Journal of Physiological Anthropology最新文献

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Epidemiology of the association between serum 25-hydroxyvitamin D levels and musculoskeletal conditions among elderly individuals: a literature review. 老年人血清25-羟基维生素D水平与肌肉骨骼状况之间关系的流行病学研究:文献综述
IF 3.1 4区 医学
Journal of Physiological Anthropology Pub Date : 2020-11-26 DOI: 10.1186/s40101-020-00249-3
Kazuhiko Arima, Satoshi Mizukami, Takayuki Nishimura, Yoshihito Tomita, Hiroki Nakashima, Yasuyo Abe, Kiyoshi Aoyagi
{"title":"Epidemiology of the association between serum 25-hydroxyvitamin D levels and musculoskeletal conditions among elderly individuals: a literature review.","authors":"Kazuhiko Arima,&nbsp;Satoshi Mizukami,&nbsp;Takayuki Nishimura,&nbsp;Yoshihito Tomita,&nbsp;Hiroki Nakashima,&nbsp;Yasuyo Abe,&nbsp;Kiyoshi Aoyagi","doi":"10.1186/s40101-020-00249-3","DOIUrl":"https://doi.org/10.1186/s40101-020-00249-3","url":null,"abstract":"<p><strong>Background: </strong>Vitamin D deficiency is associated with osteoporosis, fracture, muscle weakness, falls, and osteoarthritis in adults. Elderly individuals are more likely to present with poor musculoskeletal conditions. Recently, several epidemiological studies have assessed the correlation between serum 25-hydroxyvitamin D (25(OH)D) levels and musculoskeletal conditions in elderly individuals.</p><p><strong>Main text: </strong>Osteoporosis is a skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Numerous studies have shown a positive association between serum 25(OH)D levels and bone mineral density. Only a few studies have reported an association between serum 25(OH)D levels and quantitative ultrasound (QUS) parameters. Low serum 25(OH)D level may be a risk factor for hip fracture. However, data on the association between vitamin D deficiency and the incidence of non-hip fracture are contrasting. Falls are a major cause of mortality and morbidity in older adults. Several prospective population-based cohort studies have shown that low 25(OH)D levels are associated with an increased risk of falls. Reduced muscle strength and physical performance are risk factors for adverse events, including disability, institutionalization, and mortality. The role of vitamin D in musculoskeletal functionality (muscle weakness and physical performance) among elderly individuals is still controversial. Osteoarthritis (OA) is the most common form of arthritis and is a leading cause of disability among older adults. Data on the association between serum 25(OH)D levels and OA are contrasting.</p><p><strong>Conclusion: </strong>Some studies have shown that vitamin D deficiency may be a risk factor for poor musculoskeletal conditions, such as osteoporosis, fracture, muscle weakness, falls, and osteoarthritis in adults. However, other studies did not find an association between serum 25(OH)D levels and musculoskeletal conditions.</p>","PeriodicalId":16768,"journal":{"name":"Journal of Physiological Anthropology","volume":"39 1","pages":"38"},"PeriodicalIF":3.1,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40101-020-00249-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38309056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Malaria elimination in Malaysia and the rising threat of Plasmodium knowlesi. 马来西亚消除疟疾和不断上升的诺氏疟原虫威胁。
IF 3.1 4区 医学
Journal of Physiological Anthropology Pub Date : 2020-11-23 DOI: 10.1186/s40101-020-00247-5
Abraham Zefong Chin, Marilyn Charlene Montini Maluda, Jenarun Jelip, Muhammad Saffree Bin Jeffree, Richard Culleton, Kamruddin Ahmed
{"title":"Malaria elimination in Malaysia and the rising threat of Plasmodium knowlesi.","authors":"Abraham Zefong Chin,&nbsp;Marilyn Charlene Montini Maluda,&nbsp;Jenarun Jelip,&nbsp;Muhammad Saffree Bin Jeffree,&nbsp;Richard Culleton,&nbsp;Kamruddin Ahmed","doi":"10.1186/s40101-020-00247-5","DOIUrl":"https://doi.org/10.1186/s40101-020-00247-5","url":null,"abstract":"<p><strong>Background: </strong>Malaria is a major public-health problem, with over 40% of the world's population (more than 3.3 billion people) at risk from the disease. Malaysia has committed to eliminate indigenous human malaria transmission by 2020. The objective of this descriptive study is to understand the epidemiology of malaria in Malaysia from 2000 through 2018 and to highlight the threat posed by zoonotic malaria to the National Malaria Elimination Strategic Plan.</p><p><strong>Methods: </strong>Malaria is a notifiable infection in Malaysia. The data used in this study were extracted from the Disease Control Division, Ministry of Health Malaysia, contributed by the hospitals and health clinics throughout Malaysia. The population data used in this study was extracted from the Department of Statistics Malaysia. Data analyses were performed using Microsoft Excel. Data used for mapping are available at EPSG:4326 WGS84 CRS (Coordinate Reference System). Shapefile was obtained from igismap. Mapping and plotting of the map were performed using QGIS.</p><p><strong>Results: </strong>Between 2000 and 2007, human malaria contributed 100% of reported malaria and 18-46 deaths per year in Malaysia. Between 2008 and 2017, indigenous malaria cases decreased from 6071 to 85 (98.6% reduction), while during the same period, zoonotic Plasmodium knowlesi cases increased from 376 to 3614 cases (an 861% increase). The year 2018 marked the first year that Malaysia did not report any indigenous cases of malaria caused by human malaria parasites. However, there was an increasing trend of P. knowlesi cases, with a total of 4131 cases reported in that year. Although the increased incidence of P. knowlesi cases can be attributed to various factors including improved diagnostic capacity, reduction in human malaria cases, and increase in awareness of P. knowlesi, more than 50% of P. knowlesi cases were associated with agriculture and plantation activities, with a large remainder proportion linked to forest-related activities.</p><p><strong>Conclusions: </strong>Malaysia has entered the elimination phase of malaria control. Zoonotic malaria, however, is increasing exponentially and becoming a significant public health problem. Improved inter-sectoral collaboration is required in order to develop a more integrated effort to control zoonotic malaria. Local political commitment and the provision of technical support from the World Health Organization will help to create focused and concerted efforts towards ensuring the success of the National Malaria Elimination Strategic Plan.</p>","PeriodicalId":16768,"journal":{"name":"Journal of Physiological Anthropology","volume":"39 1","pages":"36"},"PeriodicalIF":3.1,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40101-020-00247-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38737669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 53
Low-frequency oscillations of finger skin blood flow during the initial stage of cold-induced vasodilation at different air temperatures. 不同气温下冷致血管舒张初期手指皮肤血流的低频振荡。
IF 3.1 4区 医学
Journal of Physiological Anthropology Pub Date : 2020-11-23 DOI: 10.1186/s40101-020-00248-4
Toshihiro Sera, Taiki Kohno, Yusuke Nakashima, Musashi Uesugi, Susumu Kudo
{"title":"Low-frequency oscillations of finger skin blood flow during the initial stage of cold-induced vasodilation at different air temperatures.","authors":"Toshihiro Sera,&nbsp;Taiki Kohno,&nbsp;Yusuke Nakashima,&nbsp;Musashi Uesugi,&nbsp;Susumu Kudo","doi":"10.1186/s40101-020-00248-4","DOIUrl":"https://doi.org/10.1186/s40101-020-00248-4","url":null,"abstract":"<p><strong>Background: </strong>Cold-induced vasodilation (CIVD) is known to be influenced by the ambient temperature. Frequency analysis of blood flow provides information on physiological regulation of the cardiovascular system, such as myogenic, neurogenic, endothelial nitric oxide (NO) dependent, and NO-independent activities. In this study, we hypothesized that the major origin of CIVD occurs prior to the CIVD event and investigated finger skin blood flow during the initial stage of CIVD at different ambient temperatures using frequency analysis.</p><p><strong>Methods: </strong>Eighteen healthy volunteers immersed their fingers in 5 °C water at air temperatures of 20 °C and 25 °C. Finger skin blood flow was measured using laser Doppler flowmetry and analyzed using Morlet mother wavelet. We defined the time when the rate of blood flow increased dramatically as the onset of CIVD, and defined three phases as the periods from the onset of cooling to minimum blood flow (vasoconstriction), from minimum blood flow to the onset of CIVD (prior to CIVD), and from the onset of CIVD to maximum blood flow (CIVD).</p><p><strong>Results: </strong>The increment ratio of blood flow at CIVD was significantly higher at 20 °C air temperature. In particular, at 20 °C air temperature, arteriovenous anastomoses (AVAs) might be closed at baseline, as finger skin temperature was much lower than at 25 °C air temperature, and endothelial NO-independent activity was significantly higher and neurogenic activity significantly lower during vasoconstriction than at baseline. Additionally, the differences in both activities between vasoconstriction and prior to CIVD were significant. On the other hand, there were no significant differences in endothelial NO-dependent activity between baseline and all phases at both air temperatures.</p><p><strong>Conclusions: </strong>Our results indicated that the increase of endothelial NO-independent activity and the decrease of neurogenic activity may contribute to the high increment ratio of blood flow at CIVD at 20 °C air temperature.</p>","PeriodicalId":16768,"journal":{"name":"Journal of Physiological Anthropology","volume":"39 1","pages":"37"},"PeriodicalIF":3.1,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40101-020-00248-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38737672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Effect on autonomic nervous activity of applying hot towels for 10 s to the back during bed baths. 在床上洗澡时用热毛巾敷背部 10 秒钟对自律神经活动的影响。
IF 3.1 4区 医学
Journal of Physiological Anthropology Pub Date : 2020-11-19 DOI: 10.1186/s40101-020-00245-7
Inaho Shishido, Issei Konya, Rika Yano
{"title":"Effect on autonomic nervous activity of applying hot towels for 10 s to the back during bed baths.","authors":"Inaho Shishido, Issei Konya, Rika Yano","doi":"10.1186/s40101-020-00245-7","DOIUrl":"10.1186/s40101-020-00245-7","url":null,"abstract":"<p><strong>Background: </strong>Bed baths are a daily nursing activity to maintain patients' hygiene. Those may provide not only comfort but also relaxation. Notably, applying a hot towel to the skin for 10 s (AHT10s) during bed baths helped to reduce the risk of skin tears and provided comfort and warmth in previous studies. However, it is still unclear whether autonomic nervous system is affected by bed baths. Thus, this study investigated the effect on the autonomic nervous activity of applying hot towels for 10 s to the back during bed baths.</p><p><strong>Methods: </strong>This crossover study had 50 participants (25 men and women each; average age 22.2 ± 1.6 years; average body mass index 21.4 ± 2.2 kg/m<sup>2</sup>) who took bed baths with and without (control condition: CON) AHT10s on their back. Skin temperature, heart rate variability (HRV), and blood pressure (BP) were measured. Subjective evaluations and the State-Trait Anxiety Inventory in Japanese were also performed.</p><p><strong>Results: </strong>A significant interaction of time and bed bath type on skin surface temperature was observed (p < .001). Regarding the means of skin surface temperature at each measurement time point, those for AHT10s were significantly higher than those for CON. Although the total state-anxiety score significantly decreased in both the bed bath types after intervention, the mean values of comfort and warmth were higher for bed baths with AHT10s than for CON (p < .05) during bed baths; AHT10s was significantly higher in warmth than CON after 15 min (p = .032). The interaction and main effects of time on HRV and BP and that of bed bath type were not significant.</p><p><strong>Conclusion: </strong>Bed baths that involved AHT10s caused participants to maintain a higher skin temperature and warmer feeling than under the wiping-only condition; they also provided comfort during the interventions. However, the bed baths with AHT10s did not allow participants to reach a relaxed state; moreover, there was no change in autonomic nerve activity. This may be due to participants' increased anxiety from skin exposure and the intervention being limited to one part of the body.</p>","PeriodicalId":16768,"journal":{"name":"Journal of Physiological Anthropology","volume":"39 1","pages":"35"},"PeriodicalIF":3.1,"publicationDate":"2020-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38623300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the nutritional status of rural children living in Zambia. 对赞比亚农村儿童营养状况的评价。
IF 3.1 4区 医学
Journal of Physiological Anthropology Pub Date : 2020-11-16 DOI: 10.1186/s40101-020-00244-8
Arimi Mitsunaga, Taro Yamauchi
{"title":"Evaluation of the nutritional status of rural children living in Zambia.","authors":"Arimi Mitsunaga,&nbsp;Taro Yamauchi","doi":"10.1186/s40101-020-00244-8","DOIUrl":"https://doi.org/10.1186/s40101-020-00244-8","url":null,"abstract":"<p><strong>Background: </strong>Growth references (growth charts) are used to assess the nutritional and growth status of children. In developed countries, there are growth charts based on the country's national surveys. However, many developing countries do not have their own growth references, so they usually use WHO and US CDC references. In such cases, it is known that the growth statuses of the subject are underestimated or overestimated. This study sought to accurately assess the growth status of children by developing a local growth chart for children living in the Southern Province of Zambia.</p><p><strong>Methods: </strong>Anthropometric measurements were conducted on 1135 children aged 2-19 years in the target area. The height and weight data for each sex and age were smoothed using the LMS method, and a percentile curve of height and weight was developed. Based on the US CDC reference, three indicators of undernutrition (stunting, underweight, and thinness) were calculated to determine the proportion of those who are undernourished (z-score < - 2).</p><p><strong>Results: </strong>The 50th percentile curve of height and weight in the growth chart of the target population was equivalent to the 5-25th percentile curve of the US reference, and the children of Zambia were both small and of low weight. Conversely, although many subjects are small and of low weight, it was found that there were few poor nutritional statuses as judged by BMI. Through comparison with a previous study in the Southern Province of Zambia, a secular change in the growth of children over 20 years was found. Although there was no significant increase in height and weight in the older age group, there was a significant increase in height and weight at an earlier age. This is thought to be due to an increase in the growth rate of children due to improved socioeconomic conditions, women's education level, and improvement in health care standards.</p><p><strong>Conclusions: </strong>The subjects were small and of low weight compared to the US population, but the nutritional status was not poor by BMI. The height and weight at an earlier age increased compared to 20 years ago.</p>","PeriodicalId":16768,"journal":{"name":"Journal of Physiological Anthropology","volume":"39 1","pages":"34"},"PeriodicalIF":3.1,"publicationDate":"2020-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40101-020-00244-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38608624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Correction to: Functional dissociation of hippocampal subregions corresponding to memory types and stages. 更正:与记忆类型和阶段相对应的海马亚区功能分离。
IF 3.1 4区 医学
Journal of Physiological Anthropology Pub Date : 2020-10-14 DOI: 10.1186/s40101-020-00243-9
Ji-Woo Seok, Chaejoon Cheong
{"title":"Correction to: Functional dissociation of hippocampal subregions corresponding to memory types and stages.","authors":"Ji-Woo Seok,&nbsp;Chaejoon Cheong","doi":"10.1186/s40101-020-00243-9","DOIUrl":"https://doi.org/10.1186/s40101-020-00243-9","url":null,"abstract":"<p><p>An amendment to this paper has been published and can be accessed via the original article.</p>","PeriodicalId":16768,"journal":{"name":"Journal of Physiological Anthropology","volume":"39 1","pages":"33"},"PeriodicalIF":3.1,"publicationDate":"2020-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40101-020-00243-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38487566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO2) in young Andean highlanders in Bolivia. 玻利维亚安第斯高原青年经皮动脉血氧饱和度(SpO2)血液动力学的个体差异和性别差异。
IF 3.1 4区 医学
Journal of Physiological Anthropology Pub Date : 2020-10-07 DOI: 10.1186/s40101-020-00240-y
Takayuki Nishimura, Juan Ugarte, Mayumi Ohnishi, Mika Nishihara, Guillermo Alvarez, Yoshiki Yasukochi, Hideki Fukuda, Kazuhiko Arima, Shigeki Watanuki, Victor Mendoza, Kiyoshi Aoyagi
{"title":"Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO<sub>2</sub>) in young Andean highlanders in Bolivia.","authors":"Takayuki Nishimura,&nbsp;Juan Ugarte,&nbsp;Mayumi Ohnishi,&nbsp;Mika Nishihara,&nbsp;Guillermo Alvarez,&nbsp;Yoshiki Yasukochi,&nbsp;Hideki Fukuda,&nbsp;Kazuhiko Arima,&nbsp;Shigeki Watanuki,&nbsp;Victor Mendoza,&nbsp;Kiyoshi Aoyagi","doi":"10.1186/s40101-020-00240-y","DOIUrl":"https://doi.org/10.1186/s40101-020-00240-y","url":null,"abstract":"<p><strong>Background: </strong>Many studies have reported specific adaptations to high altitude, but few studies have focused on physiological variations in high-altitude adaptation in Andean highlanders. This study aimed to investigate the relationships between SpO<sub>2</sub> and related factors, including individual variations and sex differences, in Andean highlanders.</p><p><strong>Methods: </strong>The participants were community-dwelling people in La Paz, Bolivia, aged 20 years and over (age range 20-34 years). A total of 50 men and 50 women participated in this study. Height, weight, SpO<sub>2</sub>, hemoglobin concentration, finger temperature, heart rate, and blood pressure were measured. Information about lifestyle was also obtained by interview.</p><p><strong>Results: </strong>There were individual variations of SpO<sub>2</sub> both in men (mean 89.9%, range 84.0-95.0%) and women (mean 91.0%, range 84.0-96.0%). On Student's t test, men had significantly lower heart rate (p = 0.046) and SpO<sub>2</sub> (p = 0.030) than women. On the other hand, men had significantly higher SBP (p < 0.001), hemoglobin (p < 0.001), and finger temperature (p = 0.004). In men, multiple stepwise regression analysis showed that a higher SpO<sub>2</sub> was correlated with a lower heart rate (β = - 0.089, p = 0.007) and a higher finger temperature (β = 0.308, p = 0.030) (r<sup>2</sup> for model = 0.18). In women, a higher SpO<sub>2</sub> was significantly correlated with a higher finger temperature (β = 0.391, p = 0.015) (r<sup>2</sup> for model = 0.12). A higher SpO<sub>2</sub> was related to a higher finger temperature (β = 0.286, p = 0.014) and a lower heart rate (β = - 0.052, p = 0.029) in all participants (r<sup>2</sup> for model = 0.21). Residual analysis showed that individual SpO<sub>2</sub> values were randomly plotted.</p><p><strong>Conclusion: </strong>Random plots of SpO<sub>2</sub> on residual analysis indicated that these variations were random error, such as biological variation. A higher SpO<sub>2</sub> was related to a lower heart rate and finger temperature in men, but a higher SpO<sub>2</sub> was related to finger temperature in women. These results suggest that there are individual variations and sex differences in the hemodynamic responses of high-altitude adaptation in Andean highlanders.</p>","PeriodicalId":16768,"journal":{"name":"Journal of Physiological Anthropology","volume":"39 1","pages":"31"},"PeriodicalIF":3.1,"publicationDate":"2020-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40101-020-00240-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38465186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
NOD-like receptors mediate inflammatory lung injury during plateau hypoxia exposure. nod样受体介导高原缺氧暴露期间的炎性肺损伤。
IF 3.1 4区 医学
Journal of Physiological Anthropology Pub Date : 2020-10-07 DOI: 10.1186/s40101-020-00242-w
Haiyan Wang, Xue Lin, Xiaoyan Pu
{"title":"NOD-like receptors mediate inflammatory lung injury during plateau hypoxia exposure.","authors":"Haiyan Wang,&nbsp;Xue Lin,&nbsp;Xiaoyan Pu","doi":"10.1186/s40101-020-00242-w","DOIUrl":"https://doi.org/10.1186/s40101-020-00242-w","url":null,"abstract":"<p><strong>Background: </strong>The lung is an important target organ for hypoxia treatment, and hypoxia can induce several diseases in the body.</p><p><strong>Methods: </strong>We performed transcriptome sequencing for the lungs of rats exposed to plateau hypoxia at 0 day and 28 days. Sequencing libraries were constructed, and enrichment analysis of the differentially expressed genes (DEGs) was implemented using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, experimental validation was executed by quantitative real-time PCR (qRT-PCR) and western blot.</p><p><strong>Results: </strong>The results showed that the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) signaling pathway that was involved in immunity may play a crucial function in lung injury caused by plateau hypoxia. And the expressions of NOD1, NOD2, IL-1β, TNF-α, IL-6, and IL-18 were higher at 28 days of exposure to plateau hypoxia than that at 0 day. Similarly, CARD9, MYD88, p38 MAPK, and NF-κB p65, which are related to the NF-κB and MAPK signaling pathways, also demonstrated increased expression at 28 days exposure to plateau hypoxia than at 0 day.</p><p><strong>Conclusions: </strong>Our study suggested that the NF-κBp65 and p38 MAPK signaling pathways may be activated in the lungs of rats during plateau hypoxia. Upregulated expression of NF-κBp65 and p38 MAPK can promote the transcription of downstream inflammatory factors, thereby aggravating the occurrence and development of lung tissue remodeling.</p>","PeriodicalId":16768,"journal":{"name":"Journal of Physiological Anthropology","volume":"39 1","pages":"32"},"PeriodicalIF":3.1,"publicationDate":"2020-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40101-020-00242-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38467780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Cardiorespiratory fitness is strongly linked to metabolic syndrome among physical fitness components: a retrospective cross-sectional study. 在身体健康成分中,心肺健康与代谢综合征密切相关:一项回顾性横断面研究。
IF 3.1 4区 医学
Journal of Physiological Anthropology Pub Date : 2020-10-01 DOI: 10.1186/s40101-020-00241-x
Bokun Kim, Minjae Ku, Tanaka Kiyoji, Tomonori Isobe, Takeji Sakae, Sechang Oh
{"title":"Cardiorespiratory fitness is strongly linked to metabolic syndrome among physical fitness components: a retrospective cross-sectional study.","authors":"Bokun Kim,&nbsp;Minjae Ku,&nbsp;Tanaka Kiyoji,&nbsp;Tomonori Isobe,&nbsp;Takeji Sakae,&nbsp;Sechang Oh","doi":"10.1186/s40101-020-00241-x","DOIUrl":"https://doi.org/10.1186/s40101-020-00241-x","url":null,"abstract":"<p><strong>Background: </strong>Maintaining a good level of physical fitness from engaging in regular exercise is important for the treatment and prevention of metabolic syndrome (MetS). However, which components constitutive of physical fitness confer the greatest influence remains controversial. This retrospective cross-sectional study aimed to investigate the association between MetS and physical fitness components including cardiorespiratory fitness, muscle strength, flexibility, and agility and to identify which physical fitness components have the largest influence on MetS.</p><p><strong>Methods: </strong>A total of 168 Japanese adult males aged 25-64 years were allocated into non-MetS, pre-MetS, and MetS groups according to the criteria recommended by the Japanese Society of Internal Medicine. Anthropometric measurement of body composition by whole-body dual-energy X-ray absorptiometry and measures related to MetS, including waist circumference, triglyceride level, high-density lipoprotein cholesterol level, blood pressure, glucose level, and physical fitness components, were assessed. For evaluation of cardiorespiratory fitness, muscle strength, flexibility, agility, and balance, maximal oxygen consumption (VO<sub>2peak</sub>) and oxygen uptake at anaerobic threshold (VO<sub>2AnT</sub>), handgrip strength and vertical jumping, trunk extension and flexion, stepping side to side, and single-leg balance task with the eyes closed were assessed, respectively.</p><p><strong>Results: </strong>A progressive tendency of increasing body weight, body mass index, whole-body lean and fat mass, percentage of whole-body fat mass, trunk lean and fat mass, percentage of trunk fat mass, arm fat mass, waist circumference, triglyceride level, systolic and diastolic blood pressure, and blood glucose level from the non-MetS group to the MetS group was significant (P < 0.05). Conversely, the cardiorespiratory endurance parameters VO<sub>2peak</sub> and VO<sub>2AnT</sub> and the high-density lipoprotein cholesterol level showed a progressively decreasing tendency across the groups (P < 0.01). In addition, a VO<sub>2peak</sub> below 29.84 ml·kg·min<sup>-1</sup> (P = 0.028) and VO2<sub>AnT</sub> below 15.89 ml·kg·min<sup>-1</sup> (P = 0.011) were significant risk components for pre-MetS and MetS. However, there was no significant tendency with respect to muscle strength, agility, and flexibility.</p><p><strong>Conclusion: </strong>Cardiorespiratory fitness is strongly linked to metabolic syndrome among physical fitness components.</p>","PeriodicalId":16768,"journal":{"name":"Journal of Physiological Anthropology","volume":"39 1","pages":"30"},"PeriodicalIF":3.1,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40101-020-00241-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38443060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Implications of human activities for (re)emerging infectious diseases, including COVID-19. 人类活动对(重新)出现的传染病,包括COVID-19的影响。
IF 3.1 4区 医学
Journal of Physiological Anthropology Pub Date : 2020-09-25 DOI: 10.1186/s40101-020-00239-5
Nundu Sabiti Sabin, Akintije Simba Calliope, Shirley Victoria Simpson, Hiroaki Arima, Hiromu Ito, Takayuki Nishimura, Taro Yamamoto
{"title":"Implications of human activities for (re)emerging infectious diseases, including COVID-19.","authors":"Nundu Sabiti Sabin, Akintije Simba Calliope, Shirley Victoria Simpson, Hiroaki Arima, Hiromu Ito, Takayuki Nishimura, Taro Yamamoto","doi":"10.1186/s40101-020-00239-5","DOIUrl":"10.1186/s40101-020-00239-5","url":null,"abstract":"<p><p>Since 1980, the world has been threatened by different waves of emerging disease epidemics. In the twenty-first century, these diseases have become an increasing global concern because of their health and economic impacts in both developed and resource-constrained countries. It is difficult to stop the occurrence of new pathogens in the future due to the interconnection among humans, animals, and the environment. However, it is possible to face a new disease or to reduce the risk of its spread by implementing better early warning systems and effective disease control and prevention, e.g., effective global surveillance, development of technology for better diagnostics, effective treatments, and vaccines, the global political will to respond to any threats and multidisciplinary collaboration involving all sectors in charge of good health maintenance. In this review, we generally describe some factors related to human activities and show how they can play a role in the transmission and spread of infectious diseases by using some diseases as examples. Additionally, we describe and discuss major factors that are facilitating the spread of the new pandemic known as COVID-19 worldwide.</p>","PeriodicalId":16768,"journal":{"name":"Journal of Physiological Anthropology","volume":"39 1","pages":"29"},"PeriodicalIF":3.1,"publicationDate":"2020-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40101-020-00239-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38517567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 40
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