Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO₂) in young Andean highlanders in Bolivia.

IF 3.1 4区医学 Q1 Social Sciences

Journal of Physiological Anthropology Pub Date : 2020-10-07 DOI:10.1186/s40101-020-00240-y

Takayuki Nishimura, Juan Ugarte, Mayumi Ohnishi, Mika Nishihara, Guillermo Alvarez, Yoshiki Yasukochi, Hideki Fukuda, Kazuhiko Arima, Shigeki Watanuki, Victor Mendoza, Kiyoshi Aoyagi

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引用次数: 5

Abstract

Background: Many studies have reported specific adaptations to high altitude, but few studies have focused on physiological variations in high-altitude adaptation in Andean highlanders. This study aimed to investigate the relationships between SpO₂ and related factors, including individual variations and sex differences, in Andean highlanders.

Methods: The participants were community-dwelling people in La Paz, Bolivia, aged 20 years and over (age range 20-34 years). A total of 50 men and 50 women participated in this study. Height, weight, SpO₂, hemoglobin concentration, finger temperature, heart rate, and blood pressure were measured. Information about lifestyle was also obtained by interview.

Results: There were individual variations of SpO₂ both in men (mean 89.9%, range 84.0-95.0%) and women (mean 91.0%, range 84.0-96.0%). On Student's t test, men had significantly lower heart rate (p = 0.046) and SpO₂ (p = 0.030) than women. On the other hand, men had significantly higher SBP (p < 0.001), hemoglobin (p < 0.001), and finger temperature (p = 0.004). In men, multiple stepwise regression analysis showed that a higher SpO₂ was correlated with a lower heart rate (β = - 0.089, p = 0.007) and a higher finger temperature (β = 0.308, p = 0.030) (r² for model = 0.18). In women, a higher SpO₂ was significantly correlated with a higher finger temperature (β = 0.391, p = 0.015) (r² for model = 0.12). A higher SpO₂ was related to a higher finger temperature (β = 0.286, p = 0.014) and a lower heart rate (β = - 0.052, p = 0.029) in all participants (r² for model = 0.21). Residual analysis showed that individual SpO₂ values were randomly plotted.

Conclusion: Random plots of SpO₂ on residual analysis indicated that these variations were random error, such as biological variation. A higher SpO₂ was related to a lower heart rate and finger temperature in men, but a higher SpO₂ was related to finger temperature in women. These results suggest that there are individual variations and sex differences in the hemodynamic responses of high-altitude adaptation in Andean highlanders.

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玻利维亚安第斯高原青年经皮动脉血氧饱和度(SpO2)血液动力学的个体差异和性别差异。

背景:许多研究报道了安第斯高原人对高海拔的特殊适应，但很少有研究关注安第斯高原人对高海拔适应的生理变化。本研究旨在探讨安第斯高原人SpO2与个体差异和性别差异等相关因素的关系。方法:研究对象为玻利维亚拉巴斯市社区居民，年龄在20岁及以上(20 ~ 34岁)。共有50名男性和50名女性参加了这项研究。测量身高、体重、SpO2、血红蛋白浓度、指温、心率和血压。通过访谈获得了生活方式方面的信息。结果:SpO2在男性(平均89.9%，范围84.0 ~ 95.0%)和女性(平均91.0%，范围84.0 ~ 96.0%)中均存在个体差异。在学生t检验中，男性的心率(p = 0.046)和SpO2 (p = 0.030)明显低于女性。另一方面，男性的收缩压(p < 0.001)、血红蛋白(p < 0.001)和手指温度(p = 0.004)均显著升高。在男性中，多元逐步回归分析显示，较高的SpO2与较低的心率(β = - 0.089, p = 0.007)和较高的手指温度(β = 0.308, p = 0.030)相关(模型r2 = 0.18)。在女性中，较高的SpO2与较高的手指温度显著相关(β = 0.391, p = 0.015)(模型r2 = 0.12)。在所有参与者中，较高的SpO2与较高的手指温度(β = 0.286, p = 0.014)和较低的心率(β = - 0.052, p = 0.029)相关(模型r2 = 0.21)。残差分析显示，个体SpO2值是随机绘制的。结论:残差分析的SpO2随机图表明，这些变异属于随机误差，如生物学变异。较高的SpO2与男性较低的心率和手指温度有关，而较高的SpO2与女性手指温度有关。这些结果表明，安第斯高原人的血液动力学反应存在个体差异和性别差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Physiological Anthropology Social Sciences-Human Factors and Ergonomics

CiteScore

4.80

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Physiological Anthropology (JPA) is an open access, peer-reviewed journal that publishes research on the physiological functions of modern mankind, with an emphasis on the physical and bio-cultural effects on human adaptability to the current environment. The objective of JPA is to evaluate physiological adaptations to modern living environments, and to publish research from different scientific fields concerned with environmental impact on human life. Topic areas include, but are not limited to: environmental physiology bio-cultural environment living environment epigenetic adaptation development and growth age and sex differences nutrition and morphology physical fitness and health Journal of Physiological Anthropology is the official journal of the Japan Society of Physiological Anthropology.