有效浓度在解释溶血数据中的作用。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-09-01

G H Ward, S H Yalkowsky

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引用次数: 0

摘要

讨论了测定肠外化合物溶血活性的传统方法所固有的问题。从一项密切模拟静脉注射条件的研究中获得的数据被重新检查。给出了将几个变量组合成一个参数——有效浓度的方程。发现感兴趣的化合物的有效浓度与产生的溶血之间有很强的关系。

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The role of the effective concentration in interpreting hemolysis data.

Problems inherent in traditional methods of determining the hemolytic activity of parenteral compounds are discussed. Data taken from a study which closely models the conditions present for an intravenous injection are re-examined. An equation is given which combines several variables into a single parameter, the effective concentration. A strong relationship is found between the effective concentration of the compound of interest and the hemolysis produced.

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Journal of parenteral science and technology : a publication of the Parenteral Drug Association

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