{"title":"Ovicidal activity of adulticidal insecticides against the invasive wood borer <i>Aromia bungii</i>.","authors":"Yuichi Yamamoto, Shuji Kaneko","doi":"10.1584/jpestics.D24-050","DOIUrl":"10.1584/jpestics.D24-050","url":null,"abstract":"<p><p>The development of preventive methods against the invasive wood-boring beetle <i>Aromia bungii</i>, which infests Rosaceae trees, is required in Japan. We investigated the effect on eggs of several commercial insecticides whose active ingredients are registered to kill <i>A. bungii</i> adults or larvae by tree injection or spray. The ovicidal activity was evaluated using the corrected egg hatch rates based on the control (distilled water) after dipping pieces of cardboard, on which eggs were deposited, in liquid insecticide solutions for 10 sec. The egg-dipping tests revealed highly effective ovicidal activity in the following insecticides: more than 8000 ppm for fenitrothion, 1000 ppm for acetamiprid, 400 ppm for clothianidin, and 500 ppm for dinotefuran (corrected egg-hatch rates of approximately less than 5%). In terms of current registration in Japan, only fenitrothion (SUMIPAIN emulsion) and acetamiprid (MATSUGREEN liquid solution 2) by trunk spraying during the <i>A. bungii</i> reproductive period are adulticidal insecticide candidates with preventive potential through incidental ovicidal activity.</p>","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"50 1","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research and development of an insecticide, afidopyropen.","authors":"Ryo Horikoshi, Kimihiko Goto, Masaaki Mitomi, Toshiaki Sunazuka, Satoshi Ōmura","doi":"10.1584/jpestics.J25-01","DOIUrl":"10.1584/jpestics.J25-01","url":null,"abstract":"","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"50 1","pages":"14-17"},"PeriodicalIF":1.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of <i>N</i>-alkylated octopamine derivatives and their interaction with octopamine receptor BmOAR1.","authors":"Kenji Oshima, Ryunosuke Yamamoto, Haruna Yamasaki, Maki Katayama, Keita Noda, Tomohiro Oishi, Hiroto Ohta","doi":"10.1584/jpestics.D24-054","DOIUrl":"10.1584/jpestics.D24-054","url":null,"abstract":"<p><p>A series of <i>N</i>-alkylated octopamine derivatives was synthesized, and the structure-activity relationships of these derivatives with the silkworm <i>Bombyx mori</i> octopamine receptor BmOAR1 were evaluated using a secreted placental alkaline phosphatase reporter assay system. The <i>N</i>-alkyl moiety on the ligand affected the intensity of the agonist activity in the order: CH<sub>3</sub>>(H)>C<sub>2</sub>H<sub>5</sub>. Although linear alkyl chains of C3 or higher did not exhibit any activity, the fixed C3 alkyl group forming a pyrrolidine ring showed significant activity. These results suggest that BmOAR1 has a relatively small space around the amine-binding site, and the alkyl part constituting the cyclic amine could exert the same effect as the small alkyl group.</p>","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"50 1","pages":"9-13"},"PeriodicalIF":1.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haruka Takeuchi, Masahiro Nomura, Ryo Horikoshi, Shu Aasano, Takaaki Miyake, Takeru Kobayashi, Masatoshi Murai, Ying-Ju Chen, Fergus Earley, John Mina, Andrew Crossthwaite
{"title":"Flometoquin, a novel insecticide, acts on mitochondrial complex III as a Q<sub>i</sub> inhibitor.","authors":"Haruka Takeuchi, Masahiro Nomura, Ryo Horikoshi, Shu Aasano, Takaaki Miyake, Takeru Kobayashi, Masatoshi Murai, Ying-Ju Chen, Fergus Earley, John Mina, Andrew Crossthwaite","doi":"10.1584/jpestics.D24-008","DOIUrl":"10.1584/jpestics.D24-008","url":null,"abstract":"<p><p>Flometoquin (FLO) is a novel quinoline-type insecticide that elicits a quick knock-down effect against target pests; however, its mode of action (MoA) remains unknown. In this study, we investigated its MoA systematically, using varying biochemical techniques. Since FLO-treated insects exhibited symptoms similar to those induced by respiratory inhibitors, we examined the effect of FLO on respiratory enzyme complexes using mitochondria isolated from different insects (housefly, diamondback moth, and western flower thrips). We found that FLO itself is not active; however, its deacylated metabolite, FloMet, specifically inhibits the activity of ubiquinol-cytochrome <i>c</i> oxidoreductase (complex III) in mitochondria at the nM level. Ligand binding assays and monitoring the reduction kinetics of cytochrome hemes <i>b</i> and <i>c</i> <sub>1</sub> clearly revealed that FloMet inhibits complex III by binding to the Q<sub>i</sub> site.</p>","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"49 4","pages":"203-209"},"PeriodicalIF":1.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discovery of anti-phytopathogenic fungal activity of a new type of (<i>S</i>)-coumarin bearing a phenylpropanoid unit at the 3-position.","authors":"Hazna Sartiva, Hisashi Nishiwaki, Koichi Akiyama, Satoshi Yamauchi","doi":"10.1584/jpestics.D24-038","DOIUrl":"10.1584/jpestics.D24-038","url":null,"abstract":"<p><p>The enantiospecific anti-phytopathogenic fungal activity of a new type of coumarin bearing a phenylpropanoid unit at the 3-position was found. (<i>S</i>)-3-[1-Methoxy-3-(4-methoxyphenyl)prop-2-yl]coumarin ((<i>S</i>)-<b>5</b>: EC<sub>50</sub>=16.5 µM) was 30 times more effective than the (<i>R</i>)-form against the <i>Alternaria alternata</i> Japanese pear pathotype. Derivatives bearing different substituents on the 7'-aromatic ring and the coumarin ring were synthesized to discover the more potent compounds. The 3'-CF<sub>3</sub> and 4'-CF<sub>3</sub> derivatives, <b>39</b> and <b>40</b>, respectively, had the lowest EC<sub>50</sub> values (1-2 µM) in this project, suggesting that the size of the electron-withdrawing and hydrophobic substituents at these positions gave an advantage. On the coumarin ring, the presence of the OCH<sub>3</sub> or CH<sub>3</sub> group at the 5-position accelerated the activity, as the (4'-OCH<sub>3</sub>, 5-OCH<sub>3</sub>) derivative <b>41</b> and (4'-OCH<sub>3</sub>, 5-CH<sub>3</sub>) derivative <b>45</b> were, respectively, 4-5 times more potent than the 4'-OCH<sub>3</sub> derivative (<i>S</i>)-<b>5</b>.</p>","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"49 4","pages":"262-270"},"PeriodicalIF":1.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and biological evaluation of MS-347a derivatives against plant pathogenic fungi based on a strategy of <i>laeA</i> gene introduction.","authors":"Aoi Kimishima, Sota Honma, Atsushi Kimishima, Atsuka Nishitomi, Masako Honsho, Paul Wasuwanich, Hiroki Kojima, Toshiyuki Tokiwa, Akihiro Sugawara, Yasuko Araki, Tadashi Takahashi, Takumi Chinen, Takeo Usui, Shin-Ichi Fuji, Kotaro Ito, Yukihiro Asami","doi":"10.1584/jpestics.D24-035","DOIUrl":"10.1584/jpestics.D24-035","url":null,"abstract":"<p><p>Our group previously identified MS-347a (<b>1</b>) as a new fungicide candidate from the culture broth of the mutant strain, <i>Aspergillus</i> sp. KTF-0058, which had the <i>laeA</i> gene inserted. This mutant strain was able to produce a sufficient supply of <b>1</b>, allowing for its use to investigate the structure-activity relationship. To this end, we synthesized 11 derivatives and evaluated their antifungal activity. Among these derivatives, the aldehyde derivative exhibited superior antifungal potency as compared to <b>1</b>, and some acyl derivatives were able to maintain the antifungal activity of <b>1</b> despite significant structural changes. From these results, it is found that the aldehyde derivative is one of the most promising fungicidal candidates, and the introduction of acyl groups could be utilized to create chemical probes for target-identification experiments.</p>","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"49 4","pages":"224-231"},"PeriodicalIF":1.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthetic studies on biologically active natural products with potential as agrochemicals.","authors":"Hirosato Takikawa","doi":"10.1584/jpestics.J24-01","DOIUrl":"10.1584/jpestics.J24-01","url":null,"abstract":"<p><p>The chemical synthesis of biologically active natural products has diverse objectives and missions, including 1) determining the structures of the natural products, 2) providing synthetic samples for studying the activity and function, 3) providing a basis for applied research on these compounds, <i>etc</i>. I have studied various biologically active natural products and conducted synthetic studies on these compounds with various objectives. In this review, I present the results of my research, focusing on natural products with potential as agrochemicals.</p>","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"49 4","pages":"297-302"},"PeriodicalIF":1.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Syntheses and structure-activity relationship of lignans to develop novel pesticides.","authors":"Satoshi Yamauchi","doi":"10.1584/jpestics.J24-03","DOIUrl":"https://doi.org/10.1584/jpestics.J24-03","url":null,"abstract":"<p><p>The syntheses of stereoisomers of butane, butanediol, γ-butyrolactone, tri-substituted tetrahydrofuran (7,9'-epoxy), furofuran, tetra-substituted tetrahydrofuran (7,7'-epoxy and 7,8'-epoxy-8,7'-neolignan), benzylidene, coumarin, indan, and pyran type lignans were achieved. All the stereoisomers of the butane type lignans showed larvicidal activity and anti-phytopathogenic fungal activity. The γ-butyrolactone lignan showed stereospecific cytotoxicity against insect cells. Stereo/enantiospecific plant growth inhibitory activity was observed in tri-substituted tetrahydrofuran, tetra-substituted tetrahydrofuran (7,7'-epoxy), coumarin, and pyran type lignans. The furofuran lignan both inhibited and promoted growth in plants. Stereo/enantiospecific anti-phytopathogenic fungal activity was observed in tetra-substituted tetrahydrofuran (7,7'-epoxy) and <i>E</i>-benzylidene lignans.</p>","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"49 4","pages":"311-320"},"PeriodicalIF":1.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biological properties of isofetamid, a new SDHI fungicide.","authors":"Nanami Kuwahara, Shuko Nishimi, Yuzuka Abe, Masaya Ohno, Yasuko Takii, Akihiro Nishimura, Yohei Fukumori, Shintaro Tsukuda, Munekazu Ogawa, Satoshi Araki, Shigeru Mitani, Kazumi Suzuki","doi":"10.1584/jpestics.D24-043","DOIUrl":"https://doi.org/10.1584/jpestics.D24-043","url":null,"abstract":"<p><p>The biological properties of isofetamid, a new fungicide, were examined using pot tests in a greenhouse. In addition, we investigated the practical effects of isofetamid in field trials. In greenhouse pot tests, isofetamid exhibited high preventive efficacy against cucumber gray mold, powdery mildew, Corynespora leaf spot, and stem rot even at low concentrations. Isofetamid has excellent biological properties against cucumber gray mold and powdery mildew, such as rainfastness, residual activity, curative activity, translaminar activity, and transfer activity to undeveloped leaves, even at low concentrations. In field trials, isofetamid displayed high efficacy against tomato gray mold, cucumber powdery mildew, and lettuce stem rot. Therefore, the biological properties of isofetamid revealed in greenhouse tests contributed to its good performance in field trials.</p>","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"49 4","pages":"292-296"},"PeriodicalIF":1.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}