Global Journal of Cancer Case Reports最新文献

Metaplastic Breast Carcinoma: A Rare Entity 乳腺癌化生:一种罕见的肿瘤

Global Journal of Cancer Case Reports Pub Date : 2019-10-11 DOI: 10.3126/njc.v3i1.25918

Roshani Shrestha, P. Neupane, B. Satyal

引用次数: 0

Mitochondrial DNA (mtDNA) and Cancer Pathogenesis – The Role of mtDNA Mutations: A Review 线粒体DNA (mtDNA)与癌症发病机制- mtDNA突变的作用:综述

Global Journal of Cancer Case Reports Pub Date : 1900-01-01 DOI: 10.47733/gjccr.2020.2101

N. Chrysanthakopoulos

{"title":"Mitochondrial DNA (mtDNA) and Cancer Pathogenesis – The Role of mtDNA Mutations: A Review","authors":"N. Chrysanthakopoulos","doi":"10.47733/gjccr.2020.2101","DOIUrl":"https://doi.org/10.47733/gjccr.2020.2101","url":null,"abstract":"Mitochondria are essential metabolic organelles as produce cellular energy by oxidative phosphorylation (OXPHOS), produce reactive oxygen species (ROS) as a by-product, and regulate functions such as apoptosis via the mitochondrial permeability transition pore (mtPTP). However, mitochondria are also responsible for multiple cellular functions such as, cellular development, growth, signals interaction from mitochondria to nucleus and nucleus to mitochondria, and are involved in miscellaneous metabolic pathways. Those processes are accomplished by several protein complexes and mitochondrial respiratory chains (MRC) encoded by nuclear and mitochondrial DNA (mtDNA), as are assembled from both nuclear DNA (nDNA) and mitochondrial DNA genes. The mt DNA is a circular, double-stranded molecule 16,569 base pairs (bp) in length, contains 37 genes which code 13 polypeptides, 2 genes of rRNA (12S,16S), and 22 genes of tRNA, and is present in thousands of copies in each human cell. Almost 90 years ago, Otto Warburg hypothesized that a defect in energy metabolism is the initial cause of cancer. Mitochondria have also active roles in a diversity of other processes, including inflammation, whereas their functions seem to influence some of cancer hallmarks, which include evasion of cell death, genome instability, tumor-promoting inflammation and metastasis. Defects in mitochondrial function which are associated with bioenergetic deficiencies can lead to nDNA genome instability, resistance to apoptosis and induction of NADPH oxidase which is implicated in ROS production. Researches have demonstrated that mtDNA shows a high mutations rate most of which are responsible for mild mitochondrial dysfunction and its essential role in tumorigenesis, whereas enhanced mitochondrial biogenesis is frequently recorded in cancer cells. Although mtDNA has been implicated in cancer pathogenesis, its role remains to be defined. The aim of the current article was to examine the role of mtDNA mutations in cancer pathogenesis.","PeriodicalId":165998,"journal":{"name":"Global Journal of Cancer Case Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121118799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PRIDE Complex Secondary to Cetuximab in Nasopharyngeal Carcinoma 西妥昔单抗继发于鼻咽癌的PRIDE复合体

Global Journal of Cancer Case Reports Pub Date : 1900-01-01 DOI: 10.47733/gjccr.2022.3104

R. Kothari, Karthi Kishore, A. Bhatnagar

引用次数: 0

Effect of Age and Parity on Practice of Cervical Cancer Screening Among Women of Child Bearing Age in Anambra State 年龄和胎次对阿南布拉州育龄妇女宫颈癌筛查实践的影响

Global Journal of Cancer Case Reports Pub Date : 1900-01-01 DOI: 10.47733/gjccr.2021.2201

N. Stella

{"title":"Effect of Age and Parity on Practice of Cervical Cancer Screening Among Women of Child Bearing Age in Anambra State","authors":"N. Stella","doi":"10.47733/gjccr.2021.2201","DOIUrl":"https://doi.org/10.47733/gjccr.2021.2201","url":null,"abstract":"The goal of this study was to see how age and parity affected cervical cancer screening among women of childbearing age in Anambra State. The population of the study was 1,876 women of childbearing age who registered for prenatal care in public hospitals in Anambra State during the study period. Two research questions and two research hypotheses led the investigation. A multi-stage (purposive) sampling procedure was used to choose the one hundred and eighty-five (185) participants. Cronbach alpha was used to estimate the instrument's internal consistency, which was used to determine its dependability. The Statistical Package for Social Science (SPSS) was used for data input and analysis and inferential statistics (ANCOVA) was utilized to test the null hypotheses at the 0.05 level of significance. The results showed that was no significant difference in mean cervical cancer screening practice scores of women of child bearing age of different age groups. Also there was equally no significant interaction between treatment groups and parity levels on mean cervical cancer practice scores of women of child bearing age. Important conclusions and recommendations were made based on the findings.","PeriodicalId":165998,"journal":{"name":"Global Journal of Cancer Case Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124229523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-Grade Oncocytic Tumor of Kidney: A Distinct Emerging Entity in Renal Oncocytic Neoplasms with Diagnostic Challenge in An Old Female: A Case Report 低级别肾嗜癌细胞肿瘤:一老年女性肾嗜癌细胞肿瘤中一种独特的新出现的肿瘤，具有诊断上的挑战:1例报告

Global Journal of Cancer Case Reports Pub Date : 1900-01-01 DOI: 10.47733/gjccr.2022.3103

Manahil Khan, M. Qureshi, Zeeshan Uddin

引用次数: 0

Rare Case of Asymptomatic Cardiac Metastasis in a Patient of Laryngeal Squamous Cell Carcinoma 喉鳞状细胞癌无症状心脏转移一例

Global Journal of Cancer Case Reports Pub Date : 1900-01-01 DOI: 10.47733/gjccr.2020.2104

A. Elshiekh, Abdelrahman Elhadary, Waad Fuad Bin Afif

引用次数: 0

Genetic Analysis of Medullary Thyroid Cancer in Algiers, Algeria 阿尔及利亚阿尔及尔甲状腺髓样癌的遗传分析

Global Journal of Cancer Case Reports Pub Date : 1900-01-01 DOI: 10.47733/gjccr.2022.3101

A. Chikouche, N. O. Bessi, Nawal Habak, M. Boudissa, S. Fedala, Malika Rezoug, L. Griene

引用次数: 0

Trousseau’s Syndrome Anticipating Lung Adenocarcinoma: A Combination of Novel Direct Oral Anticoagulant and Osimertinib to Treat It 特鲁索综合征预示肺腺癌:新型直接口服抗凝剂和奥西替尼联合治疗

Global Journal of Cancer Case Reports Pub Date : 1900-01-01 DOI: 10.47733/gjccr.2020.2105

I. Pecora, C. Tibaldi, E. Perrone, Laura Bassani, E. Baldini

{"title":"Trousseau’s Syndrome Anticipating Lung Adenocarcinoma: A Combination of Novel Direct Oral Anticoagulant and Osimertinib to Treat It","authors":"I. Pecora, C. Tibaldi, E. Perrone, Laura Bassani, E. Baldini","doi":"10.47733/gjccr.2020.2105","DOIUrl":"https://doi.org/10.47733/gjccr.2020.2105","url":null,"abstract":"Trousseau’s syndrome was the unexpected manifestation of thrombotic events, often associated with the diagnosis of malignancies, since cancer has been recognized as a prothrombotic state. There is a wide experience using low molecular weight heparin or Fondaparinux, while the use of direct oral anticoagulants, as Rivaroxaban, had less extent. A 76-year-old woman was diagnosed by a Trousseau’s syndrome, with multiple arterial and venous thrombotic events, representing the alarm signals of an advanced non-small cell lung cancer (NSCLC). The patient’s burden of disease rapidly widespread, with unexpected and polidistrectual thrombotic events and an advanced NSCLC with pleural effusion carrying EGFR mutation. After the treatment with an inhibitor of activated Factor X, the thrombotic events did not stop. Starting new direct oral anticoagulant drug and the oral EGFR Tyrosine Kinase Inhibitor (TKI), according to the molecular features of lung cancer, she rapidly achieved good response on overall global burden of disease. The aim of this article was to report a case of Trousseau’s syndrome anticipating lung cancer diagnosis that was successfully treated with a quick start of proper anticoagulant and targeted oncological treatments. The interruption of thromboembolic events represented the first sign of disease response to treatments.","PeriodicalId":165998,"journal":{"name":"Global Journal of Cancer Case Reports","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115670785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Transoral Excision of a Pedunculated Pleomorphic Sarcoma 经口切除一例带蒂多形性肉瘤

Global Journal of Cancer Case Reports Pub Date : 1900-01-01 DOI: 10.47733/gjccr.2020.2102

Blanca Alonso Martinez, Paula Martínez Pascual, R. Sabag, Juan Cantón de Seoane

引用次数: 0

A Novel Effective Treatment of Advanced Prostate Cancer: A Single Case Report 一种新的有效治疗晚期前列腺癌的方法:1例报告

Global Journal of Cancer Case Reports Pub Date : 1900-01-01 DOI: 10.47733/gjccr.2021.2204

R. Seljelid, J. Bøgwald

引用次数: 0