Journal of Pesticide Science最新文献

Acibenzolar-S-methyl inhibits accumulation of replication-associated DNA of tomato yellow leaf curl virus. 酸性苯并唑- s -甲基抑制番茄黄曲叶病毒复制相关DNA的积累。

IF 1.5 4区农林科学

Journal of Pesticide Science Pub Date : 2026-08-20 DOI: 10.1584/jpestics.D26-012

Nahid Akter, Haruka Shinji, Kagari Sakugawa, Md Nazrul Islam, Tsutomu Arie, Ken Komatsu

{"title":"Acibenzolar-S-methyl inhibits accumulation of replication-associated DNA of tomato yellow leaf curl virus.","authors":"Nahid Akter, Haruka Shinji, Kagari Sakugawa, Md Nazrul Islam, Tsutomu Arie, Ken Komatsu","doi":"10.1584/jpestics.D26-012","DOIUrl":"10.1584/jpestics.D26-012","url":null,"abstract":"Acibenzolar-S-methyl (ASM), a functional analogue of salicylic acid, induces systemic acquired resistance and restricts infection by several RNA viruses, yet its mechanisms against DNA viruses remain unknown. By examining the accumulation of tomato yellow leaf curl virus (TYLCV) DNA in inoculated leaves of Nicotiana benthamiana, we investigated whether ASM suppresses begomovirus infection. TYLCV was inoculated by agroinfiltration, and virion-sense (VS) and complementary-sense (CS) strands of TYLCV DNA were quantified separately using two-step strand-specific qPCR. ASM pretreatment significantly reduced the total TYLCV DNA accumulation at 1, 2, and 3 days post-inoculation. To determine whether this reduction reflected a direct effect on TYLCV rather than impaired Agrobacterium-mediated T-DNA delivery, we used a replication-defective mutant (TYLCVΔC1) as a delivery control and confirmed that ASM did not affect T-DNA delivery. Both VS and CS strands of wild-type TYLCV were substantially reduced by ASM treatment, providing the first direct evidence that ASM suppresses begomovirus infection by targeting viral DNA accumulation at the replication stage.","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"51 3","pages":"151-158"},"PeriodicalIF":1.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and structure-activity relationship studies of clavatol as an antifungal compound against pathogenic plant fungi using a drug-hypersensitive fission yeast screening system. 利用药物超敏裂变酵母筛选系统鉴定克拉瓦醇抗植物致病性真菌及其构效关系研究。

IF 1.5 4区农林科学

Journal of Pesticide Science Pub Date : 2026-08-20 DOI: 10.1584/jpestics.D26-008

Aoi Kimishima, Sota Negami, Wakana Yoda, Taichi Kamo, Sota Honma, Shigehiro A Kawashima, Yoko Yashiroda, Paul Wasuwanich, Yukiko Ujie, Shin-Ichi Fuji, Toshiyuki Tokiwa, Hiroki Kojima, Akihiro Sugawara, Takumi Chinen, Takeo Usui, Yukihiro Asami

{"title":"Identification and structure-activity relationship studies of clavatol as an antifungal compound against pathogenic plant fungi using a drug-hypersensitive fission yeast screening system.","authors":"Aoi Kimishima, Sota Negami, Wakana Yoda, Taichi Kamo, Sota Honma, Shigehiro A Kawashima, Yoko Yashiroda, Paul Wasuwanich, Yukiko Ujie, Shin-Ichi Fuji, Toshiyuki Tokiwa, Hiroki Kojima, Akihiro Sugawara, Takumi Chinen, Takeo Usui, Yukihiro Asami","doi":"10.1584/jpestics.D26-008","DOIUrl":"10.1584/jpestics.D26-008","url":null,"abstract":"Our original drug-hypersensitive fission yeast-based fungicide screening system identified clavatol (1) as a selective active compound against drug-hypersensitive fission yeast (more than 30-fold selectivity over multidrug-sensitive budding yeast). Compound 1, which was originally isolated from Penicillium species, has several biological activities including a very weak antifungal activity against Botrytis cinerea (the 50% effective concentration (EC50) value was 0.058 mg/mL). However, the selectivity of 1 against drug-hypersensitive fission yeast over the budding yeast prompted us to investigate overlooked antifungal activities. After evaluation, we revealed that 1 showed great antifungal activity against quinone outside inhibitors (QoI)-resistant Pyricularia oryzae. Furthermore, we evaluated the anti-P. oryzae activity of 8 compounds having structural features similar to those of 1 in order to elucidate the structure-activity relationship. Our research indicates that the drug-hypersensitive fission yeast-based fungicide screening system is a useful approach for discovering new fungicidal candidates and that 1 has great potential and would be a promising natural product as an agrochemical seed.","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"51 3","pages":"145-150"},"PeriodicalIF":1.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The discovery of pesticide lead compounds from microbial secondary metabolites. 微生物次生代谢产物中农药铅化合物的发现。

IF 1.5 4区农林科学

Journal of Pesticide Science Pub Date : 2026-08-20 DOI: 10.1584/jpestics.J26-03

Aoi Kimishima

{"title":"The discovery of pesticide lead compounds from microbial secondary metabolites.","authors":"Aoi Kimishima","doi":"10.1584/jpestics.J26-03","DOIUrl":"10.1584/jpestics.J26-03","url":null,"abstract":"Microbial secondary metabolites have historically provided numerous agrochemicals with novel chemical scaffolds and distinctive modes of action, contributing substantially to modern pesticide science. However, the long-term accumulation of natural product screening efforts has resulted in the frequent rediscovery of known compounds, and this issue, combined with the global spread of pesticide-resistant pests and pathogens, has become a serious challenge in agrochemical research. This commemorative review summarizes the research achievements of the author focusing on the discovery of pesticide seed compounds from microbial secondary metabolites. Particular emphasis is placed on two original strategies developed by the author: the activation of silent biosynthetic gene clusters in filamentous fungi via introduction of the global transcriptional regulator laeA and the construction of innovative bioassay platforms for antifungal and insecticidal screening using drug-hypersensitive model organisms. These approaches successfully expanded accessible chemical diversity, markedly improved hit rates, and enabled the identification of bioactive compounds with novel molecular targets. Collectively, these studies demonstrate a practical and versatile framework for natural-product-based pesticide discovery that supports sustainable crop protection.","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"51 3","pages":"193-197"},"PeriodicalIF":1.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emamectin benzoate seed coating provides systemic protection of maize against fall armyworm (Spodoptera frugiperda). 苯甲酸埃维菌素包种剂对玉米抗秋粘虫有系统的保护作用。

IF 1.5 4区农林科学

Journal of Pesticide Science Pub Date : 2026-08-20 DOI: 10.1584/jpestics.D25-082

Jariya Roddee, Wissanee Pola, Sudarat Pimkhonburee, Siriwan Nawong, Nichada Jearanaikoon

{"title":"Emamectin benzoate seed coating provides systemic protection of maize against fall armyworm (Spodoptera frugiperda).","authors":"Jariya Roddee, Wissanee Pola, Sudarat Pimkhonburee, Siriwan Nawong, Nichada Jearanaikoon","doi":"10.1584/jpestics.D25-082","DOIUrl":"10.1584/jpestics.D25-082","url":null,"abstract":"The fall armyworm, Spodoptera frugiperda, is a major invasive pest causing severe damage to maize. This study evaluated the efficacy of emamectin benzoate (EB) as a seed-coating insecticide and examined its systemic movement within maize plants. EB coatings did not affect seed germination or seedling vigor. Larval mortality was significantly higher in EB-treated plants, with PRIME GREEN G106 (PG)+EB at 0.5-1.0% producing 69-72% mortality at 20 days after germination. Leaf injury in treated plants remained below 25%, as compared with more than 40% in controls. Synchrotron FTIR (SR-FTIR) and principal component analysis (PCA) confirmed EB absorption and upward translocation from roots to leaves. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) detected EB residue in leaf tissues up to 30 days, while stems showed no detectable levels, indicating preferential foliar accumulation. Overall, EB seed coating provides adequate early-season protection against S. frugiperda and represents a promising component of sustainable maize pest management.","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"51 3","pages":"181-192"},"PeriodicalIF":1.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insecticidal effects of oxazosulfyl result from synaptic inhibition by targeting the vesicular acetylcholine transporter. 恶唑磺酰的杀虫作用是通过靶向囊泡乙酰胆碱转运体的突触抑制作用产生的。

IF 1.5 4区农林科学

Journal of Pesticide Science Pub Date : 2026-08-20 DOI: 10.1584/jpestics.D26-007

Takeshi Kojima, Fukumatsu Iwahashi

{"title":"Insecticidal effects of oxazosulfyl result from synaptic inhibition by targeting the vesicular acetylcholine transporter.","authors":"Takeshi Kojima, Fukumatsu Iwahashi","doi":"10.1584/jpestics.D26-007","DOIUrl":"10.1584/jpestics.D26-007","url":null,"abstract":"Oxazosulfyl is the first insecticide in the sulfyl (alkylsulfone) class developed for rice protection. While the vesicular acetylcholine transporter (VAChT) has been proposed as its primary molecular target, its mode of action has not yet been extensively examined in major agricultural pests. In this study, we investigated the binding affinity of oxazosulfyl to VAChT derived from the brown planthopper (BPH), a significant rice pest, and evaluated the relationship between its insecticidal activity and binding affinity. Oxazosulfyl bound to VAChT, heterologously expressed in cultured cells, with a Kd of 1.7 nM. The displacement potency of its analogs strongly correlated with their insecticidal activity against BPH in a rice foliar spray test. Combined with the observation that oxazosulfyl blocks excitatory synaptic transmission in the cercal reflex circuit of the American cockroach, these results indicate that oxazosulfyl functions as a synaptic transmission inhibitor, exerting potent insecticidal activity against BPH, primarily through VAChT inhibition.","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"51 3","pages":"159-171"},"PeriodicalIF":1.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavior of controlled-release pyrimisulfan in the soil and its herbicidal activity on Echinochloa oryzicola seedlings under various irrigation conditions. 不同灌溉条件下土壤中控释嘧硫丹的行为及其对米紫锥藻幼苗的除草活性

IF 1.5 4区农林科学

Journal of Pesticide Science Pub Date : 2026-08-20 DOI: 10.1584/jpestics.D26-006

Junya Goto, Yudai Hotta, Hideyuki Inui

{"title":"Behavior of controlled-release pyrimisulfan in the soil and its herbicidal activity on Echinochloa oryzicola seedlings under various irrigation conditions.","authors":"Junya Goto, Yudai Hotta, Hideyuki Inui","doi":"10.1584/jpestics.D26-006","DOIUrl":"10.1584/jpestics.D26-006","url":null,"abstract":"Pyrimisulfan is a highly effective, water-soluble, and paddy herbicide used against various annual weeds, such as Echinochloa spp. Pyrimisulfan was released into surface water, and it migrated into soil water; it formed a herbicide-treated layer within seven days of the water-holding period upon the application of granules with uncontrolled formulation under the flooded condition. Although pyrimisulfan efficacy declined under overflow conditions before forming the herbicide-treated layer, the decrease in herbicidal activity was suppressed after layer formation. In addition to uncontrolled formulation, a controlled-release formulation was tested. Although time for the formation of the herbicide-treated layer increased, water fluctuation resistance improved. As a benchmark, the concentration of pyrimisulfan in soil water on the target date, after adsorption equilibrium, was 57.6 ppb. Although herbicidal activity generally decreases in soils with high organic carbon content, pyrimisulfan showed no loss of activity. This study provides fundamental insights into the mechanism of herbicide-treated layer formation.","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"51 3","pages":"172-180"},"PeriodicalIF":1.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, and insecticidal activity evaluation of piperine-phenylene diamine derivatives. 胡椒-苯二胺衍生物的设计、合成及杀虫活性评价。

IF 1.5 4区农林科学

Journal of Pesticide Science Pub Date : 2026-05-20 DOI: 10.1584/jpestics.D25-065

Lin Chen, Hong-Ying Chen, Xiao-Hong Lai, Yi-Dan Zhao, Shuai Huang, Xian-Li Zhou

{"title":"Design, synthesis, and insecticidal activity evaluation of piperine-phenylene diamine derivatives.","authors":"Lin Chen, Hong-Ying Chen, Xiao-Hong Lai, Yi-Dan Zhao, Shuai Huang, Xian-Li Zhou","doi":"10.1584/jpestics.D25-065","DOIUrl":"10.1584/jpestics.D25-065","url":null,"abstract":"Based on the structure of the natural active molecule piperine, a series of novel piperidine-phenylenediamine derivatives were designed and synthesized using a molecular hybridization strategy. The antifeedant activity of all of the compounds against Spodoptera exigua and their cytotoxicity toward Sf9 insect cells were evaluated. The results showed that most of the derivatives exhibited good antifeedant activity, which correlated with their structures. Among them, compound D5 showed the strongest antifeedant activity (EC50=0.184 mg/mL). In the cytotoxicity study, compounds D15 and J1 showed particularly potent antiproliferative effects, with IC50 values of 4.137 µM and 3.726 µM, respectively. Mechanistic studies revealed that both compounds inhibit proliferation by inducing apoptosis and arresting the cell cycle, as evidenced by cell morphology observation, fluorescence staining, and flow cytometry analysis. In summary, the present study provides potential candidates for the development of new environmentally friendly insecticides based on the combination principle.","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"51 2","pages":"130-139"},"PeriodicalIF":1.5,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13265267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological activity of 2-methylbenzimidazole derivatives with heterocyclic rings on development of Bombyx mori. 杂环2-甲基苯并咪唑衍生物对家蚕发育的生物活性。

IF 1.5 4区农林科学

Journal of Pesticide Science Pub Date : 2026-05-20 DOI: 10.1584/jpestics.D25-076

Udawaththa Kankanamge Don Sahan Suganda Gunasekara, Konatsu Inoue, Wataru Tsuchiya, Keisuke Kutsuwada, Shuhei Henmi, Takahiro Shiotsuki

{"title":"Biological activity of 2-methylbenzimidazole derivatives with heterocyclic rings on development of Bombyx mori.","authors":"Udawaththa Kankanamge Don Sahan Suganda Gunasekara, Konatsu Inoue, Wataru Tsuchiya, Keisuke Kutsuwada, Shuhei Henmi, Takahiro Shiotsuki","doi":"10.1584/jpestics.D25-076","DOIUrl":"10.1584/jpestics.D25-076","url":null,"abstract":"Derivatives of 1-heterocyclic 2-methylbenzimidazoles (HMBIs), prepared from previously reported 1-benzyl-2-methylbenzimidazoles, were synthesized to assess their larvicidal activity against the silkworm, Bombyx mori. Among the series, 2-methyl-1-(thiophen-2-yl)-methylbenzimidazole (SGH2) produces a distinctive biological phenotype characterized by growth retardation arising from epidermal abnormalities, together with defects in molting and pupation. To explore the basis of these effects, we examined the potential disruption of endocrine signaling as a causal mechanism. Specifically, we evaluated the binding of SGH2 to lepidopteran hemolymph juvenile hormone (JH)-binding protein (JHBP), an important modulator of insect hormone function, using a fluorescence-based ligand-sensor system that couples JHBP to two reporter fluorophores. SGH2 exhibited binding to JHBP with an EC50 of 2.13±0.34 µM, a potency comparable to that of JH. These findings indicate that HMBI derivatives, such as SGH2, can interfere with JH-mediated developmental processes in Lepidoptera and identify a promising scaffold for the design of novel insect growth regulators aimed at controlling lepidopteran pests.","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"51 2","pages":"100-110"},"PeriodicalIF":1.5,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of the activity of scorpion short-chain antimicrobial peptides by addition of basic residues at the C-terminus. 在蝎短链抗菌肽c端添加碱性残基增强其活性。

IF 1.5 4区农林科学

Journal of Pesticide Science Pub Date : 2026-05-20 DOI: 10.1584/jpestics.D26-003

Alhussin Mohamed Abdelhakeem Megaly, Amal Mokhtar, Mohammed Abdel-Wahab, Yoshiaki Nakagawa, Masahiro Miyashita

{"title":"Enhancement of the activity of scorpion short-chain antimicrobial peptides by addition of basic residues at the C-terminus.","authors":"Alhussin Mohamed Abdelhakeem Megaly, Amal Mokhtar, Mohammed Abdel-Wahab, Yoshiaki Nakagawa, Masahiro Miyashita","doi":"10.1584/jpestics.D26-003","DOIUrl":"10.1584/jpestics.D26-003","url":null,"abstract":"Scorpion venom contains antimicrobial peptides (AMPs). These AMPs are classified into three families based on peptide length: long-chain (>35 residues), intermediate-chain (20-35 residues), and short-chain (13-19 residues) AMPs. Previously, we identified both short- and intermediate-chain AMPs from the venom of the scorpion Isometrus maculatus. A comparative analysis of their antibacterial activities revealed that short-chain AMPs exhibit relatively weaker activity than intermediate-chain AMPs. A structural comparison indicated that intermediate-chain AMPs possess a longer C-terminal region enriched in basic residues, a feature absent in short-chain AMPs. Removal of this C-terminal basic region from intermediate-chain AMPs resulted in a marked loss of antibacterial activity. Conversely, the addition of basic residues at the C-termini of short-chain AMPs significantly enhanced their activity. These results demonstrate that basic residues in the C-terminal region of scorpion intermediate-chain AMPs are crucial for antibacterial activity.","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"51 2","pages":"140-144"},"PeriodicalIF":1.5,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degradation of the pyrethroid insecticide dimefluthrin in a water-sediment system: detailed insight into the non-extractable residues. 除虫菊酯类杀虫剂二甲氟菊酯在水-沉积物系统中的降解：对不可提取残留物的详细了解。

IF 1.5 4区农林科学

Journal of Pesticide Science Pub Date : 2026-05-20 DOI: 10.1584/jpestics.D26-002

Kenji Okuda, Yusuke Suzuki, Takuo Fujisawa

{"title":"Degradation of the pyrethroid insecticide dimefluthrin in a water-sediment system: detailed insight into the non-extractable residues.","authors":"Kenji Okuda, Yusuke Suzuki, Takuo Fujisawa","doi":"10.1584/jpestics.D26-002","DOIUrl":"10.1584/jpestics.D26-002","url":null,"abstract":"The environmental fate of dimefluthrin (DIM), 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl (1R,3R)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylate, was investigated in a water-sediment system in the USA. The study focused on the formation of degradation products and non-extractable residues (NER) using 14C-DIM labelled either at the benzyl or cyclopropyl carbon. The degradation half-life was calculated to be 15.6 days at 20°C, which is well below the regulatory persistence threshold of 120 days. The primary degradation pathway was hydrolysis of the ester linkage. Other reactions, such as oxidation at various positions, produced several minor metabolites that were subsequently mineralised to CO2 and/or incorporated into NER. Specifically, in the cyclopropyl-labelled samples, NER exceeded 10% of the applied radioactivity (% AR) with 78-86% of the total NER consisting of non-hazardous biogenic residues (type-III NER) as verified by 14C-labelled amino acid analysis. Potentially hazardous type-I NER were negligible, accounting for less than 0.5% AR for both labels. These insights into NER formation, particularly regarding the role of microbial activity in the environmental distribution of DIM and its metabolites, indicate minimal environmental risks from such residues.","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":"51 2","pages":"111-120"},"PeriodicalIF":1.5,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0