Journal of Pain & Palliative Care Pharmacotherapy最新文献_第9页

Acute Kounis Syndrome Induced by Tramadol: A Case Report. 曲马多致急性库尼斯综合征1例。

IF 1

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-06-01 Epub Date: 2025-12-17 DOI: 10.1080/15360288.2025.2600075

Anthony Benjamín Ayala-Inga, Erik Saúl Ayala-Inga, Carlos Alberto Dávila-Hernandez

引用次数: 0

Safety Analysis of IV Methadone vs. IV Hydromorphone in Post-Procedural Adults. 成人术后静脉注射美沙酮与氢吗啡酮的安全性分析。

IF 1

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-06-01 Epub Date: 2026-01-20 DOI: 10.1080/15360288.2026.2615074

Arienne Serniak, Pamela J McCormick, Marci L Pursglove, Michael R Gionfriddo, Nicole M Verdecchia, Vladislav I Shick

{"title":"Safety Analysis of IV Methadone vs. IV Hydromorphone in Post-Procedural Adults.","authors":"Arienne Serniak, Pamela J McCormick, Marci L Pursglove, Michael R Gionfriddo, Nicole M Verdecchia, Vladislav I Shick","doi":"10.1080/15360288.2026.2615074","DOIUrl":"10.1080/15360288.2026.2615074","url":null,"abstract":"IV Methadone may be used post-procedurally to manage pain; however, it carries risks of respiratory depression and QTc prolongation. The purpose of this study is to compare safety profiles of multiple doses of intravenous (IV) methadone and IV hydromorphone in post-procedural patients. The primary outcome was incidence of respiratory event, defined as oxygen saturation (O2Sat) less than 90%, respiratory rate less than 8 breaths per minute (bpm), increased supplemental oxygen, or naloxone administration within 24 h of IV methadone or hydromorphone. Secondary outcomes included incidence of QTc prolongation and additional opioid, benzodiazepine, or ketamine doses. After exclusion assessment, 154 patients met inclusion criteria. Patients were grouped by receiving methadone (n = 85) or hydromorphone (n = 69). The primary outcome occurred 111 times in the methadone group and 40 times in the hydromorphone group (p < 0.0001). Among patients who had a respiratory event, patients who received methadone had more respiratory events compared to those who received hydromorphone (IRR: 2.25, 95% CI (1.56-3.32), p < 0.0001). Patients who received methadone also received more opioid and ketamine doses (p < 0.0001). Post-procedural methadone may be unsafe due to increased incidence of respiratory events, possible because of methadone's long half-life causing drug accumulation.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"195-200"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Sublingual Levodopa in Advanced Multiple System Atrophy. 病例报告：舌下左旋多巴治疗晚期多系统萎缩。

IF 1

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-06-01 Epub Date: 2026-04-30 DOI: 10.1080/15360288.2026.2653551

Monica De Leon, Mark Lee, Jonathan Hindmarsh

引用次数: 0

Transdermal Buprenorphine Dosing Interval Optimization from 7 Days to 5 Days: A Case Series. 丁丙诺啡经皮给药间隔优化从7天到5天：一个病例系列。

IF 1

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-06-01 Epub Date: 2026-04-04 DOI: 10.1080/15360288.2026.2653549

Heather Curtis, Naomi Bailey, Kyla Dickey, Joseph Ineck

引用次数: 0

IF 1

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-06-01 Epub Date: 2026-01-18 DOI: 10.1080/15360288.2025.2606257

Maria Cristina Pedrazini, Thereza Cristina Pedrazini de Castilho, Victor Augusto Benedicto Dos Santos

引用次数: 0

That "Dear Daughter" Letter. 那封“亲爱的女儿”的信。

IF 1

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-06-01 Epub Date: 2026-02-10 DOI: 10.1080/15360288.2026.2619590

Zhaohui Su

引用次数: 0

Evaluating Methadone as Treatment for Refractory Cancer-Induced Bone Pain. 美沙酮治疗难治性癌性骨痛的疗效评价。

IF 1

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-06-01 Epub Date: 2026-01-09 DOI: 10.1080/15360288.2026.2613836

Lindsey Dahlquist, Rebecca Peterson, Rachel Cook, Joshua Jacoby, Tyler Fenton, Kamah Ellena

{"title":"Evaluating Methadone as Treatment for Refractory Cancer-Induced Bone Pain.","authors":"Lindsey Dahlquist, Rebecca Peterson, Rachel Cook, Joshua Jacoby, Tyler Fenton, Kamah Ellena","doi":"10.1080/15360288.2026.2613836","DOIUrl":"10.1080/15360288.2026.2613836","url":null,"abstract":"This retrospective chart review aimed to evaluate the effectiveness of methadone for cancer-induced bone pain (CIBP) in inpatient and outpatient settings. The primary objective of this study was to analyze the change in pain scores utilizing the numeric rating scale (NRS) after 28 days of receiving methadone therapy compared to previous failed opioids trialed. Secondary objectives included assessing the daily total morphine milliequivalent (MME) of breakthrough opioid medications required, change in Eastern Cooperative Oncology Group (ECOG) and Palliative Performance Scale (PPS) scores before and after the initiation of methadone. Twenty-seven patients with CIBP received at least twenty-eight days of methadone between January 2020 and August 2024. Reported pain scores utilizing the NRS prior to the initiation of methadone and after at least twenty-eight days of methadone therapy were 7 (IQR 5,8) and 4 (IQR 4,5) respectively (p = 0.013). Reported amount of breakthrough MME prior to methadone and after twenty-eight days of methadone were 90 MME and 31 MME respectively (p = 0.021). No change was seen in ECOG or PPS scores before [1.0 ± 1.02]; (70% (IQR 60%,80%]) and after [1.5 ± 0.831]; (70% (IQR 60%,80%)) methadone, respectively (p = 0.104); (p = 0.855). Methadone demonstrated effectiveness in reducing pain and the amount of breakthrough medication needed in patients with CIBP.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"187-194"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Pharmacist-Led Low-Dose Buprenorphine Initiations (Microinductions): A Case Series. 临床药师主导的低剂量丁丙诺啡起始（微诱导）：一个案例系列。

IF 1.3

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-06-01 Epub Date: 2026-02-17 DOI: 10.1080/15360288.2026.2624497

Lauren Shiplett, Neil K Shah, Nicholas Field, Stephen Gruver, Anita Hu

{"title":"Clinical Pharmacist-Led Low-Dose Buprenorphine Initiations (Microinductions): A Case Series.","authors":"Lauren Shiplett, Neil K Shah, Nicholas Field, Stephen Gruver, Anita Hu","doi":"10.1080/15360288.2026.2624497","DOIUrl":"10.1080/15360288.2026.2624497","url":null,"abstract":"Buprenorphine is a semi-synthetic opioid approved for pain and opioid use disorder (OUD). A challenge in its initiation is the risk of precipitated withdrawal if a large sublingual buprenorphine dose is administered too soon after a full mu opioid receptor (MOR) agonist. This experience can be so discomforting that it might prevent further efforts to transition patients to an otherwise safe and effective treatment for OUD and/or chronic pain. Recent evidence supports a newer initiation method that may not carry as great of a risk, known as low-dose buprenorphine initiations (LDBI). While current literature demonstrates LDBIs in addiction medicine extensively, there is limited evidence detailing its use in pain, and even less detailing LDBIs led by clinical pharmacy practitioners. This case series describes five successful pharmacist-led LDBIs at a Veterans Affairs Medical Center (VAMC) among patients with chronic pain and/or OUD who required urgent transitions from their full MOR agonist to sublingual buprenorphine where a standard induction strategy would have been highly challenging and unrealistic. These cases demonstrate the versatility and clinical utility of LDBI across a variety of urgent clinical settings with unique baseline opioid regimens and continue to reinforce its possible role as a first-line induction strategy for buprenorphine.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"355-365"},"PeriodicalIF":1.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Baclofen Really Have a Role in the Management of Acute Lower Backpain: A Prospective Study. 巴氯芬在急性腰痛治疗中真的有作用吗：一项前瞻性研究

IF 1

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-06-01 Epub Date: 2026-04-06 DOI: 10.1080/15360288.2026.2649366

Bushu Harna, Shivali Arya, Aditya Banta

{"title":"Does Baclofen Really Have a Role in the Management of Acute Lower Backpain: A Prospective Study.","authors":"Bushu Harna, Shivali Arya, Aditya Banta","doi":"10.1080/15360288.2026.2649366","DOIUrl":"10.1080/15360288.2026.2649366","url":null,"abstract":"Acute lower back pain (LBP) is a common musculoskeletal condition with significant clinical and socioeconomic impact. Nonsteroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants are frequently prescribed; however, the additional benefit of combination therapy remains uncertain. This prospective, double-blinded, randomized comparative study evaluated the efficacy of etoricoxib alone versus etoricoxib combined with baclofen in patients aged 18-65 years with acute mechanical LBP of less than 6 weeks' duration. A total of 310 patients were allocated into two groups: Group A (n = 150) received etoricoxib 60 mg twice daily with topical diclofenac gel, while Group B (n = 160) received etoricoxib 60 mg plus baclofen 20 mg twice daily, along with topical diclofenac gel. All patients underwent standardized physiotherapy, including core strengthening and interferential therapy. Pain and functional outcomes were assessed using the Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and Roland-Morris Disability Questionnaire (RMDQ) at baseline and day 6. Both groups showed significant improvement (p < 0.001), with no significant intergroup differences at day 6 (VAS: p = 0.21; ODI: p = 0.18; RMDQ: p = 0.23). Etoricoxib alone provides comparable short-term outcomes, and routine addition of baclofen may not offer additional benefit.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"223-229"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Postoperative Opioid Prescribing in Veterans Undergoing Total Hip or Knee Arthroplasties. 优化退伍军人全髋关节或膝关节置换术后阿片类药物处方。

IF 1

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-06-01 Epub Date: 2026-01-28 DOI: 10.1080/15360288.2026.2621756

Taylor Lueder, Brittany Faley, Tamara Dixon

{"title":"Optimizing Postoperative Opioid Prescribing in Veterans Undergoing Total Hip or Knee Arthroplasties.","authors":"Taylor Lueder, Brittany Faley, Tamara Dixon","doi":"10.1080/15360288.2026.2621756","DOIUrl":"10.1080/15360288.2026.2621756","url":null,"abstract":"Opioid prescribing following orthopedic surgeries, such as total hip arthroplasties (THA) and total knee arthroplasties (TKA), is a critical focus area given the risks of dependence, adverse effects, and overprescribing. This single-center, retrospective quality improvement study evaluated postoperative opioid prescribing patterns among 142 opioid-naïve Veterans discharged from the Kansas City Veterans Affairs Medical Center (KCVAMC) following THA or TKA between September 2023 and September 2024. Patients who underwent TKA received higher inpatient and discharge morphine equivalent daily doses (MEDD) than THA patients, despite similar pain scores. Notably, 11% of patients were discharged with opioids despite no inpatient opioid use in the 24-h period immediately preceding discharge. The findings from this study reveal inconsistent prescribing and documentation practices, highlighting opportunities to improve care. Recommendations include implementing a standardized multimodal analgesia discharge order set with guideline-concordant opioid quantities, encouragement of non-opioid analgesic use, and inclusion of a naloxone prescription.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"201-206"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146064276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0