Journal of parenteral science and technology : a publication of the Parenteral Drug Association最新文献_第7页

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-11-01

S Kopp-Kubel

引用次数: 0

Poloxamer 407-mediated changes in plasma cholesterol and triglycerides following intraperitoneal injection to rats. 波洛沙姆407介导大鼠腹腔注射后血浆胆固醇和甘油三酯的变化。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-11-01

Z G Wout, E A Pec, J A Maggiore, R H Williams, P Palicharla, T P Johnston

{"title":"Poloxamer 407-mediated changes in plasma cholesterol and triglycerides following intraperitoneal injection to rats.","authors":"Z G Wout, E A Pec, J A Maggiore, R H Williams, P Palicharla, T P Johnston","doi":"","DOIUrl":"","url":null,"abstract":"Poloxamer (Pluronic) nonionic surfactant vehicles are a series of chemically-related block copolymers finding widespread use in parenteral formulations as solubilizing and wetting agents for traditional, low-molecular weight organic drug molecules, as well as stabilizing agents for proteins and polypeptide drugs. We report the effects of poloxamer 407 (Pluronic F-127) on plasma cholesterol and triglyceride concentrations in rats. Poloxamer 407 injected into rats by intraperitoneal injection (dose = 1.5 gm/kg) resulted in sustained (greater than 96 hour) hypercholesterolemia and hypertriglyceridemia. A larger dose of poloxamer 407 was required to elevate plasma triglyceride relative to total cholesterol. Ingestion of commercial rat chow had a negligible effect on plasma cholesterol and triglycerides levels in control (no poloxamer injection) animals, but consumption of food by animals that received an intraperitoneal injection of poloxamer 407 (30% w/w) resulted in significantly (p < .05) greater elevations in plasma cholesterol and triglycerides than in fasted animals administered poloxamer 407. The route of poloxamer 407 administration, namely intramuscular vs. intraperitoneal injection, was observed to be a more important factor for poloxamer-induced elevations in plasma cholesterol than poloxamer-mediated elevations in plasma triglycerides. Our results also provide suggestive evidence that the mechanism responsible for the elevation of plasma cholesterol following intraperitoneal injection of a poloxamer 407 solution (30% w/w) to rats may be due to stimulation of 3-hydroxy-3-methylglutaryl-co-enzyme A (HMG-CoA) reductase activity in the liver by the poloxamer vehicle.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":16667,"journal":{"name":"Journal of parenteral science and technology : a publication of the Parenteral Drug Association","volume":"46 6","pages":"192-200"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12643714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of bioavailability of aluminium in neonatal parenteral nutrition solutions by prior complexation in the dosage form. 新生儿肠外营养液中铝的生物利用度因剂量形式的预先络合而降低。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-09-01

P Hayes, T P Martin, J Pybus, J Hunt, R S Broadbent

{"title":"Reduction of bioavailability of aluminium in neonatal parenteral nutrition solutions by prior complexation in the dosage form.","authors":"P Hayes, T P Martin, J Pybus, J Hunt, R S Broadbent","doi":"","DOIUrl":"","url":null,"abstract":"Aluminium (Al ) is abundant in our environment and is a contaminant of electrolyte solutions used in the manufacture of Total Parenteral Nutrition (TPN) solutions administered to neonates, who are unable to tolerate oral feeding. Previous studies by McHalsky et al. (1) have shown concern over the levels of aluminium in parenteral products, and there are special considerations needed with regard to neonatal TPN solutions, (2). It is felt that neurotoxicology and abnormalities of bone histology may be seen with aluminium deposition in the tissues. In the present study it was shown that the average aluminium contamination in TPN solutions was in the order of 205 micrograms/L. It is well documented that aluminium is chelated successfully in dialysis solutions by desferrioxamine (DFO), Allain et al. (3). Using an AA spectrophotometer equipped with a graphite furnace, the average amount of aluminium in compounded neonatal TPN solutions was determined. Equimolar amounts of DFO to aluminium were added to various neonatal TPN formulations, and the physical stability of each solution was determined using microscopic and electronic particle counting analysis. This study suggests that aluminium can be irreversibly chelated with DFO and stable TPN solutions can be prepared.","PeriodicalId":16667,"journal":{"name":"Journal of parenteral science and technology : a publication of the Parenteral Drug Association","volume":"46 5","pages":"169-75"},"PeriodicalIF":0.0,"publicationDate":"1992-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12603389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The insufficiency of single point diffusive air flow integrity testing. 单点扩散气流完整性测试的不足。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-09-01

H Haughney

引用次数: 0

Presentation: Basel International Congress. Advanced technologies for Manufacturing of Aseptic & Terminally Sterilized Pharmaceuticals & Biopharmaceuticals. 演讲:巴塞尔国际大会。无菌和终末灭菌药品及生物制药生产的先进技术。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-09-01

G F Meyer

引用次数: 0

Validation of automated systems--system definition. 自动化系统的验证——系统定义。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-09-01

R W Stotz, K G Chapman

引用次数: 0

The role of the effective concentration in interpreting hemolysis data. 有效浓度在解释溶血数据中的作用。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-09-01

G H Ward, S H Yalkowsky

引用次数: 0

A novel method of determination of protein stability. 一种测定蛋白质稳定性的新方法。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-09-01

D J Burgess, J K Yoon, N O Sahin

引用次数: 0

Improved direct epifluorescent filter technique for rapid bioburden control in intravenous solutions. 改进的直接荧光过滤技术用于静脉溶液的生物负荷快速控制。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-09-01

J M Esteban, M L Diaz, F Soriano, E Marin

引用次数: 0

Evaluation of biodegradable microspheres as vaccine adjuvant for hepatitis B surface antigen. 可生物降解微球作为乙型肝炎表面抗原疫苗佐剂的评价。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-09-01

R V Nellore, P G Pande, D Young, H R Bhagat

{"title":"Evaluation of biodegradable microspheres as vaccine adjuvant for hepatitis B surface antigen.","authors":"R V Nellore, P G Pande, D Young, H R Bhagat","doi":"","DOIUrl":"","url":null,"abstract":"Biodegradable microspheres were evaluated as vaccine adjuvants based on their ability to provide prolonged release of incorporated agents. Hepatitis B surface antigen (HBSA) prepared by recombinant DNA technology was chosen as a model antigen and encapsulated into polyglycolic acid (PGA) by solvent extraction and solvent evaporation techniques. Five microsphere formulations were prepared to evaluate effect of microsphere size and the presence of immunostimulants such as muramyl dipeptide (MDP) or aluminum hydroxide. The microspheres were characterized for size distribution, surface morphology and antigenicity. Guinea pigs were chosen as the animal model for evaluation of antigenicity of the formulations. The animals were divided into seven groups of four animals each and the microsphere formulations were injected intraperitoneally, using alum adsorbed HBSA as positive control and placebo microspheres as negative control. Blood samples were withdrawn from the animals by toe clipping at two, four, six and sixteen weeks and plasma was analyzed for antibodies against hepatitis B by an enzyme linked immunoassay. At sixteen weeks, the animals were reinjected and evaluated for antibody response at two, four and six weeks post second injection. Antibody response to the microspheres was higher than control. Smaller size microspheres elicited earlier antibody response while the larger size microspheres provided delayed and longer duration of antibody production. Microspheres with MDP potentiated the antibody response. The results demonstrate the applicability of biodegradable microspheres for immunization against hepatitis B.","PeriodicalId":16667,"journal":{"name":"Journal of parenteral science and technology : a publication of the Parenteral Drug Association","volume":"46 5","pages":"176-80"},"PeriodicalIF":0.0,"publicationDate":"1992-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12504181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0