Journal of Personalized Medicine最新文献

{"title":"The Influence of a Specialized Dementia Ward on the Treatment of Alzheimer's Disease Patients.","authors":"Youngsoon Yang, Kyoon Huh, Yong Tae Kwak","doi":"10.3390/jpm15030082","DOIUrl":"https://doi.org/10.3390/jpm15030082","url":null,"abstract":"<p><p><b>Background:</b> Hospitalization for severe neuropsychiatric symptoms in Alzheimer's disease (AD) presents challenges, often requiring environments that ensure safety while addressing therapeutic needs. Traditional closed wards, originally designed for psychiatric conditions like schizophrenia, may not fully address the unique needs of AD patients. This study evaluates the effectiveness of a Specialized Dementia Ward (SDW) tailored for AD patients compared to a General Ward (GW). <b>Methods:</b> A retrospective study compared 51 AD patients in an SDW (February 2018-January 2019) and 40 AD patients in a GW (December 2017-January 2018). Patients met NINCDS-ADRDA criteria, with a Clinical Dementia Rating (CDR) ≤ 2 and a Korean Mini-Mental State Examination (K-MMSE) ≤ 20. Clinical assessments at admission and four weeks included K-MMSE, Resident Assessment Instrument Minimum Data Set Version 2.0 (RAI-MDS), and Neuropsychiatric Inventory Questionnaire (NPI-Q). Psychotropic medication use, length of stay, and discharge destination were also analyzed. <b>Results:</b> No statistically significant differences emerged between SDW and GW groups regarding baseline demographics, cognitive function, ADL, or neuropsychiatric symptoms. At four weeks, both groups exhibited trends toward improved K-MMSE, RAI-MDS, and NPI-Q scores and reduced psychotropic usage, but these did not reach statistical significance. Although mean length of stay was shorter for SDW patients (3.2 vs. 4.9 months; <i>p</i> = 0.078), the difference was not significant. Notably, a significantly higher proportion of SDW patients were discharged home (58.8% vs. 37.5%; <i>p</i> = 0.049). <b>Conclusions:</b> Although clinical outcomes were comparable, the SDW demonstrated advantages in facilitating discharge to home, suggesting that tailored ward environments may better support AD patients. These findings underscore the importance of therapeutic environments in dementia care and highlight the need for further research on specialized dementia ward designs to improve outcomes and patient satisfaction.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Public Knowledge of Precision Medicine and Genomic Research: A Survey in the Aosta Valley.","authors":"Matteo Mongelli, Biagio De Angelis, Valeria Delle Cave, Giuliano Greco, Arianna De Arcangelis, Andrea Bernagozzi, Chiara Salvemini, Matteo Calabrese, Jean Marc Christille, Andrea Cavalli, Stefano Gustincich, Maria Grazia Monaci","doi":"10.3390/jpm15030080","DOIUrl":"https://doi.org/10.3390/jpm15030080","url":null,"abstract":"<p><p><b>Background</b>: Precision medicine (PM) considers the genetic variability of individuals to identify tailored diagnosis and treatments. It relies on the possibility of gathering the widest possible health data and genetic information from individuals to obtain a broad pool of comparative data. To achieve this goal, the Region of Valle d'Aosta, since 2019, has co-financed the research center CMP³VdA, aiming to sequence 5000 genomes of patients with neurodevelopmental, neurodegenerative, oncological, and organ transplantation diseases, and to investigate the genetic variability of the resident population. <b>Methods:</b> This paper presents the results of an online survey of 472 (328F) respondents regarding willingness to participate in the genomic project and awareness, attitudes, and concerns about PM. <b>Results</b>: The main results show that the vast majority (92.6%) would be willing to participate-a higher percentage than in previous studies. Age, education, and prior experience in the healthcare sector are significant factors influencing the awareness of PM. Additionally, subgroups organized by age, gender, and religiosity show significant differences with respect to participants' reasons for participating in research and which types of biological samples they would be willing to donate. <b>Conclusions</b>: Our findings can serve as a guide for stakeholders-particularly policymakers-to target institutional communication and achieve maximum participation in genomic research projects.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obeticholic Acid Improves Cholestasis, Liver Fibrosis, and Liver Function in Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid.","authors":"Matthias Buechter, Paul Manka, Kerem Bulut, Guido Gerken, Alisan Kahraman","doi":"10.3390/jpm15030079","DOIUrl":"https://doi.org/10.3390/jpm15030079","url":null,"abstract":"<p><p><b>Background and Aims:</b> Primary biliary cholangitis (PBC) leads to the slow, progressive destruction of the small bile ducts with consecutive cholestasis and intrahepatic cholangitis. If this disease remains untreated, liver parenchyma will be damaged resulting in fibrosis and end-stage liver disease with the need for transplantation. The approval of the Farnesoid X receptor agonist obeticholic acid (Ocaliva; OCA) in early 2017 expanded the drug therapy options of PBC, which previously consisted primarily of the administration of ursodeoxycholic acid (UDCA). <b>Patients and Methods:</b> Included in our prospective pilot study were 16 patients with a confirmed diagnosis of PBC who were treated with an add-on therapy with OCA (5 mg/d). None of the patients had an overlap to autoimmune hepatitis. Patients were investigated between 09/2022 and 09/2023. <b>Results:</b> The majority of patients was female (15/16, 93.75%), and the mean age was 57.63 ± 9.59 (43-77) years. OCA treatment led to a statistically significant decrease in aspartate aminotransferase (AST; AST baseline: 38.50 [26.25; 50.00] IU/L vs. AST 6-month follow-up: 23.50 [21.50; 44.25] IU/L, <i>p</i> = 0.0012), alanine aminotransferase (ALT; ALT baseline: 55.50 [28.75; 97.00] IU/L vs. ALT 6-month follow-up: 36.50 [28.00; 57.25] IU/L, <i>p</i> = 0.0035), and gamma-glutamyl transferase (GGT; GGT baseline: 168.00 [100.30; 328.50] IU/L vs. GGT 6-month follow-up: 88.00 [44.50; 259.80] IU/L, <i>p</i> = 0.0063), while the decrease in alkaline phosphatase (AP) was not statistically significant (AP baseline: 197.00 [170.00; 253.30] IU/L vs. AP 6-month follow-up: 196.00 [134.00; 227.00] IU/L, <i>p</i> = 0.0915). In addition, liver stiffness measurement (LSM) showed a statistically significant decrease after six months of treatment with OCA (LSM baseline: 7.85 [5.55; 10.13] kPa vs. LSM 6-month follow-up: 5.95 [4.55; 8.225] kPa, <i>p</i> = 0.0001). However, the increase in enzymatic liver function measured by LiMAx failed to reach statistical significance, but showed a positive trend (LiMAx baseline: 402.50 [341.50; 469.80] μg/kg/h vs. LiMAx 6-month follow-up: 452.50 [412.50; 562.00] μg/kg/h, <i>p</i> = 0.0625). In none of our patients did therapy with obeticholic acid have to be stopped due to pruritus or poor tolerability. <b>Conclusions:</b> In patients with PBC without adequate response to UDCA, OCA is a promising alternative, which in our group of 16 patients led to a significant improvement of liver enzymes, the amelioration of liver fibrosis, and an increase in liver function capacity in a short-term clinical course.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trachelectomy and Cerclage Placement as Fertility-Sparing Surgery for Cervical Cancer-An Expert Survey.","authors":"Anke Smits, Janneke T Wolswinkel, Mieke L G Ten Eikelder, Nadeem R Abu-Rustum, Glauco Baiocchi, Jogchum J Beltman, Allan Covens, Karlijn M C Cornel, Henrik Falconer, Christina Fotopoulou, Cornelis G Gerestein, Blanca Gil-Ibanez, Peter Hillemanns, Christhardt Köhler, Ali Kucukmetin, Luc R C W van Lonkhuijzen, Philippe Morice, Joo Hyun Nam, Myriam B Perrotta, Jan Persson, Marie Plante, Denis Querleu, Reitan Ribeiro, Laszlo Ungár, Maaike A P C van Ham, Petra L M Zusterzeel","doi":"10.3390/jpm15030077","DOIUrl":"https://doi.org/10.3390/jpm15030077","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences for cerclage use among expert centers globally regarding FSS in patients with early stage cervical cancer. <b>Methods</b>: We conducted a cross-sectional survey from May to July 2023 involving expert centers identified through their scientific contributions and participation in international workgroups and conferences.. The survey, comprising 27 questions, evaluated existing practices in FSS. <b>Results</b>: Out of the centers surveyed, 21 (36.2%) gynecologic oncologists responded. For tumors <2 cm, 86% of centers preferred radical trachelectomy, primarily via the vaginal approach, while 13.6% favored a simple trachelectomy. Three experts preferred simple trachelectomy (13.6%). For tumors >2 cm, 47.6% utilized neoadjuvant chemotherapy before trachelectomy. Others did not offer FSS or performed an abdominal radical trachelectomy. Over time, there has been a shift towards less radical surgeries for tumors <2 cm and increased use of neoadjuvant chemotherapy for larger tumors. Some abandoned the minimally invasive surgical approach. Nearly all experts (90.5%) placed a cerclage immediately following trachelectomy. <b>Conclusions</b>: The majority of experts opt for radical trachelectomy in early stage cervical cancer, with immediate cerclage placement being a common practice. However, considerable international variations highlight the urgent need for standardized guidelines and further research to optimize treatment strategies, balancing oncological safety with fertility outcomes.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Syndrome Indicators and Cardiovascular/Endocrine Risks in Rural Ecuador: A Cross-Sectional Study.","authors":"Guillermo Fernando León-Samaniego, Holguer Estuardo Romero Urréa, Freddy Espinoza-Carrasco, Mariana de Jesús Llimaico Noriega, Grecia Elizabeth Encalada Campos, Pedro Herrera, Angela Chavez-Cembellin, Marco Faytong-Haro","doi":"10.3390/jpm15030078","DOIUrl":"https://doi.org/10.3390/jpm15030078","url":null,"abstract":"<p><p><b>Background/Objectives:</b> This study assessed the prevalence of metabolic syndrome (MetS) and its association with cardiovascular and endocrine diseases in a rural Ecuadorian parish population. <b>Methods:</b> This cross-sectional study included 200 participants. Descriptive statistics were computed for glucose, total cholesterol, and triglyceride levels. Logistic regression estimated the odds ratios (ORs) for the likelihood of cardiovascular (hypertension, coronary artery disease, stroke) and endocrine diseases (diabetes and other metabolic disorders) in relation to MetS biomarkers. <b>Results:</b> The study included 200 participants, with average glucose (123.09 mg/dL), cholesterol (229.58 mg/dL), and triglycerides (188.75 mg/dL) levels exceeding standard thresholds. Logistic regression analysis showed that glucose was the strongest predictor, increasing cardiovascular disease odds by 6.9% (OR = 1.069, <i>p</i> < 0.001) and endocrine disease odds by 11.8% (OR = 1.118, <i>p</i> < 0.001) after adjustment. Cholesterol and triglycerides also significantly contributed to the risk of both diseases. The models demonstrated a high predictive performance (AUC: 0.933 for cardiovascular disease and 0.993 for endocrine diseases). <b>Conclusions:</b> MetS was significantly associated with cardiovascular and endocrine disease risks in the rural population. Integrating personalized healthcare, such as tailored dietary counseling, culturally adapted interventions, and mobile health technologies, is crucial for improving the early detection and management of MetS in underserved communities.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Methodological Framework for AI-Assisted Diagnosis of Ovarian Masses Using CT and MR Imaging.","authors":"Pratik Adusumilli, Nishant Ravikumar, Geoff Hall, Andrew F Scarsbrook","doi":"10.3390/jpm15020076","DOIUrl":"10.3390/jpm15020076","url":null,"abstract":"<p><p><b>Background:</b> Ovarian cancer encompasses a diverse range of neoplasms originating in the ovaries, fallopian tubes, and peritoneum. Despite being one of the commonest gynaecological malignancies, there are no validated screening strategies for early detection. A diagnosis typically relies on imaging, biomarkers, and multidisciplinary team discussions. The accurate interpretation of CTs and MRIs may be challenging, especially in borderline cases. This study proposes a methodological pipeline to develop and evaluate deep learning (DL) models that can assist in classifying ovarian masses from CT and MRI data, potentially improving diagnostic confidence and patient outcomes. <b>Methods:</b> A multi-institutional retrospective dataset was compiled, supplemented by external data from the Cancer Genome Atlas. Two classification workflows were examined: (1) whole-volume input and (2) lesion-focused region of interest. Multiple DL architectures, including ResNet, DenseNet, transformer-based UNeST, and Attention Multiple-Instance Learning (MIL), were implemented within the PyTorch-based MONAI framework. The class imbalance was mitigated using focal loss, oversampling, and dynamic class weighting. The hyperparameters were optimised with Optuna, and balanced accuracy was the primary metric. <b>Results:</b> For a preliminary dataset, the proposed framework demonstrated feasibility for the multi-class classification of ovarian masses. The initial experiments highlighted the potential of transformers and MIL for identifying the relevant imaging features. <b>Conclusions:</b> A reproducible methodological pipeline for DL-based ovarian mass classification using CT and MRI scans has been established. Future work will leverage a multi-institutional dataset to refine these models, aiming to enhance clinical workflows and improve patient outcomes.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 2","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodality Imaging in the Diagnosis of Coronary Microvascular Disease: An Update.","authors":"Ana Margarida Martins, Miguel Nobre Menezes, Pedro Alves da Silva, Ana G Almeida","doi":"10.3390/jpm15020075","DOIUrl":"10.3390/jpm15020075","url":null,"abstract":"<p><p>Coronary microvascular dysfunction (CMD) is characterized by structural and functional abnormalities in the coronary microvasculature which can lead to ischaemia and angina and is increasingly recognized as a major contributor to adverse cardiovascular outcomes. Despite its clinical importance, the diagnosis of CMD remains limited compared with traditional atherosclerotic coronary artery disease. Furthermore, the historical lack of non-invasive methods for detecting and quantifying CMD has hindered progress in understanding its pathophysiology and clinical implications. This review explores advancements in non-invasive cardiac imaging that have enabled the detection and quantification of CMD. It evaluates the clinical utility, strengths and limitation of these imaging modalities in diagnosing and managing CMD. Having improved our understanding of CMD pathophysiology, cardiac imaging can provide insights into its prognosis and enhance diagnostic accuracy. Continued innovation in imaging technologies is essential for advancing knowledge about CMD, leading to improved cardiovascular outcomes and patient care.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 2","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Choi et al. Prognostic Value of Radiomic Analysis Using Pre- and Post-Treatment ¹⁸F-FDG-PET/CT in Patients with Laryngeal Cancer and Hypopharyngeal Cancer. <i>J. Pers. Med.</i> 2024, <i>14</i>, 71.","authors":"Joon Ho Choi, Joon Young Choi, Sang-Keun Woo, Ji Eun Moon, Chae Hong Lim, Soo Bin Park, Seongho Seo, Yong Chan Ahn, Myung-Ju Ahn, Seung Hwan Moon, Jung Mi Park","doi":"10.3390/jpm15020074","DOIUrl":"10.3390/jpm15020074","url":null,"abstract":"<p><p>In the original publication [...].</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 2","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTED: Yen et al. Brevilin A Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis and Reduces Th17 Differentiation in Psoriasis Patients. <i>J. Pers. Med.</i> 2022, <i>12</i>, 1888.","authors":"Ling-Jung Yen, Chung-Yang Yen, Chia-Ling Li, En-Chih Liao, Kai-Chun Wang, Meng-Chieh Shih, Hung-Sen Huang, Ying-Chin Chen, Ling-Ying Lu, Sheng-Jie Yu","doi":"10.3390/jpm15020072","DOIUrl":"10.3390/jpm15020072","url":null,"abstract":"<p><p>The journal retracts the article \"Brevilin A Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis and Reduces Th17 Differentiation in Psoriasis Patients\" [...].</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 2","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pioneering Respiratory and Emergency Medicine Research During the COVID-19 Era.","authors":"Ioannis Pantazopoulos, Georgios Mavrovounis, Konstantinos Gourgoulianis","doi":"10.3390/jpm15020073","DOIUrl":"10.3390/jpm15020073","url":null,"abstract":"<p><p>Respiratory and emergency medicine have undergone significant transformations in recent years, shaped by advancements in critical care, the integration of artificial intelligence (AI), and the evolving understanding of post-infectious sequelae [...].</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 2","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}