Journal of Pharmaceutical Research International最新文献

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Evaluation of the Reporting System of Chemical Poisoning and Drug Safety Program in the Governmental and Private Hospitals in Jeddah City, Saudi Arabia, A Cross-Sectional Study 对沙特阿拉伯吉达市政府医院和私立医院化学中毒报告系统和药物安全计划的评估,一项横断面研究
Journal of Pharmaceutical Research International Pub Date : 2023-12-23 DOI: 10.9734/jpri/2023/v35i337476
Mohammed Abdulaziz Kareem, Khalid Mohammed Alzahrani, A. S. Alshehri, Nedal Jamal A. Almasri, Wael Abdi Almutairi, Adel Saed Alghamdi
{"title":"Evaluation of the Reporting System of Chemical Poisoning and Drug Safety Program in the Governmental and Private Hospitals in Jeddah City, Saudi Arabia, A Cross-Sectional Study","authors":"Mohammed Abdulaziz Kareem, Khalid Mohammed Alzahrani, A. S. Alshehri, Nedal Jamal A. Almasri, Wael Abdi Almutairi, Adel Saed Alghamdi","doi":"10.9734/jpri/2023/v35i337476","DOIUrl":"https://doi.org/10.9734/jpri/2023/v35i337476","url":null,"abstract":"Background: Chemical poisoning is a major health issue. This study aimed to assess and evaluate the reporting system of chemical poisoning and drug safety program (CSP) in the governmental and private hospitals in Jeddah city, Saudi Arabia. Methods: This descriptive and analytical cross-sectional study was conducted in Jeddah city, Saudi Arabia in the period from January to June 2022. we included 30 governmental and private hospitals that included more than 150 beds. To collect data, this study used a 17-item evaluation form that was approved and used by the Saudi Ministry of Health to evaluate the reporting systems in the hospitals in the country. Results: Regarding the Reporting system in the public health departments (PHD), the Ministry of Health (MOH) memo for reporting cases of chemical and drug overdose is present in 80% of the hospitals, 30% reported that samples sent to the toxicology center are received. Regarding the Reporting system in the emergency department, 46.7% reported that death cases are immediately reported to the PHD. Regarding the Reporting system in hospital laboratory, 46.5% reported that chemical and drug overdose samples are sent to the Toxicology Center. Reporting system in the public health department and Reporting system in the emergency department were better in the Private hospitals (p =0.042 and p=0.045, respectively). Conclusion: Low adherence was found in the recruited hospitals. Less adherence was found in the governmental hospitals, particularly in the reporting system in the public health departments and the reporting system in the emergency departments. Some hospitals scored low in the three domains of the evaluation form.","PeriodicalId":16718,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"15 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139162519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Incidence of the Associated Meniscal Ligament (ML) With the Anterior Cruciate Ligament (ACL) Tears 前十字韧带(ACL)撕裂时相关半月板韧带(ML)的发生率
Journal of Pharmaceutical Research International Pub Date : 2023-12-22 DOI: 10.9734/jpri/2023/v35i337473
Mahmoud S. Babiker, Awatif M Omer, Amel F. Alzain, Meaad Elbashir, Rufida E. Ahmed, Omima Adam Ahmed, Esra Salam Mohamed
{"title":"The Incidence of the Associated Meniscal Ligament (ML) With the Anterior Cruciate Ligament (ACL) Tears","authors":"Mahmoud S. Babiker, Awatif M Omer, Amel F. Alzain, Meaad Elbashir, Rufida E. Ahmed, Omima Adam Ahmed, Esra Salam Mohamed","doi":"10.9734/jpri/2023/v35i337473","DOIUrl":"https://doi.org/10.9734/jpri/2023/v35i337473","url":null,"abstract":"Objective: To assess the incidence of the associated meniscal ligament (ML) with the anterior cruciate ligament (ACL) tears in hospital A in Medina-KSA. And to see the effect of sports activities in comparison between males and females.  Materials and Methods: In a retrospective study, ninety-nine patients' knee magnetic resonance imaging (MRI) records were selected conveniently from the (A) hospital's picture archiving and communication system (PACS). Patients with suspected anterior cruciate and meniscal ligament' tears were included. Patients with posterior cruciate ligament (PCL) tear, medial collateral ligament (MCL) or lateral collateral ligament (LCL) injury, and previously operated index knees were excluded. All patients were scanned by a 1.5T MRI machine using standard MRI knee scanning protocol. The categorical and continuous variables were presented as percentages, frequencies, and descriptive statistics. The cross-tabulations and chi-square test were applied to obtain the statistical associations between the study variables. A statistical association was considered significant if the P-value was < 0.05.  Results: 72 males and 27 females were included, with a mean age of 33 ± 2.43. 42.4% of the knee tears were ML tears, followed by associated (ACL with ML) tears, noted in 31.3%, and 26.3% were ACL tears. The tears were more frequent in the age group (31-40), reported in 35.3% (out of 99). There was no statistical association between the tears and the participants' age, gender, or sports activities; P value = 0.3, 0.5, and 0.9, respectively.  Conclusion: The study concluded that the isolated ML tears were more frequent than the associated (ACL with ML) tears—moreover, there was no significant statistical association between the participants' age, gender, or sports activities.","PeriodicalId":16718,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"86 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139163262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Injecting Quality Care: Syringes and their Impact on Precision Medicine in Healthcare 注射优质护理:注射器及其对医疗保健领域精准医疗的影响
Journal of Pharmaceutical Research International Pub Date : 2023-12-21 DOI: 10.9734/jpri/2023/v35i327471
Akash Sharma, Chandra Prakash, Ankur Vora
{"title":"Injecting Quality Care: Syringes and their Impact on Precision Medicine in Healthcare","authors":"Akash Sharma, Chandra Prakash, Ankur Vora","doi":"10.9734/jpri/2023/v35i327471","DOIUrl":"https://doi.org/10.9734/jpri/2023/v35i327471","url":null,"abstract":"This paper explores the pivotal role of syringes in the era of precision medicine, shedding light on their historical significance, technological advancements, and the profound impact they have on healthcare quality. By delving into the design features of precision syringes and their application in various medical fields, this paper aims to underline the critical role these instruments play in achieving optimal patient outcomes. The discussion also addresses challenges, solutions, and the regulatory landscape, offering a comprehensive overview of the synergy between syringes and precision medicine.","PeriodicalId":16718,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"25 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139166108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Effects of Vitamin C Supplementation in Wound Healing Post Dental Implant Surgery: A Clinical Study 评估维生素 C 补充剂对植牙术后伤口愈合的影响:临床研究
Journal of Pharmaceutical Research International Pub Date : 2023-12-21 DOI: 10.9734/jpri/2023/v35i337472
Sarangal Vandana, Goyal Pankaj, S. Tej, Kaur Supreet, Suchdev Vasudha
{"title":"Evaluation of Effects of Vitamin C Supplementation in Wound Healing Post Dental Implant Surgery: A Clinical Study","authors":"Sarangal Vandana, Goyal Pankaj, S. Tej, Kaur Supreet, Suchdev Vasudha","doi":"10.9734/jpri/2023/v35i337472","DOIUrl":"https://doi.org/10.9734/jpri/2023/v35i337472","url":null,"abstract":"Aim: The present study was conducted to assess the role of vitamin C in wound healing following dental implant surgery. Materials and Methods: 60 patients receiving dental implants were divided into two groups of 30 each. group A and group B. Group A included 30 patients who underwent dental implant surgery along with vitamin C supplementation, 500 mg twice a day post-surgery for 5 days and group B included 30 patients who underwent dental implant surgery alone. The Wound Healing Index, Wound Evaluation score and Visual Analog Scale were the following indices evaluated. Results: The results of the present study showed that there was a significant improvement in all indices in both group A and group B, but results in group A were statistically more significant than group B and indicating that maximum healing was seen in the first 7 days post-operative, thereafter, remaining more or less the same. In reference to vitamin C for pain relief, there was no statistically difference between the study groups. Conclusion: Using vitamin C supplementation post-operative healing following dental implant surgery in patients given vitamin C. However, vitamin C supplementation does not decrease the post operative pain associated with dental pain and anxiety.","PeriodicalId":16718,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"20 S5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmaceutical Studies of Leaf and Bark Extracts of Mammea suriga (Buch.-Ham. ex Roxb.) Kosterm. Mammea suriga(Buch.-Ham. ex Roxb.)
Journal of Pharmaceutical Research International Pub Date : 2023-12-18 DOI: 10.9734/jpri/2023/v35i327470
Trupthi N. Rane, Rama Bhat P.
{"title":"Pharmaceutical Studies of Leaf and Bark Extracts of Mammea suriga (Buch.-Ham. ex Roxb.) Kosterm.","authors":"Trupthi N. Rane, Rama Bhat P.","doi":"10.9734/jpri/2023/v35i327470","DOIUrl":"https://doi.org/10.9734/jpri/2023/v35i327470","url":null,"abstract":"Mammea suriga is a familiar endemic medicinal plant belonging to the family Guttiferae/Clusiaceae, grows abundantly in the Western Ghats of India. The present investigation focuses on studying the phytoconstituents as well as antioxidant and antimicrobial properties of bark and leaf extracts. Phytochemical screening showed the presence of carbohydrates, phenolics, flavonoids, alkaloids, cardiac glycosides, terpenoids, triterpenoids, steroids and saponins. The carbohydrate contents were highest in leaf methanol (140.90 ± 1.19 mg/g), phenolic contents highest in leaf methanol (154.32 ± 1.80 mg/g), the highest flavonoid content were observed in bark aqueous extract (437.3878 ± 0.09mg/g). In the antioxidant screening assay, the highest inhibition concentration was found to be IC­50 (53.33 ± 0.13) for leaf methanol for DPPH, highest ferric reducing activity was observed in both the bark extracts at 300μg/mL concentrations, antioxidant activity for phoshomolybdenum assay was observed highest (75%) in leaf methanol extract at 300μg/mL. Antibacterial activity was carried out  by agar well diffusion method using extracts against E. coli, K. pneumoniae, P. aeruginosa and S. aureus which showed inhibition  zone diameter ranging  from 12-22mm. Antifungal test by poison bait method against Fusarium solani and Colletotrichum gloeosporioides have shown good results.","PeriodicalId":16718,"journal":{"name":"Journal of Pharmaceutical Research International","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138994771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Social Work Services on the Quality of Care in Mental Health Complex in Jeddah: A Study of Healthcare Professionals’ Perceptions 社会工作服务对吉达心理健康综合医院护理质量的影响:医疗保健专业人员的看法研究
Journal of Pharmaceutical Research International Pub Date : 2023-12-16 DOI: 10.9734/jpri/2023/v35i327469
Waseem Mohammed Alkhaldi, Ohoud Fouad Abuatallah, Nesreen Abdullah AL-Ghamdi, Bandar Allahyani, Salman Safar Alghamdi, Mohammed Ali Alqarni, Ibrahim Abdullah Alzahrani
{"title":"The Impact of Social Work Services on the Quality of Care in Mental Health Complex in Jeddah: A Study of Healthcare Professionals’ Perceptions","authors":"Waseem Mohammed Alkhaldi, Ohoud Fouad Abuatallah, Nesreen Abdullah AL-Ghamdi, Bandar Allahyani, Salman Safar Alghamdi, Mohammed Ali Alqarni, Ibrahim Abdullah Alzahrani","doi":"10.9734/jpri/2023/v35i327469","DOIUrl":"https://doi.org/10.9734/jpri/2023/v35i327469","url":null,"abstract":"Aim: This study aims to investigate the influence of social work services on the quality of care at Eradah and Mental Health Complex in Jeddah. \u0000Duration of the Study: This study employs one year of conduction from December 2022 to November 2023. \u0000Methods: A cross-sectional study was conducted using the SERVQUL questionnaire as the main scale to assess the degree of social work influence on the overall quality of the healthcare setting to be distributed among selected healthcare workers. \u0000Results: Among randomly selected 240 healthcare workers, among these, 20.8% were aged between 25 and 30 years, the majority (68.3%) were male, about 45.4% had a bachelor’s degree, also, about 67.5% of them were married, 52.5% were laboratory technicians. The results indicated a moderate healthcare rating with a mean score of 58.29 and a moderate healthcare adherence rating with a mean score of 98.37. The results revealed a significant difference in the quality of healthcare among patients due to education (P-value =0.012) and there was a significant difference with job title (p-value = 0.001). However, no significant differences were observed about age, or marital status. \u0000Conclusion: It can be concluded that social work is a crucial type of work that must be implemented among healthcare workers to enhance cooperation and serve society, it has been found that healthcare adherence was rated as moderate. Nevertheless, variables such as age, gender, education level, and marital status did not exert a substantial impact.","PeriodicalId":16718,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"56 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical Error’ Incidence and Its Relation to Psychological Stressors among Nurses in Jeddah, Saudi Arabia 沙特阿拉伯吉达护士的 "医疗事故 "发生率及其与心理压力的关系
Journal of Pharmaceutical Research International Pub Date : 2023-12-15 DOI: 10.9734/jpri/2023/v35i327468
Wajdi Alansari, Abdullah Hasan Alshaikhi, Mohanna Almutairi, Dalia Khalid H. Kaki, Ali Ghurmullah Alzahrani
{"title":"Medical Error’ Incidence and Its Relation to Psychological Stressors among Nurses in Jeddah, Saudi Arabia","authors":"Wajdi Alansari, Abdullah Hasan Alshaikhi, Mohanna Almutairi, Dalia Khalid H. Kaki, Ali Ghurmullah Alzahrani","doi":"10.9734/jpri/2023/v35i327468","DOIUrl":"https://doi.org/10.9734/jpri/2023/v35i327468","url":null,"abstract":"Aim: This review aimed to assess the correlation between nurses’ exposure to psychosocial stressors and the occurrence of medical and medication errors in some hospitals of Jeddah and its correlation to other hospitals. \u0000Methods: The study utilized a range of approaches. To conduct a thorough literature search, a total of five databases CINAHL, PubMed, COCHRANE, Google Scholar and Web of Science were employed. \u0000Results: Using date filters, we ensured that the literature we retrieved was accurate and up to date for the last 5 years across all databases to ensure updated deep analysis evidence to find that from a total of 6019 studies, only seventeen studies were relevant to this review to be analyzed and discussed to find that to mitigate the likelihood of medical incidents/errors, it is imperative to consider factors such as current/recent illness, bodily discomfort, and emotional role as personal challenges for nurses. Additionally, addressing break periods during the night shift and working conditions as administrative concerns is crucial. \u0000Conclusion: Research has demonstrated that medical errors constitute the most widespread kind of errors, posing a significant risk to patient safety. Many psychological factors are concerned with rising rates of errors among nurses. The implementation of proactive methods is a successful approach to mitigating medical errors within healthcare settings.","PeriodicalId":16718,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"15 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139001255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimaging and Neuropsychological Performance in Parkinson's Disease Patients with Normal Cognition: A Systematic Review 认知正常的帕金森病患者的神经影像学和神经心理学表现:系统回顾
Journal of Pharmaceutical Research International Pub Date : 2023-12-14 DOI: 10.9734/jpri/2023/v35i327467
Abeer Alanazi, Reema Albakheit, Hamad Alzahrani
{"title":"Neuroimaging and Neuropsychological Performance in Parkinson's Disease Patients with Normal Cognition: A Systematic Review","authors":"Abeer Alanazi, Reema Albakheit, Hamad Alzahrani","doi":"10.9734/jpri/2023/v35i327467","DOIUrl":"https://doi.org/10.9734/jpri/2023/v35i327467","url":null,"abstract":"Introduction: Cognitive decline is one of Parkinson's disease's (PD) non-motor symptoms that is most frequently observed. Patients with PD exhibit quick cognitive decline in a variety of cognitive domains, particularly in the areas of executive functions, attention, language, memory, and visuospatial abilities. The scope of PD patients with normal cognition (PD-NC) and its relationship to specific regions of the brain as shown by neuroimaging, have not received much attention in the literature. \u0000Objective: This review was to summarise the existing literature that explored cognitive performance in PD-NC using different neuroimaging techniques. \u0000Methods: A comprehensive search was conducted on PubMed and Web of Science databases. This review focused on papers that investigated neuroimaging and neuropsychological performance in patients with PD. A total of 17 articles have met the criteria. \u0000Results: The findings of this review were that executive functions appear to be the most critical cognitive domain to be damaged in PD-NC. Global cognitive ability was found to have insignificant decline overall between PD-NC and healthy controls (HC). Attention and executive functions were associated with the prefrontal cortex. Memory was mainly associated with hippocampal atrophy. Language was associated with cerebrospinal fluid and grey matter. Visuospatial ability was associated with the anterior cingulate cortex. \u0000Conclusion:  This review illustrated that PD-NC seemed to experience different cognitive patterns and neuroanatomical changes compared with HC. These results suggested that PD-NC may develop specific cognitive impairments associated with specific brain regions. Therefore, it indicated that PD-NC may need to have specific treatments tailored to their needs.","PeriodicalId":16718,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"21 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139002594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of Customized Ocular Prosthesis using a Surface Sealant and Modified Laboratory Technique Using Stainless Steel Wire 使用表面密封剂和改良实验室技术(使用不锈钢丝)制作定制眼球假体
Journal of Pharmaceutical Research International Pub Date : 2023-12-12 DOI: 10.9734/jpri/2023/v35i317466
Madhura Titar, P. Sanyal, Shubha Joshi
{"title":"Fabrication of Customized Ocular Prosthesis using a Surface Sealant and Modified Laboratory Technique Using Stainless Steel Wire","authors":"Madhura Titar, P. Sanyal, Shubha Joshi","doi":"10.9734/jpri/2023/v35i317466","DOIUrl":"https://doi.org/10.9734/jpri/2023/v35i317466","url":null,"abstract":"Eye defects are surgically classified as evisceration, enucleation, and exenteration. It causes psychological trauma as an individual is visually and esthetically compromised. Eye defects can be restored with silicone or acrylic-based prosthesis. This is a case report of a patient with a customized ocular prosthesis where emphasis has been given to securing the iris shell during the laboratory process. A surface sealant has been used to provide glossiness to the prosthesis. The appearance of the patient was enhanced with the eye prosthesis.","PeriodicalId":16718,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"13 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of Alkaloids in Sophora Flavescens with Liquid Chromatography Tandem Data-Dependent Acquisition Mass Spectrometry 用液相色谱-串联数据采集质谱法筛选红花槐中的生物碱
Journal of Pharmaceutical Research International Pub Date : 2023-11-27 DOI: 10.9734/jpri/2023/v35i317465
Hua Wang, Hui Ding
{"title":"Screening of Alkaloids in Sophora Flavescens with Liquid Chromatography Tandem Data-Dependent Acquisition Mass Spectrometry","authors":"Hua Wang, Hui Ding","doi":"10.9734/jpri/2023/v35i317465","DOIUrl":"https://doi.org/10.9734/jpri/2023/v35i317465","url":null,"abstract":"A novel and simple hyphenated method was applied for the screening of alkaloids in S. flavescens. The approach combined easy sample extraction with an ultra-high-performance liquid chromatography (UPLC) and a high-resolution mass spectrometry (HRMS) in the data-dependent acquisition (DDA) method. With the optimized chromatographic program, ten alkaloids were screened. Among them, matrine, oxymatrine, oxysophoridine, sophocarpine, and oxysophocarpine were identified and quantified. The other five alkaloids were identified with accurate m/z value in MS1 and product ions in MS2. The quantification method was validated with specificity, linearity, recovery, and precision. The LOD and LOQ were determined. In twelve batches of collected S. flavescens roots, the identified ten alkaloids were all observed. The oxymatrine was the most abundant component, and sophocarpine was the least abundant in these samples. This comprehensive method is a powerful tool for the biochemical and clinical research of S. flavescens. It can also be adopted in resource utilization and related medicine quality control.","PeriodicalId":16718,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139229027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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