Journal of Pharmacognosy and Phytotherapy最新文献_第10页

Comparative study between effects of ethanol extract of Zingiber officinale and Atorvastatine on lipid profile in rats 生姜乙醇提取物与阿托伐他汀对大鼠血脂影响的比较研究

Journal of Pharmacognosy and Phytotherapy Pub Date : 2016-08-31 DOI: 10.5897/JPP2015.0369

A. Berroukche, A. Attaoui, M. Loth

{"title":"Comparative study between effects of ethanol extract of Zingiber officinale and Atorvastatine on lipid profile in rats","authors":"A. Berroukche, A. Attaoui, M. Loth","doi":"10.5897/JPP2015.0369","DOIUrl":"https://doi.org/10.5897/JPP2015.0369","url":null,"abstract":"Zingiber officinale is known for its cholesterol-lowering and antioxidant properties. The use of traditional medicine reduces the use of drugs with a risk of toxicity. This study aims to assess the effects of ethanol extract of Z. officinale and atorvastatin on lipid parameters in rats fed with high-fat diet. The experiment was carried out on 40 rats during 9 weeks. The animals were divided into 4 groups; group 1 (normal healthy controls), group 2 (hypercholesterolemic diet controls), group 3 (treated with ethanol extract of Z. officinal at 500 mg / kg / day) and group 4 (treated with Atorvastatin at 20 mg/kg/day). It has been shown, respectively in groups 3 and 4, a stable body weight (289 vs 282 g) and a highly significant reduction of cholesterol (295.9 vs 275.1 mg/dl), total triglycerides (46.8 vs 41.9 mg/dl) and LDL (278.2 vs 259.1 mg/dl), but not a significant increase in HDL (8.6 vs 7.8 mg/dl). Results showed that Z. officinale is similar to Atorvastatin as a cholesterol-lowering agent in the treatment of patients exposed to risk of obesity and cardiovascular disease. Therefore, combination regimens containing ginger and low dose of statins could be advantageous in treating hypercholesterolemic patients. \u0000 \u0000 Key words: Zingiber officinale, cholesterol, antioxidant, Atorvastatine, cardiovascular disease.","PeriodicalId":16801,"journal":{"name":"Journal of Pharmacognosy and Phytotherapy","volume":"11 1","pages":"155-162"},"PeriodicalIF":0.0,"publicationDate":"2016-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86614897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anti-cancer efficacy of ethanolic extracts from various parts of Annona Squamosa on MCF-7 cell line 番荔枝不同部位乙醇提取物对MCF-7细胞的抗癌作用

Journal of Pharmacognosy and Phytotherapy Pub Date : 2016-07-31 DOI: 10.5897/JPP2016.0398

S. Veerakumar, Safreen Shaikh Dawood Amanulla, K. Ramanathan

{"title":"Anti-cancer efficacy of ethanolic extracts from various parts of Annona Squamosa on MCF-7 cell line","authors":"S. Veerakumar, Safreen Shaikh Dawood Amanulla, K. Ramanathan","doi":"10.5897/JPP2016.0398","DOIUrl":"https://doi.org/10.5897/JPP2016.0398","url":null,"abstract":"Medicinal plant extracts are known to possess breast cancer antidote. The present investigation is focused on anticancer efficacy of various parts of Annona squamosa. The organic (ethanol) extracts from various parts of Annona squamosa were prepared using soxhlet apparatus and tested for in vitro anticancer efficacy on Breast cancer cell line MCF-7 by MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The results obtained from MTT assay showed that the inhibitory concentration values of bark, peel and seed were found to be approximately 20, 30 and 10 μg/ml, respectively The ethanolic seed extract had high anticancer activity with IC50 value of 10 ug/ml, reveals that A. squamosa inhibits the proliferation of MCF-7 by inducing apoptosis. The plant investigated has anti-cancer activity; hence further studies should be carried out for the isolation of the lead molecules from the parts of the plant to treat the breast cancer. \u0000 \u0000 Key words: Annona squamosa, MCF-7 cell line, 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, anti-cancer activity.","PeriodicalId":16801,"journal":{"name":"Journal of Pharmacognosy and Phytotherapy","volume":"36 1","pages":"147-154"},"PeriodicalIF":0.0,"publicationDate":"2016-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81639344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Evaluation of anti-bacterial activity and bioactive chemical analysis of Ocimum basilicum using Fourier transform infrared (FT-IR) and gas chromatography-mass spectrometry (GC-MS) techniques 傅里叶变换红外(FT-IR)和气相色谱-质谱(GC-MS)技术评价罗勒的抗菌活性和生物活性化学分析

Journal of Pharmacognosy and Phytotherapy Pub Date : 2016-06-30 DOI: 10.5897/JPP2015.0366

M. Kadhim, Azhar Abdulameer Sosa, I. Hameed

{"title":"Evaluation of anti-bacterial activity and bioactive chemical analysis of Ocimum basilicum using Fourier transform infrared (FT-IR) and gas chromatography-mass spectrometry (GC-MS) techniques","authors":"M. Kadhim, Azhar Abdulameer Sosa, I. Hameed","doi":"10.5897/JPP2015.0366","DOIUrl":"https://doi.org/10.5897/JPP2015.0366","url":null,"abstract":"The objective of this research was to determine the chemical composition of aerial parts extract from methanol. The phytochemical compound screened by gas chromatography-mass spectrometry (GC-MS) method. Thirty one bioactive phytochemical compounds were identified in the methanolic extract of Ocimum basilicum. The identification of phytochemical compounds is based on the peak area, retention time molecular weight, molecular formula, MS fragment-ions and pharmacological actions. GC-MS and Fourier transform infrared (FT-IR) analyses of O. basilicum revealed the existence of Paromomycin, Stevioside, Campesterol and Ascaridole epoxide, aliphatic fluoro compounds, alcohols, ethers, carboxlic acids, esters, nitro compounds, alkanes, H-bonded H-X group, hydrogen bonded alcohols and phenols. Methanolic extract of bioactive compounds of O. basilicum was assayed for in vitro antibacterial activity against Pseudomonas aerogenosa, Proteus mirabilis, Escherichia coli, Staphylococcus aureus and Klebsiella pneumonia by using the diffusion method in agar. The zone of inhibition was compared with different standard antibiotics. The diameters of inhibition zones ranged from 5.70±0.10 to 0.55±0.29 mm for all treatments. \u0000 \u0000 Key words: GC/MS, Bioactive compounds, Fourier transform infrared (FT-IR), Ocimum basilicum.","PeriodicalId":16801,"journal":{"name":"Journal of Pharmacognosy and Phytotherapy","volume":"64 1","pages":"127-146"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91539621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 62

Design and optimisation of novel Huperzine A analogues capable of modulating the acetylcholinesterase receptor for the management of Alzheimers disease 设计和优化新型石杉碱A类似物，能够调节乙酰胆碱酯酶受体，用于阿尔茨海默病的管理

Journal of Pharmacognosy and Phytotherapy Pub Date : 2016-05-31 DOI: 10.5897/JPP2015.0374

Sara Bonavia, C. Shoemake

{"title":"Design and optimisation of novel Huperzine A analogues capable of modulating the acetylcholinesterase receptor for the management of Alzheimers disease","authors":"Sara Bonavia, C. Shoemake","doi":"10.5897/JPP2015.0374","DOIUrl":"https://doi.org/10.5897/JPP2015.0374","url":null,"abstract":"This is a de novo drug design study that aimed to create novel structures based on the alkaloid Huperzine A, capable of inhibiting the acetylcholinesterase (AChE) enzyme ligand binding pocket (AChE_LBP) for the management of Alzheimer’s disease. The X-ray crystallographic model of the Torpedo Californica AChE complexed to Huperzine A was identified from the Protein Data Bank (PDB ID 1VOT). Molecular visualisation and modelling was carried out using SYBYL® 1.2, in silico predicted ligand binding affinity (LBA) was quantified using XSCORE_V1.3 and de novo drug design was carried out using LIGBUILDER®V1.2. Two seed structures were constructed in SYBYL® 1.2 according to a methodology that took into account the relationship between molecular structure and biological activity as described in the literature. Based on SAR data derived from Huperzine A, the points considered to be critical for binding were retained in each seed and planted into the AChE_LBP with growth being allowed according to defined parameters of LIGBUILDER®V1.2. The implication of this study consequently is that novel structures compliant to Lipinski’s Rule of 5 may be promoted to second level drug design which could lead to identification of novel AChE inhibitors with better potency and a low side effect profile. \u0000 \u0000 \u0000 \u0000 Key words: de novo drug design, Huperzine A, acetylcholinesterase, Alzheimer’s disease, Lipinski’s Rule of 5.","PeriodicalId":16801,"journal":{"name":"Journal of Pharmacognosy and Phytotherapy","volume":"26 1","pages":"99-108"},"PeriodicalIF":0.0,"publicationDate":"2016-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78311096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of bioactive chemical compounds of Euphorbia lathyrus using gas chromatography-mass spectrometry and Fourier-transform infrared spectroscopy 气相色谱-质谱联用及傅里叶变换红外光谱分析大戟的生物活性成分

Journal of Pharmacognosy and Phytotherapy Pub Date : 2016-05-31 DOI: 10.5897/JPP2015.0371

Azhar Abduameer Sosa, Suhaila Husaein Bagi, I. Hameed

{"title":"Analysis of bioactive chemical compounds of Euphorbia lathyrus using gas chromatography-mass spectrometry and Fourier-transform infrared spectroscopy","authors":"Azhar Abduameer Sosa, Suhaila Husaein Bagi, I. Hameed","doi":"10.5897/JPP2015.0371","DOIUrl":"https://doi.org/10.5897/JPP2015.0371","url":null,"abstract":"The aim of this study was determination the phytochemical composition of methanolic seeds extract of Euphorbia lathyrus. Gas chromatography-mass spectrometry (GC-MS) analysis of E. lathyrus revealed the existence of the Carbonic acid, (ethyl)(1,2,4-triazol-1-ylmethyl) diester, 1H-Pyrrole,2,5-dihydro-1-nitroso, Hexanal dimethyl acetal, Isosorbide dinitrate, DL-Arabinose, Cyclopropane,1-fluoro-1-(2-bromoethenyl)-2,2,3,3-tetramethyl, α-D-Glucopyranoside, O-α-D-glucopyranosyl-(1.fwdarw.3)-s-d-fruc, Desulphosinigrin, D-Glucose, 6-O-α-D-galactopyranosyl, Octanoic acid, Benzofuran,2,3-dihydro, 6-Acetyl-s-d-mannose, Estragole, Ascaridole epoxide, 3-Allyl-6-methoxyphenol, 4-Amino-1,5,pentandioic acid, l-Gala-l-ido-octonic lactone, y-Sitosterol, Tetradecanoic acid, l-(+)-Ascorbic acid 2,6-dihexadecanoate, Estra -1,3,5(10)-trien-17s-ol, Propanoic acid,2-(3-acetoxy-4,4,14-trimethylandrost-8-en-17-yl), Cis-13-Eicosenoic acid, Eicosanoic acid, 3-Pyrinecarboxylic acid, 2,7,10-tris(acetyloxy)-1,1a,2,3,4,6,7,10, Oleic acid, eicosyl ester, Butanoic acid, 4-chloro-,1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a, Ethyl iso–allocholate, Ethyl iso –allocholate, Olean-12-ene-3,15,16,21,22,28-hexol, (3s,15α,16α,21s,22α)- and 2,4,6-Decatrienoic acid,1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihy. The Fourier-transform infrared spectroscopy (FTIR) analysis of E. lathyrus seeds proved the presence of alkenes, aliphatic fluoro compounds, alcohols, ethers, carboxlic acids, esters, nitro compounds, alkanes, hydrogen bonded alcohols, and phenols. \u0000 \u0000 \u0000 \u0000 Key words: Gas chromatography-mass spectrometry (GC/MS), bioactive compounds, Fourier-transform infrared spectroscopy (FT-IR), Euphorbia lathyrus.","PeriodicalId":16801,"journal":{"name":"Journal of Pharmacognosy and Phytotherapy","volume":"183 1","pages":"109-126"},"PeriodicalIF":0.0,"publicationDate":"2016-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80435145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

The interaction between the gall wasp Leptocybe invasa and Eucalyptus camaldulensis leaves: A study of phyto-volatile metabolites 入侵瘿蜂(Leptocybe invasa)与桉叶的相互作用:植物挥发性代谢物的研究

Journal of Pharmacognosy and Phytotherapy Pub Date : 2016-04-30 DOI: 10.5897/JPP2015.0384

M. Mohamed

{"title":"The interaction between the gall wasp Leptocybe invasa and Eucalyptus camaldulensis leaves: A study of phyto-volatile metabolites","authors":"M. Mohamed","doi":"10.5897/JPP2015.0384","DOIUrl":"https://doi.org/10.5897/JPP2015.0384","url":null,"abstract":"A comparative study of the volatile terpene fraction isolated from the leaves of Eucalyptus camaldulensis attacked by the gall wasp (Leptocybe invasa) and from the healthy leaves of the plant was carried out using gas chromatography-mass spectrometry. A total of 59 components representing 89.13 and 88.6%, respectively, of their total volatile fraction contents were analyzed. Of these volatiles, 26 compounds with concentrations greater than (0.1± 0.02%) have been used for statistical comparison. A number of 21of these compounds were identified, in different concentrations, in the leaves volatile fraction of both healthy plants and plants attacked by the wasps. The other 5 volatiles: p-mentha-2-4(8) diene, δ-elemene, β-elemene, E-caryophyllene and bicyclogermacrene, were exclusively found in the volatile fraction of the attacked leaves. The newly produced compounds in the attacked leaves or the change in concentration of those commonly found in that fraction, could be part of the plant defense mechanisms, or/and an element of the plant allelopathic and communication mechanisms. Identifying the components of the gall wasp-damaged leaves can help in their recycling for different physiological, pharmacological and medicinal uses. \u0000 \u0000 Key words: Eucalyptus, gall wasp, plant defense mechanisms, plant recycling, terpene fraction.","PeriodicalId":16801,"journal":{"name":"Journal of Pharmacognosy and Phytotherapy","volume":"26 1","pages":"90-98"},"PeriodicalIF":0.0,"publicationDate":"2016-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78200156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Study of chemical composition of Foeniculum vulgare using Fourier transform infrared spectrophotometer and gas chromatography - mass spectrometry 傅里叶变换红外分光光度计和气相色谱-质谱联用技术研究小茴香的化学成分

Journal of Pharmacognosy and Phytotherapy Pub Date : 2016-03-31 DOI: 10.5897/JPP2015.0372

Hussein J. Hussein, M. Hadi, I. Hameed

引用次数: 67

Phytochemical screening of methanolic dried galls extract of Quercus infectoria using gas chromatography-mass spectrometry (GC-MS) and Fourier transform-infrared (FT-IR) 气相色谱-质谱联用-傅里叶变换-红外(FT-IR)技术筛选感染栎甲醇干瘿提取物

Journal of Pharmacognosy and Phytotherapy Pub Date : 2016-03-31 DOI: 10.5897/JPP2015.0368

A. Hussein, G. Mohammed, M. Hadi, I. Hameed

{"title":"Phytochemical screening of methanolic dried galls extract of Quercus infectoria using gas chromatography-mass spectrometry (GC-MS) and Fourier transform-infrared (FT-IR)","authors":"A. Hussein, G. Mohammed, M. Hadi, I. Hameed","doi":"10.5897/JPP2015.0368","DOIUrl":"https://doi.org/10.5897/JPP2015.0368","url":null,"abstract":"The main objective of this study was to determine the phytochemical composition from the dried galls of Quercus infectoria, using methanolic extraction and report the main functional components by using infrared (IR) technique. The phytochemical compound screened by gas chromatography-mass spectrometry (GC-MS) method. Twelve bioactive phytochemical compounds were identified in the methanolic extract of Q. infectoria. The identification of phytochemical compounds is based on the peak area, retention time molecular weight, and molecular formula. GC-MS analysis of Q. infectoria revealed the existence of the Cis-p-mentha -1(7),8-dien-2-ol, 3-Nonynoic acid, Urea, N,N´-bis(2-hydroxyethyl)-, 3-Trifluoroacetoxypentadecane, Pterin -6-carboxylic acid, 2,2-Difluoroheptacosanoic acid, y-Sitosterol, Spirost-8-en-11-one, 3-hydroxy-, (3s,5α,14s,20s,22s,25R)-, Curan,16,17-didehydro-,(20xi.)-, 17.alfa.21s-28,30-Bisnorhopane, Ethyl iso-allocholate, Milbemycin B,6,28-anhydro-15-chloro-25-isopropyl-13-dehydro-5-. The Fourier transform-infrared (FTIR) analysis of Q. infectoria proved the presence of alkenes, aliphatic fluoro compounds, nitro compounds, alkanes, hydrogen bonded alcohols, and phenols. \u0000 \u0000 Key words: Quercus infectoria, Fourier transform-infrared (FT-IR), gas chromatography-mass spectrometry (GC-MS) analysis, phytochemicals.","PeriodicalId":16801,"journal":{"name":"Journal of Pharmacognosy and Phytotherapy","volume":"35 1","pages":"49-59"},"PeriodicalIF":0.0,"publicationDate":"2016-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84684293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58

Determination of metabolites products by Cassia angustifolia and evaluate antimicobial activity 决明子代谢产物的测定及抑菌活性评价

Journal of Pharmacognosy and Phytotherapy Pub Date : 2016-02-29 DOI: 10.5897/JPP2015.0367

A. Al-Marzoqi, M. Hadi, I. Hameed

{"title":"Determination of metabolites products by Cassia angustifolia and evaluate antimicobial activity","authors":"A. Al-Marzoqi, M. Hadi, I. Hameed","doi":"10.5897/JPP2015.0367","DOIUrl":"https://doi.org/10.5897/JPP2015.0367","url":null,"abstract":"Phytochemicals are chemical compounds often referred to as secondary metabolites. Forty four bioactive phytochemical compounds were identified in the methanolic leaves extract of Cassia angustifolia. The identification of phytochemical compounds is based on the peak area, retention time molecular weight and molecular formula. Gas chromatography-mass spectrometry (GC-MS) analysis of C. angustifolia revealed the existence of the 2,5-dimethyl-4-hydroxy-3(2H)-furanon, 2-propyl-tetrahydropyran-3-ol, estragole, benzene, 1-ethynyl-4-fluoro-, 5-hydroxymethylfurfural, anethole, 7-oxabicyclo[4.1.0]heptan-2-one,6-methyl-3-(1-methylethyl)-, 2-methoxy-4-vinylphenol, 1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid, E-9-tetradecenoic acid, caryophyllene, cholestan-3-ol,2-methylene-, (3s,5α)-, Benzene, 1-(1,5-dimethyl-4-hexenyl)-4-methyl-, s-curcumene, 7-epi-cis-sesquisabinene hydrate, Cyclohexene, 3-(1,5-dimethyl-4-hexenyl)-6-methylene-,[S-(R*,S*)]-m, octahydrobenzo[b]pyran, 4a-acetoxy-5,5,8a,-trimethyl, dodecanoic acid, 3-hydroxy, tetraacetyl-d-xylonic nitrile, 1-ethenyl 3, trans(1,1-dimethylethyl)-4,cis-methoxycyclohexan-1-ol, phen-1,4-diol,2,3-dimethyl-5-trifluoromethyl, 5-benzofuranacetic acid, 6-ethenyl-2,4,5,6,7,7a-hexahydro-3,6-dime, 5-benzofuranacetic acid, 6-ethenyl-2,4,5,6,7,7a-hexahydro-3,6-dime, phytol, acetate, desulphosiniqrin, oxiraneundecanoic acid, 3-pentyl-,methyl ester, cis,Phytol, 9,12,15-Octadecatrienoic acid, 2-phenyl-1,3-dioxan-5-yl ester, butanoic acid, 1a,2,5,5a,6,9,10,10a-octahydro-5,5adihydroxy-4-(h), 9-Octadecenoic acid, 1,2,3-propanetriyl ester, (E,E,E) and Diisooctyl phthalate. C. angustifolia was highly active against Aspergillus terreus (6.01±0.27). \u0000 \u0000 Key words: Antifungal, gas chromatography-mass spectrometry, fourier-transform infrared spectroscopy, phytochemicals, Cassia angustifolia.","PeriodicalId":16801,"journal":{"name":"Journal of Pharmacognosy and Phytotherapy","volume":"83 1","pages":"25-48"},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75910592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 70

Analysis of bioactive chemical compounds of Nigella sativa using gas chromatography-mass spectrometry 气相色谱-质谱联用分析黑草的生物活性成分

Journal of Pharmacognosy and Phytotherapy Pub Date : 2016-02-29 DOI: 10.5897/JPP2015.0364

M. Hadi, G. Mohammed, I. Hameed

{"title":"Analysis of bioactive chemical compounds of Nigella sativa using gas chromatography-mass spectrometry","authors":"M. Hadi, G. Mohammed, I. Hameed","doi":"10.5897/JPP2015.0364","DOIUrl":"https://doi.org/10.5897/JPP2015.0364","url":null,"abstract":"Phytochemicals are chemical compounds often referred to as secondary metabolites. Twenty eight bioactive phytochemical compounds were identified in the methanolic extract of Nigella sativa. The identification of phytochemical compounds is based on the peak area, retention time molecular weight, and molecular formula. Gas chromatography-mass spectrometry (GC-MS) analysis of Nigella sativa revealed the existence of the s-Pinene, D-Glucose, 6-O-α-Dgalactopyranosyl, O-Cymene, DL-Arabinose, Trans-4-methoxy thujane, 2-Propyl-tetrahydropyran-3-ol, Terpinen-4-ol, α- D-Glucopyranoside, O-α-D-glucopyranosyl-(1.fwdarw.3)-s-D-fruc, Thymoquinone, 2-Isopropylidene-5-methylhex-4-enal, Limonen-6-ol, pivalate, Longifolene, 2-(4-Nitrobutyryl)cyclooctanone, s-Bisabolene, 1,1-Diphenyl-4-phenylthiobut-3-en-1-ol, Phenol, 4-methoxy-2,3,6-trimethyl, Pyrrolidin-2-one-3s-(propanoic acid, methyl ester),5-methylene-4α, Cholestan-3-ol, 2-methylene-,(3s,5α), l-(+)-Ascorbic acid 2,6-dihexadecanoate, 9,12-Octadecadienoic acid (Z,Z)-, methyl ester, 1-Heptatriacotanol, 10,13-Eicosadienoic acid, methyl ester, E,E,Z-1,3,12-Nonadecatriene-5,14-diol, 9-Octadecenamide,(Z), 2H-Benzo[f]oxireno[2,3-E]benzofuran-8(9H)-one,9-[2-(dimethylar, Phthalic acid, decyl oct-3-yl ester, 1,2-Benzenedicarboxylic acid, bis(8-methylnonyl) ester and Stiqmasterol. \u0000 \u0000 Key words: Gas chromatography-mass spectrometry, Fourier-transform infrared spectroscopy, Nigella sativa, phytochemicals.","PeriodicalId":16801,"journal":{"name":"Journal of Pharmacognosy and Phytotherapy","volume":"124 1","pages":"8-24"},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73535462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 122