Journal of Personalized Medicine最新文献

{"title":"Cardiac Autonomic Measures Predict Clinician-Rated Anxiety and Behavioral Response to Propranolol in Autistic Children and Young Adults.","authors":"Carrina Appling, Nanan Nuraini, Ryan Holem, Samantha Hunter, Kathy Hirst, Nicole Takahashi, Micah O Mazurek, Stephen M Kanne, Bradley Ferguson, David Q Beversdorf","doi":"10.3390/jpm15070286","DOIUrl":"10.3390/jpm15070286","url":null,"abstract":"<p><p>Propranolol, a nonselective beta-adrenergic antagonist, has shown potential for improving anxiety in autistic individuals. Heart rate variability (HRV), a noninvasive cardiac marker of autonomic nervous system functioning, may help identify individuals most likely to benefit from propranolol. <b>Objectives</b>: Determine if baseline resting HRV and other cardiac measures predict the response to propranolol for anxiety and core autism symptomology in autistic children and young adults. <b>Methods:</b> Sixty-two autistic individuals (ages 7-24) participated in a two-phase (i.e., a 12-week randomized controlled trial and a 12-week open-label extension) trial of propranolol. Baseline (i.e., resting state, prior to treatment) HRV and other cardiac measures were obtained from an electrocardiogram. Clinical global impression for anxiety symptoms and overall behavioral treatment impact were assessed after the 12-week trial period. Group-level (i.e., all participants) and responder groups (i.e., strong, minimal, and non-responders to propranolol) were analyzed for treatment effects. <b>Results:</b> HRV variables predicted group-level anxiety response to propranolol, particularly for strong responders. Also, lower baseline values of parasympathetic HRV indices were significantly correlated with greater behavioral improvement after treatment with propranolol. Last, several baseline cardiac variables were associated with improvement in multiple behavioral domains after treatment with propranolol. <b>Conclusions:</b> HRV may be a potential biomarker for predicting reduced anxiety and behavioral symptoms in response to propranolol in autistic children and young adults. Identifying autonomic profiles associated with positive treatment outcomes could guide future personalized interventions in autism. The results presented herein should be regarded as preliminary until the findings are replicated in future clinical trials.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12299718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate MRI Using Deep Learning Reconstruction in Response to Cancer Screening Demands-A Systematic Review and Meta-Analysis.","authors":"Stephan Ursprung, Georgios Agrotis, Petra J van Houdt, Leon C Ter Beek, Thierry N Boellaard, Regina G H Beets-Tan, Derya Yakar, Anwar R Padhani, Ivo G Schoots","doi":"10.3390/jpm15070284","DOIUrl":"10.3390/jpm15070284","url":null,"abstract":"<p><p><b>Background/Objectives</b>: There is a growing need for efficient prostate MRI protocols due to their increasing use in managing prostate cancer (PCa) and potential inclusion in screening. Deep learning reconstruction (DLR) may enhance MR acquisitions and improve image quality compared to conventional acceleration techniques. This systematic review examines DLR approaches to prostate MRI. <b>Methods</b>: A search of PubMed, Web of Science, and Google Scholar identified eligible studies comparing DLR to conventional reconstruction for prostate imaging. A narrative synthesis was performed to summarize the impact of DLR on acquisition time, image quality, and diagnostic performance. <b>Results</b>: Thirty-three studies showed that DLR can reduce acquisition times for T₂w and DWI imaging while maintaining or improving image quality. It did not significantly affect clinical tasks, such as biopsy decisions, and performed comparably to human readers in PI-RADS scoring and the detection of extraprostatic extension. However, AI models trained on conventional data might be less accurate with DLR images. The heterogeneity in image quality metrics among the studies prevented quantitative synthesis. <b>Discussion</b>: DLR has the potential to achieve substantial time savings in prostate MRI while maintaining image quality, which is especially relevant because of increased MRI demands. Future research should address the effect of DLR on clinically relevant downstream tasks, including AI algorithms' performances and biopsy decisions, and explore task-specific accelerated protocols for screening, image-guided biopsy, and treatment.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to Establish the Baseline for Non-Invasive Technological Regenerative Esthetic Medicine in the Face and Neck Region: A Literature Review.","authors":"Ornella Rossi, Giovanna Perrotti, Riccardo Scaini, Massimo Del Fabbro, Giovanni Damiani, Tiziano Testori","doi":"10.3390/jpm15070283","DOIUrl":"10.3390/jpm15070283","url":null,"abstract":"<p><p>(1) <b>Background</b>: Esthetic regenerative medicine is increasingly in demand for facial and neck rejuvenation due to its proven efficacy, safety profile, and minimal downtime. This study aimed to evaluate the role of standardized assessment tools in optimizing the outcomes of non-invasive regenerative esthetic technologies, both during the treatment course and in follow-up. (2) <b>Methods</b>: A literature review of the main articles published in peer-reviewed journals was conducted to identify high-quality studies addressing the use of validated esthetic scales and questionnaires (patient-reported outcomes) for evaluating the effectiveness of non-invasive regenerative treatments for the face and neck using accessible clinical tools such as photographs and 3D facial scanning. (3) <b>Results</b>: Clinician-reported outcomes (CROs) can be collected using standardized and reproducible photographic documentation and facial scans. The esthetic scales and classifications target both specific facial areas (e.g., upper third, perioral, periorbital) and overall skin appearance. Furthermore, advanced software allows overlay facial scan analysis and wrinkle mapping for precise quantification of improvements. In addition to objective CROs, patient-reported outcomes (PROs) offer essential insights into perceived esthetic changes, satisfaction, and emotional well-being, completing a multidimensional evaluation of treatment efficacy. (4) <b>Conclusions</b>: Standardized evaluation protocols based on accessible tools such as clinical photographs, 3D facial scans, and validated PRO questionnaires are essential for guiding effective, personalized regenerative treatments. Their integration into routine practice enhances clinical decision-making and patient satisfaction. While advanced tools like dermal probes may further refine assessments, they require specific expertise and resources and may be less practical for daily clinical use.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12299628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shoulder and Scapular Function Before and After a Scapular Therapeutic Exercise Program for Chronic Shoulder Pain and Scapular Dyskinesis: A Pre-Post Single-Group Study.","authors":"Ana S C Melo, Ana L Soares, Catarina Castro, Ricardo Matias, Eduardo B Cruz, J Paulo Vilas-Boas, Andreia S P Sousa","doi":"10.3390/jpm15070285","DOIUrl":"10.3390/jpm15070285","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Scapular adaptations have been associated with shoulder pain. However, conflicting findings have been reported after scapular-focused interventions. The present study aims to evaluate scapula-related outcomes before and after a scapular therapeutic exercise program. <b>Methods</b>: Eighteen adult volunteers with chronic shoulder pain participated in an 8-week scapular therapeutic exercise program that was personalized according to their pain condition and the presence of scapular dyskinesis. This program included preparation and warm-up, scapular neuromotor control, and strengthening and stretching exercises. Both self-reported (shoulder pain and function, psychosocial factors, and self-impression of change) and performance-based outcomes (scapular muscular stiffness and activity level, tridimensional motion, rhythm, and movement quality, measured while participants drank a bottle of water) were used for analysis. <b>Results</b>: After the intervention, participants presented reduced shoulder pain (<i>p</i> < 0.0001) and pain catastrophizing (<i>p</i> = 0.004) and increased shoulder function (<i>p</i> < 0.0001). Additionally, the participants presented changes in scapular winging (<i>p</i> < 0.0001 to <i>p</i> = 0.043), increased scapular downward rotation (<i>p</i> < 0.0001) and depression (<i>p</i> = 0.038), and decreased global movement smoothness (<i>p</i> = 0.003). These were associated with changes in serratus anterior activity (<i>p</i> = 0.016 to <i>p</i> = 0.035), decreased middle (<i>p</i> < 0.0001 to <i>p</i> = 0.002) and lower trapezius (<i>p</i> < 0.0001) and levator scapulae (<i>p</i> = 0.048) activity levels, and decreased middle trapezius muscle stiffness (<i>p</i> = 0.014). Patients' self-perception of change was rated favorably. <b>Conclusions</b>: After a scapular therapeutic exercise program, changes were observed in both self-reported and performance-based outcomes. These results need to be confirmed by a randomized controlled trial.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12299646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Evaluation of Shear Wave Elastography and C-Peptide Index for Predicting Need of Insulin Therapy in Type 2 Diabetes: A Pilot Study.","authors":"Moeno Sugita-Hamada, Takeshi Yokoo, Nao Nakajima, Yoshifumi Takahashi, Akihiko Osaki, Masaki Maruyama, Masaaki Takamura, Nobuo Waguri, Osamu Isokawa, Shuji Terai","doi":"10.3390/jpm15070277","DOIUrl":"10.3390/jpm15070277","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Recently, shear wave elastography (SWE) and dispersion (SWD) targeting the pancreas have been attempted as noninvasive procedures to evaluate personalized conditions. This study aimed to analyze the feasibility of utilizing them for evaluating the individual need of introducing insulin therapy, combined with the C-peptide index (CPI), in patients with type 2 diabetes mellitus (T2DM). <b>Methods</b>: This study involved 51 patients with T2DM aged ≥20 years old and 20 control subjects without impaired glucose tolerance (CTRL). T2DM were divided into non-insulin-treated (non-INS) and insulin-treated (INS) groups. Their background data, shear wave speed (SWS), and dispersion slope (DS) of the pancreas were obtained on the same day. <b>Results</b>: Pancreatic SWS was higher in T2DM than in CTRL (<i>p</i> < 0.0001), with an AUC of 0.840, sensitivity of 89.1%, and specificity of 70.6%, using a Youden index cutoff of 1.31 m/s. INS and non-INS were discriminated with the cutoff value of 1.70 m/s (<i>p</i> = 0.031, AUC 0.736, sensitivity 55.6% and specificity 89.2%). Pancreatic DS of INS and non-INS was 13.52 and 12.16 (m/s)/kHz, respectively (<i>p</i> = 0.046). Using 12.38 (m/s)/kHz as the cutoff, AUC was 0.718, with sensitivity of 88.9%, specificity of 56.8% and negative predictive value of 95.5%. CPI had AUC of 0.724, sensitivity of 66.7% and specificity of 83.3% with the cutoff of 0.63. With combination of SWS and CPI, all patients with SWS < 1.70 m/s and CPI > 0.476 belonged to non-INS. <b>Conclusions</b>: Simultaneous non-invasive SWE and CPI evaluation showed the feasibility for estimating personalized insulin initiation needs in T2DM, integrating biophysical and hormonal perspectives. Further investigation with a larger, multi-center study population is warranted to enhance the level of evidence.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Multigene Molecular Testing Results of MRI-Target Versus Systematic Prostate Needle Biopsies of Candidates for and Under Active Surveillance.","authors":"Nicholas J Lanzotti, Chris Du, Julia Hall, Joseph Saba, Maria M Picken, Gopal N Gupta","doi":"10.3390/jpm15070279","DOIUrl":"10.3390/jpm15070279","url":null,"abstract":"<p><p><b>Introduction:</b> The multigene molecular testing of prostate cancer tissue after biopsy provides individualized information to guide further management. The utility of selective genetic testing for MRI-visible target versus systematic cancer in patients as well as during different time points of active surveillance (AS) is unknown. The objective of this study was to compare Prolaris^TM results of MRI-target cancers versus systematic cancers on prostate needle biopsy as well as both during consideration for initial AS candidacy and candidacy for remaining on AS. <b>Methods:</b> Our prospectively maintained institutional multiparametric (mp) MRI prostate cancer active surveillance database (2013-2024) was queried for patients that underwent Prolaris^TM genetic testing of positive biopsy cores. Baseline information for PSA, PSA density, and Prolaris^TM calculated data were collected. Information on the timing of the Prolaris testing, defined as during the initial cancer diagnostic biopsy or on a subsequent confirmatory biopsy was collected. SPSS v29.0 was used to compare the selective Prolaris^TM results of MRI-target cancers versus systematic cancers during different points of AS. <b>Results:</b> 264 patients with a Prolaris^TM test were identified, 86 with MRI-target and 178 on systematic cancers. 182 Prolaris^TM tests were sent on a diagnostic biopsy and 81 on a subsequent biopsy. Overall, MRI-target cancers had similar risk scores (3.23 vs. 3.14, <i>p =</i> 0.18). Prolaris^TM scores were higher for GG2 systematic than GG1 target cancers (3.40 vs. 3.18, <i>p =</i> 0.023). The GG2 systematic lesion cohort also had higher predicted the 10-year disease-specific mortality (DSM) (3.40% vs. 2.30%, <i>p <</i> 0.01) and 10-year metastasis risk (1.90% vs. 1.20%, <i>p =</i> 0.013), and more aggressive recommended treatment. Analyses of the Prolaris^TM results sent during a diagnostic biopsy yielded similar results. Finally, on an analysis of the Prolaris^TM results sent during subsequent biopsy, a systematic GG2 biopsy was noted to have a higher 10-year DSM and metastasis rate, but similar risk scores and treatment recommendations. <b>Conclusions:</b> Prolaris^TM tests can be sent at multiple time points of AS, and selectively for MRI-visible versus higher grade cancers. There is no consistent association between MRI-visible cancer and Prolaris risk profile. When utilizing multigene molecular testing in prostate cancer, each individual patient must be evaluated to decide the appropriate level of care.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12299066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic vs. External Dacryocystorhinostomy in Granulomatosis with Polyangiitis: A Scoping Review of the Literature and Our Experience with Endoscopic Dacryocystorhinostomy.","authors":"Nitish Kumar, Lisa A Marks, Pedro Lança Gomes, Devyani Lal","doi":"10.3390/jpm15070278","DOIUrl":"10.3390/jpm15070278","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Although endoscopic dacryocystorhinostomy (DCR) has been widely accepted as the procedure of choice for nasolacrimal duct obstruction (NLDO) management due to most etiologies, concerns regarding the reactivation of disease and involvement of surrounding structures add to hesitation in its utilization for granulomatosis with polyangiitis (GPA) patients. No study has directly compared outcomes of external vs. endoscopic DCR in GPA patients. This information can be helpful for patient counselling and choosing a personalized surgical approach for the best results. <b>Methods</b>: A scoping review of the literature was performed in January 2024. The following databases were searched using a combination of MeSH (Medical Subject Headings) and keywords: Ovid MEDLINE, Ovid EMBASE, Scopus, and Web of Science. This scoping review is not registered. Medical records of two GPA patients who underwent endoscopic DCR at our center were reviewed. <b>Results</b>: The search yielded 96 articles; 15 articles met the inclusion criteria for a full review. Six studies with 22 procedures reported 100% success with endoscopic DCR. Nine studies with 122 procedures reported success in 88.5% of cases with external DCRs. Additional perioperative immunosuppression was recommended in patients with severe mucosal inflammation. The case series presents the disease course, details of surgery, and perioperative management in two GPA patients with NLDO who underwent endoscopic DCR successfully. <b>Conclusions</b>: Endoscopic DCR was associated with equivalent or better success rates and lower complications compared to external DCR in GPA patients. Ensuring disease remission state and appropriate immunomodulatory therapy can help prevent the proposed risk of endonasal disease reactivation with endoscopic DCR.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Preoperative Risk Factors on Unplanned Readmission After Day Surgery: A Meta-Analysis.","authors":"Hanqing Zhang, Xinglian Gao, Zhen Chen","doi":"10.3390/jpm15070281","DOIUrl":"10.3390/jpm15070281","url":null,"abstract":"<p><p><b>Objective</b>: This research seeks to explore and determine the principal pre-surgical risk elements associated with unplanned readmissions following day surgery, providing evidence-based guidance for clinical practice to optimize preoperative evaluations and reduce the incidence of readmissions. <b>Background</b>: As day surgery becomes increasingly common across global healthcare systems, ensuring effective postoperative recovery and preventing readmissions have become critical challenges. Numerous studies have explored the impact of various preoperative risk factors on postoperative readmissions. This study synthesizes existing evidence through a meta-analysis to identify the key preoperative factors associated with increased readmission risk. <b>Methods</b>: An extensive literature review was conducted across various databases, such as Web of Science, PubMed, CINAHL, Scopus, Embase, the Cochrane Library, and CNKI, to gather all relevant clinical research on pre-surgical risk elements for day surgery procedures, with studies included up to 15 January 2025. A structured analysis was undertaken, and the findings were integrated using a random-effects approach to assess the influence of key preoperative risk factors on subsequent readmissions in day surgery environments. <b>Results</b>: A total of 12 studies, involving 704,568 patients, were incorporated into the final analysis. The findings identified several preoperative factors that were significantly associated with an increased risk of postoperative readmission. These risk factors included: age ≥ 60 years (OR = 2.38, 95% CI: 1.74-3.26, <i>p</i> < 0.00001), ASA classification ≥ 3 (OR = 1.96, 95% CI: 1.61-2.38, <i>p</i> < 0.00001), presence of chronic diseases (OR = 11.78, 95% CI: 9.99-13.90, <i>p</i> < 0.00001), general anesthesia (OR = 2.42, 95% CI: 1.51-3.86, <i>p</i> = 0.0002), infection risk (OR = 1.68, 95% CI: 1.35-2.10, <i>p</i> < 0.00001), gender (OR = 2.45, 95% CI: 2.21-2.71, <i>p</i> < 0.00001), complex surgery type (OR = 2.83, 95% CI: 2.03-3.93, <i>p</i> < 0.00001), and bleeding disorders (OR = 1.82, 95% CI: 1.53-2.17, <i>p</i> < 0.00001). <b>Conclusions</b>: This study highlights several key preoperative risk factors associated with unexpected readmissions following day surgery. These factors include age, ASA classification, presence of chronic diseases, general anesthesia, infection risk, gender, complex surgery type, and bleeding disorders. These findings provide valuable insights for preoperative assessments. Clinicians should focus on these high-risk factors during preoperative assessment and management to minimize postoperative readmission rates and improve surgical safety and recovery outcomes for patients.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12300345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Acetabular Fractures with Total Hip Replacement: A Narrative Literature Review.","authors":"Domenico Tigani, Luigigiuseppe Lamattina, Andrea Assenza, Giuseppe Melucci, Alex Pizzo, Cesare Donadono","doi":"10.3390/jpm15070282","DOIUrl":"10.3390/jpm15070282","url":null,"abstract":"<p><p>Open reduction and internal fixation (ORIF) is widely regarded as the primary treatment for acetabular fractures, but limitations arise in complex cases, leading to non-anatomical reductions and increased risk of post-traumatic osteoarthritis. Given the high incidence of secondary arthritis (12-57%) following ORIF, total hip arthroplasty (THA) is often necessitated, particularly in scenarios unsuitable for ORIF, such as extensive comminution or combined femoral head and neck fractures. The surgical landscape has shifted from a traditional \"fix or replace\" to a more integrated \"fix and replace\" approach, especially beneficial in managing elderly patients with osteoporotic bones. THA is applied across various timelines, including acute (0-3 weeks), delayed (3 weeks to 3 months), and late (beyond 3 months), each presenting distinct challenges and requiring specific strategies to optimize outcomes. The importance of precise bone defect classifications and the role of dual mobility cups in reducing dislocation risks are highlighted, alongside the use of modern surgical and fixation techniques to improve stability and patient outcomes. Enhanced recovery protocols and meticulous postoperative management are critical to addressing complications, such as infections and hardware interference, tailoring treatment approaches to each patient's needs, and advancing care for complex acetabular fractures.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12300385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic Assessment of Calcium Pyrophosphate Deposition Disease: A Comprehensive Review.","authors":"Lissiane Karine Noronha Guedes, Letícia Queiroga de Figueiredo, Fernanda Oliveira de Andrade Lopes, Luis Fernando Fernandes Ferrari, Karina Rossi Bonfiglioli","doi":"10.3390/jpm15070280","DOIUrl":"10.3390/jpm15070280","url":null,"abstract":"<p><p>Calcium pyrophosphate deposition disease (CPPD) is a common crystal arthropathy characterized by the deposition of calcium pyrophosphate crystals in joints and soft tissues. Ultrasonography (US) has emerged as a valuable imaging modality for diagnosing CPPD, offering real-time visualization of crystal deposits and joint inflammation. In the context of personalized medicine, US plays a critical role in enabling individualized patient assessment, facilitating early and accurate diagnosis, and supporting tailored therapeutic decisions based on specific imaging findings. This article reviews the ultrasonographic features of CPPD, their diagnostic utility, and clinical applications, emphasizing the relevance of US in stratifying patients and guiding personalized management approaches.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12299270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}