Journal of Pharmacology and Experimental Therapeutics最新文献

{"title":"Corrigendum to \"Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment Ameliorate Acetaminophen-Induced Liver Injury in Mice via Central Cholinergic System Regulation\" [The Journal of Pharmacology and Experimental Therapeutics 359 (2016) 374-382].","authors":"Jianqiao Zhang, Leiming Zhang, Xue Sun, Yanting Yang, Liang Kong, Chengwen Lu, Guangyao Lv, Tian Wang, Hongbo Wang, Fenghua Fu","doi":"10.1016/j.jpet.2025.103699","DOIUrl":"https://doi.org/10.1016/j.jpet.2025.103699","url":null,"abstract":"","PeriodicalId":16798,"journal":{"name":"Journal of Pharmacology and Experimental Therapeutics","volume":"392 10","pages":"103699"},"PeriodicalIF":3.8,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of flavorants on nicotine vapor self-administration in adolescent mice: Cherry on top?","authors":"Kendra M Loedige, Jibran Y Khokhar","doi":"10.1016/j.jpet.2025.103700","DOIUrl":"https://doi.org/10.1016/j.jpet.2025.103700","url":null,"abstract":"","PeriodicalId":16798,"journal":{"name":"Journal of Pharmacology and Experimental Therapeutics","volume":"392 10","pages":"103700"},"PeriodicalIF":3.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clot formation: Novel regulators, drugs, and targets.","authors":"Jeremy P Wood, Fadi T Khasawneh","doi":"10.1016/j.jpet.2025.103707","DOIUrl":"https://doi.org/10.1016/j.jpet.2025.103707","url":null,"abstract":"","PeriodicalId":16798,"journal":{"name":"Journal of Pharmacology and Experimental Therapeutics","volume":"392 10","pages":"103707"},"PeriodicalIF":3.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xylazine and fentanyl: A potent concoction for cardiorespiratory collapse.","authors":"Nathan A Baertsch","doi":"10.1016/j.jpet.2025.103701","DOIUrl":"https://doi.org/10.1016/j.jpet.2025.103701","url":null,"abstract":"","PeriodicalId":16798,"journal":{"name":"Journal of Pharmacology and Experimental Therapeutics","volume":"392 10","pages":"103701"},"PeriodicalIF":3.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"γ-Secretase modulation and plaque regression in Alzheimer's disease.","authors":"Shampa Ghosh, Rakesh Bhaskar, Krishna Kumar Singh, Jitendra Kumar Sinha","doi":"10.1016/j.jpet.2025.103687","DOIUrl":"https://doi.org/10.1016/j.jpet.2025.103687","url":null,"abstract":"","PeriodicalId":16798,"journal":{"name":"Journal of Pharmacology and Experimental Therapeutics","volume":"392 10","pages":"103687"},"PeriodicalIF":3.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor on \"γ-Secretase modulation and plaque regression in Alzheimer's disease\".","authors":"Gunnar Nordvall, Ping Yan, Lotta Agholme, Johan Lundkvist, Johan Sandin, Henrik Biverstål, Bengt Winblad, Henrik Zetterberg, Rebecka Klintenberg, Mats Ferm, John R Cirrito, Jin-Moo Lee","doi":"10.1016/j.jpet.2025.103688","DOIUrl":"https://doi.org/10.1016/j.jpet.2025.103688","url":null,"abstract":"","PeriodicalId":16798,"journal":{"name":"Journal of Pharmacology and Experimental Therapeutics","volume":"392 10","pages":"103688"},"PeriodicalIF":3.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liking isn't enough: You got to want it.","authors":"Daniele Piomelli","doi":"10.1016/j.jpet.2025.103685","DOIUrl":"https://doi.org/10.1016/j.jpet.2025.103685","url":null,"abstract":"","PeriodicalId":16798,"journal":{"name":"Journal of Pharmacology and Experimental Therapeutics","volume":"392 10","pages":"103685"},"PeriodicalIF":3.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Pharmacology: A new article type for The Journal of Pharmacology and Experimental Therapeutics.","authors":"Giorgio Minotti, Beverley Greenwood-Van Meerveld","doi":"10.1016/j.jpet.2025.103686","DOIUrl":"https://doi.org/10.1016/j.jpet.2025.103686","url":null,"abstract":"","PeriodicalId":16798,"journal":{"name":"Journal of Pharmacology and Experimental Therapeutics","volume":"392 10","pages":"103686"},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise is required to maintain unacylated ghrelin response in adult male rat skeletal muscle, regardless of dietary fat consumption.","authors":"Nicole M Notaro, Joshua M Budd, Liam A Green, Brielle R Caruso, David J Dyck","doi":"10.1016/j.jpet.2025.103712","DOIUrl":"https://doi.org/10.1016/j.jpet.2025.103712","url":null,"abstract":"<p><p>Unacylated ghrelin (unAG) stimulates fatty acid oxidation (FAO) in isolated male rat skeletal muscle. However, 6 weeks of high-fat feeding results in \"ghrelin resistance,\" or loss of this effect. Recent work has indicated that sedentary behavior may be a main contributor to the loss of skeletal muscle unAG response, potentially representing an early disruption in lipid metabolism in the development of metabolic disease. Therefore, the objective of this study was to investigate whether exercise is required to maintain the stimulatory effect of unAG on FAO in skeletal muscle and if the exercise intensity needed is dependent on dietary fat intake. Male rats were fed either a low- or high-fat diet for 6 weeks while remaining sedentary, or performing low- or high-intensity exercise. Soleus muscle strips were isolated and assessed for their ability to respond to unAG by increasing FAO. High-intensity exercise preserved unAG response under both low-fat and high-fat dietary conditions, an effect not observed in sedentary or low-exercise groups. Additional soleus muscle strips were collected from all groups to assess the activation of the AMP-activated protein kinase-acetyl-CoA carboxylase axis and Ca2+ signaling in response to unAG; however, these pathways were not found to be significantly activated. Exercise also increased corticotropin-releasing factor 2 receptor content, the putative receptor through which unAG signals in skeletal muscle, whereas high-fat feeding had an overall effect to reduce it. However, unAG treatment did not activate cAMP/protein kinase A signaling. These findings demonstrate a protective role of exercise in maintaining skeletal muscle unAG response, although mechanisms remain to be fully elucidated. SIGNIFICANCE STATEMENT: Unacylated ghrelin stimulates fatty acid oxidation and protects insulin response in skeletal muscle; this response is lost with physical inactivity. We demonstrate that high-intensity exercise preserves this response, potentially due to changes in corticotropin-releasing factor 2 receptor content.</p>","PeriodicalId":16798,"journal":{"name":"Journal of Pharmacology and Experimental Therapeutics","volume":"392 10","pages":"103712"},"PeriodicalIF":3.8,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dependence of psychopharmacological drug effects on early social stress experience: An analysis aligned with the research domain criteria framework.","authors":"Margarita Moreno-Montoya, Elena Martín-González, Jeffrey W Dalley","doi":"10.1016/j.jpet.2025.103710","DOIUrl":"https://doi.org/10.1016/j.jpet.2025.103710","url":null,"abstract":"<p><p>Early life stress (ELS) refers to maltreatment, deprivation, and other traumatic events experienced early in life. This form of uncontrollable stress is widely acknowledged to cause long-term maladaptive changes in the developing nervous system, resulting in an increased risk for affective mood disorders with lasting impacts on mnemonic and other cognitive functions. ELS is often investigated in mice and rats by presenting stressors either during the perinatal period, repeatedly separating offspring from maternal care prior to the start of adolescence, or interventions involving maternal neglect. As discussed in this article, early social and environmental variables have profound and persistent effects on brain neurochemistry, which subsequently affect the pharmacological actions of psychoactive drugs, often in a sexually dimorphic manner. We first review the behavioral and neurochemical effects of ELS in rodents within the context of the research domain criteria framework, with a specific focus on different ELS protocols. We then discuss how ELS affects the pharmacological actions of psychoactive drugs that primarily target the brain monoaminergic, glutamatergic, and endocannabinoid systems. Our analysis demonstrates that ELS is a powerful modulator of neuropsychiatric drug action with implications for therapeutic efficacy in a range of affective and cognitive disorders in humans. SIGNIFICANCE STATEMENT: This review provides a comprehensive survey of salient research findings on the behavioral and neurochemical effects of early life stress (ELS) in experimental animals. Our analysis is informed with reference to the research domain criteria framework to evaluate the broader impacts of ELS on mental health. In addition, we discuss the effects of neuropharmacological agents to prevent or reverse the effects of ELS in adulthood.</p>","PeriodicalId":16798,"journal":{"name":"Journal of Pharmacology and Experimental Therapeutics","volume":"392 10","pages":"103710"},"PeriodicalIF":3.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}