Journal of Pharmaceutics and Therapeutics最新文献

The Impact of Family Support on Medication Adherence and Glycemic Control of Type 2 Diabetes Outpatients in a Nigerian Tertiary Hospital 尼日利亚某三级医院家庭支持对2型糖尿病门诊患者服药依从性及血糖控制的影响

Journal of Pharmaceutics and Therapeutics Pub Date : 2019-05-15 DOI: 10.18314/JPT.V5I1.1653

C. Anene-Okeke, M. Adibe, C. Ukwe, C. Aguwa

{"title":"The Impact of Family Support on Medication Adherence and Glycemic Control of Type 2 Diabetes Outpatients in a Nigerian Tertiary Hospital","authors":"C. Anene-Okeke, M. Adibe, C. Ukwe, C. Aguwa","doi":"10.18314/JPT.V5I1.1653","DOIUrl":"https://doi.org/10.18314/JPT.V5I1.1653","url":null,"abstract":"Background: Diabetes management rarely target family support as a means of promoting diabetes self-care behaviour among adults. The potential influence of family member on individuals with Type 2 diabetes has not been fully explored. The study aims to examine the impact of family support on medication adherence and glycemic control of their Type 2 diabetes out-patients in a tertiary hospital.Methods: The study was a prospective cross-sectional survey conducted on Type 2 diabetes out-patients attending endocrinology clinic at the University of Nigeria Teaching Hospital (UNTH) between October 2013 and April 2014. The Diabetes Family Behavioral Checklist (DFBC-13) was used to assess family support while the MMAS-8 (Morisky medication Adherence Scale) was used to assess medication adherence. Fasting blood glucose readings were obtained from patients’ case files.Data were analysed using SPSS (Statistical package for social sciences) version 16 and level of statistical significance set at p<0.05. Result: A total number of 250 patients were assessed. The mean score for family support was 42 of 65 (range 13 to 65). Family support score (diet, glucose, exercise, diabetic self-care) associated with educational status (socio-demographic characteristics) r = 0.171** p = 0.007. Family support was inversely correlated to adherence and glycemic control (-0.161**, P = 0.011, r = -0.098, p = 0.147) respectively. Medication adherence was low as only 1.6% of the respondents adhered to their medication.Conclusion: Family support had little influence on medication adherence and glycemic control.","PeriodicalId":16742,"journal":{"name":"Journal of Pharmaceutics and Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89656659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tacrolimus Pharmacokinetics in Living-Donor and Deceased-Donor Liver Transplant in Saudi Patients 他克莫司在沙特活体和死亡肝移植患者中的药代动力学

Journal of Pharmaceutics and Therapeutics Pub Date : 2019-04-10 DOI: 10.18314/JPT.V5I1.1678

H. Abou-Auda, Eqbal Qaddour, Hussein Alsisi, A. Ajlan, M. Alsebayel

{"title":"Tacrolimus Pharmacokinetics in Living-Donor and Deceased-Donor Liver Transplant in Saudi Patients","authors":"H. Abou-Auda, Eqbal Qaddour, Hussein Alsisi, A. Ajlan, M. Alsebayel","doi":"10.18314/JPT.V5I1.1678","DOIUrl":"https://doi.org/10.18314/JPT.V5I1.1678","url":null,"abstract":"Introduction: Tacrolimus is a macrolide immunosuppressant. It has a narrow therapeutic index and serious side effects which necessitate monitoring of tacrolimus blood concentration. The trough concentration of the drug may also differ based on the type of liver transplant. This study was conducted to investigate differences in pharmacokinetics between transplant types and to determine tacrolimus population pharmacokinetic in liver transplant recipients in Saudi Arabia. \u0000Method: Patients on tacrolimus, as the main immunosuppressant, who underwent liver transplant throughout2012-2014 were retrospectively studied. Demographic characteristic, tacrolimus blood trough concentrations, liver, renal, biochemistry, and hematology lab results were all collected. The pharmacokinetic parameters were estimated assuming one compartment model. \u0000Results: Tacrolimus pharmacokinetic parameters were found to be as following; elimination rate constant () 0.094 ± 0.0123, apparent volume of distribution () 112.48±63.033 L/hr, elimination half-life () 7.46± 1.01 hr and apparent total body clearance () 10.27± 5.69 L/hr (mean ± SD). \u0000Statistically significant difference was found between living-donor and deceased-donor liver transplant with respect to apparent clearance and apparent volume of distribution. Living-donor liver transplant recipients have apparent volume of distribution of 97.39±47.00 L (mean ± SD) and an apparent clearance of 8.89±4.24L/hr (mean± SD). On the other hand, deceased-donor liver transplant has an apparent clearance of 12.97±7.09L/hr (mean ± SD) and an apparent volume of distribution of 142.17± 78.65 L (mean ± SD). \u0000Conclusions: Tacrolimus pharmacokinetics parameters were accurately determined in liver transplant recipients in Saudi Arabia. The results of the present study can be clinically used in the therapeutic drug monitoring of tacrolimus in the individualization of drug dosage and taking the appropriate clinical decisions to prevent allograft rejection.","PeriodicalId":16742,"journal":{"name":"Journal of Pharmaceutics and Therapeutics","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84002100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pharmacological Options for Viral Induced Hemorrhagic Cystitis Management: A Review of the Literature 病毒性出血性膀胱炎治疗的药理学选择:文献综述

Journal of Pharmaceutics and Therapeutics Pub Date : 2019-04-04 DOI: 10.18314/JPT.V5I1.1645

Amber B. Giles, Alyson G Wilder, M. Ritter, A. Wright, S. A. Afeli

{"title":"Pharmacological Options for Viral Induced Hemorrhagic Cystitis Management: A Review of the Literature","authors":"Amber B. Giles, Alyson G Wilder, M. Ritter, A. Wright, S. A. Afeli","doi":"10.18314/JPT.V5I1.1645","DOIUrl":"https://doi.org/10.18314/JPT.V5I1.1645","url":null,"abstract":"Background: Viral induced hemorrhagic cystitis (VIHC) is very common among patients who become immunocompromised following organ transplantation. However, there is neither consensus on the standard of care nor clear guidelines to aid in clinical decision making when treatment VIHC. This review discusses currently available pharmacologic agents, presents investigational drug therapies, and outlines alternative treatment options that could be effective against VIHC.Recent findings: Letermovir is a novel antiviral agent approved for CMV prophylaxis in patients post-hematopoietic stem cell transplantation (HSCT). Although no studies have yet been conducted in patients with VIHC, this new antiviral agent shows promise in preventing emergence of CMV in patients after HSCT. Additionally, newer studies addressing the efficacy of brincidofovir, an experimental drug derived from cidofovir, against CMV infection may provide preliminary evidence for brincidofovir’s role in therapy and therefore warrant further investigation.Conclusion: Polyoma BK virus (BKV), cytomegalovirus (CMV), and adenovirus (ADV) are the primary culprits for HC occurrence in patients undergoing renal transplantation or allogeneic HSCT. CMV-associated HC could be prevented or treated by ganciclovir and valganciclovir because these agents’ effectiveness has been clearly established in other non-HC infections related to CMV. ADV-associated HC could be mitigated by brincidofovir and ribavirin, however the high toxicity associated with these agents may be a limiting factor for their use. BKV-associated HC is best managed by cidofovir and leflunomide, but not by fluoroquinolones. Finally, intravesicular instillation should be preferred in patients who experience toxicities associated with systemic use of antivirals.","PeriodicalId":16742,"journal":{"name":"Journal of Pharmaceutics and Therapeutics","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78825379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Molecularly Structured Ben Oil in Gentamicin Entrapped Lipospheres 分子结构本油在庆大霉素包埋脂球中的应用

Journal of Pharmaceutics and Therapeutics Pub Date : 2019-03-19 DOI: 10.18314/JPT.V5I1.1594

S. Chime, I. V. Onyishi, I. O. Eze

引用次数: 3

Use of Ketamine to Treat Depressive Symptoms in Schizoaffective Disorder 氯胺酮治疗分裂情感性障碍患者抑郁症状

Journal of Pharmaceutics and Therapeutics Pub Date : 2019-03-15 DOI: 10.18314/JPT.V5I1.1602

Isaac G. Freedman, D. Rabin, Prabhneet Pannu, Tariq Bandoo, B. Nandra, I. Wiesman, F. Podbielski

引用次数: 0

Effect of Juglan Regiaon Patients Having Metabolic Syndrome: A Controlled Feeding Trial 核桃地区代谢综合征患者的控制喂养试验

Journal of Pharmaceutics and Therapeutics Pub Date : 2019-03-07 DOI: 10.18314/JPT.V5I1.1581

S. Sikander, M. Imran, Ali Hassan, Fasiha Ahsan, Sana Noreen, M. H. Mughal

{"title":"Effect of Juglan Regiaon Patients Having Metabolic Syndrome: A Controlled Feeding Trial","authors":"S. Sikander, M. Imran, Ali Hassan, Fasiha Ahsan, Sana Noreen, M. H. Mughal","doi":"10.18314/JPT.V5I1.1581","DOIUrl":"https://doi.org/10.18314/JPT.V5I1.1581","url":null,"abstract":"Metabolic syndrome is a cluster of disorders diagnosed simultaneously in an individual. The percentage of individuals affected from this syndrome is escalating around the globe as well as in Pakistan mainly due to more consumption of energy dense foods and sedentary lifestyle. Dietary modification with nutrient dense foods is a globally adapted strategy to reduce the complexity of this issue. This present project has been designed to see the impact of nutrient dense walnuts consumption on selective biomarkers in human subjects. The screening of human subjects was done by taking the anthropometric measurements, lipid profile, blood glucose level and blood pressure whereas the dietary pattern of patients was collected by validated food frequency questionnaire. The proximate analysis of walnuts was also done. Twenty patients were selected and divided into two groups randomly. Experimental group consumed walnuts daily for 8 weeks and placebo group consumed the diet without walnut. Selective physical parameters included BMI was performed at the regular basis whereas, the blood samples were collected at 1st , 4th and 8th week of the study period followed by the evaluation of serum triglyceride and high density lipoprotein cholesterol level. Walnuts were found to be high in fat content i.e 64.6% and also contained all other important nutrients as moisture (3.9%), ash (1.5%), protein (15.3%), fiber (1.5%) and nitrogen free extract (10.7%). Walnuts reduced triglycerides significantly and HDL was also raised significantly. No significant change was observed in BMI. Statistical analysis was employed to draw the conclusive outcomes of the research studies.","PeriodicalId":16742,"journal":{"name":"Journal of Pharmaceutics and Therapeutics","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82011008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Strategies of Quetiapine Fumarate Delivery in Management of Bipolar Disorder and Schizophrenia 富马酸喹硫平治疗双相情感障碍和精神分裂症的当前策略

Journal of Pharmaceutics and Therapeutics Pub Date : 2019-03-07 DOI: 10.18314/JPT.V5I1.1554

D. Patil, Seema V. Pattewar, Sarvesh Paliwal, G. Singh, Swapnil Sharma

引用次数: 0

Formulation Development and Evaluation of Rosuvastatin Sustained Release Tablets 瑞舒伐他汀缓释片的处方开发与评价

Journal of Pharmaceutics and Therapeutics Pub Date : 2019-02-06 DOI: 10.18314/JPT.V5I1.1459

R. Gunda, Prasada Rao Manchineni

{"title":"Formulation Development and Evaluation of Rosuvastatin Sustained Release Tablets","authors":"R. Gunda, Prasada Rao Manchineni","doi":"10.18314/JPT.V5I1.1459","DOIUrl":"https://doi.org/10.18314/JPT.V5I1.1459","url":null,"abstract":"Purpose: The main objective of present research investigation is to formulate the sustained release formulation of Rosuvastatin. Rosuvastatin, an antihyperlipidemic agent, belongs BCS class-II agent.Methods: The SR tablets of Rosuvastatin were prepared employing different concentrations of HPMCK4M and SCMC in different combinations by Direct Compression using 32 factorial design. The concentration of Polymers , HPMCK4M and SCMC required to achieve the desired drug release was selected as independent variables, X1 and X2 respectively whereas, time required for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90% (t90%) were selected as dependent variables.Results and Discussion: Totally nine formulations were designed and are evaluated for hardness, friability, thickness, % drug content, In-vitro drug release. From the Results it was concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept, slope & regression coefficient were calculated. Polynomial equations were developed for dependent variables. Validity of developed polynomial equations were verified by designing 2 check point formulations (C1, C2). According to SUPAC guidelines the formulation (F4) containing 30 mg of HPMCK4M and 40 mg of SCMC, is the most similar formulation (similarity factor f2= 89.561, dissimilarity factor f1= 1.543 & No significant difference, t= 0.0056) to marketed product (CRESTOR).Conclusion: The selected formulation (F4) follows Zero order, Higuchi’s kinetics, and the mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.963).","PeriodicalId":16742,"journal":{"name":"Journal of Pharmaceutics and Therapeutics","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80788676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Case Report on Warfarin Induced Skin Necrosis: Drug-drug Interaction or Inappropriate Therapy 华法林致皮肤坏死1例:药物相互作用或治疗不当

Journal of Pharmaceutics and Therapeutics Pub Date : 2018-11-27 DOI: 10.18314/jpt.v4i1.1445

Dutta S, S. Pk, Misra Ak, Kumar R, Rai S, Chaudhary R

{"title":"A Case Report on Warfarin Induced Skin Necrosis: Drug-drug Interaction or Inappropriate Therapy","authors":"Dutta S, S. Pk, Misra Ak, Kumar R, Rai S, Chaudhary R","doi":"10.18314/jpt.v4i1.1445","DOIUrl":"https://doi.org/10.18314/jpt.v4i1.1445","url":null,"abstract":"Introduction: Warfarin is one of the most frequently prescribed oral anticoagulant. Necrosis and/or gangrene ofskin and other tissues is an uncommon but serious risk associated with warfarin. The incidence of warfarin inducedtissue necrosis is about 0.01 % to 0.1%.Case description: A 62-year-old male presented to emergency with a complaint of skin discoloration and edema onleft lower limb diagnosed as warfarin induced skin necrosis. He had an episode of hemiparesis 20 days back for whichhe was started on oral warfarin along with other medications. On diagnosis warfarin was stopped and fresh frozenplasma (FFP) was given along with vitamin K. Due to progressing tissue necrosis, above knee limb amputation wasdone. We assume that an interaction between rosuvastatin and warfarin or possibly lack of adequate bridge therapywith heparin resulted in this complication.Conclusion: Warfarin induced skin necrosis is a known early complication of the therapy. Though late onsetappearance of this event is rare but not unknown. Bridging therapy with heparin and avoiding use of interactingdrugs concomitantly could prevent many such reactions.","PeriodicalId":16742,"journal":{"name":"Journal of Pharmaceutics and Therapeutics","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76837221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role and Advantageousness of Ketamine in Obese and Non-Obese Patients: Peri-Interventional Considerations 氯胺酮在肥胖和非肥胖患者中的作用和优势:围介入期考虑

Journal of Pharmaceutics and Therapeutics Pub Date : 2018-11-06 DOI: 10.18314/jpt.v4i1.1404

Weinbroum Aa, Amit U

{"title":"Role and Advantageousness of Ketamine in Obese and Non-Obese Patients: Peri-Interventional Considerations","authors":"Weinbroum Aa, Amit U","doi":"10.18314/jpt.v4i1.1404","DOIUrl":"https://doi.org/10.18314/jpt.v4i1.1404","url":null,"abstract":"Obese and morbidly obese patients are a growing group of individuals that generates medical, social and economicproblems worldwide. They undergo various interventions that require anesthesia and/or analgesia. Despite theirhealthy look, these individuals are graded at high ASA physical status, mainly because of their impaired respiratoryand cardiovascular conditions, and the metabolic changes their body undergoes. Opioids are the default drugsfor perioperative analgesia. Nevertheless, their use has reached a frightening epidemic-like condition worldwide.Multimodal analgesia regimens have been recommended as a perioperative standard of care, particularly useful in theobese. These regimens employ combinations of opioids and non-opioid compounds that reciprocate each analgesicpotencies, thus providing superior pain relief at rest, movement, or on effort, while reducing opioid consumption andtheir concerned adverse effects. The most important perioperative IV adjuvant currently employed is ketamine thatsees resurgence among physicians from diverse medical specialties. After summarizing obese patients’ perioperativedrawbacks, this review will illustrate ketamine’s neuropharmacology, and will describe its therapeutic usefulness asan analgesic adjuvant. Since data regarding the use of the drug in obese patients is scarce, brief exemplifications ofits benefits in non-obese cohorts will be portrayed as well.","PeriodicalId":16742,"journal":{"name":"Journal of Pharmaceutics and Therapeutics","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75152158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1