Journal of Pediatric Hematology/Oncology最新文献_第4页

Autologous Cord Blood Transplantation for Idiopathic Severe Aplastic Anemia. 自体脐带血移植治疗特发性重度再生障碍性贫血。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-11 DOI: 10.1097/MPH.0000000000003106

Anselm Chi-Wai Lee

引用次数: 0

Concomitant Azole Initiation Decreases Time to Stable Goal Sirolimus Concentrations in Pediatric Allogeneic Transplant Recipients. 儿童同种异体移植受者同时服用唑可减少西罗莫司浓度达到稳定目标的时间。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-08 DOI: 10.1097/MPH.0000000000003093

Diana Wu, Megan R Williams, Akshay A Patwardhan, Yu Bi, Subodh Selukar, Jennifer L Pauley, John McCormick, Akshay Sharma

{"title":"Concomitant Azole Initiation Decreases Time to Stable Goal Sirolimus Concentrations in Pediatric Allogeneic Transplant Recipients.","authors":"Diana Wu, Megan R Williams, Akshay A Patwardhan, Yu Bi, Subodh Selukar, Jennifer L Pauley, John McCormick, Akshay Sharma","doi":"10.1097/MPH.0000000000003093","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003093","url":null,"abstract":"Variability of sirolimus pharmacokinetics, often compounded by interactions with azole antifungal therapy, leads to concentrations outside the goal range and increased risk of related complications. We assessed the time to initial attainment of stable goal sirolimus concentrations in patients who either concomitantly initiated azole therapy and sirolimus (concomitant group) or initiated an azole after sirolimus initiation (delayed group). The median time to attainment of stable goal sirolimus concentrations was 8.0 days in the delayed group versus 6.0 days in the concomitant group. Patients in the concomitant group reached stable goal concentrations earlier than those in the delayed group (hazard ratio: 0.27, 95% CI: 0.14-0.5, P<0.001), after adjusting for age, sex, and race. The delayed group was estimated to have concentrations outside of goal range at almost 2 times the rate in the concomitant group (P<0.001), after adjusting for age, sex, and race. Thus, we conclude that concomitant initiation of sirolimus and azoles may facilitate the achievement of stable goal sirolimus concentrations sooner after allogeneic cell transplant.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal Assessment of Health-Related Quality of Life in Childhood Acute Lymphoblastic Leukemia During Active Treatment in Indonesia. 印度尼西亚儿童急性淋巴细胞白血病积极治疗期间健康相关生活质量的纵向评估

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-08 DOI: 10.1097/MPH.0000000000003097

Braghmandita W Indraswari, Eddy Supriyadi, Gertjan J L Kaspers, Mei N Sitaresmi

{"title":"Longitudinal Assessment of Health-Related Quality of Life in Childhood Acute Lymphoblastic Leukemia During Active Treatment in Indonesia.","authors":"Braghmandita W Indraswari, Eddy Supriyadi, Gertjan J L Kaspers, Mei N Sitaresmi","doi":"10.1097/MPH.0000000000003097","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003097","url":null,"abstract":"Children with acute lymphoblastic leukemia (ALL) are at risk for poor health-related quality of life (HRQOL) due to the treatment and disease itself. This study presents a serial measurement of the HRQOL of children with ALL during cancer treatment and investigates the impact of demographic, socioeconomic, and medical patient characteristics on their HRQOL. A prospective HRQOL longitudinal study of children with ALL was conducted at an academic hospital between 2016 and 2020. HRQOL was measured using PedsQL 4.0 and PedsQL 3.0 at 3 treatment phases: induction, consolidation, and maintenance. The HRQOL of children 2 to 18 years of age was assessed using a proxy report, and children 5 to 18 years also reported themselves using patient self-report. The comparison scores between subsequent treatment phases of those interviewed in each time measurement were measured using a repeated measures ANOVA test and a post hoc analysis with the Bonferroni test. One hundred thirteen children 5 to 18 years of age and 221 parents participated. The mean age at diagnosis was 6.6±4.0 years. Children had standard-risk ALL (51%) and were boys (56%). The total score of HRQOL and most subscales significantly improved during treatment. Physical health, school functioning, procedural anxiety, and communication were most affected in early treatment. Although all scores improved over time, school functioning and communication remained lower than other subscales. The age classification impacted the improvement of most HRQOL subscales. In conclusion, the HRQOL improved during treatment. Interventions to maintain physical health and reduce procedural anxiety in early treatment are required. Improving health care providers' communication skills and facilitating hospital schooling will ameliorate HRQOL.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitor Development in Severe Congenital Factor V Deficiency. 严重先天性因子V缺乏症的抑制剂发展。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-07 DOI: 10.1097/MPH.0000000000003099

Clara Guilbault, Arnaud Bonnefoy, Georges-Étienne Rivard, Marie-Claude Pelland-Marcotte

引用次数: 0

The ETV6::NCOA2 Fusion, a Recurrent Cytogenetic Abnormality in Childhood Leukemia With Defining Properties. ETV6::NCOA2融合：一种具有明确特性的儿童白血病复发性细胞遗传学异常

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-06 DOI: 10.1097/MPH.0000000000003095

Zayan Safi, Mahdi Fakhouri, Carla Monsef, Nada Assaf

引用次数: 0

The Effect of Iron Deficiency Anemia and Serum Ferritin Deficiency on Cognitive Functions in Children 1 to 5 Years Old. 缺铁性贫血和血清铁蛋白缺乏对1 ~ 5岁儿童认知功能的影响。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-04 DOI: 10.1097/MPH.0000000000003090

Bahri Can Duran, Yilmaz Ay, Hidayet Imancli, Gurbuz Akcay

{"title":"The Effect of Iron Deficiency Anemia and Serum Ferritin Deficiency on Cognitive Functions in Children 1 to 5 Years Old.","authors":"Bahri Can Duran, Yilmaz Ay, Hidayet Imancli, Gurbuz Akcay","doi":"10.1097/MPH.0000000000003090","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003090","url":null,"abstract":"Objective: We aimed to investigate the effects of iron deficiency anemia and serum ferritin deficiency on mental and motor functions in children 1 to 5 years of age and whether these effects could be improved by treatment.Materials and methods: The study was conducted between February 2021 and July 2021 and included a total of 79 children between 1 and 5 years old. Participants were divided into 3 groups according to their blood results: iron deficiency anemia (n = 19), nonanemic iron deficiency (n = 21), and control group (n = 39). Ankara Developmental Screening Inventory (ADSI) was administered to all participants before treatment. The case groups were subjected to 3-month iron treatment, and participants were reevaluated with ADSI.Results: The ADSI T-scores of the case groups were significantly lower than the control group. A significant increase in T-scores was observed in both case groups after treatment. In addition, positive and moderate correlation was observed between serum ferritin level and language-cognitive activity, fine-motor development, gross-motor development, and social skills-self-care, and, positive and strong correlation was observed between serum ferritin level and general development and T-scores.Conclusion: We observed that the decrease in serum ferritin levels, an early indicator of iron deficiency, negatively affected cognitive functions and that this effect could be partially corrected by treatment.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cobalamin E Disease: An Ultrarare Treatable Cause of Hemolytic Anemia in Infancy. 钴胺素E病：婴幼儿溶血性贫血的罕见可治病因。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI: 10.1097/MPH.0000000000003072

Pankaj Prasun, Jennifer R Suarez, Katelyn J Watkin

引用次数: 0

Exocrine Pancreatic Insufficiency Following Asparaginase-induced Pancreatitis in Pediatric Acute Lymphoblastic Leukemia Patients: A Case Series. 儿童急性淋巴细胞白血病患者天冬酰胺酶诱导的胰腺炎后外分泌胰腺功能不全：一个病例系列。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-01 Epub Date: 2025-06-06 DOI: 10.1097/MPH.0000000000003058

Rachel Hill, Lindsey Thomas, David Farbo, Kenneth Heym

引用次数: 0

Methemoglobinemia Induced by Food During Chemotherapy in a Boy With Acute Lymphoblastic Leukemia and Literature Review. 急性淋巴细胞白血病男童化疗期间食物致高铁血红蛋白血症1例及文献复习。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-01 Epub Date: 2025-07-01 DOI: 10.1097/MPH.0000000000003061

Yanqing Wang, Xiuping Chen, Chanjuan Tong, Bin Lin, Yongmin Tang, Meixin Fang

引用次数: 0

Severe Hypertriglyceridemia Secondary to Long-acting Asparaginase in Pediatric Patients With Acute Lymphoblastic Leukemia. 小儿急性淋巴细胞白血病继发于长效天冬酰胺酶的严重高甘油三酯血症。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-01 Epub Date: 2025-06-25 DOI: 10.1097/MPH.0000000000003077

Amr Elgehiny, Alexander Hsu, David McCall, Amber Gibson, Branko Cuglievan, Cesar Nunez, Miriam B Garcia, Luz Castellanos, Alexander Funck, Shehla Razvi

{"title":"Severe Hypertriglyceridemia Secondary to Long-acting Asparaginase in Pediatric Patients With Acute Lymphoblastic Leukemia.","authors":"Amr Elgehiny, Alexander Hsu, David McCall, Amber Gibson, Branko Cuglievan, Cesar Nunez, Miriam B Garcia, Luz Castellanos, Alexander Funck, Shehla Razvi","doi":"10.1097/MPH.0000000000003077","DOIUrl":"10.1097/MPH.0000000000003077","url":null,"abstract":"Pegylated asparaginase is now standard in US treatment protocols for acute lymphoblastic leukemia (ALL). However, they are associated with significant side effects, including severe hypertriglyceridemia. In this case series, we report 8 patients with severe (triglyceride >1000 mg/dL) hypertriglyceridemia after receiving long-acting asparaginase for ALL and describe their clinical course. The 8 patients included 3 females and 5 males (aged 2 to 14 y; median=12 y); 7 were Hispanic and 1 was Middle Eastern. The median time from dose to peak hypertriglyceridemia was 17 days and to resolution was 25 days. Presentations included isolated hypertriglyceridemia, pseudohyponatremia, hypoglycemia, and lipemia interfering with complete blood count results. Median length of hospitalization was 3.5 days. Management included hydration, a low-fat diet, omega-3 supplements, fenofibrates, statins, and levocarnitine. An insulin drip was used in 2 patients in the intensive care unit. Asparaginase treatment continued per protocol after triglyceride levels were <1000 mg/dL. In conclusion, severe hypertriglyceridemia can occur after long-acting asparaginase and is typically asymptomatic and transient, not requiring a pause or modification in treatment. We recommend monitoring for hypertriglyceridemia closely in patients with risk factors who are resuming long-acting asparaginase therapy after triglyceride levels fall <1000 mg/dL.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"e215-e221"},"PeriodicalIF":0.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0