SunText Review of Medical & Clinical Research最新文献_第4页

Do Sodium-Glucose Cotransporters Type 2 Inhibitors Cause Hypercalcemia? 钠-葡萄糖共转运蛋白2型抑制剂会引起高钙血症吗?

SunText Review of Medical & Clinical Research Pub Date : 1900-01-01 DOI: 10.51737/2766-4813.2022.067

M. N

引用次数: 0

Multiple Sclerosis as a Cause of Disturbances in the Activity of the Heart and Brain; the Role of Glycine and N-Acetylcysteine in the Treatment and Prevention of these Conditions in the Elderly Using Resonance Therapy 多发性硬化症是心脏和大脑活动紊乱的原因甘氨酸和n -乙酰半胱氨酸在磁共振治疗和预防老年人这些疾病中的作用

SunText Review of Medical & Clinical Research Pub Date : 1900-01-01 DOI: 10.51737/2766-4813.2023.079

Victor P

引用次数: 1

Abdominal Trauma by Firearm in a Malnourished Patient: Clinical Case 火器致腹部创伤1例营养不良患者:临床病例

SunText Review of Medical & Clinical Research Pub Date : 1900-01-01 DOI: 10.51737/2766-4813.2023.069

Arredondo Gp

引用次数: 0

A Case Report of High Degree Atrioventricular Block Simulating As a Seizure 高程度房室传导阻滞模拟癫痫发作1例

SunText Review of Medical & Clinical Research Pub Date : 1900-01-01 DOI: 10.51737/2766-4813.2023.078

Yanamadala A

引用次数: 0

Hypofractionated Radiosurgery Re-Irradiation in Large Solitary Brain Metastasis from HER2 Positive Breast Carcinoma 低分割放疗在HER2阳性乳腺癌大孤立性脑转移中的应用

SunText Review of Medical & Clinical Research Pub Date : 1900-01-01 DOI: 10.51737/2766-4813.2022.049

Marinova L, Vassileva V, Petrov V, Gabrovski I

{"title":"Hypofractionated Radiosurgery Re-Irradiation in Large Solitary Brain Metastasis from HER2 Positive Breast Carcinoma","authors":"Marinova L, Vassileva V, Petrov V, Gabrovski I","doi":"10.51737/2766-4813.2022.049","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.049","url":null,"abstract":"In improved therapeutic capabilities, late progression of locally advanced HER2 positive breast cancer (BC) is increasingly diagnosed after complex treatment by expression of late solitary brain metastasis (BM). We present a 35-year-old woman with left invasive ductal BC /pT2N1M0, grade G3 with positive estrogen, progesterone and HER2 receptors expression. Complex treatment was carried out, including radical mastectomy with axillary dissection followed by adjuvant treatment- chemotherapy (Ch), radiotherapy (RT), targeted therapy (TT) with trastuzumab and endocrine therapy with LHRH agonist plus tamoxifen. After 8 years a single brain metastasis has been found, extirpated and histologically verified. Postoperative whole-brain radiotherapy (WBRT) up to total dose (TD) 25 Gy with daily dose (DD) 2,5 Gy and boost in brain metastasis up to biologically effective dose/BED 49,5Gy was conducted. August-October 2020 after 1 year of WBRT, against the background of complex treatment with 2 targeted agents/ trastuzumab/pertuzumab and endocrine therapy, CT visualized elevated vasogenic peritumor edema with the progress of the mass effect. The only therapeutic alternative was re-irradiation of brain metastasis by hypofractionated radiosurgery (HFRS). The purpose of this article is to present the efficient healing combination of targeted therapy and HFRS re-irradiation in late solitary BM from HER2 positive BC, not only in terms of local control but also on prolonged survival.","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131316947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged Survival in Metastatic Gastrointestinal Cancer and the Significance of the Modulation of the Activity of Cells of the Tumor Microenvironment 转移性胃肠癌的延长生存期及肿瘤微环境细胞活性调节的意义

SunText Review of Medical & Clinical Research Pub Date : 1900-01-01 DOI: 10.51737/2766-4813.2022.057

Koch Ba, Uflacker L

引用次数: 0

The Relationship between Cerebral Small Vessel Disease and Inflamate-Immune Response: A Review 脑血管病与炎症免疫反应关系的研究进展

SunText Review of Medical & Clinical Research Pub Date : 1900-01-01 DOI: 10.51737/2766-4813.2022.060

J. Z., L. L., Zhenyun Y, C. H., J. Y, S. H

{"title":"The Relationship between Cerebral Small Vessel Disease and Inflamate-Immune Response: A Review","authors":"J. Z., L. L., Zhenyun Y, C. H., J. Y, S. H","doi":"10.51737/2766-4813.2022.060","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.060","url":null,"abstract":"Cerebral Small Vessel Disease (CSVD) is not only a single disease, but a kind of clinical and pathological syndrome caused by various factors, such as intracranial arterioles, perforating arteries and venules, which can result in structural and functional changes. CSVD accounts for about 25% of ischemic stroke. It is related to cognitive dysfunction, emotional disorder and even defecation disorder in the elderly, which seriously affects the quality of life. The clinical manifestations and prognosis that different patients suffer from are different. The reasons why some patients’ clinical symptoms are differ from others’ are that besides stroke location, stroke area and other factors we talked about usually, in addition, inflammatory immune response also plays an significant role in CSVD. Inflammatory response is a defense mechanism for us, so that we can respond to a variety of stimulating factors quickly, by causing a series of effects such as activating inflammatory cells to release inflammatory factors and other bioactive substances. Similarly, the immune system of our body is composed of a variety of immune organs and immune cells, which has the functions of immune defense and immune regulation. Inflammatory immune response occurs in all systems of the body, which is regulated by immune cells, inflammatory factors and other mediators, and plays an important role in the occurrence and development of diseases.","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126137224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SunText Review of Medical &amp; Clinical Research最新文献

SunText Review of Medical & Clinical Research最新文献