Journal of Orthopaedic Translation最新文献

{"title":"Emerging mechanisms and translational advances in musculoskeletal diseases","authors":"Tingting Xia, Bin Li","doi":"10.1016/j.jot.2026.101199","DOIUrl":"10.1016/j.jot.2026.101199","url":null,"abstract":"","PeriodicalId":16636,"journal":{"name":"Journal of Orthopaedic Translation","volume":"59 ","pages":"Article 101199"},"PeriodicalIF":9.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148843032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Deer antler polypeptides promote osteogenesis for fracture healing via activating neurosensory PGE2/EP4/p-CREB axis’ [J Orthop Translat 58 (2026) 1–15/101112]","authors":"Yunfan He, Jihao Xi, Haoqiang Dai, Liang Fang, Yihe Yu, Yonggan Ying, Jin Li, Danqing Fu, Chenjie Xia","doi":"10.1016/j.jot.2026.101162","DOIUrl":"10.1016/j.jot.2026.101162","url":null,"abstract":"","PeriodicalId":16636,"journal":{"name":"Journal of Orthopaedic Translation","volume":"59 ","pages":"Article 101162"},"PeriodicalIF":9.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's reply to the Letters regarding ‘Selecting between UKA and HTO in the grey zone’","authors":"Jianbin Guo, Zhibo Liu, Yong Ding","doi":"10.1016/j.jot.2026.101136","DOIUrl":"10.1016/j.jot.2026.101136","url":null,"abstract":"","PeriodicalId":16636,"journal":{"name":"Journal of Orthopaedic Translation","volume":"59 ","pages":"Article 101136"},"PeriodicalIF":9.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148843031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effect of mitochondrial transfer on bone tissue diseases: treatment strategy of mitochondrial transplantation and delivery technology","authors":"Zuping Wu,&nbsp;Yuzhe Guan,&nbsp;Ruifeng Song,&nbsp;Peng Chen,&nbsp;Xinyi Fang,&nbsp;Qian chen,&nbsp;Xiaoyan Chen","doi":"10.1016/j.jot.2026.101143","DOIUrl":"10.1016/j.jot.2026.101143","url":null,"abstract":"<div><div>Disruptions in bone tissue metabolic balance can lead to osteoporosis, osteoarthritis, rheumatoid arthritis, and bone tumors. This disruption typically manifests as reduced or abnormal bone mass, accompanied by pathological changes such as inflammation, fractures, and pain. Recent studies have revealed that mitochondrial dysfunction is prevalent in the aforementioned pathological processes, participating in the regulation of bone tissue cell function and intracellular immune function. Mitochondrial transfer, a newly discovered physiological phenomenon in recent years, can regulate mitochondrial function within recipient cells, thereby influencing metabolic activities, proliferation, differentiation, apoptosis, and immune function of various bone tissue cells. This article primarily reviews the regulatory effects of mitochondrial transfer associated with MSCs on various cells in bone and joint tissues. Given the role of mitochondrial transfer in regulating bone metabolism, we elucidate the application of mitochondrial transfer therapy in the treatment of osteoporosis, osteoarthritis, rheumatoid arthritis, and other bone tissue diseases.</div><div>The Translational Potential of this Article: This review elaborates in detail on the therapeutic strategies provided by mitochondrial transplantation technology or targeted mitochondrial delivery systems for the treatment of bone tissue diseases, based on the occurrence of mitochondrial transfer in bone tissue tips and its therapeutic effects on related diseases such as OA, RA, osteoporosis.</div></div>","PeriodicalId":16636,"journal":{"name":"Journal of Orthopaedic Translation","volume":"59 ","pages":"Article 101143"},"PeriodicalIF":9.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13314807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide alleviates osteoarthritis independent of weight loss via GLP-1R–mediated activation of autophagy through AKT/mTOR inhibition","authors":"Junming Lin,&nbsp;Mengliang Luo,&nbsp;Huaxin Tang,&nbsp;Kaifeng Lu,&nbsp;Yuexi Mou,&nbsp;Qilong Jiang,&nbsp;Xiaojun Yuan,&nbsp;Zhongliang Deng,&nbsp;Wenhua Xu,&nbsp;Mao Nie,&nbsp;Xianding Sun","doi":"10.1016/j.jot.2026.101166","DOIUrl":"10.1016/j.jot.2026.101166","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;&lt;strong&gt;Objective&lt;/strong&gt;&lt;/h3&gt;&lt;div&gt;The development of osteoarthritis (OA) is closely associated with systemic metabolic disorders, yet there remains a lack of disease-modifying therapeutic strategies that simultaneously target metabolic abnormalities and inflammatory responses. This study aims to systematically evaluate the therapeutic potential of semaglutide, a long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist used for diabetes management, in OA and to elucidate its underlying molecular mechanisms.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;&lt;strong&gt;Methods&lt;/strong&gt;&lt;/h3&gt;&lt;div&gt;We utilized a zebrafish cartilage injury repair model to screen and assess the impact of several hypoglycemic drugs on cartilage regeneration. OA was induced in C57BL/6 mice by destabilization of the medial meniscus (DMM) surgery. Using systemic &lt;em&gt;Glp-1r&lt;/em&gt; knockout mice, we systematically evaluated the effects of semaglutide on joint structure, function, and pain-related behaviors &lt;em&gt;in vivo&lt;/em&gt;. RNA sequencing was performed to explore the regulator effects of semaglutide on extracellular matrix metabolism, associated signaling pathways, and autophagy in IL-1β-stimulated primary mouse chondrocytes. To verify the functional loss, the GLP-1R antagonist Exendin (9-39) and the autophagy inhibitor Bafilomycin A1 were employed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;&lt;strong&gt;Results&lt;/strong&gt;&lt;/h3&gt;&lt;div&gt;Drug screening using a zebrafish cartilage injury model demonstrated that semaglutide exerted the most significant pro-regenerative effects, markedly promoting cartilage repair. In wild-type (WT) mice with DMM-induced OA, semaglutide treatment significantly improved gait abnormalities and mechanical hyperalgesia without significantly affecting body weight, and alleviated cartilage destruction, synovitis, and subchondral bone sclerosis associated with abnormal chondrocyte metabolism. However, GLP-1R inhibition or &lt;em&gt;Glp-1r&lt;/em&gt; knockout completely abolished the protective effects of semaglutide on chondrocyte metabolism and its therapeutic efficacy in OA. Moreover, &lt;em&gt;Glp-1r&lt;/em&gt; gene deficiency exacerbated cartilage degeneration and bone structural damage, indicating that GLP-1R signaling is indispensable for maintaining cartilage homeostasis. Mechanistically, semaglutide inhibited the AKT/mTOR pathway through GLP-1R activation, thereby reversing IL-1β- and DMM-induced autophagy suppression and restoring the balance of extracellular matrix metabolism in chondrocytes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;&lt;strong&gt;Conclusion&lt;/strong&gt;&lt;/h3&gt;&lt;div&gt;Semaglutide exerts protective effects against OA by activating GLP-1R in chondrocytes, inhibiting the AKT/mTOR pathway, and enhancing chondrocyte autophagy. It alleviates abnormal cartilage metabolism in OA independently of body weight changes.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Translational potential of this study&lt;/strong&gt;: This study demonstrates, for the first time, that semaglutide exerts protective effects against OA independent of weight loss by directly activating chondrocyte GLP-1R, in","PeriodicalId":16636,"journal":{"name":"Journal of Orthopaedic Translation","volume":"59 ","pages":"Article 101166"},"PeriodicalIF":9.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging era of robotics and artificial intelligence in orthopaedic trauma surgery","authors":"Ronald Man Yeung Wong,&nbsp;Minghui Yang,&nbsp;Chun Sing Chui,&nbsp;Emil H. Schemitsch,&nbsp;Peter V. Giannoudis","doi":"10.1016/j.jot.2026.101179","DOIUrl":"10.1016/j.jot.2026.101179","url":null,"abstract":"","PeriodicalId":16636,"journal":{"name":"Journal of Orthopaedic Translation","volume":"59 ","pages":"Article 101179"},"PeriodicalIF":9.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histone H3K18 lactylation: An exercise-induced epigenetic mechanism that inhibits osteoclast activity and protects against osteoporosis","authors":"Zhenru He,&nbsp;Yun Wu,&nbsp;Yuan You,&nbsp;Ting Li,&nbsp;Yilin Liao,&nbsp;Jingqiu Chen,&nbsp;Yuting Wang,&nbsp;Yue Sheng,&nbsp;Yaoyu Zhao,&nbsp;Wengwanyue Ye,&nbsp;Mengjie Yin,&nbsp;Peiqi Zhang,&nbsp;Ji Li,&nbsp;Huilin Tang,&nbsp;Jingyang Lou,&nbsp;Xiazhou Fu,&nbsp;Xiaohong Yang,&nbsp;Yaoting Ji","doi":"10.1016/j.jot.2026.101147","DOIUrl":"10.1016/j.jot.2026.101147","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoclasts, through their excessive production, are the primary cause of postmenopausal osteoporosis. However, the influence of metabolism on osteoclastogenesis remains poorly understood. This study reveals that protein lactylation plays a critical role in osteoclast differentiation.</div></div><div><h3>Methods</h3><div>The ovariectomized (OVX) mouse model was used to investigate osteoporosis by examining glycolysis and lactate levels during osteoclast differentiation. Bone resorption was assessed through histomorphometric analysis. The effects of elevating lactate levels were tested both endogenously via exercise and exogenously through sodium lactate (NaLac) administration. Protein lactylation, focusing on histone modifications, was analyzed, and key osteoclastogenesis genes, including cathepsin K (<em>Ctsk</em>), matrix metalloproteinase 9 (<em>Mmp9</em>), and matrix metalloproteinase 12 (<em>Mmp12</em>), were quantified. The enzymes responsible for lactylation and delactylation were identified through cleavage under targets and tagmentation (CUT&amp;Tag) and RNA-Seq analyses.</div></div><div><h3>Results</h3><div>Our findings showed that glycolysis and lactate levels were reduced during osteoclast differentiation in the OVX model, despite increased bone resorption. Elevating lactate through exercise or sodium lactate supplementation increased protein lactylation and mitigated OVX-induced bone loss. Mechanistically, lactate enhanced histone H3 lysine-18 lactylation (H3K18la), which suppressed osteoclast differentiation by downregulating key osteoclastogenesis genes like <em>Ctsk, Mmp9</em>, and <em>Mmp12</em>. Alanyl-tRNA synthetase 1 (AARS1) was identified as the lactylation “writer” that mediates H3K18la, with sirtuin 6 (SIRT6) acting as an “eraser” in a regulatory circuit.</div></div><div><h3>Conclusions</h3><div>Lactate suppresses osteoclast differentiation and alleviates osteoporosis through histone H3K18 lactylation, which downregulates osteoclastogenic genes including <em>Ctsk, Mmp9</em>, and <em>Mmp12</em>. The dynamic regulation of H3K18la involves AARS1 as the lactylation “writer”and SIRT6 as an “eraser”.</div></div><div><h3>The translational potential of this article</h3><div>This study reveals an epigenetic mechanism by which lactate regulates osteoclast function and suggests that exercise-induced lactate elevation or lactate supplementation may represent a viable therapeutic strategy for postmenopausal osteoporosis.</div></div>","PeriodicalId":16636,"journal":{"name":"Journal of Orthopaedic Translation","volume":"59 ","pages":"Article 101147"},"PeriodicalIF":9.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Metformin prevents mandibular bone loss in a mouse model of accelerated aging by correcting dysregulated AMPK-mTOR signaling and osteoclast differentiation” [J Orthop Transl 46 (2024) 129–142]","authors":"Boyang Liu,&nbsp;Jiao Zhang,&nbsp;Jinge Zhang,&nbsp;Xiaolei Ji,&nbsp;Rong Wang,&nbsp;Aixiu Gong,&nbsp;Dengshun Miao","doi":"10.1016/j.jot.2026.101121","DOIUrl":"10.1016/j.jot.2026.101121","url":null,"abstract":"","PeriodicalId":16636,"journal":{"name":"Journal of Orthopaedic Translation","volume":"59 ","pages":"Article 101121"},"PeriodicalIF":9.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13355038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising bionic pore designs in a spiral blade implant to enhance bone ingrowth and stability: A combined CFD and large-animal study","authors":"Meng-Xuan Yao,&nbsp;Tai-Long Shi,&nbsp;Yu-Qin Zhang,&nbsp;Yi-Fan Zhang,&nbsp;Chuan Ren,&nbsp;Shi-Wu Dong,&nbsp;Zhi-Yong Hou,&nbsp;Ying-Ze Zhang,&nbsp;Hong-Zhi Lv,&nbsp;Wei Chen","doi":"10.1016/j.jot.2026.101165","DOIUrl":"10.1016/j.jot.2026.101165","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;This study aimed to evaluate the effects of different Bionic Pore geometries (circular, triangular, and rectangular) and diameters (0.8 mm, 1 mm, 2 mm, and 3 mm) on fluid shear stress (FSS) distribution and bone ingrowth in a bionic spiral blade implant.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Twelve Bionic Pore structures were modeled using CAD software, and computational fluid dynamics (CFD) analysis was performed to simulate the FSS distribution in a bone environment. Based on these simulation results, the circular hole design was selected and manufactured via electron beam melting (EBM). It was then incorporated into a bionic spiral blade (length: 50 mm, outer diameter: 6 mm, and a central canal of 2 mm for surgical pin placement). Four female sheep (weighing 35–40 kg) were implanted with these spiral blades, divided into 3-month and 6-month follow-up groups. After surgery, X-ray imaging, micro-CT, and histological evaluation were used to assess implant stability, bone bridging, and tissue response within the bionic pores.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;CFD simulations showed that circular pores generated a more optimal and uniform FSS distribution; the 0.8 mm circular pore produced an average FSS of 0.0086 ± 0.00013 Pa, representing a 79.1% and 68.0% reduction compared to identically sized triangular (0.0412 ± 0.0176 Pa) and rectangular pores (0.0269 ± 0.0056 Pa), respectively. In vivo experiments demonstrated that small-diameter holes significantly accelerated osteogenesis. At 3 months, the 0.8 mm group achieved a bone tissue area ratio (BTA/BHA) of 15.44 ± 1.94%, which was 98.7% higher than that of the 3 mm group (7.77 ± 3.03%). By 6 months, the 0.8 mm group reached a BTA/BHA of 39.79 ± 7.80%, demonstrating a 131.2% greater bone occupancy compared to the 3 mm group (17.21 ± 3.97%, &lt;em&gt;p&lt;/em&gt; &lt; 0.01), alongside significantly higher bone volume fractions (BV/TV, &lt;em&gt;p&lt;/em&gt; &lt; 0.0001). Larger holes (2 mm and 3 mm) initially exhibited fibrous tissue formation, but as the pores gradually narrowed over time, local FSS increased, supporting later-stage bone formation. Radiographic and histological analyses confirmed that the bionic spiral blades remained stable in vivo.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This study indicates that optimizing the geometry and size of bionic pores can improve FSS conditions and promote bone ingrowth. Small-diameter circular holes, in particular, favor early and robust osseointegration. Moreover, this work underscores the potential of combining advanced manufacturing techniques with mechanobiological principles to design customized bionic implants for enhanced orthopedic outcomes. Importantly, the close agreement between CFD predictions and in vivo outcomes validates computational fluid dynamics as a practical prescreening tool for optimizing pore designs in load-bearing implants.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;The translational potential of this article&lt;/h3&gt;&lt;div&gt;This \"bench-to-bedside\" re","PeriodicalId":16636,"journal":{"name":"Journal of Orthopaedic Translation","volume":"59 ","pages":"Article 101165"},"PeriodicalIF":9.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From episodic imaging to real-time sensor monitoring: translational advances in assessing fracture healing dynamics","authors":"Fawwaz Al-Smadi,&nbsp;Ze Lin,&nbsp;Na Li,&nbsp;Jiewen Liao,&nbsp;Sajeda Al-Smadi,&nbsp;Xiayidan Abudourusuli,&nbsp;Xudong Xie,&nbsp;Chenyan Yu,&nbsp;Yiming Li,&nbsp;Mengfei Liu,&nbsp;Bobin Mi,&nbsp;Guohui Liu","doi":"10.1016/j.jot.2026.101172","DOIUrl":"10.1016/j.jot.2026.101172","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Fracture healing culminates in restoration of mechanical competence, yet clinical monitoring remains largely dependent on episodic imaging and subjective assessment, which provide delayed structural information and limited insight into the evolving stability of the fracture construct, contributing to uncertainty in clinical decision-making and delayed recognition of impaired healing. Advances in bioelectronics, implantable sensors, and wearable systems are enabling longitudinal assessment of fracture recovery by capturing quantitative signals related to mechanical load transfer, local tissue state, and functional activity in real-world settings. In this review, we synthesize recent developments in sensor-based fracture monitoring and propose a conceptual framework that integrates three complementary dimensions of healing assessment: mechanical competence, biological progression, and functional recovery. Among these, load-path sensing of implant–bone load transfer provides the most direct proxy for fracture stiffness and currently represents the most translationally mature approach, supported by emerging preclinical and early clinical studies. In contrast, biological sensing strategies, including impedance- and dielectric-based approaches, aim to detect earlier changes in callus composition but remain at lower levels of translational readiness, while wearable monitoring technologies offer scalable insights into rehabilitation trajectories but provide indirect measures of fracture stability. Collectively, these approaches support a transition from episodic structural imaging toward continuous, data-driven characterization of healing dynamics. Achieving clinical implementation will require workflow-integrated sensing systems, interpretable analytical frameworks linking sensor outputs to clinically actionable endpoints, and multicentre validation establishing standardized thresholds across fracture types and treatment strategies.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;The translational potential of this article&lt;/h3&gt;&lt;div&gt;Current literature on fracture healing monitoring is largely technology-centric, with limited integration of sensing outputs into clinically actionable frameworks. This review addresses that gap by providing a unified, decision-oriented synthesis that links mechanical, biological, and functional sensing paradigms to the core clinical endpoint of fracture healing, restoration of mechanical competence, and to key management decisions such as weight-bearing progression, follow-up intensity, and early detection of delayed union. By contextualizing existing technologies within a translational maturity (TRL) framework and evaluating evidence from benchtop, preclinical, and early human studies, this work identifies which sensing strategies are closest to clinical implementation and what barriers remain, including the need for standardized protocols, validated decision thresholds, workflow integration, and scalable data interpretation. The translation","PeriodicalId":16636,"journal":{"name":"Journal of Orthopaedic Translation","volume":"59 ","pages":"Article 101172"},"PeriodicalIF":9.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13355026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}