat pada ekstrak etil asetat dengan nilai Rf masing-masing sebesar 0,14 dan 0,84. Rataan nilai IC50 pada ekstrak etil asetat dan vitamin C secara berturut-turut adalah 4,54 ppm dan 2,85 ppm. Secara analisis statistik kedua nilai tersebut berbeda signifikan (p<0,05). Pigmen warna ungu sebagai flavonoid terdapat pada ekstrak etil asetat bunga harendong yang memberikan aktivitas antioksidan dengan kategori sangat kuat. Kata Kunci : Antioksidan; Bunga Harendong; Pigmen Warna Ungu","PeriodicalId":16805,"journal":{"name":"Journal of Pharmacopolium","volume":"175 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77777109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PENGARUH KUANTITAS BAWANG PUTIH TUNGGAL (Allium sativum, L.) PADA FERMENTASI MADU TERHADAP DAYA HAMBAT BAKTERI 一粒大蒜数量的影响(Allium sativum, L)对蜂蜜的发酵对细菌的抑制

Journal of Pharmacopolium Pub Date : 2022-08-31 DOI: 10.36465/jop.v5i2.916

Aan Kunaedi

{"title":"PENGARUH KUANTITAS BAWANG PUTIH TUNGGAL (Allium sativum, L.) PADA FERMENTASI MADU TERHADAP DAYA HAMBAT BAKTERI","authors":"Aan Kunaedi","doi":"10.36465/jop.v5i2.916","DOIUrl":"https://doi.org/10.36465/jop.v5i2.916","url":null,"abstract":"Bacteria are one of the pathogenic microorganisms that cause infection. Honey has been used in ancient times as a topical antibacterial for the treatment of surface infections, especially open wounds. Allicin is the active substance in garlic and has antibacterial properties. The purpose of this study was to determine whether the fermented pure honey and single garlic had an inhibitory effect on Esherichia coli bacteria, in addition to knowing whether variations in the use of onions and the length of fermentation time affected the inhibitory activity of Esherichia coli bacteria. The inhibition test was carried out using the paper disc diffusion method. The sample used was fermented pure honey with a single garlic ratio of 1:2, 1:1 and 2:1 at the 2nd, 3rd and 4th weeks. Positive control using amoxicillin injection concentration of 0.01%, negative control using sterile distilled water and pure honey as a comparison. The results showed that fermented honey with a ratio of 1:2, 1:1 and 2:1 had a strong category of inhibitory activity at weeks 2, 3 and 4. Fermented honey has inhibitory activity against Esherichia coli bacteria and there is an effect of comparison ratio and length of fermentation time on inhibitory activity against Esherichia coli bacteria.","PeriodicalId":16805,"journal":{"name":"Journal of Pharmacopolium","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90093593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TOKSISITAS SUBKRONIK FRAKSI ETIL ASETAT BIJI LIMUS (Mangifera foetida Lour.) TERHADAP HEPAR DAN GINJAL PADA TIKUS PUTIH GALUR WISTAR 利姆斯种子(Mangifera foetida Lour)的乙基乙酸衍生物毒性。对于灰褐色老鼠的肝和肾脏

Journal of Pharmacopolium Pub Date : 2022-08-31 DOI: 10.36465/jop.v5i2.928

Vera Nurviana

引用次数: 0

Pengujian Aktivitas Antioksidan Menggunakan Metode FRAP dan Penentuan Kadar Fenol Total pada Ekstrak Air Kulit Buah Naga Merah (Hylocereus polyrhizus) 测试抗氧化剂活性的方法

Journal of Pharmacopolium Pub Date : 2022-08-07 DOI: 10.36465/jop.v5i2.917

Kiki Mulkiya Yuliawati

引用次数: 2

OPTIMASI FORMULA LULUR KRIM DAUN MAREME (Glochidion arborescens Blume.) SEBAGAI ANTIOKSIDAN DENGAN VARIASI TEPUNG JAGUNG DAN TEPUNG BERAS MENGGUNAKAN DESAIN FAKTORIAL 优化MAREME叶子霜配方(Glochidion arborescens Blume)。作为一种抗氧化剂，以玉米粉和米粉的变体使用阶梯式设计

Journal of Pharmacopolium Pub Date : 2022-05-30 DOI: 10.36465/jop.v5i1.874

Indra Indra, Lia Rahmawati, Vera Nurviana

{"title":"OPTIMASI FORMULA LULUR KRIM DAUN MAREME (Glochidion arborescens Blume.) SEBAGAI ANTIOKSIDAN DENGAN VARIASI TEPUNG JAGUNG DAN TEPUNG BERAS MENGGUNAKAN DESAIN FAKTORIAL","authors":"Indra Indra, Lia Rahmawati, Vera Nurviana","doi":"10.36465/jop.v5i1.874","DOIUrl":"https://doi.org/10.36465/jop.v5i1.874","url":null,"abstract":"One way to maintain healthy skin is through skincare that incorporates natural ingredient scrubs. Free radicals contribute to the onset of cell damage associated with skin aging. Mareme leaves (Glochidion arborescens Blume.) contain antioxidants that can inhibit the reaction of free radicals in the body. The purpose of this study was to incorporate the ethanol extract of mareme leaves into a scrub formulation containing cornflour and rice flour. This study begins with a phytochemical screen, followed by TLC analysis of antioxidant activity using the DPPH-free radical scavenging test, evaluation of cream scrubs, and ANOVA data analysis. According to research, the ethanol extract of mareme leaves possesses a significant antioxidant activity of 4.32 parts per million. The effect of variations in cornstarch and rice flour on the formulation of cream scrubs was determined through organoleptic testing of all semisolid preparations, with an emphasis on different smells and colors; all formulas have a pH suitable for the skin of 4.5-8, and each formula contains less than 50 ppm of potent antioxidant activity. A significant value of 0.05 indicates that there is a significant difference between the four formulas based on the ANOVA test comparing IC50 values between preparations. It has to do with the addition of cornstarch scrub and rice flour to each formula. It can be concluded that the ethanol extract of mareme leaves (Glochidion arborescens Blume) possesses exceptional antioxidant activity. According to the stability test, the best formula for cream scrub preparations is formula 3.","PeriodicalId":16805,"journal":{"name":"Journal of Pharmacopolium","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74081995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IN SILICO DESIGN OF B-CELL EPITOPE BASED PEPTIDE VACCINE FOR ZIKA VIRUS 基于b细胞表位的寨卡病毒肽疫苗的芯片设计

Journal of Pharmacopolium Pub Date : 2022-05-19 DOI: 10.36465/jop.v5i1.880

Firasti AN Sumadi, Annisa ZS Ariadne, A. Jamil, M. A. Muchlisin, Hidajah Rachmawati

{"title":"IN SILICO DESIGN OF B-CELL EPITOPE BASED PEPTIDE VACCINE FOR ZIKA VIRUS","authors":"Firasti AN Sumadi, Annisa ZS Ariadne, A. Jamil, M. A. Muchlisin, Hidajah Rachmawati","doi":"10.36465/jop.v5i1.880","DOIUrl":"https://doi.org/10.36465/jop.v5i1.880","url":null,"abstract":"Zika virus infection attracted the attention of the medical community since it is transmitted by the Aedes mosquito and humans act as hosts. The disease affects fetal development and causes severe neurodevelopmental disorders, such as GBS (Guillain-Barre Syndrome), and CZS (Congenital Zika Syndrome) in pregnant women, including congenital microcephaly, and fetal death. Therefore, a vaccine is needed for prevention. Epitope-based peptide vaccines have advantages in terms of both selectivity and safety. The use of computational methods is a cost-efficient way of developing vaccines. This research aims to look at conserved areas and see the phylogenetic tree of the zika virus E protein sequences obtained from various countries, to see the most immunogenic epitope notifications of the ZIKV E protein sequence using the in-silico method, to see the potential for the most immunogenic epitopes of protein sequences. Zika virus as a vaccine candidate through the use of in silico. This study was using a descriptive observational study using in-silico tools for Zika virus peptide vaccine candidates. Some software and websites that were used are MEGA-X, IEDB, VaxiJen 2.0, BLASTp NCBI. From the 41 sequences that have been collected, 3 epitope candidates had antigenic properties and also passed the similarity test so the potential to develop a peptide vaccine; SLGLDCE, ETDENRAKVEVTPNSPRAEATLG, and AHAKRQ. Keywords: Vaccine, Peptide, Epitope, Zika Virus, In Silico","PeriodicalId":16805,"journal":{"name":"Journal of Pharmacopolium","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89706053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PREDIKSI BIOAVAILABILITAS DAN INTERAKSI SENYAWA METABOLIT SEKUNDER BUAH PLUM (Prunus domestica) TERHADAP HMG-CoA REDUKTASE SECARA IN SILICO 对李子果实(Prunus家蝇)的生物适应和相互作用的预测

Journal of Pharmacopolium Pub Date : 2022-05-19 DOI: 10.36465/jop.v5i1.875

M. A. Muchlisin, Wardah Firdausiyah, E. J. Astuti, Agustin Rafikayanti

{"title":"PREDIKSI BIOAVAILABILITAS DAN INTERAKSI SENYAWA METABOLIT SEKUNDER BUAH PLUM (Prunus domestica) TERHADAP HMG-CoA REDUKTASE SECARA IN SILICO","authors":"M. A. Muchlisin, Wardah Firdausiyah, E. J. Astuti, Agustin Rafikayanti","doi":"10.36465/jop.v5i1.875","DOIUrl":"https://doi.org/10.36465/jop.v5i1.875","url":null,"abstract":"Hyperlipidemia is a condition in which one or more lipid profiles in the blood have increased. Plum fruit (Prunus domestica) was empirically used to treat hyperlipidemia by reducing the production of cholesterol in the blood. This study has the purpose to predict the bioavailability and interaction of the secondary metabolites of P. domestica fruit against HMG-CoA reductase using in silico method. This study uses the SwissADME webserver with the Boiled-Egg method to predict bioavailability and PyRx0.8 to predict the interaction of compounds by molecular docking. From 108 secondary metabolites, 37 compounds were predicted to have good bioavailability. There were two compounds (cyaniding and tryptamine) that were predicted to have potential as anti hyperlipidemia similar to or better than antihyperlipidemic drugs of the statin class (simvastatin). Cyanidin and tryptamine have binding energy values (-5.12 kcal/mol and -4.95 kcal/mol) and estimated inhibition constant (117.15 µM and 234.67 µM) better than simvastatin (-4.96 kcal/mol and 231.44 µM). Both compounds also have similar amino acid residues interaction (Lys735 for cyanidin and Glu559 for tryptamine) with simvastatin.","PeriodicalId":16805,"journal":{"name":"Journal of Pharmacopolium","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78945392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

PENGARUH PEMBERIAN EKSTRAK ETANOL BIJI MELON (Cucumis melo L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL 瓜籽乙醇提取物(Cucumis melo L)的影响。雄性白老鼠体内的平均胆固醇水平下降

Journal of Pharmacopolium Pub Date : 2022-04-30 DOI: 10.36465/jop.v5i1.881

Tita Nofianti

引用次数: 0

KADAR FLAVONOID TOTAL BEBERAPA TUMBUHAN FAMILI ASTERACEAE

Journal of Pharmacopolium Pub Date : 2022-04-30 DOI: 10.36465/jop.v5i1.882

Himyatul Hidayah

{"title":"KADAR FLAVONOID TOTAL BEBERAPA TUMBUHAN FAMILI ASTERACEAE","authors":"Himyatul Hidayah","doi":"10.36465/jop.v5i1.882","DOIUrl":"https://doi.org/10.36465/jop.v5i1.882","url":null,"abstract":"ABSTRACTIndonesia is a country with abundant biological wealth which has 25% of plant species in the world which reaches 20,000 species that are useful in medicine. Plants of the Asteraceae family are often used by the community as traditional medicine. The pharmacological effects of Asteraceae plants can be attributed to various phytochemical compounds, including polyphenols, phenolic acids, flavonoids, acetylene and triterpenes. Flavonoids have been shown to have high activity for inhibiting xanthine oxidase. The aim of this study was to determine the total flavonoid content of several members of the Aseteraceae family (Taraxacum officinale, Crassocephalum crepidioides, Elephantopus scaber, Gynura procumbens, Ageratum conyzoides, Sonchus arvensis) using UV-Visspectrophotometry. The results showed that all Asteraceae family plants tested positive for flavonoid compounds. Determination of total flavonoid levels was carried out based on the AlCl3 method with total flavonoids expressed in QE (Quercetin equivalent) at a maximum wavelength of 415 nm. The results showed that the average content of total flavonoids of Crassocephalum crepidioides 3.4345% ± 0.2706, Taraxacum officinale 2.3217% ± 0.032, Ageratum conyzoides, L 3.3764% ± 0.257, Sonchus arvencis L. 2.7279% ± 0.0399, Gynura procumbens 2 .2825% ± 0.1370, and Elephantopus scaber 2.5294% ± 0.0861. The conclusion of this study was that the highest total flavonoid content was in Crassocephalum crepidioides and Gynura procumbens plants with the lowest total flavonoid content. Keywords: Phytochemical Screening, Total Flavonoid, Family Asteraceae","PeriodicalId":16805,"journal":{"name":"Journal of Pharmacopolium","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78480902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0