细胞外囊泡在股骨头骨坏死中的多重作用

IF 5.9 1区医学 Q1 ORTHOPEDICS

Journal of Orthopaedic Translation Pub Date : 2025-04-10 DOI:10.1016/j.jot.2025.03.009

Hongxu Li , Haoyang Liu , Yu Zhou , Liming Cheng , Bailiang Wang , Jinhui Ma

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引用次数: 0

摘要

股骨头坏死（Osteonecrosis of femoral head， ONFH）是一种严重的疾病，其特征是由于血管损伤导致骨组织坏死，常导致关节塌陷，需要手术干预。细胞外囊泡（EVs）是细胞间通讯的重要介质，影响骨生成、血管生成和免疫调节。本文综述了ev在ONFH发病机制和坏死后骨修复中的双重作用，重点介绍了ev介导的各种信号通路对骨再生的影响以及这些通路之间潜在的相互作用。此外，电动汽车有望作为诊断性生物标志物或造影剂，补充传统的ONFH检测成像技术。通过阐明ev在骨坏死中的作用和解决当前的挑战，我们希望为ONFH的及时识别和治疗奠定基础。本文的翻译潜力：本文全面探讨了EVs在ONFH中的作用，为其诊断和治疗提供了创新和有希望的见解，也为EVs在ONFH中的临床应用奠定了理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The multifaceted roles of extracellular vesicles in osteonecrosis of the femoral head

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The multifaceted roles of extracellular vesicles in osteonecrosis of the femoral head

Osteonecrosis of the femoral head (ONFH) is a severe disease characterized by bone tissue necrosis due to vascular impairment, often leading to joint collapse and requiring surgical intervention. Extracellular vesicles (EVs) serve as crucial mediators of intercellular communication, influencing osteogenesis, angiogenesis, and immune regulation. This review summarizes the dual role of EVs in both the pathogenesis of ONFH and post-necrosis bone repair, highlighting the impact of various EV-mediated signaling pathways on bone regeneration and the potential crosstalk among these pathways. Additionally, EVs hold promise as diagnostic biomarkers or contrast agents to complement conventional imaging techniques for ONFH detection. By elucidating the role of EVs in osteonecrosis and addressing the current challenges, we aspire to establish a foundation for the timely identification and treatment of ONFH.

The translational potential of this article: This review comprehensively discusses the role of EVs in ONFH, providing innovative and promising insights for its diagnosis and treatment, which also establishes a theoretical foundation for the future clinical application of EVs in ONFH.

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来源期刊

Journal of Orthopaedic Translation Medicine-Orthopedics and Sports Medicine

CiteScore

11.80

自引率

13.60%

发文量

审稿时长

29 days

期刊介绍： The Journal of Orthopaedic Translation (JOT) is the official peer-reviewed, open access journal of the Chinese Speaking Orthopaedic Society (CSOS) and the International Chinese Musculoskeletal Research Society (ICMRS). It is published quarterly, in January, April, July and October, by Elsevier.