Journal of Parathyroid Disease最新文献

{"title":"Persistent hyperparathyroidism after kidney transplantation; updates on the risk factors and its complications","authors":"C. Thongprayoon, W. Cheungpasitporn","doi":"10.15171/JPD.2018.09","DOIUrl":"https://doi.org/10.15171/JPD.2018.09","url":null,"abstract":"","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"794 1","pages":"26-28"},"PeriodicalIF":0.0,"publicationDate":"2017-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78863262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic impact of cholecalciferol in patients with psychiatric disorders receiving olanzapine","authors":"Somayeh Kaviyani, M. Bahadoram, G. Houshmand, Samaneh Bahadoram","doi":"10.15171/JPD.2018.07","DOIUrl":"https://doi.org/10.15171/JPD.2018.07","url":null,"abstract":"Introduction: Psychiatric disorders such as schizophrenia require appropriate treatment. Second-generation antipsychotics, including olanzapine, are administered as an appropriated treatment for these disorders. However, this drug has several complications, such as obesity and increased waist circumference which reduces the acceptance of the treatment. Objectives: The aim of this study was to investigate the effects of vitamin D3 therapy on waist circumference caused by olanzapine. Patients and Methods: In this randomized clinical trial, 50 hospitalized women with psychiatric disorders receiving olanzapine were divided into two groups of intervention and control groups. Before the intervention, the waist circumference, hip circumference, and waist-hip ratio were measured. Then, for 12 weeks, the intervention group received vitamin D3 and the control group received paraffin as the placebo, one pearl every 2 weeks. Waist circumference, hip circumference, and waist-hip ratio were re-measured and the collected data were analyzed by pair t test. Results: Our findings showed that there is a significant decrease in waist circumference and waist-hip ratio in intervention group (P<0.001). However, these changes were not significant in the placebo group. Hip circumference was not changed significantly in both groups. Conclusion: Vitamin D can be administered concomitant with 0lanzapine to improve side effects of olanzapine such as increasing waist circumference.","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"41 1","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"2017-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73440530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iatrogenic vitamin D overdose resulting in acute pancreatitis with acute kidney injury","authors":"Rajesh Singh, M. Balwani, U. Godhani, Pravin Ghule, P. Tolani, V. Kute","doi":"10.15171/JPD.2018.10","DOIUrl":"https://doi.org/10.15171/JPD.2018.10","url":null,"abstract":"Vitamin D deficiency is prevalent worldwide. Most of patients with mild vitamin D deficiency are often over-treated with higher dose of vitamin D supplementation than required resulting in toxic levels of vitamin D. While correcting, one should regularly look for adverse effects of overcorrection resulting in hypervitaminosis D. We discuss here a similar case of 34-year-old woman who presented to us with persistent acute abdominal pain since 48 hours and oliguria since 24 hours. She was found to have hypercalcemia induced pancreatitis with acute kidney injury. Cause of hypercalcemia was found to be hypervitaminosis D. Thereafter, she was treated with aggressive hydration and diuretics, and required calcitonin for control of hypercalcemia to which she responded. Thus we suggest that in any patient who presents with hypercalcemia with low parathyroid levels, hypervitaminosis D should be suspected. Primary care physicians should be alerted of such cases, to avoid overcorrection of vitamin D. Mild vitamin D deficiency should be initially corrected with adequate sunlight exposure and fortified/enriched vitamin D food supplements.","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"141 1","pages":"29-31"},"PeriodicalIF":0.0,"publicationDate":"2017-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75869683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency in healthy people and its relationship with gender and age","authors":"Z. Khazaei, S. Khazaei, S. Beigrezaei, H. Nasri","doi":"10.15171/JPD.2018.06","DOIUrl":"https://doi.org/10.15171/JPD.2018.06","url":null,"abstract":"Introduction: Vitamin D is a fat-soluble steroid prohormone. Vitamin D is an important regulator of calcium absorption and bone growth. Objectives: There is considerable controversy and conflicting studies on relationship between serum vitamin D in healthy individuals and ageing. The aim of this study is to test the relationship between serum 25-hydroxyvitamin vitamin D with age groups and gender in a group of Iranian healthy individuals. Patients and Methods: In this current cross-sectional study, 102 healthy individuals were selected. Serum vitamin D levels were measured using ELISA kit. According to the history and laboratory tests, patients with the history of diabetes, any active or chronic infections, liver disease, diabetes or malignancy were excluded from the study. Any history of administration of vitamin D was also an exclusion criterion. All participants had normal renal function detected by normal serum creatinine and blood urea nitrogen (BUN). To determine the relationship between gender (two categories) and age group (three categories) with vitamin D levels, Mann-Whitney U and Kruskal-Wallis tests were used respectively. Results: The average age of the participants was 42.97±15.54 years. The mean vitamin D level was 17.32±12.16 ng/mL. In this study, 73% of individuals had vitamin D deficiency, 18 % had marginal deficiency and 9% had a normal vitamin D levels. This study showed a significant relationship between vitamin D and age of subjects(r=0.23, P=0.02). Conclusion: High percentage of vitamin D deficiency in the participants of our study requires more attention to this public health entity. A direct relationship between serum vitamin D level and the age of healthy individuals requires further investigation.","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"23 1","pages":"16-18"},"PeriodicalIF":0.0,"publicationDate":"2017-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72803409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum magnesium in association with parathyroid hormone levels in routine hemodialysis patients","authors":"Milad Fooladgar, A. Malekpour, Shahin Asgari-Savadjani, Saeed Mardani","doi":"10.15171/JPD.2018.05","DOIUrl":"https://doi.org/10.15171/JPD.2018.05","url":null,"abstract":"Abstract \u0000Introduction: The homeostasis of magnesium (Mg) is perturbed in chronic kidney disease. It has been supposed that plasma Mg \u0000has a principal role to regulate the secretion of parathyroid hormone (PTH). Plasma Mg is capable of modulating secretion of PTH. \u0000Recent investigations showed that low serum Mg levels in patients with kidney disease have been linked to increased mortality. \u0000Objectives: The aim of this study was to determine the relationship between serum Mg and PTH levels in hemodialysis patients. \u0000Patients and Methods: This cross-sectional study was conducted on 56 hemodialysis patients in hemodialysis center of Hajar hospital \u0000of Shahrekord in 2015. Regular hemodialysis patients who had at least three months history of dialysis were enrolled to the study. \u0000The serum levels of Mg, calcium, phosphorus, intact PTH (iPTH), alkaline phosphatase, albumin and bicarbonate were measured. \u0000Results: In this study, 61.5% of the 52 patients were male. Mean ± standard deviation (SD) of patients’ age was 60.5 ± 17.7 years \u0000with median of 63 years old. The average duration of dialysis was 44±39.5 months (median 36 months). Additionally the dialysis \u0000dose was 517 ± 479 weeks (median; 414 weeks). Mean ± SD of serum iPTH and Mg were 360.1 ± 238.2 pg/mL and 2.2 ± 0.2 mg/mL \u0000respectively. In this study we found a significantly positive correlation of iPTH with serum Mg levels (r=0.28, P=0.04). \u0000Conclusion: This study shows impact of Mg on parathormone secretion. Our findings require further investigations with larger and \u0000multicentric studies. \u0000Please cite this paper as: Fooladgar M, Malekpour A, Asgari-Savadjani S, Mardani S. Serum magnesium in association with \u0000parathyroid hormone levels in routine hemodialysis patients. J Parathyr Dis. 2018;6(1):13-15. DOI: 10.15171/jpd.2018.05. \u0000Copyright © 2018 The Author(s); Published by Nickan Research Institute. This is an open-access article distributed under the terms \u0000of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, \u0000provided the original work is","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"73 1","pages":"13-15"},"PeriodicalIF":0.0,"publicationDate":"2017-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80993875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency and autism; a review on recent findings","authors":"N. Sotodehasl, M. Tamadon, F. Malek","doi":"10.15171/JPD.2018.04","DOIUrl":"https://doi.org/10.15171/JPD.2018.04","url":null,"abstract":"Autism is a group of lifelong developmental disabilities with various genetic and environmental risk factors which is generally not curable. The proportion of children with autism spectrum disorders (ASDs) has risen over the past decade. Few studies have focused on vitamin D status of patients with autism. Therefore, this study was aimed to further investigate the relationship between vitamin D deficiency and autism. In this short review, we discuss the relationship between vitamin D deficiency and ASDs. Our literature review yielded over 80 articles published since 2006 in the electronic databases of the Web of Knowledge, EBSCO, OVID and PubMed. As the results showed, no significant difference between children with and without autism regarding vitamin D serum levels was obtained. According to the controversial results on the correlation of vitamin D serum value and autism in children with ASD, it is necessary to conduct further studies in this field.","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"1 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2017-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89712368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast growth factor 23 and cardiovascular disease in chronic kidney disease; new trends","authors":"A. Baradaran","doi":"10.15171/JPD.2018.01","DOIUrl":"https://doi.org/10.15171/JPD.2018.01","url":null,"abstract":"","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"19 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85102129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excessive production of parathyroid hormone in association with left ventricular dysfunction in regular hemodialysis patients","authors":"H. Nasri","doi":"10.15171/JPD.2018.02","DOIUrl":"https://doi.org/10.15171/JPD.2018.02","url":null,"abstract":"Parathyroid hormone (parathormone) is a main regulator of calcium and is a principal regulator of bone and mineral homeostasis (1). Heart and vessel disease starts early during the progression of chronic renal failure and is the mainly common cause of death in these individuals (1). Parathyroid hormone is a polypeptide containing 84 amino acids secreted by parathyroid glands (1,2). Mechanisms of extension of heart and vessel disease are ill-understood. However, dysregulated homeostasis of parathyroid hormone, vitamin D, calcium and phosphorus are responsible partly in cardiac dysfunction in chronic renal failure patients (2-4). Secretion of parathormone is moderated by alterations in concentration of calcium in the blood. In fact, reduced calcium concentration stimulate PTH secretion by the calcium-sensing receptors located in the parathyroid gland. Parathormone forms a tightly controlled feedback cycle and to response to hypocalcemia, this hormone has various targets to increase serum calcium concentration (35). Parathormone is also a key stimulator of vitamin D production in renal tissue and its major physiologic regulator is circulating ionized calcium. The impact of parathormone on intestinal cells, renal tissue, and also bone leads to maintain serum calcium levels within a narrow range. However, elevated levels of parathyroid hormone have been correlated with increased risks of congestive heart failure, cardiovascular mortality hypertension and hypertrophy of left ventricle (1-4). Indeed, disturbed arterial function due to endothelia cell dysfunction is responsible for the above mentioned organ dysfunctions. Thus, cardiac tissue is one of the target organs of parathyroid hormone. Parathormone has a direct hypertrophic property on heart myocytes. Parathyroid hormone has a direct effect on cardiomyocytes, to activate protein kinase C that further stimulates hypertrophic growth and re-expression of fetal type proteins in heart tissue. Parathyroid hormone is also a potent activator of protein kinase A (6-9). The hypertrophic effect of parathyroid hormone on cardiac cells also is detected by a close association between parathormone levels and proportion of left ventricular mass (5-9). To find the relationship of parathyroid hormone with left ventricular function and structure in hemodialysis (HD) patients, we conducted a study on 73 HD patients. The age of individuals was 46.5 ±16 years. The length of time individuals had been on HD was 21.5 ±23.5 months. We found a significant inverse association of serum alkaline phosphatase with proportion of left ventricular ejection fraction. We also detected a significant inverse association between serum intact parathyroid hormone with proportion of left ventricular ejection fraction in nonImplication for health policy/practice/research/medical education Inappropriate parathyroid hormone secretion is intensely associated with establishment and progression of cardiac diseases in hemodialysis patients. Thus ","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"3 1","pages":"3-4"},"PeriodicalIF":0.0,"publicationDate":"2017-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84971401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenging look at therapeutic trend of chronic kidney disease–mineral bone disorder in children","authors":"Afshin Safaei-Asl","doi":"10.15171/JPD.2018.03","DOIUrl":"https://doi.org/10.15171/JPD.2018.03","url":null,"abstract":"","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"34 1","pages":"5-6"},"PeriodicalIF":0.0,"publicationDate":"2017-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86582191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D status and its relationship with age in type 2 diabetic patients","authors":"Leila Mahmodnia, M. Tamadon, M. Sadoughi, S. Beigrezaei","doi":"10.15171/JPD.2017.05","DOIUrl":"https://doi.org/10.15171/JPD.2017.05","url":null,"abstract":"Introduction: Type 2 diabetes has become a chronic worldwide epidemic with advancing complications and has caused many premature deaths. Its global prevalence is about 9.7%, with 92.4 million suffering from the disease. Vitamin D level has been recently considered as an adjustable risk factor of cardiovascular diseases in individuals with type 2 diabetes. Objectives: The aim of the current study is to investigate the frequency of vitamin D deficiency and the relationship between vitamin D serum levels and age in type 2 diabetes patients. Patients and Methods: In this descriptive-analytic study, 101 type 2 diabetes patients of Imam Ali clinic in Shahrekord were investigated. Serum vitamin D levels of the participants were measured by DRG (USA) Elisa kits. The results were analyzed using SPSS software with a 95% confidence level. Results: Of 101 studied patients, 32 were male and 69 were female. The average age of the subjects was 61.25 ± 11.75 years. The average age of the males was 63.09 ± 11.15 years and the average age of the females was 60.39 ± 12 years. Around 72 subjects were vitamin D deficient. No significant difference of vitamin D levels between males and females (P = 0.985) was detected. Serum vitamin D levels of type 2 diabetes patients were significantly positive correlated with their ages (r = 0.282, P = 0.004). Conclusion: In the present study the prevalence of vitamin D deficiency in type 2 diabetes patients was 71.3 %. We found a positive significant relationship between the vitamin D level and age. It is possible that ageing process is not one of the causes of vitamin D deficiency.","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"26 1","pages":"45-48"},"PeriodicalIF":0.0,"publicationDate":"2017-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84172873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}