{"title":"Selective Serotonin Reuptake Inhibitors May Increase Implant Failure","authors":"Michael S. Block DMD , Don Mercante PhD","doi":"10.1016/j.joms.2025.02.005","DOIUrl":"10.1016/j.joms.2025.02.005","url":null,"abstract":"<div><h3>Background</h3><div>Patients receiving dental implants may take selective serotonin reuptake inhibitors (SSRI). There may be an association with taking an SSRI at implant placement and implant failure.</div></div><div><h3>Purpose</h3><div>The study's purpose was to estimate the association between SSIR exposure and implant failure.</div></div><div><h3>Study design</h3><div>The study design was a retrospective cohort study. The sample was patients who received dental implants between December 1, 2007, and February 29, 2020. Patients were excluded if the follow-up was <12 months.</div></div><div><h3>Predictor variable</h3><div>The predictor variable was SSRI exposure at the time of implant placement coded as exposed or not exposed.</div></div><div><h3>Outcome variable</h3><div>The primary outcome variable was implant status at 1 year, coded as survived or failed.</div></div><div><h3>Covariates</h3><div>The covariates were age, sex, and implant location and per subject, and comorbidities included smoking, diabetes, osteoporosis, and frailty.</div></div><div><h3>Analyses</h3><div>Bivariate statistics assessed the association between SSRI exposure at the time of implant placement and failure with significance at <em>P</em> value < .05.</div></div><div><h3>Results</h3><div>The sample was composed of 1,611 subjects (mean age 57.3 ± 15.8 years, 893 (55.4%) females) with 3,184 implants placed. There were 1,514 (94%) subjects who did not take an SSRI at implant placement (mean age 57.5 ± 15.5 years, 813 (53.7%) females) and there were 97 (6%) subjects who did take an SSRI at implant placement (mean age 61.6 ± 13.1 years, 80 (82.5%) females). The failure rate was 6.7% (101 subjects) for non-SSRI exposed subjects and 18.6% (18 subjects) who took an SSRI at implant placement. SSRI exposure was associated with implant failure at 1-year relative risk = 2.8; 1.8-4.4 (relative risk, 95% confidence interval). Covariates with association with failure: smoking odds ratio (OR) = 0.98, 1.5-5.5 (OR, 95% confidence limits, <em>P</em> < .0001), diabetes (OR = 1.8, 95% confidence interval [CI], <em>P</em> = .048), alcohol (OR = 1.9, 95% CI, <em>P</em> = .045), osteoporosis (OR = 14.1, 95% CI, <em>P</em> < .0001), debilitation (OR = 20.7, 95% CI, <em>P</em> < .0001), and bisphosphonates (OR = 0.09, 95% CI, <em>P</em> = .004).</div></div><div><h3>Conclusions</h3><div>Patients who take SSRI at the time of implant surgery may have an increased risk for implant failure.</div></div>","PeriodicalId":16612,"journal":{"name":"Journal of Oral and Maxillofacial Surgery","volume":"83 5","pages":"Pages 585-591"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Davisson Alves Pereira PhD, DDS, Mariana da Silva Bonatto PhD, DDS, Eduvaldo Campos Soares Jr. PhD, DDS, Pedro Gomes Junqueira Mendes MSc, Roberto Sales e Pessoa PhD, DDS, Guilherme José Pimentel Lopes de Oliveira PhD, DDS
{"title":"REPLY: Photobiomodulation With Infrared and Dual-Wavelength Laser Induces Similar Repair and Control of Inflammation After Third Molar Extraction. A Double-Blinded Split-Mouth Randomized Controlled Trial","authors":"Davisson Alves Pereira PhD, DDS, Mariana da Silva Bonatto PhD, DDS, Eduvaldo Campos Soares Jr. PhD, DDS, Pedro Gomes Junqueira Mendes MSc, Roberto Sales e Pessoa PhD, DDS, Guilherme José Pimentel Lopes de Oliveira PhD, DDS","doi":"10.1016/j.joms.2025.01.009","DOIUrl":"10.1016/j.joms.2025.01.009","url":null,"abstract":"","PeriodicalId":16612,"journal":{"name":"Journal of Oral and Maxillofacial Surgery","volume":"83 5","pages":"Page 509"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"May 2025 AAOMS News and Announcements","authors":"","doi":"10.1016/j.joms.2025.02.002","DOIUrl":"10.1016/j.joms.2025.02.002","url":null,"abstract":"","PeriodicalId":16612,"journal":{"name":"Journal of Oral and Maxillofacial Surgery","volume":"83 5","pages":"Pages 640-644"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonard B. Kaban DMD, MD, Jeffrey C. Posnick DMD, MD, David A. Keith BDS, DMD
{"title":"RE: TMJ Concepts Patient-Fitted Temporomandibular Joint Reconstruction Prosthesis System: Results From a Food and Drug Administration Postmarket Surveillance Prospective Cohort Study","authors":"Leonard B. Kaban DMD, MD, Jeffrey C. Posnick DMD, MD, David A. Keith BDS, DMD","doi":"10.1016/j.joms.2025.01.017","DOIUrl":"10.1016/j.joms.2025.01.017","url":null,"abstract":"","PeriodicalId":16612,"journal":{"name":"Journal of Oral and Maxillofacial Surgery","volume":"83 5","pages":"Page 507"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simon Youn MD, DDS , Katherine Scheker DDS , Samuel Sheridan DDS , Colin Hayashi BS , Trevor A. Pickering PhD , John Costandi MD, DDS
{"title":"Does Liposomal Bupivacaine Reduce Postoperative Pain Following Third Molar Extractions? A Double-Blinded Randomized Controlled Trial","authors":"Simon Youn MD, DDS , Katherine Scheker DDS , Samuel Sheridan DDS , Colin Hayashi BS , Trevor A. Pickering PhD , John Costandi MD, DDS","doi":"10.1016/j.joms.2025.01.004","DOIUrl":"10.1016/j.joms.2025.01.004","url":null,"abstract":"<div><h3>Background</h3><div>Liposomal bupivacaine (LB) is a long-lasting local anesthetic providing analgesia for several days. The current literature examining the efficacy of LB in pain management following third molar extractions remains unclear.</div></div><div><h3>Purpose</h3><div>The purpose of this study was to compare postoperative pain management between LB and standard bupivacaine (SB) in mandibular third molar extractions.</div></div><div><h3>Study Design</h3><div>A double-blinded randomized controlled trial of subjects undergoing bilateral mandibular third molar extractions at our institution from 2022 to 2024 was conducted using a split-mouth study design. Subjects were excluded if they received additional mandibular teeth extractions, were unable to complete the questionnaire, or had medical contraindications.</div></div><div><h3>Predictor Variable</h3><div>The predictor variable was postsurgical local anesthetic agent, and the sides of mouth were randomly assigned to LB or SB.</div></div><div><h3>Main Outcome Variable(s)</h3><div>Primary outcome was postoperative pain on a 10-point numerical rating scale (NRS), and the mean cumulative pain rating via area under the curve (AUC) analysis. Secondary outcomes were adverse events and ibuprofen or acetaminophen consumption.</div></div><div><h3>Covariates</h3><div>Demographics, procedure time, preoperative and perioperative local anesthetics used, and procedural difficulty coded as nonsurgical or surgical were collected.</div></div><div><h3>Analyses</h3><div>We used mixed-effects models to compare the NRS scores during each time period and paired t-tests to compare AUC values. Statistical tests included 95% CIs with alpha = 0.05.</div></div><div><h3>Results</h3><div>The study sample included 72 subjects (mean age 25.8, SD: 9). Pain was lower in the LB versus SB group on surgery day (NRS difference −0.75; <em>P</em> = .002) until the morning of postoperative day 2 (−0.68, <em>P</em> = .003). When limiting the analysis to bilateral surgical extractions, it was statistically significant until the morning of postoperative day 3 (−0.61, <em>P</em> = .02). AUC analysis showed cumulative pain reduction for the LB group in comparison to the SB group through all 4 postoperative days for the overall cohort (average AUC<sub>0-96</sub> difference 93.5, <em>P</em> = .005), with a similar effect for bilateral surgical extractions (101.88, <em>P</em> = .006).</div></div><div><h3>Conclusion</h3><div>LB modestly reduces pain following third molar extractions, with this difference more pronounced following surgical extractions. This suggests that LB may be more beneficial in complex extractions and greater pain-inducing surgeries.</div></div>","PeriodicalId":16612,"journal":{"name":"Journal of Oral and Maxillofacial Surgery","volume":"83 5","pages":"Pages 592-600"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Opioids in Oral and Maxillofacial Surgery: The Past, Present, and Future","authors":"Tara Aghaloo DDS, MD, PhD","doi":"10.1016/j.joms.2025.02.003","DOIUrl":"10.1016/j.joms.2025.02.003","url":null,"abstract":"","PeriodicalId":16612,"journal":{"name":"Journal of Oral and Maxillofacial Surgery","volume":"83 5","pages":"Pages 501-502"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haya H.R. Al-Bayyati , Gert-Jan Hassing MD, DDS, PhD , Egbert P. van der Hoeve MD, DDS , Laurens Koppendraaier MD, DDS , Maurits H.T. de Ruiter MD, DDS, PhD
{"title":"Patient-Reported Outcomes With Focus on Health-Related Quality of Life in Patients With Obstructive Sleep Apnea Treated With Maxillomandibular Advancement Surgery: A Systematic Review and Meta-Analysis","authors":"Haya H.R. Al-Bayyati , Gert-Jan Hassing MD, DDS, PhD , Egbert P. van der Hoeve MD, DDS , Laurens Koppendraaier MD, DDS , Maurits H.T. de Ruiter MD, DDS, PhD","doi":"10.1016/j.joms.2025.01.010","DOIUrl":"10.1016/j.joms.2025.01.010","url":null,"abstract":"<div><h3>Purpose</h3><div>Maxillomandibular advancement (MMA) surgery for obstructive sleep apnea (OSA) has shown to be effective according to objective measures; however, patient-reported outcome measures (PROMs), especially health-related quality of life (HRQoL), are also crucial but have not been systematically assessed in relation to MMA surgery for OSA yet. Therefore, this study aims to conduct a systematic review on the effect of MMA surgery on PROMs focusing on HRQoL in patients with OSA.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines with a literature search performed in PubMed and Medline to identify relevant studies from database inception to May 2024 evaluating PROMs focusing on HRQoL in adult OSA patients treated with MMA surgery. The primary variables are the PROMs outcomes. Screening and eligibility assessments were carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis framework, and study quality was evaluated using the ROBINS-I tool. The data extraction for the meta-analysis included PROMs outcomes and was carried out in SPSS using a fixed-effects model to report effect sizes as mean differences.</div></div><div><h3>Results</h3><div>Thirty-three studies were screened of which 12 were included in this systematic review encompassing 317 patients. The studies reported PROMs in a heterogeneous manner, but MMA consistently showed an improvement postoperatively in mean differences. In the most used PROMs instruments MMA surgery was associated with a 5.35-point improvement in the Epworth Sleepiness Scale (95% CI −6.57 to −4.14; Z = −8.62; <em>P</em> < .001), a 3.96-point improvement on the Functional Outcomes of Sleep Questionnaire (95% CI 3.11, 4.80; Z = 11.60; <em>P</em> < .001) and an improvement in all domains of the Short Form 36 Health Survey.</div></div><div><h3>Conclusion</h3><div>MMA surgery for patients with OSA shows significant improvements in PROMs related to quality of life. The PROMs are positive, demonstrating satisfaction across various domains. This indicates that MMA surgery is well received by patients and results in clinically meaningful improvements in PROMs related to HRQoL.</div></div>","PeriodicalId":16612,"journal":{"name":"Journal of Oral and Maxillofacial Surgery","volume":"83 5","pages":"Pages 543-557"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Balancing Occupational Demands: How Sport Selection Influences the Long-Term Health of Oral and Maxillofacial Surgeons","authors":"Ricardo Grillo PhD , Christian Klausener","doi":"10.1016/j.joms.2025.02.010","DOIUrl":"10.1016/j.joms.2025.02.010","url":null,"abstract":"","PeriodicalId":16612,"journal":{"name":"Journal of Oral and Maxillofacial Surgery","volume":"83 5","pages":"Pages 503-504"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}