Justin White MD, BSc , Vladimir Varin BHSc (in-progress) , Marjorie Farley BSc RM, RDMS , Clara Qianqian Wu MD, MSc
{"title":"Quadruplet Pregnancy (Two Sets of Monochorionic Twins) from Elective Single Embryo Transfer in a Stimulated Cycle","authors":"Justin White MD, BSc , Vladimir Varin BHSc (in-progress) , Marjorie Farley BSc RM, RDMS , Clara Qianqian Wu MD, MSc","doi":"10.1016/j.jogc.2024.102691","DOIUrl":"10.1016/j.jogc.2024.102691","url":null,"abstract":"","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ann E. Sprague RN, PhD , Nicole F. Roberts MSc , Carolina Lavin Venegas BScN, MSc , Tatung Nath MSc , Prakesh S. Shah MD, MSc , Jon Barrett MBBch, MD, MRCOG , Jocelynn Cook PhD, MBA , Elizabeth K. Darling RM, MSc, PhD , Rohan D’Souza MD, PhD , Sharon Dore RN, PhD , Wesley Edwards MBBS, MPH , Naomi Kasman MSc , Susie Dzakpasu PhD , Joel Ray MD , Mark Walker MD, MSc, MSHCM
{"title":"Mortality Following Childbirth in Ontario: A 20-Year Analysis of Temporal Trends and Causes","authors":"Ann E. Sprague RN, PhD , Nicole F. Roberts MSc , Carolina Lavin Venegas BScN, MSc , Tatung Nath MSc , Prakesh S. Shah MD, MSc , Jon Barrett MBBch, MD, MRCOG , Jocelynn Cook PhD, MBA , Elizabeth K. Darling RM, MSc, PhD , Rohan D’Souza MD, PhD , Sharon Dore RN, PhD , Wesley Edwards MBBS, MPH , Naomi Kasman MSc , Susie Dzakpasu PhD , Joel Ray MD , Mark Walker MD, MSc, MSHCM","doi":"10.1016/j.jogc.2024.102689","DOIUrl":"10.1016/j.jogc.2024.102689","url":null,"abstract":"<div><h3>Objectives</h3><div>Maternal death during or after pregnancy is often preventable and accurate surveillance is key to prevention. We examined the number and causes of maternal death in Ontario over 20 years.</div></div><div><h3>Methods</h3><div>Retrospective cohort study including all hospital livebirths and stillbirths from 2002–2022 in the Canadian Institute for Health Information Discharge Abstracts (for hospitalizations) and National Ambulatory Care System (for emergency department encounters) linked to the Better Outcomes and Registry and Network births. Death was ascertained from childbirth to 365 days thereafter; all deaths were reviewed by at least 3 clinicians.</div></div><div><h3>Results</h3><div>There were 485 deaths among 2 764 214 live and stillbirths over 20 years—a maternal mortality ratio (MMR) of 17.5 per 100 000 (95% CI 16.0–19.2). There were 222 (45.8%) early deaths within 42 days of birth (MMR of 8.0 per 100 000; 95% CI 7.0–9.2), and 263 (54.2%) late deaths from 43 to 365 days after birth (MMR 9.5 per 100 000; 95% CI 8.4–10.7). Death was pregnancy-related in 169/485 cases (34.8%). Early death causes were predominantly hemorrhage, infection, preeclampsia, and pulmonary embolism. The top causes of 263 late deaths were cancer, injury, and cardiac arrest, or unknown.</div></div><div><h3>Conclusions</h3><div>Most deaths within 1 year of childbirth are not related to obstetrical factors; however, pregnancy complications factor in early deaths. Causes of early and late deaths differ, but examining late deaths is equally important to identify factors not regularly examined in maternal mortality. As death in early pregnancy or outside hospitals is not reported, mortality is likely higher.</div></div>","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivie Izekor BS , Steven Lindheim MD , Jessica C. Ehrig MD , Robert S. White MD, MS , Michael P. Hofkamp MD
{"title":"Racial Disparities in Parturient Urine Drug Screening at a Texas Level IV Maternal Care Centre: A Single-Centre Retrospective Study","authors":"Ivie Izekor BS , Steven Lindheim MD , Jessica C. Ehrig MD , Robert S. White MD, MS , Michael P. Hofkamp MD","doi":"10.1016/j.jogc.2024.102679","DOIUrl":"10.1016/j.jogc.2024.102679","url":null,"abstract":"<div><h3>Objectives</h3><div>We hypothesized that Black or African American (hereby referred to as Black) and Hispanic patients would have higher rates of urine drug screening (UDS) during pregnancy compared with White or Caucasian (herby referred to as White) patients at our hospital.</div></div><div><h3>Methods</h3><div>Patients who delivered at our hospital between 1 December 2020 and 31 May 2021 and between 1 December 2022 and 31 May 2023 and who were Black, Hispanic, or White were included in the final analysis. We performed separate bivariate analyses comparing White patients to either Black patients or Hispanic patients. We performed a multivariate logistic regression, including variables of interest designed to predict risk factors for UDS during pregnancy.</div></div><div><h3>Results</h3><div>A total of 457 Black, 813 Hispanic, and 1252 White patients were identified. During pregnancy, 187 (40.9%) Black patients had UDS compared with 265 (21.2%) White patients (<em>P</em> < 0.001). In addition, 258 (31.7%) Hispanic patients had UDS during pregnancy, which was statistically different compared with White patients (<em>P</em> < 0.001). A multivariate logistic regression found that identification as Black was independently associated with UDS during pregnancy (adjusted OR [aOR] 1.871; 95% CI 1.382–2.534, <em>P</em> < 0.001), identification as Hispanic was not independently associated (aOR 1.177; 95% CI 0.900–1.538, <em>P</em> = 0.234), and patients who delivered after the COVID-19 pandemic were less likely to receive UDS (aOR 0.783; 95% CI 0.621–0.987, <em>P</em> = 0.039).</div></div><div><h3>Conclusion</h3><div>Identification as Black and delivery during the COVID-19 pandemic were independently associated with increased adjusted odds of UDS during pregnancy at our hospital.</div></div>","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alicia R. Berard PhD , Samantha Knodel BSc , Christina Farr Zuend PhD , Laura Noël-Romas MSc , Kenzie D. Birse MSc , Peter McQueen PhD , Marlon De Leon BSc , Kateryna Kratzer BSc , Oluwatobiloba A. Taylor BSc , Samantha Bailey BSc , Helen Pymar MD , Adam D. Burgener PhD , Vanessa Poliquin MD
{"title":"A Description of the THRIVE (The Study of Host-Bacterial Relationships and Immune Function in Different Vaginal Environments) Bacterial Vaginosis Observational Study","authors":"Alicia R. Berard PhD , Samantha Knodel BSc , Christina Farr Zuend PhD , Laura Noël-Romas MSc , Kenzie D. Birse MSc , Peter McQueen PhD , Marlon De Leon BSc , Kateryna Kratzer BSc , Oluwatobiloba A. Taylor BSc , Samantha Bailey BSc , Helen Pymar MD , Adam D. Burgener PhD , Vanessa Poliquin MD","doi":"10.1016/j.jogc.2024.102667","DOIUrl":"10.1016/j.jogc.2024.102667","url":null,"abstract":"<div><h3>Objectives</h3><div>Bacterial vaginosis (BV) contributes to poor reproductive health and is characterized by a displacement of <em>Lactobacillus</em> in the vaginal microbiome. However, treatment for BV is limited to antibiotics and half of the women treated experience recurrence within a year. THRIVE (The Study of Host-Bacterial Relationships and Immune Function in Different Vaginal Environments) is a prospective study in Winnipeg, Manitoba, Canada, which is designed to capture the daily variation of the microbiome and host mucosal immunity during treatment. The objective of this study is to identify host and bacterial factors that associate with vaginal microbiome stability to better inform therapeutic interventions.</div></div><div><h3>Methods</h3><div>Women treated for BV, and controls, are followed for 6 months collecting daily vaginal swabs and monthly questionnaires. Comprehensive mucosal sampling, including swabs, cytobrushes, biopsies, and blood are collected at baseline, months 1 and 6 post-enrolment.</div></div><div><h3>Results</h3><div>We performed analysis on the first 52 participants, (19 BV+, 33 BV–). Molecular profiling by 16s RNA sequencing showed 20 women with non-<em>Lactobacillus-</em>dominant microbiomes and 32 with <em>Lactobacillus-</em>dominant microbiomes, with increased microbial diversity in non-<em>Lactobacillus-</em>dominant microbiomes (<em>P =</em> 3.1E-05). A pilot analysis in 2 participants demonstrates that multi-omics profiling of self-collected daily swabs provides high-quality data identifying 73 bacterial species, 1773 mucosal proteins and 117 metabolites. Initial flow cytometry analysis showed an increased cluster of differentiation (CD)4+ T cells and neutrophil activation (CD11b+CD62L<sup>neg/dim</sup>) in the positive participant at baseline, while after treatment these shifted and resembled the control participant.</div></div><div><h3>Conclusions</h3><div>This study provides a framework to comprehensively investigate the kinetics of vaginal mucosal microbiome alterations, providing further insight into host and molecular features predicting BV recurrence.</div></div>","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Claire Mazzia MSc , Sarah Daisy Kosa PhD , Anne Harris PhD , Ashley Waddington MD, MPA , Anne Berndl MD, MSc
{"title":"Contraception Used by People Assigned Female at Birth With Spinal Cord Injury","authors":"Claire Mazzia MSc , Sarah Daisy Kosa PhD , Anne Harris PhD , Ashley Waddington MD, MPA , Anne Berndl MD, MSc","doi":"10.1016/j.jogc.2024.102673","DOIUrl":"10.1016/j.jogc.2024.102673","url":null,"abstract":"<div><h3>Objectives</h3><div>There is limited data on contraception used by people assigned female at birth with spinal cord injury (SCI). Pregnancy in people with SCI can be medically complex, therefore access to contraception to prevent unplanned pregnancies is essential. This study aimed to assess the availability of contraception from health care providers (HCPs) to people with SCI and the contraception methods used.</div></div><div><h3>Methods</h3><div>An online international questionnaire was distributed. Demographic data and reproductive histories were recorded. Overall, 780 responses were received from participants in 33 different countries. Most participants lived in North America and self-identified as White. In total, 75% had a traumatic SCI. Most SCIs were at cervical and thoracic levels and American Spinal Injury Association-A and American Spinal Injury Association-B. Descriptive and χ<sup>2</sup> statistics were used.</div></div><div><h3>Results</h3><div>The recruitment rate was 85.4% and the completion rate was 73.8%. Overall, 93.6% of participants reported ever having been sexually active, while 60.7% reported sexual activity over the past year. Of people who were injured under the age of 50 years and who have been sexually active, 63.6% were offered birth control by an HCP. Condoms were used by 44.5% of participants, withdrawal by 20.1%, the combined oral contraceptive pill by 28.4% and intrauterine device by 20.1% of respondents.</div></div><div><h3>Conclusions</h3><div>This is the largest known study on SCI and contraception. Most people with SCI are sexually active. The withdrawal method and no contraception are used by many individuals, which may increase the risk of unplanned pregnancy. Increased use of highly effective contraception in this population may be achieved through HCP-initiated conversations about sexual health.</div></div>","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Consensus clinique N<sup>o</sup> 455 : Déterminer et révéler le sexe fœtal.","authors":"Michiel C Van den Hof, Venu Jain, Ori Nevo","doi":"10.1016/j.jogc.2024.102676","DOIUrl":"10.1016/j.jogc.2024.102676","url":null,"abstract":"","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Excerpts From the World Medical Literature: Gynaecology","authors":"Paul J. Yong MD, PhD","doi":"10.1016/j.jogc.2024.102640","DOIUrl":"10.1016/j.jogc.2024.102640","url":null,"abstract":"","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SOGC Guideline Retirement Notice No. 9","authors":"","doi":"10.1016/j.jogc.2024.102674","DOIUrl":"10.1016/j.jogc.2024.102674","url":null,"abstract":"<div><div>These documents have been archived because they contain outdated information. They should not be consulted for clinical use, but for historical research only. Please visit the journal website for the most recent guidelines.</div><div><strong>Endometrial Ablation in the Management of Abnormal Uterine Bleeding [J Obstet Gynaecol Can 37 (2014) 362-376]</strong></div><div>Authors</div><div>Philippe Laberge, MD, Quebec QC</div><div>Nicholas Leyland, MD, Ancaster ON</div><div>Ally Murji, MD, Toronto ON</div><div>Claude Fortin, MD, Montreal QC</div><div>Paul Martyn, MD, Sydney, Australia</div><div>George Vilos, MD, London ON<span><div><h2>Avis d’archivage des directives de la SOGC n° 9</h2><div><div>Ces documents ont étés archivés, car ils contiennent des informations périmées. Ils ne devraient pas êtres consultés pour un usage clinique, mais uniquement pour des recherches historiques. Veuillez consulter le site web du journal pour les directives les plus récentes.</div><div><strong>Ablation de l’endomètre dans la prise en charge des saignements utérins anormaux [J Obstet Gynaecol Can 37 (2014) 377-379]</strong></div><div>Auteurs</div><div>Philippe Laberge, MD, Quebec QC</div><div>Nicholas Leyland, MD, Ancaster ON</div><div>Ally Murji, MD, Toronto ON</div><div>Claude Fortin, MD, Montreal QC</div><div>Paul Martyn, MD, Sydney, Australia</div><div>George Vilos, MD, London ON</div></div></div></span></div></div>","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ann Tran MD , Gwen Clarke MD , Jeannie L. Callum MD , Graeme Smith MD, PhD , David Somerset MD , Julie Thorne MD, MPH , Lani Lieberman MD
{"title":"Corrigendum to Reconsidering Routine Repeat Group and Screens During Pregnancy-Personalizing Pregnancy Care, Journal of Obstetrics and Gynaecology Canada, Volume 46, Issue 5, May 2024, 102351","authors":"Ann Tran MD , Gwen Clarke MD , Jeannie L. Callum MD , Graeme Smith MD, PhD , David Somerset MD , Julie Thorne MD, MPH , Lani Lieberman MD","doi":"10.1016/j.jogc.2024.102653","DOIUrl":"10.1016/j.jogc.2024.102653","url":null,"abstract":"","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}