Journal of Personalized Medicine最新文献

{"title":"Orthodontic Extrusion in Daily Clinical Practice: Management of Fractured or Damaged Anterior Teeth.","authors":"Giuseppina Malcangi, Grazia Marinelli, Maral Di Giulio Cesare, Sharon Di Serio, Marialuisa Longo, Andrea Carbonara, Francesco Inchingolo, Alessio Danilo Inchingolo, Ioana Roxana Bordea, Andrea Palermo, Angelo Michele Inchingolo, Gianna Dipalma","doi":"10.3390/jpm15090408","DOIUrl":"10.3390/jpm15090408","url":null,"abstract":"<p><p><b>Background</b>. Orthodontic extrusion (OE), or forced eruption, is a conservative technique used to recover teeth affected by coronal fractures, traumatic intrusions, or severe caries. It involves applying light, continuous forces to induce vertical tooth movement, promoting tissue remodeling through periodontal ligament stimulation. <b>Materials and Methods</b>. This narrative review included studies investigating OE as a therapeutic approach for the management of deep or subgingival carious lesions, traumatic dental injuries (such as intrusion or fracture), or for alveolar ridge augmentation in implant site development. OE is typically performed using fixed appliances such as the straight-wire system or, in selected cases, clear aligners. Forces between 30 and 100 g per tooth are applied, depending on the clinical situation. In some protocols, OE is combined with fiberotomy to minimize gingival and bone migration. <b>Results</b>. Studies show that OE leads to significant vertical movement and increases in buccal bone height and interproximal septa. It enhances bone volume in targeted sites, making it valuable in implant site development. Compared to surgical crown lengthening, OE better preserves periodontal tissues and improves esthetics. <b>Conclusions</b>. In this narrative review is analized how OE is effective for managing traumatic intrusions and compromised periodontal sites, particularly when paired with early endodontic treatment. It reduces the risks of ankylosis and root resorption while avoiding invasive procedures like grafting. Although clear aligners may limit axial tooth movement, OE remains a minimally invasive, cost-effective alternative in both restorative and implant dentistry.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Nucleotide Polymorphisms Related to Glioblastoma Risk and Worldwide Epidemiology: A Systematic Review and Meta-Analysis.","authors":"Giovanna Gilioli da Costa Nunes, Francisco Cezar Aquino de Moraes, Rita de Cássia Calderaro Coelho, Marianne Rodrigues Fernandes, Sidney Emanuel Batista Dos Santos, Ney Pereira Carneiro Dos Santos","doi":"10.3390/jpm15090401","DOIUrl":"10.3390/jpm15090401","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Glioblastomas are a part of adult-type diffuse gliomas, the most common and most aggressive primary brain tumors in adults (glioblastoma, IDH-wildtype). The identification of the genetic factors associated with glioblastoma could be an important contribution to the diagnosis and early prevention of this disease. We compiled data from the global literature and analyzed clinically relevant variants implicated in glioblastoma risk. <b>Methods</b>: PubMed, Web of Science, and Scopus were used as databases. Associations between the SNPs and glioblastoma risk were calculated as a measure of pooled odds ratios (ORs) and 95% confidence intervals. Pearson's analysis was used for epidemiological correlation (only <i>p</i>-values less than 0.05 were statistically significant), and data were obtained from the World Health Organization platform and the 1000 Genomes Project. Statistical analysis was performed using Review Manager (RevMan) 5.4 and BioEstat 5.0. <b>Results</b>: <i>CCDC26</i> rs891835 G/T, G/G, and G/T-G/G genotypes were analyzed and determined to increase glioblastoma risk (G/T OR = 1.96, 95% CI: 1.38-2.77, <i>p</i> = 0.0002, I² = 0%; G/G OR = 1.33, 95% CI: 0.46-3.85, <i>p</i> = 0.60, I² = 0%; G/T - G/G OR = 1.96, 95% CI: 1.39-2.76, <i>p</i> = 0.0001, I² = 0%). Epidemiological correlation also demonstrated that the higher the frequency of the <i>CCDC26</i> rs891835 variant, the higher the incidence of that variant in the European population. <b>Conclusions</b>: <i>CCDC26</i> rs891835 may serve as a predictive biomarker for glioblastoma, IDH-wildtype risk and may influence higher glioblastoma incidence rates in the European population.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in the Diagnosis of Pediatric Rare Diseases: From Real-World Data Toward a Personalized Medicine Approach.","authors":"Nikola Ilić, Adrijan Sarajlija","doi":"10.3390/jpm15090407","DOIUrl":"10.3390/jpm15090407","url":null,"abstract":"<p><p><b>Background:</b> Artificial intelligence (AI) is increasingly applied in the diagnosis of pediatric rare diseases, enhancing the speed, accuracy, and accessibility of genetic interpretation. These advances support the ongoing shift toward personalized medicine in clinical genetics. Objective: This review examines current applications of AI in pediatric rare disease diagnostics, with a particular focus on real-world data integration and implications for individualized care. <b>Methods:</b> A narrative review was conducted covering AI tools for variant prioritization, phenotype-genotype correlations, large language models (LLMs), and ethical considerations. The literature was identified through PubMed, Scopus, and Web of Science up to July 2025, with priority given to studies published in the last seven years. <b>Results:</b> AI platforms provide support for genomic interpretation, particularly within structured diagnostic workflows. Tools integrating Human Phenotype Ontology (HPO)-based inputs and LLMs facilitate phenotype matching and enable reverse phenotyping. The use of real-world data enhances the applicability of AI in complex and heterogeneous clinical scenarios. However, major challenges persist, including data standardization, model interpretability, workflow integration, and algorithmic bias. <b>Conclusions:</b> AI has the potential to advance earlier and more personalized diagnostics for children with rare diseases. Achieving this requires multidisciplinary collaboration and careful attention to clinical, technical, and ethical considerations.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyte Importance Analysis in Machine Learning-Based Detection of Wrong-Blood-in-Tube Errors Using Complete Blood Count Data.","authors":"Barış Gün Sürmeli, René Staritzbichler, Clemens Ringel, Saleem Al-Dakkak, Helene Dörksen, Thorsten Kaiser","doi":"10.3390/jpm15090404","DOIUrl":"10.3390/jpm15090404","url":null,"abstract":"<p><p><b>Background</b>: Wrong blood in tube (WBIT) is a critical pre-analytical error in laboratory medicine in which a blood sample is mislabeled with the wrong patient identity. These errors are often undetected due to the limitations of current detection strategies (e.g., delta checks). <b>Methods</b>: We evaluated Random Forest models for WBIT detection and conducted a detailed analyte importance analysis. In total, 799,721 samples from a German tertiary care center were analyzed and filtered for applicability. Model input features were derived by pairing consecutive same-patient samples for non-WBIT cases, simulating WBIT by pairing samples from different patients, and computing per-analyte first-order differences for each pair. We exhaustively searched all subsets of nine CBC analytes and evaluated models using F1 score, AUC, sensitivity, and PPV. Analyte importance was assessed via SHAP, permutation, and impurity decrease. <b>Results</b>: Models using as few as three analytes (MCV, RDW, MCH) reached F1 scores above 90%, with performance plateauing beyond six analytes. MCV and RDW were consistently top-ranked. Two-dimensional and three-dimensional visualizations revealed interpretable decision boundaries. <b>Conclusions</b>: Findings demonstrate that robust WBIT detection is achievable using a minimal subset of CBC analytes, offering a practical, interpretable, and broadly generalizable ML-based solution suitable for diverse clinical environments.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Approaches to the Management of Rheumatic Diseases in Pregnancy: Risk Stratification, Therapeutic Advances, and Maternal-Fetal Outcomes.","authors":"Aikaterini-Gavriela Giannakaki, Maria-Nektaria Giannakaki, Anastasia Bothou, Konstantinos Nikolettos, Nikolaos Machairiotis, Kalliopi I Pappa, Panagiotis Tsikouras","doi":"10.3390/jpm15090406","DOIUrl":"10.3390/jpm15090406","url":null,"abstract":"<p><p><b>Background:</b> Autoimmune rheumatic diseases, including systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), Sjögren's syndrome, systemic sclerosis (SSc), and rheumatoid arthritis (RA), pose significant challenges during pregnancy and are associated with increased risks of adverse maternal and fetal outcomes, such as preeclampsia, fetal growth restriction (FGR), miscarriage, and preterm birth. The aim of this review is to synthesize recent evidence on pregnancy-related risks, preconception counseling, and therapeutic strategies for these conditions, with a particular focus on the importance of disease remission, pregnancy-compatible medications, and the selective use of biologics. <b>Methods:</b> A structured narrative review was conducted through a comprehensive PubMed search (2020-2025). Eligible studies addressed maternal-fetal outcomes, therapeutic approaches, and predictive factors in pregnant individuals with autoimmune rheumatic diseases. <b>Results:</b> Pregnancy outcomes have improved with early disease control and multidisciplinary care; however, major challenges persist. These include limited access to novel therapies, underrepresentation of diverse populations in clinical trials, and insufficient data on long-term neonatal outcomes. The strongest predictors of adverse outcomes remain disease activity at conception, specific autoantibody profiles, and systemic organ involvement. <b>Conclusions:</b> Optimal pregnancy outcomes for women with autoimmune rheumatic diseases require coordinated multidisciplinary care, the use of pregnancy-compatible medications, and achievement of prolonged disease remission prior to conception. Further research is needed to close existing knowledge gaps and ensure equitable, high-quality maternal-fetal care.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing LI-RADS Through Semi-Automated Quantification of HCC Lesions.","authors":"Anna Jöbstl, Piera Maria Tierno, Anna-Katharina Gerstner, Gudrun Maria Feuchtner, Benedikt Schaefer, Herbert Tilg, Gerlig Widmann","doi":"10.3390/jpm15090400","DOIUrl":"10.3390/jpm15090400","url":null,"abstract":"<p><strong>Background/objectives: </strong>Hepatocellular carcinoma (HCC) is the most common primary malignant tumour of the liver. In a cirrhotic liver, each nodule larger than 10 mm demands further work-up using CT or MRI. The Liver Imaging Reporting and Data System (LI-RADS) is still based on visual assessment and measurements. The purpose of this study was to evaluate whether semi-automated quantification of visual LR-5 lesions is appropriate and can objectify HCC classification for personalized radiomic research.</p><p><strong>Methods: </strong>A total of 52 HCC patients (median age 67 years, 17% females, 83% males) from a retrospective data collection were evaluated visually and compared by the results using an oncology software with features of LI-RADS-based structured tumour evaluation and documentation, semi-automated tumour segmentation, and texture analysis.</p><p><strong>Results: </strong>Software-based evaluation of non-rim arterial-phase hyperenhancement (APHE) and non-peripheral washout, as well as the LI-RADS-score, showed no statistically significant differences compared with visual assessment (<i>p</i> = 0.2, 0.7, 0.17), with a consensus between a human reader and the software approach in 98% (APHE), 89% (washout), and 93% (threshold growth) of cases, respectively. The software provided automated LI-RADS classification, structured reporting, and quantitative features for HCC registries and radiomic research.</p><p><strong>Conclusions: </strong>The presented work may serve as an outlook for LI-RADS-based automated qualitative and quantitative evaluation. Future research may show if texture analysis can be used to foster personalized medical approaches in HCC.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of the Microbiome in Oropharyngeal Squamous Cell Carcinoma: A Systematic Review.","authors":"Jérôme R Lechien","doi":"10.3390/jpm15090399","DOIUrl":"10.3390/jpm15090399","url":null,"abstract":"<p><p><b>Objective</b>: This systematic review aimed to investigate existing evidence regarding the implications of the microbiome in the initiation and progression of oropharyngeal squamous cell carcinoma (OPSCC). <b>Methods</b>: PubMed, Scopus, and Cochrane Library systematic searches were conducted according to the PRISMA statements to identify the relevant studies examining microbiome signatures, underlying molecular mechanisms, and their associations with clinical and oncological outcomes in OPSCC. The bias analysis was conducted with the MINORS. <b>Results</b>: Of the 83 identified papers, 12 met the inclusion criteria (298 OPSCC patients). <i>Spirochaetes</i> and most <i>Bacteroidetes</i> may be predominant in OPSCC versus control specimens, while <i>Proteobacteria</i> may be predominant in control tissues compared to tumor. <i>Leptotrichia</i>, <i>Selenomonas</i>, and <i>Treponema</i> trended to be overrepresented in OPSCC compared to control specimens. <i>Neisseria</i>, <i>Porphyromonas</i>, <i>Rothia</i>, <i>Streptococcus</i>, and <i>Veillonela</i> were predominantly reported in normal compared to OPSCC patient specimens. Microbiome compositional shifts were associated with chemoradiation response, HPV status, and addictions. Methodological heterogeneity was noted in sampling protocols, control selection, and analytical approaches, with limited statistical power due to small cohort sizes. <b>Conclusions</b>: OPSCC demonstrates different microbiome signatures from healthy tissues, influenced by HPV status and addictions. A microbiome shift is plausible from pre- to post-chemoradiotherapy, with the baseline microbiome acting as a predictive response factor; however, the low number of studies and substantial methodological heterogeneity across investigations limit the drawing of valid conclusions. The identification of key species is important in the development of OPSCC for developing personalized medicine considering bacterial mediators in terms of prevention, and targeted therapy using the microbiome-tumor-host interaction pathways.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty as an Independent Predictor of Mortality in Patients with Sepsis.","authors":"Alejandro Interián, Fernando Ramasco, Angels Figuerola, Rosa Méndez","doi":"10.3390/jpm15090398","DOIUrl":"10.3390/jpm15090398","url":null,"abstract":"<p><p><b>Objectives</b>: Personalized sepsis care requires understanding how pre-existing health status can influence outcomes. The aim of this study is to evaluate its impact on in-hospital and 12-month mortality in patients with sepsis, taking into account age, comorbidities, the Charlson Comorbidity Index, frailty, anemia, and the Sequential Organ Failure Score Assessment (SOFA) in the first 24 h. <b>Methods</b>: An observational and retrospective study was conducted using data from the Sepsis Code program at the Hospital Universitario de La Princesa. The relationship between risk factors and mortality, as well as Intensive Care Unit (ICU) admission, was analyzed for the period 2016-2018 using bivariate and multivariate logistic regression. <b>Results</b>: A total of 547 patients were included. In the multivariate analysis, the risk factors independently associated with mortality were Rockwood Clinical Frailty Scale ≥ 5 (OR 2.45, <i>p</i> < 0.05); SOFA ≥ 4 (OR 2.13, <i>p</i> < 0.05); age (OR 1.98, <i>p</i> < 0.05); anemia (OR 1.85, <i>p</i> < 0.05); and specific comorbidities such as ischemic heart disease (OR 2.34, <i>p</i> < 0.05), severe liver disease (OR 3.62, <i>p</i> < 0.05), and metastatic cancer (OR 3.14, <i>p</i> < 0.05). Patients who were frail, had dementia, or heart failure were less likely to be admitted to the ICU. <b>Conclusions</b>: Frailty, comorbidities, age, and anemia are associated with outcomes in patients with sepsis and could be incorporated into mortality prediction models to guide tailored treatment strategies.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D Printing and Virtual Surgical Planning in Craniofacial and Thoracic Surgery: Applications to Personalised Medicine.","authors":"Freddy Patricio Moncayo-Matute, Jhonatan Heriberto Vázquez-Albornoz, Efrén Vázquez-Silva, Ana Julia Hidalgo-Bravo, Paúl Bolívar Torres-Jara, Diana Patricia Moya-Loaiza","doi":"10.3390/jpm15090397","DOIUrl":"10.3390/jpm15090397","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The application of additive manufacturing in medicine, and specifically in personalised medicine, has achieved notable development. This article aims to present the results and benefits of applying a comprehensive methodology to simulate, plan, and manufacture customised three-dimensional medical prosthetic devices for use in surgery to restore bone structures with congenital and acquired malformations. <b>Methods:</b> To digitally reconstruct a bone structure in three dimensions from a medical image, a segmentation process is developed to correlate the anatomical model. Then, this model is filtered using a post-processing step to generate stereolithography (STL) files, which are rendered using specialised software. The segmentation of tomographic images is achieved by the specific intensity selection, facilitating the analysis of compact and soft tissues within the anatomical region of interest. With the help of a thresholding algorithm, a three-dimensional digital model of the anatomical structure is obtained, ready for printing the required structure. <b>Results:</b> The described cases demonstrate that the use of anatomical test models, cutting guides, and customised prostheses reduces surgical time and hospital stay, and achieves better aesthetic and functional results. Using materials such as polylactic acid (PLA) for presurgical models, appropriate resins for cutting guides, and biocompatible materials such as polyether ether ketone (PEEK) or polymethylmethacrylate (PMMA) for prostheses, the described improvements are achieved. <b>Conclusions:</b> The achievements attained demonstrate the feasibility of applying these techniques, their advantages and their accessibility in Ecuador. They also reinforce the ideas of personalised medicine in the search for medical treatments and procedures tailored to the needs of each patient.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataract Surgery in Pseudoexfoliation Syndrome Using the Eight-Chop Technique.","authors":"Tsuyoshi Sato","doi":"10.3390/jpm15090396","DOIUrl":"10.3390/jpm15090396","url":null,"abstract":"<p><p><b>Objectives:</b> This study aimed to evaluate the safety and efficacy of the eight-chop technique in cataract surgery in patients with pseudoexfoliation (PEX) syndrome and assess the intraoperative parameters, changes in corneal endothelial cells, intraocular pressure (IOP), and intraoperative complications. <b>Methods:</b> This technique was applied in patients with and without PEX syndrome. Preoperative and postoperative assessments were conducted on best-corrected visual acuity, IOP, corneal endothelial cell density (CECD), coefficient of variation, percentage of hexagonal cells, and central corneal thickness. Intraoperative recordings included operative time, phaco time, aspiration time, cumulative dissipated energy (CDE), and fluid of volume used. <b>Results:</b> We analyzed 150 eyes from 150 patients (mean age, 75.5 ± 5.7 years; 59 men, 91 women). In the PEX group, operative time, phaco time, aspiration time, CDE, and volume of fluid used were 6.7 min, 17.4 s, 85.2 s, 6.91 µJ, and 33.4 mL, respectively, demonstrating favorable surgical metrics. On the other hand, in the control group, operative time, phaco time, aspiration time, CDE, and volume of fluid used were 4.5 min, 14.3 s, 64.0 s, 5.83 µJ, and 25.5 mL, respectively. In addition, CECD losses were 3.7% at week 7 and 2.7% at week 19 in the PEX group and 2.7% and 1.6%, respectively, in the control group. Significant decreases were observed at 7 and 19 weeks postoperatively in the PEX and control groups. No eye in the PEX group required a capsular tension ring due to zonular dialysis. <b>Conclusions:</b> The eight-chop technique in cataract surgery demonstrates excellent intraoperative parameters in patients with PEX, is effective against zonular weakness, and does not require the use of a capsular tension ring. This technique will aid in establishing personalized treatment strategies and improve cataract management and treatment.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}