Journal of Personalized Medicine最新文献

{"title":"Milieu Therapy in Patients with Dementia.","authors":"Yong Tae Kwak, Young Soon Yang","doi":"10.3390/jpm15060222","DOIUrl":"10.3390/jpm15060222","url":null,"abstract":"<p><p>This review explores the origins and principles of milieu therapy, which is traditionally rooted in psychiatric settings, and examines how these concepts can be adapted for patients with dementia. While milieu therapy initially focused on long-term psychiatric inpatients, the increasing prevalence of dementia-often with complex neuropsychiatric symptoms and extended care needs-warrants a renewed look at structured therapeutic environments. Unlike psychiatric conditions that may show significant improvement with medication, dementia typically involves progressive cognitive decline and multiple comorbidities, calling for a greater emphasis on safety, predictability, and emotional support. Core principles-therapeutic environment, social interaction, consistency, shared responsibility, empowerment, and individualized interventions-can be tailored to address dementia-specific needs, including orientation aids, simplified routines, and nonverbal communication strategies. Moreover, considering that dementia predominantly affects older adults, comprehensive geriatric care becomes crucial, requiring a collaborative team approach that includes medical, psychiatric, and rehabilitative expertise. In such environments, the focus shifts from cure to maximizing well-being, dignity, self-control, and residual abilities, underscoring the relevance of milieu therapy in modern dementia care.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiological Assessment After Pancreaticoduodenectomy for a Precision Approach to Managing Complications: A Narrative Review.","authors":"Fabrizio Urraro, Vittorio Patanè, Alfredo Clemente, Nicoletta Giordano, Damiano Caputo, Roberto Cammarata, Gianluca Costa, Alfonso Reginelli","doi":"10.3390/jpm15060220","DOIUrl":"10.3390/jpm15060220","url":null,"abstract":"<p><p>Radiological assessment following pancreaticoduodenectomy is critical for the prompt diagnosis and management of postoperative complications, significantly influencing patient outcomes. Pancreaticoduodenectomy, or the Whipple procedure, is the standard surgical intervention for pancreatic and periampullary malignancies, but it involves notable risks, especially from complications like fistulas, bleeding, or leakage. Cross-sectional imaging, particularly contrast-enhanced computed tomography, serves as the primary diagnostic tool due to its rapid acquisition, high resolution, and effective delineation of postoperative anatomy and complications. Magnetic resonance imaging (with cholangiopancreatography and hepatobiliary contrast agents) complements CT by providing superior contrast resolution for specific complications, notably in the biliary system and pancreatic duct. This narrative review discusses various imaging techniques and their applications, highlighting characteristic radiological features of common postoperative complications. It underscores the importance of a multidisciplinary approach, emphasizing close collaboration between radiologists and surgeons to optimize surgical decision-making and improve patient management post-pancreatic surgery.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous Pancreatic Neoplasms Involving Pancreatic Ductal Adenocarcinoma: A Systematic Review of Case Reports.","authors":"Daniel Paramythiotis, Eleni Karlafti, Dimitrios Tsavdaris, Alexandros Mekras, Aristeidis Ioannidis, Stavros Panidis, Elizabeth Psoma, Panos Prassopoulos, Antonios Michalopoulos","doi":"10.3390/jpm15060221","DOIUrl":"10.3390/jpm15060221","url":null,"abstract":"<p><p><b>Background:</b> Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy and is characterized by a very unfavorable prognosis. Rarely, patients may develop synchronous PDAC and another distinct primary pancreatic tumor, such as a pancreatic neuroendocrine tumor. This systematic review consolidates published case reports describing the presentation, imaging characteristics, management, and outcomes of patients with synchronous PDAC and other pancreatic malignancies. <b>Methods</b>: A comprehensive search of PubMed and Scopus identified 26 relevant case reports, with inclusion criteria focused on histologically confirmed synchronous pancreatic tumors and exclusion of metastatic disease. <b>Results</b>: The majority of patients present with two pancreatic lesions, often located in both the body and tail of the pancreas. Diagnostic imaging modalities, such as computed tomography and endoscopic ultrasound, reveal common findings. Tumor markers, particularly CA 19-9, are often elevated and aid in the diagnosis. Surgical approaches also vary according to tumor location and staging, with procedures ranging from Whipple surgery to total pancreatectomy. Chemotherapy is frequently employed postoperatively. Notably, lymph node involvement and larger tumor size are associated with poorer prognoses. <b>Conclusions</b>: In conclusion, these patients may present with a common or non-common clinical picture as well as laboratory and imaging findings, constituting an important and unique diagnostic and therapeutic challenge.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Guided Chemotherapy Optimization in Lung Cancer Using Genomic and Survival Data.","authors":"Hojin Moon, Phan N Nguyen, Jaehee Park, Minho Lee, Sohyul Ahn","doi":"10.3390/jpm15060218","DOIUrl":"10.3390/jpm15060218","url":null,"abstract":"<p><p><b>Background</b>: Adjuvant chemotherapy (ACT) can improve survival outcomes for patients with early-stage non-small cell lung cancer (NSCLC), but its benefit varies significantly across individuals. Identifying patients who are likely to benefit from ACT remains a critical challenge in precision oncology. <b>Methods</b>: We constructed a meta-database from two publicly available NSCLC gene expression datasets (GSE37745 and GSE29013) to address population heterogeneity. Feature selection was performed using Cox-based univariate screening with leave-one-out cross-validation. We then developed and compared three survival modeling frameworks: bagging with elastic net penalized Cox regression, Random Survival Forests (RSF), and DeepSurv neural survival networks. All models incorporated clinical covariates and selected genomic features to predict survival and recommend ACT versus observation (OBS). <b>Results</b>: Across 155 patients, RSF achieved the highest predictive performance, with a test concordance index (C-index) of0.885. Model-based recommendations were associated with improved survival in both training and test datasets, as confirmed by Kaplan-Meier analysis. Key genomic features identified included TTR, MTURN, and ETV3, suggesting their potential relevance in treatment response stratification. DeepSurv demonstrated strong predictive accuracy (C-index = 0.982) but less distinct survival curve separation compared to RSF. <b>Conclusions</b>: Our findings demonstrate that machine learning-driven survival models, particularly RSF, can effectively identify NSCLC patients who may benefit from ACT. This approach supports data-driven, individualized chemotherapy decision-making and contributes to advancing personalized treatment strategies in early-stage NSCLC.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Assisted Emergency Department Vertical Patient Flow Optimization.","authors":"Nicole R Hodgson, Soroush Saghafian, Wayne A Martini, Arshya Feizi, Agni Orfanoudaki","doi":"10.3390/jpm15060219","DOIUrl":"10.3390/jpm15060219","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Recent advances in artificial intelligence (AI) and machine learning (ML) enable targeted optimization of emergency department (ED) operations. We examine how reworking an ED's vertical processing pathway (VPP) using AI- and ML-driven recommendations affected patient throughput. <b>Methods</b>: We trained a non-linear ML model using triage data from 49,350 ED encounters to generate a personalized risk score that predicted whether an incoming patient is suitable for vertical processing. This model was integrated into a stochastic patient flow framework using queueing theory to derive an optimized VPP design. The resulting protocol prioritized a vertical assessment for patients with Emergency Severity Index (ESI) scores of 4 and 5, as well as 3 when the chief complaints involved skin, urinary, or eye issues. In periods of ED saturation, our data-driven protocol suggested that any waiting room patient should become VPP eligible. We implemented this protocol during a 13-week prospective trial and evaluated its effect on ED performance using before-and-after data. <b>Results</b>: Implementation of the optimized VPP protocol reduced the average ED length of stay (LOS) by 10.75 min (4.15%). Adjusted analyses controlling for potential confounders during the study period estimated a LOS reduction between 7.5 and 11.9 min (2.89% and 4.60%, respectively). No adverse effects were observed in the quality metrics, including 72 h ED revisit or hospitalization rates. <b>Conclusions:</b> A personalized, data-driven VPP protocol, enabled by ML predictions, significantly improved the ED throughput while preserving care quality. Unlike standard fast-track systems, this approach adapts to ED saturation and patient acuity. The methodology is customizable to patient populations and ED operational characteristics, supporting personalized patient flow optimization across diverse emergency care settings.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Traits of Bariatric Surgery Candidates and Predictors of Outcomes.","authors":"Abed Hadipour Lakmehsari, Carmela Mento, Claudia Scaramuzzino, Federica Arena, Fabrizio Turiaco, Maria Rosaria Anna Muscatello, Giuseppe Navarra, Gianluca Pandolfo, Clara Lombardo","doi":"10.3390/jpm15060215","DOIUrl":"10.3390/jpm15060215","url":null,"abstract":"<p><p><b>Background:</b> Obesity is associated with a reduced life expectancy of 5 to 20 years, depending on the severity of the condition and the presence of comorbidities. Beyond first- and second-line interventions such as lifestyle changes, pharmacotherapy, which includes appetite suppressants, drugs that reduce fat absorption or regulate neurohormonal pathways, and endoscopic procedures, bariatric surgery is currently considered one of the most effective long-term interventions for severe obesity. This exploratory study investigates the psychological functioning of bariatric surgery candidates in the preoperative phase, aiming to identify risk factors and potential predictors of response to surgery in an Italian sample. <b>Methods:</b> This is a retrospective, observational study with follow-up. Participants, evaluated between September 2021 and September 2022 at Messina University Hospital, were recontacted approximately one year after surgery for re-evaluation. Of the 97 initial patients, 33 agreed to complete online questionnaires for follow-up. <b>Results</b>: The baseline data showed no significant differences between men and women in psychological assessments. In the subgroup that completed the follow-up, significant changes were observed, including a reduction in BMI and an increase in the discomfort index (Body Uneasiness Test) post-surgery, with large effect sizes in both cases. However, despite these changes, the regression analysis revealed that preoperative BMI values were not directly related to postoperative body image difficulties. These findings suggest a limited psychological impact of bariatric surgery, emphasizing the need for tailored psychological interventions to address these issues. <b>Conclusions</b>: While the intervention confirmed its effectiveness in reducing BMI, improvements in psychological well-being were less pronounced. In particular, a significant increase in body image concerns (PSDI) emerged after surgery, suggesting the need to address body-related distress in post-surgical care. These findings may suggest multidisciplinary approaches that integrate physical and psychological interventions may be needed to maximise long-term benefits. Further research should explore strategies to enhance patient awareness of treatment options, body image issues, and potential complications. These results should be interpreted with caution considering the limitations associated with this study such as a small sample size, lack of a control group, and the use of self-report and online methods to gather data, among others.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of Fatigue and Body Composition in Women with Long COVID After Non-Aerobic Therapeutic Exercise Program.","authors":"María Miana, Ricardo Moreta-Fuentes, Carmen Jiménez-Antona, César Moreta-Fuentes, Sofía Laguarta-Val","doi":"10.3390/jpm15060217","DOIUrl":"10.3390/jpm15060217","url":null,"abstract":"<p><p><b>Background/Objective</b>: Fatigue is one of the most recurrent and most disabling symptoms of long COVID (LC) and is associated with a worse quality of life. Reducing body fat in these patients could be important to mitigate fatigue and post-exertional worsening. Aerobic exercise may not be indicated in LC patients who have orthostatic tachycardia and post-exertional worsening. The aim of this study was to evaluate the effects of a personalized supine therapeutic motor control exercise program on fatigue and fat tissue in women with LC. <b>Methods</b>: A single-arm exploratory case study, with a pre-post format, was conducted on 17 women with LC to test the effects of a plank-based strengthening exercise program on fatigue, which was evaluated by the Modified Fatigue Impact Scale and fat tissue assessed by bioimpedance. The twelve-week program included two weekly sessions. The exercise program was personalized, considering the symptoms and characteristics of the patients. <b>Results</b>: Participants with overweight or obesity (n = 12) comprised 70% of the entire sample. After completing the exercise program this value decreased by 5.9 percentage points. Significant differences were found in the total [(MD  = -1.72, 95% CI -2.57 to -0.86), r = 0.73], trunk, upper and inner limbs body fat percentages (<i>p</i> < 0.05). The overall fatigue decreased at 12 weeks [(MD  =  -14.00, 95% CI -21.69 to -6.31), r = 0.69] as well as the physical and psychosocial fatigue sub-scale (<i>p</i>  <  0.001); no differences were observed in the cognitive sub-scale. <b>Conclusions</b>: The plank-based personalized strengthening exercise program showed rapid improvements in fatigue and fat percentages. It could be an effective strategy to achieve improvements for LC patients.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiology of Chylous Anasarca Caused by Lymphatic Occlusion: A Case Report and Review of the Literature.","authors":"Antoine Mathivet, Martin Bertrand, Isabelle Quere, Jean-Christophe Gris, Julien Ghelfi, Julien Frandon","doi":"10.3390/jpm15060216","DOIUrl":"10.3390/jpm15060216","url":null,"abstract":"<p><p><b>Objective:</b> The aim of this study was to propose a pathophysiological hypothesis for the occurrence of non-traumatic chylous effusions and Central Conducting Lymphatic Anomalies (CCLAs) related to lymphatic occlusion. <b>Methods</b>: We investigated the case of a 39-year-old woman managed at Nîmes University Hospital for chylous anasarca related to an endoluminal lymphatic occlusion. We then conducted a comprehensive review of the literature on CCLAs. <b>Results</b>: Lymphatic drainage is a dynamic process. Obstacles to lymphatic drainage via the thoracic duct can lead to chylous anasarca, depending on where the obstruction is. Lymphatic occlusion seems to be an explanation for certain CCLAs. <b>Conclusions</b>: Understanding CCLAs via the theory of lymph occlusion opens the way to new therapeutic options, but requires further investigation in order to personalize the patient's treatment.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRP Therapy for Stress Urinary Incontinence and Pelvic Organ Prolapse: A New Frontier in Personalized Treatment?","authors":"Anna Pitsillidi, Laura Vona, Stefano Bettocchi, Sven Schiermeier, Günter Karl Noé","doi":"10.3390/jpm15060214","DOIUrl":"10.3390/jpm15060214","url":null,"abstract":"<p><p><b>Background:</b> Pelvic organ prolapse (POP) and stress incontinence (SUI) are very common medical conditions, affecting women's quality of life worldwide. Current surgical and conservative therapies often yield variable outcomes and carry risks of complications or recurrence. Platelet-rich plasma (PRP) has emerged as a promising regenerative approach in various medical disciplines. Its application in urogynecology remains relatively new and emerging. The objective of this study was to review and consolidate existing evidence regarding the application of PRP injections for treating POP and/or SUI. <b>Methods:</b> This scoping review was conducted in accordance with the Preferred Reporting Items for Scoping Reviews (PRISMA-ScR). The search strategy included MEDLINE (PubMed), Web of Science, and Scopus databases, covering articles published up to February 2025, with no restrictions on publication date. <b>Results:</b> We included in our review a total of 13 manuscripts and 320 patients at the end of the screening process. A total of ten SUI studies, comprising 273 patients, and three POP studies, involving 47 patients, satisfied all the review criteria. Both clinical entities reported high subjective improvement following PRP treatment. Moreover, PRP appeared to have no significant adverse effects. <b>Conclusions:</b> Our scoping review suggests that PRP may have potential benefits in the treatment of POP and SUI. Nevertheless, the current evidence on its application in this area remains limited. Therefore, well-designed, large-scale randomized controlled trials (RCTs) with extended follow-up periods are urgently needed, in the era of personalized medicine.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interstitial Lung Diseases and Lung Cancer: A Review on Similarities, Common Pathogenesis and Therapeutic Approach.","authors":"Gioele Castelli, Elisabetta Cocconcelli, Giuliana Grimaudo, Irene Di Leo, Serena Bellani, Giordano Fiorentù, Giacomo Giulianelli, Nicol Bernardinello, Elisabetta Balestro, Paolo Spagnolo","doi":"10.3390/jpm15050213","DOIUrl":"10.3390/jpm15050213","url":null,"abstract":"<p><p>Interstitial lung disease (ILD) prevalence and survival are increasing due to improvement in scientific research together with clinical complications typical of advanced disease. Lung cancer (LC) is described as a possible event occurring in lung parenchyma in the context of fibrotic abnormalities that worsen patients' prognosis. This growth of malignant cells on a fibrotic background has also been called scar-cinoma. For this reason, not only an early diagnosis but also personalized decisions on the best treatment approach should be considered for each patient in a multidisciplinary discussion, since in some cases chemotherapy or surgery could be detrimental for patients with pulmonary fibrosis. LC and lung fibrosis may share common pathogenetic mechanisms like an altered healing process in response to repeated tissue damage from environmental exposure in genetically susceptible individuals. Smoking history and air pollution together with mutations in telomere and surfactant protein genes lead to the production of cytokines and nitro derivatives in the microenvironment that facilitate the carcinomatous transformation during fibrogenesis. The evolution of LC therapy and the implementation of immunotherapy acting on targetable immune checkpoints have raised interest in evaluating ILD-LC actionable mutations. The main pathogenetic mechanisms, clinical presentations and treatment implications are presented in this review.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}