Keimyung Medical Journal最新文献_第5页

Post-recovery Stress, Anxiety, Depression and Stigma in Early COVID-19 Pandemic Patients COVID-19大流行早期患者的康复后压力、焦虑、抑郁和耻辱感

Keimyung Medical Journal Pub Date : 2022-06-13 DOI: 10.46308/kmj.2022.00080

Daehyun Kim

引用次数: 1

Clinical and Prognostic Values of DNMT3B Expression in Hepatocellular Carcinoma DNMT3B在肝细胞癌中表达的临床及预后价值

Keimyung Medical Journal Pub Date : 2022-05-30 DOI: 10.46308/kmj.2022.00045

Jongwan Kim, Jae-Hee Park, Jae-Ho Lee

{"title":"Clinical and Prognostic Values of DNMT3B Expression in Hepatocellular Carcinoma","authors":"Jongwan Kim, Jae-Hee Park, Jae-Ho Lee","doi":"10.46308/kmj.2022.00045","DOIUrl":"https://doi.org/10.46308/kmj.2022.00045","url":null,"abstract":"De novo methylation is occurred frequently during the early embryogenesis and is faithfully copied following DNA replication at each cell cycle [1]. DNA methylation is involved in many embryonic developments, biological processes, and cell differentiation [2]. The dysregulation of DNA methyltransferases (DNMTs) and subsequent aberrant DNA methylation is a key feature of human malignancies [3,4]. DNMT1, DNMT3A, and DNMT3B are the enzymatic players of DNA methylation [1,2]. DNMT3B overexpression is frequently found in tumors, especially in 30% of breast cancers [5,6]. And it result into variation in the targeting efficiency and abnormal catalytic activity contributing to cancer development and progression. Therefore, DNMT3B may act as an oncogene, and its overexpression induces an unfavorable prognosis [3-6]. Hepatocellular carcinoma (HCC) is a majority of human cancers in worldwide, and is a leading cause of death in Korea [7,8]. Recent studies about HCC showed an alteration of DNA methylation by dysregulation of DNMT3B [9,10]. Yu et al. described that telomerase reverse transcriptase (TERT) regulates DNMT3B expression in HCC and their co-operation may predict a poorer prognosis [11]. Recent advances in genomic profiling using next-generation sequencing have made it possible to identify the genetic characteristics of cancer. Large-scale cancer genome studies such as The Cancer Genome Atlas (TCGA) used to investigate genes in different cancer types [12]. However, clinicopathopISSN 2092-8335 · eISSN 2733-5380 Keimyung Med J 2021[Epub ahead of print] https://doi.org/10.46308/kmj.2022.00045 Original Article","PeriodicalId":166951,"journal":{"name":"Keimyung Medical Journal","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123419827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Case of Leukocytoclastic Vasculitis Following COVID-19 Vaccination COVID-19疫苗接种后发生白细胞破裂性血管炎1例

Keimyung Medical Journal Pub Date : 2022-04-19 DOI: 10.46308/kmj.2022.00010

Y. Ryoo, Yu-Sin Kim, Ji-Min Yun, Sung-Ae Kim

引用次数: 0

The Role of High Resolution Manometry in Non-Cardiac Chest Pain 高分辨率测压在非心源性胸痛中的作用

Keimyung Medical Journal Pub Date : 2021-12-07 DOI: 10.46308/kmj.2021.00178

Won-Young Jang, Seung Wan Kim, Jin-Wook Lee, J. Y. Lee

{"title":"The Role of High Resolution Manometry in Non-Cardiac Chest Pain","authors":"Won-Young Jang, Seung Wan Kim, Jin-Wook Lee, J. Y. Lee","doi":"10.46308/kmj.2021.00178","DOIUrl":"https://doi.org/10.46308/kmj.2021.00178","url":null,"abstract":"The most common cause of noncardiogenic chest pain is gastroesophageal reflux disease, and other esophageal motility disorders are also frequent. Esophageal manometry is important for diagnosing esophageal motility disease. Recently, high resolution manometry (HRM) has emerged and is reported to be more useful than conventional esophageal manometry in evaluating primary esophageal motility disease. In this study, the role and usefulness of HRM in noncardiac chest pain were investigated. From August 2018 to April 2021, 136 patients with chest pain were enrolled. Classification was carried out according to Chicago classification version 3.0, and 95 out of 136 patients showed normal findings, and 23 patients showed ineffective esophageal motility. When gastroesophageal reflux disease was classified according to Los Angeles (LA) classification, LA-M was 20% (6/30), LA-A was 63.3% (19/30), LA-B was 16.6% (5/30), and LA-C was, there were no patients with LA-D. Through this study, it was confirmed that about 22% of patients with noncardiogenic chest pain had reflux esophagitis, and about 30% of patients had esophageal motility disease. High-resolution esophageal manometry appears to be useful for the differentiation of noncardiogenic chest pain caused by esophageal motility disorders other than reflux esophagitis. After diagnosis of esophageal motor disease, follow-up studies on whether non-cardiac chest pain improves after drug treatment is required.","PeriodicalId":166951,"journal":{"name":"Keimyung Medical Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116874060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Coronavirus Disease 2019 Vaccine 2019冠状病毒病疫苗

Keimyung Medical Journal Pub Date : 2021-12-06 DOI: 10.46308/kmj.2021.00185

Seung-Hwa Lee, S. Ahn, Bongyoung Kim, Jaehyuk Lee, Dae-Hyun Kim

引用次数: 2

The Development of Evaluation Methods for Outcomes in Medical Humanities Curriculum of a Medical School 某医学院医学人文课程成果评价方法的发展

Keimyung Medical Journal Pub Date : 2021-12-02 DOI: 10.46308/kmj.2021.00157

Hye‐Jin Park, Sun-Young Kwon, D. Keum, D. Kim, Dong-Eun Kim, J. Kim, Jinhee Kim, W. Baek, J. Ha, I. Hwang, Jung-Jeung Lee, Aehwa Lee, Seon-Kyoung Kim, Ha-Young Jung, W. Park

引用次数: 0

Analysis of the Cancer Genome Atlas Data to Determine the Prognostic Value of GABPB1L and TERT in Glioblastoma 肿瘤基因组图谱数据分析确定GABPB1L和TERT在胶质母细胞瘤中的预后价值

Keimyung Medical Journal Pub Date : 2021-12-01 DOI: 10.46308/kmj.2021.00171

Jongwan Kim, Soo-Jung Jung, Jae-Ho Lee

{"title":"Analysis of the Cancer Genome Atlas Data to Determine the Prognostic Value of GABPB1L and TERT in Glioblastoma","authors":"Jongwan Kim, Soo-Jung Jung, Jae-Ho Lee","doi":"10.46308/kmj.2021.00171","DOIUrl":"https://doi.org/10.46308/kmj.2021.00171","url":null,"abstract":"Glioblastoma multiforme (GBM) is the most lethal type in primary brain tumors, with most patients dying within one year after initial diagnosis. Its treatment as surgery with radiotherapy and chemotherapy has induced 2 and 5 years survival rates of 25 and 10%, respectively [1]. Moreover, clinical trials have validated only limited benefits of targeted regimens, because of invasive nature and low proliferative activity of GBM [2]. Transcription factors have chief roles in the regulation of cell development and maintenance; they are essential for cell maintenance, proliferation and apoptosis [3]. In these factors, GA-binding protein A forms a heterotetramer complex with its partner GA Binding Protein Transcription Factor Subunit Beta (GABPB) 1 or GABPB2; GABPB1 gene encodes the GABPB1 with its isoforms GABPB1-longer (GABPB1L) and GABPB1-shorter as the products of a different mRNA splicing. Similar to many other E-twenty-six (ETS) factors, they also had oncogenic activities and were associated with the pathogenesis of leukemia, prostate cancer, and other malignancies [4-6]. Recent study introduced novel role of GABPB1L and telomerase reverse transcriptase (TERT) in GBM [7]. When combined with temozolomide chemotherapy, inducible GABPB1L knockdown and the associated TERT reduction led to an impaired DNA damage response that resulted in profoundly reduced growth of GBM tumor in pISSN 2092-8335 · eISSN 2733-5380 Keimyung Med J 2021[Epub ahead of print] https://doi.org/10.46308/kmj.2021.00171 Original Article","PeriodicalId":166951,"journal":{"name":"Keimyung Medical Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121506491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Understanding of Glucocorticoid Induced Osteoporosis 糖皮质激素所致骨质疏松的认识

Keimyung Medical Journal Pub Date : 2021-11-23 DOI: 10.46308/kmj.2021.00164

C. Son

引用次数: 0

Association between Skipping Breakfast and Overweight in Korean Adolescents: Analysis of the 13th Korea Youth Risk Behavior Web-based Survey 韩国青少年不吃早餐与超重之间的关系:第13次韩国青少年风险行为网络调查分析

Keimyung Medical Journal Pub Date : 2021-11-23 DOI: 10.46308/kmj.2021.00136

Sung Hee Chang, Wan Hong, Y. Suh, D. Kim

{"title":"Association between Skipping Breakfast and Overweight in Korean Adolescents: Analysis of the 13th Korea Youth Risk Behavior Web-based Survey","authors":"Sung Hee Chang, Wan Hong, Y. Suh, D. Kim","doi":"10.46308/kmj.2021.00136","DOIUrl":"https://doi.org/10.46308/kmj.2021.00136","url":null,"abstract":"Breakfast, as a meal that balances all other meals in a day, affects whether an individual has lunch and how they distribute snacks and meals during the day [1-3]. Individuals who eat breakfast show better health overall than those who skip breakfast as they consume more essential nutrients and dietary fiber; moreover, they also have better academic achievement as breakfast improves their memory [2]. In addition, skipping breakfast is correlated with obesity and abnormal menstruation and increases the risk of anemia caused by iron deficiency, diabetes, metabolic syndrome, and mortality [3-6]. As adolescence is the period during which individuals grow physically and mentally at a rapid pace, breakfast is critical in terms of providing nutrients. In particular, skipping breakfast during adolescence may contribute to the development of eating habits associated with chronic disease in adulthood. According to the Korea National Health and Nutrition Examination Survey conducted by the pISSN 2092-8335 · eISSN 2733-5380 Keimyung Med J 2021[Epub ahead of print] https://doi.org/10.46308/kmj.2021.00136 Original Article","PeriodicalId":166951,"journal":{"name":"Keimyung Medical Journal","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131734292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Fever in the Emergency Department: before Versus after COVID-19 急诊科的发烧:在COVID-19之前和之后

Keimyung Medical Journal Pub Date : 2021-11-04 DOI: 10.46308/kmj.2021.00122

Donguk Yu, J. Jeon, Yaerim Kim, U. Park, Keuntae Kim

{"title":"The Fever in the Emergency Department: before Versus after COVID-19","authors":"Donguk Yu, J. Jeon, Yaerim Kim, U. Park, Keuntae Kim","doi":"10.46308/kmj.2021.00122","DOIUrl":"https://doi.org/10.46308/kmj.2021.00122","url":null,"abstract":"A high body temperature, i.e. fever, is a crucial vital sign, and suggests the patient’s infection or inflammation. COVID-19 has changed the lifestyle, and led to the changes in medical use behavior of febrile patients. We investigated the change in etiologies of fever in the emergency department (ED) before and after COVID-19. The medical records of patients with fever who visited the ED of a university hospital before and after the outbreak of COVID-19 in Daegu metropolitan city, South Korea. The cause of fever and its classification were carefully decided and established by agreement through a discussion among board-certified clinicians in emergency medicine, neurology, general surgery, and internal medicine. The etiology of fever and its prevalence in ED were compared between before and after COVID-19. A total of 3,041 patients with fever (> 37.7°C) in the ED were investigated, with 1,400 men (46.0%). Their mean age was 55.88 ± 20.59, and the average number of patients with fever in ED was 8.16 ± 3.94 per a day. The most common etiology before COVID-19 was respiratory system infection (n = 535, 30.5%), followed by gastrointestinal (n = 313, 17.8%) and urinary tract infection (n = 209, 11.9%). However, after COVID-19, gastrointestinal cause became the most common (n = 247, 27.3%), followed by respiratory system (n = 126, 13.9%) and urinary tract infection (n = 102, 11.3%). There has been paradigm-shifting in fever etiology in the emergency department. It is necessary to cope with the changed fever etiology in the COVID-19 era.","PeriodicalId":166951,"journal":{"name":"Keimyung Medical Journal","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125585441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0