Journal of Neurological Surgery Part B: Skull Base最新文献

{"title":"De Novo Skull Base Atypical Meningioma: Incidence and Outcome.","authors":"Z James,&nbsp;M Makwana,&nbsp;C Hayhurst","doi":"10.1055/a-1757-3212","DOIUrl":"https://doi.org/10.1055/a-1757-3212","url":null,"abstract":"<p><p><b>Objective</b>  Atypical meningiomas are uncommon in skull base practice and present a management challenge. We aimed to review all de novo atypical skull base meningioma cases within a single unit to analyze presentation and outcome. <b>Methods</b>  A retrospective review of all patients undergoing surgery for intracranial meningioma identified consecutive cases of de novo atypical skull base meningioma. Electronic case records were analyzed for patient demographics, tumor location and size, extent of resection, and outcome. Tumor grading is based on the 2016 WHO criteria. <b>Results</b>  Eighteen patients with de novo atypical skull base meningiomas were identified. The most common tumor location was the sphenoid wing in 10 patients (56%). Gross total resection (GTR) was achieved in 13 patients (72%) and subtotal resection (STR) in 5 patients (28%). There was no tumor recurrence recorded in patients who had undergone GTR. Patients with tumors >6 cm were more likely to undergo a STR as opposed to a GTR ( <i>p</i>  < 0.01). Patients who had undergone a STR were more likely to have postoperative tumor progression and be referred for radiotherapy ( <i>p</i>  = 0.02 and <0.01, respectively). On multiple regression analysis, tumor size is the only significant factor correlating with overall survival ( <i>p</i>  = 0.048). <b>Conclusion</b>  The incidence of de novo atypical skull base meningioma is higher in our series than currently published data. Tumor size was a significant indicator for patient outcome and extent of resection. Those undergoing a STR were more likely to have tumor recurrence. Multicenter studies of skull base meningiomas with associated molecular genetics are needed to guide management.</p>","PeriodicalId":16513,"journal":{"name":"Journal of Neurological Surgery Part B: Skull Base","volume":"84 2","pages":"113-118"},"PeriodicalIF":0.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991523/pdf/10-1055-a-1757-3212.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9084920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of K _i -67 Index in Evaluating Sporadic Vestibular Schwannoma Recurrence: Systematic Review and Meta-analysis.","authors":"Kunal Vakharia,&nbsp;Hirotaka Hasegawa,&nbsp;Christopher Graffeo,&nbsp;Mohammad H A Noureldine,&nbsp;Salomon Cohen-Cohen,&nbsp;Avital Perry,&nbsp;Matthew L Carlson,&nbsp;Colin L W Driscoll,&nbsp;Maria Peris-Celda,&nbsp;Jamie J Van Gompel,&nbsp;Michael J Link","doi":"10.1055/a-1760-2126","DOIUrl":"https://doi.org/10.1055/a-1760-2126","url":null,"abstract":"<p><p><b>Introduction</b>  K _i -67 is often used as a proliferation index to evaluate how aggressive a tumor is and its likelihood of recurrence. Vestibular schwannomas (VS) are a unique benign pathology that lends itself well to evaluation with K _i -67 as a potential marker for disease recurrence or progression following surgical resection. <b>Methods</b>  All English language studies of VSs and K _i -67 indices were screened. Studies were considered eligible for inclusion if they reported series of VSs undergoing primary resection without prior irradiation, with outcomes including both recurrence/progression and K _i -67 for individual patients. For published studies reporting pooled K _i -67 index data without detailed by-patient values, we contacted the authors to request data sharing for the current meta-analysis. Studies reporting a relationship between K _i -67 index and clinical outcomes in VS for which detailed patients' outcomes or K _i -67 indices could not be obtained were incorporated into the descriptive analysis, but excluded from the formal (i.e., quantitative) meta-analysis. <b>Results</b>  A systematic review identified 104 candidate citations of which 12 met inclusion criteria. Six of these studies had accessible patient-specific data. Individual patient data were collected from these studies for calculation of discrete study effect sizes, pooling via random-effects modeling with restricted maximum likelihood, and meta-analysis. The standardized mean difference in K _i -67 indices between those with and without recurrence was calculated as 0.79% (95% confidence interval [CI]: 0.28-1.30; <i>p</i>  = 0.0026). <b>Conclusion</b>  K _i -67 index may be higher in VSs that demonstrate recurrence/progression following surgical resection. This may represent a promising means of evaluating tumor recurrence and potential need for early adjuvant therapy for VSs.</p>","PeriodicalId":16513,"journal":{"name":"Journal of Neurological Surgery Part B: Skull Base","volume":"84 2","pages":"119-128"},"PeriodicalIF":0.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991525/pdf/10-1055-a-1760-2126.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9454332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Alcoholization of the Pituitary Gland Does Not Reduce the Recurrence Rate of Growth Hormone Secreting Pituitary Adenomas.","authors":"Amarbir S Gill,&nbsp;Jorgen Sumsion,&nbsp;Jeremiah A Alt,&nbsp;Michael Karsy,&nbsp;William T Couldwell,&nbsp;Sarah T Menacho","doi":"10.1055/s-0042-1744129","DOIUrl":"https://doi.org/10.1055/s-0042-1744129","url":null,"abstract":"<p><p><b>Objective</b>  Although the role of intraoperative alcoholization of the pituitary gland has been examined for the management of malignant tumor metastases and Rathke's cleft cysts, no such studies have been conducted relating to growth hormone (GH) secreting pituitary tumors, despite the high rate of recurrence in this cohort of patients. Here, we sought to understand the impact of adjunctive intraoperative alcoholization of the pituitary gland on recurrence rates and perioperative complications associated with resection of GH-secreting tumors. <b>Methods</b>  This is a single-institution retrospective cohort study analyzing recurrence rates and complications among patients with GH-secreting tumors who received intraoperative alcoholization of the pituitary gland postresection versus those that did not. Welch's <i>t</i> -tests and analysis of variance (ANOVA) analyses were employed to compare continuous variables between groups, whereas chi-squared tests for independence or Fisher's exact tests were used for comparing categorical variables. <b>Results</b>  A total of 42 patients ( <i>n</i>  = 22 no alcohol and <i>n</i>  = 20 alcohol) were included in the final analysis. The overall recurrence rates did not significantly differ between the alcohol and no alcohol groups (35 and 22.7%, respectively; <i>p</i>  = 0.59). The average time to recurrence in the alcohol and no alcohol groups was 22.9 and 39 months, respectively ( <i>p</i>  = 0.63), with a mean follow-up of 41.2 and 53.5 months ( <i>p</i>  = 0.34). Complications, including diabetes insipidus, were not significantly different between the alcohol and no alcohol groups (30.0 vs. 27.2%, <i>p</i>  = 0.99). <b>Conclusion</b>  Intraoperative alcoholization of the pituitary gland after resection of GH-secreting pituitary adenomas does not reduce recurrence rates or increase perioperative complications.</p>","PeriodicalId":16513,"journal":{"name":"Journal of Neurological Surgery Part B: Skull Base","volume":"84 2","pages":"164-169"},"PeriodicalIF":0.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991521/pdf/10-1055-s-0042-1744129.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9079862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Outcomes Following Vestibular Schwannoma Resection in Patients over the Age of Sixty-five.","authors":"Ben A Strickland,&nbsp;Rob Rennert,&nbsp;Gabriel Zada,&nbsp;Shane Shahrestani,&nbsp;Jonathan J Russin,&nbsp;Rick A Friedman,&nbsp;Steven L Giannotta","doi":"10.1055/a-1771-0504","DOIUrl":"https://doi.org/10.1055/a-1771-0504","url":null,"abstract":"<p><p><b>Objective</b>  Vestibular schwannoma (VS) are benign, often slow growing neoplasms. Some institutions opt for radiosurgery in symptomatic patients of advanced age versus surgical resection. The aim of the study is to analyze surgical outcomes of VS in patients over the age of 65 who were either not candidates for or refused radiosurgery. <b>Methods</b>  This includes retrospective analysis of VS patients between 1988 and 2020. Demographics, tumor characteristics, surgical records, and clinical outcomes were recorded. Patient preference for surgery over radiosurgery was recorded in the event that patients were offered both. Facial nerve outcomes were quantified using House-Brackmann (HB) scores. Tumor growth was defined by increase in size of >2 mm. <b>Results</b>  In total, 64 patients were included of average age 72.4 years (65-84 years). Average maximum tumor diameter was 29 mm (13-55 mm). Forty-five patients were offered surgery or GKRS, and chose surgery commonly due to radiation aversion (48.4%). Gross total resection was achieved in 39.1% ( <i>n</i>  = 25), near total 32.8% ( <i>n</i>  = 21), and subtotal 28.1% ( <i>n</i>  = 18). Average hospitalization was 5 days [2-17] with 75% ( <i>n</i>  = 48) discharged home. Postoperative HB scores were good (HB1-2) in 43.8%, moderate (HB3-4) in 32.8%, and poor (HB5-6) in 23.4%. HB scores improved to good in 51.6%, moderate in 31.3%, and remained poor in 17.1%, marking a rate of facial nerve improvement of 10.9%. Tumor control was achieved in 95.3% of cases at an average follow-up time of 37.8 months. <b>Conclusion</b>  VS resection can be safely performed in patients over the age of 65. Advanced age should not preclude a symptomatic VS patient from being considered for surgical resection.</p>","PeriodicalId":16513,"journal":{"name":"Journal of Neurological Surgery Part B: Skull Base","volume":"84 2","pages":"129-135"},"PeriodicalIF":0.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991522/pdf/10-1055-a-1771-0504.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9101388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Pontine Cavernoma Operated by Anterior Petrosal Approach-Two-Dimensional Operative Video.","authors":"Leonardo Desessards Olijnyk,&nbsp;Adriana Azeredo Coutinho Abrão,&nbsp;Carlos Eduardo da Silva","doi":"10.1055/a-1775-1207","DOIUrl":"https://doi.org/10.1055/a-1775-1207","url":null,"abstract":"<p><p>Brainstem cavernoma is a challenging neurosurgical pathology and microsurgery remains the only treatment option. Although the decision-making between interventional and conservative approach to this disease may be complex, malformations presenting multiple bleedings are usually good candidates for surgery. 1 On the other hand, microsurgical resection of cavernomas can offer an effective resolution with acceptable morbidity. In this video, we present a case of pontine cavernoma with multiple hemorrhages in a young patient. The anatomical characteristic of the lesion defines the best suitable craniotomy for surgery. In this case, an anterior petrosal approach 2 3 4 was used to access the peritrigeminal area and safely perform the resection. Anatomical considerations are described on this skull base approach along with the rationale and benefits of this exposure. Electrophysiological neuromonitoring is essential for this kind of procedure and preoperative tractography also enabled the best understanding of the disease. Finally, we also discuss alternative managements and potential complications. 5 With the patient's consent, we also show the excellent clinical evolution after few weeks of recovery and the restoration of the corticospinal tract, previously displaced by the cavernoma, to its original position.</p>","PeriodicalId":16513,"journal":{"name":"Journal of Neurological Surgery Part B: Skull Base","volume":"84 2","pages":"192-193"},"PeriodicalIF":0.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991526/pdf/10-1055-a-1775-1207.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9498689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fat in the Fossa and the Sphenoid Sinus: A Simple and Effective Solution to CSF Leaks in Transsphenoidal Surgery. Cohort Study and Systematic Review.","authors":"Asfand Baig Mirza,&nbsp;Timothy Boardman,&nbsp;Mohamed Okasha,&nbsp;Hazem Mohamed El-Hariri,&nbsp;Qusai Al Banna,&nbsp;Christoforos Syrris,&nbsp;Kaumal Baig Mirza,&nbsp;Amisha Vastani,&nbsp;Ravindran Visagan,&nbsp;Jonathan Shapey,&nbsp;Eleni Maratos,&nbsp;Sinan Barazi,&nbsp;Nick Thomas","doi":"10.1055/a-1757-3069","DOIUrl":"https://doi.org/10.1055/a-1757-3069","url":null,"abstract":"<p><p><b>Objectives</b>  Cerebrospinal fluid (CSF) leak following endoscopic transsphenoidal surgery (TSS) remains a challenge and is associated with high morbidity. We perform a primary repair with f at in the pituitary f ossa and further fat in the s phenoid sinus (FFS). We compare the efficacy of this FFS technique with other repair methods and perform a systematic review. <b>Design, Patients, and Methods</b>  This is a retrospective analysis of patients undergoing standard TSS from 2009 to 2020, comparing the incidence of significant postoperative CSF rhinorrhea (requiring intervention) using the FFS technique compared with other intraoperative repair strategies. Systematic review of current repair methods described in the literature was performed following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. <b>Results</b>  In all, there were 439 patients, with 276 patients undergoing multilayer repair, 68 patients FFS repair, and 95 patients no repair. No significant differences were observed in baseline demographics between the groups. Postoperative CSF leak requiring intervention was significantly lower in the FFS repair group (4.4%) compared with the multilayer (20.3%) and no repair groups (12.6%, <i>p</i>  < 0.01). This translated to fewer reoperations (2.9% FFS vs. 13.4% multilayer vs. 8.4% no repair, <i>p</i>  < 0.05), fewer lumbar drains (2.9% FFS vs. 15.6% multilayer vs. 5.3% no repair, <i>p</i>  < 0.01), and shorter hospital stay (median days: 4 [3-7] FFS vs. 6 (5-10) multilayer vs. 5 (3-7) no repair, <i>p</i>  < 0.01). Risk factors for postoperative leak included female gender, perioperative lumbar drain, and intraoperative leak. <b>Conclusion</b>  Autologous fat on fat graft for standard endoscopic transsphenoidal approach effectively reduces the risk of significant postoperative CSF leak with reduced reoperation and shorter hospital stay.</p>","PeriodicalId":16513,"journal":{"name":"Journal of Neurological Surgery Part B: Skull Base","volume":"84 2","pages":"143-156"},"PeriodicalIF":0.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991530/pdf/10-1055-a-1757-3069.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discontinuation of Postoperative Prophylactic Antibiotics for Endoscopic Endonasal Skull Base Surgery.","authors":"Yosef Dastagirzada,&nbsp;Carolina Benjamin,&nbsp;Julia Bevilacqua,&nbsp;Jason Gurewitz,&nbsp;Chandra Sen,&nbsp;John G Golfinos,&nbsp;Dimitris Placantonakis,&nbsp;Jafar J Jafar,&nbsp;Seth Lieberman,&nbsp;Rich Lebowitz,&nbsp;Ariane Lewis,&nbsp;Donato Pacione","doi":"10.1055/a-1771-0372","DOIUrl":"https://doi.org/10.1055/a-1771-0372","url":null,"abstract":"<p><p><b>Background</b>  Postoperative prophylactic antibiotic usage for endoscopic skull base surgery varies based on the institution as evidence-based guidelines are lacking. The purpose of this study is to determine whether discontinuing postoperative prophylactic antibiotics in endoscopic endonasal cases led to a difference in central nervous system (CNS) infections, multi-drug resistant organism (MDRO) infections, or other postoperative infections. <b>Methods</b>  This quality improvement study compared outcomes between a retrospective cohort (from September 2013 to March 2019) and a prospective cohort (April 2019 to June 2019) after adopting a protocol to discontinue prophylactic postoperative antibiotics in patients who underwent endoscopic endonasal approaches (EEAs). Our primary end points of the study included the presence of postoperative CNS infection, <i>Clostridium difficile</i> ( <i>C. diff</i> ), and MDRO infections. <b>Results</b>  A total of 388 patients were analyzed, 313 in the pre-protocol group and 75 in the post-protocol group. There were similar rates of intraoperative cerebrospinal fluid leak (56.9 vs. 61.3%, <i>p</i>  = 0.946). There was a statistically significant decrease in the proportion of patients receiving IV antibiotics during their postoperative course ( <i>p</i>  = 0.001) and those discharged on antibiotics ( <i>p</i>  = 0.001). There was no significant increase in the rate of CNS infections in the post-protocol group despite the discontinuation of postoperative antibiotics (3.5 vs. 2.7%, <i>p</i>  = 0.714). There was no statistically significant difference in postoperative <i>C. diff</i> (0 vs. 0%, <i>p</i>  = 0.488) or development of MDRO infections (0.3 vs 0%, <i>p</i>  = 0.624). <b>Conclusion</b>  Discontinuation of postoperative antibiotics after EEA at our institution did not change the frequency of CNS infections. It appears that discontinuation of antibiotics after EEA is safe.</p>","PeriodicalId":16513,"journal":{"name":"Journal of Neurological Surgery Part B: Skull Base","volume":"84 2","pages":"157-163"},"PeriodicalIF":0.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991524/pdf/10-1055-a-1771-0372.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9079865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors and Functional Outcomes with Early Neurological Deterioration after Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke.","authors":"Hongwei Liu,&nbsp;Yi Zhang,&nbsp;Haixia Fan,&nbsp;Chao Wen","doi":"10.1055/a-1762-0167","DOIUrl":"https://doi.org/10.1055/a-1762-0167","url":null,"abstract":"<p><p>Early neurological deterioration (END) is associated with a poor survival after mechanical thrombectomy (MT) in acute ischemic stroke (AIS). To assess risk factors and functional outcomes of END after MT in patients, we analyzed data from 79 patients who received MT with large-vessel occlusion. END after MT in patients is defined as an increase of two points or more in the National Institute of Health Stroke Scale (NIHSS) score, compared with the best neurological status within 7 days. The mechanism of END can be classified into: AIS progression, sICH, and encephaledema. A total of 32 AIS patients (40.5%) had END after MT. Risk factors for END after MT included: history of oral antiplatelet and/or anticoagulation drugs before MT (OR = 9.56,95% CI = 1.02-89.57), higher NIHSS score when admitted to hospital (OR = 1.24, 95% CI = 1.04-1.48), under the subtype of atherosclerotic stroke (OR = 17.36, 95% CI = 1.51-199.56), ASITN/SIR< 2 (OR = 15.78, 95% CI = 1.65-151.26), and prolonged period from AIS onset to the first revascularization (OR = 1.01, 95% CI = 1.00-1.02). AIS patients who had END at early stages were more likely to experience poor outcomes (Modified Rankin Scale [mRS] >2) at 90 days after MT (OR = 6.829, 95% CI = 1.573-29.655). Thus, AIS patients who had experienced END at early stages were more likely to have poor outcomes (mRS >2) at 90 days after MT, and the risk factors of END were connected to the mechanism of END.</p>","PeriodicalId":16513,"journal":{"name":"Journal of Neurological Surgery Part B: Skull Base","volume":"84 2","pages":"183-191"},"PeriodicalIF":0.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991527/pdf/10-1055-a-1762-0167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9084918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Outcomes Using Combined Intra- and Extradural versus Extradural-Only Repair of Tegmen Defects.","authors":"Omaditya Khanna,&nbsp;Glen D'Souza,&nbsp;Ellina Hattar-Medina,&nbsp;Michael Karsy,&nbsp;Rebecca C Chiffer,&nbsp;Thomas O Willcox,&nbsp;Christopher J Farrell,&nbsp;James J Evans","doi":"10.1055/a-1757-0328","DOIUrl":"https://doi.org/10.1055/a-1757-0328","url":null,"abstract":"<p><p><b>Objective</b>  Tegmen tympani or tegmen mastoideum defects involve dehiscence of the temporal bone that can be a source of cerebrospinal fluid (CSF) otorrhea. Herein, we compare a combined intra-/extradural repair strategy with an extradural-only repair as it pertains to surgical and clinical outcomes. <b>Design</b>  A retrospective review from our institution was performed of patients with tegmen defects requiring surgical intervention. <b>Participants</b>  Patients with tegmen defects who underwent surgery (combined transmastoid and middle fossa craniotomy) for repair of tegmen defects between 2010 and 2020 were inclined in this study. <b>Results</b>  A total of 60 patients with 40 intra-/extradural (mean follow-up time: 1,060 ± 1,103 days) and 20 extradural-only (mean follow-up time: 519 ± 369 days) repairs were identified. No major differences in demographic factors or presenting symptoms were identified between the two cohorts. There was no difference in hospital length of stay between the two patient cohorts (mean: 4.15 vs. 4.35 days, <i>p</i>  = 0.8). In the extradural-only repair technique, synthetic bone cement was more frequently used (100 vs. 7.5%, <i>p</i>  < 0.01), whereas in the combined intra-/extradural repair, synthetic dural substitute was used more often (80 vs. 35%, <i>p</i>  < 0.01), with similar successful surgical outcomes achieved. Despite disparities in the techniques and materials used for repair, there were no differences in complication rates (wound infection, seizures, and ossicular fixation), 30-day readmission rates, or persistent CSF leak between the two treatment cohorts. <b>Conclusion</b>  The results of this study suggest no difference in clinical outcomes between combined intra-/extradural versus extradural-only repair of tegmen defects. A simplified extradural-only repair strategy can be effective, and may reduce the morbidity of intradural reconstruction (seizures, stroke, and intraparenchymal hemorrhage).</p>","PeriodicalId":16513,"journal":{"name":"Journal of Neurological Surgery Part B: Skull Base","volume":"84 2","pages":"136-142"},"PeriodicalIF":0.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991520/pdf/10-1055-a-1757-0328.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9273933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Decade of Global Skull Base Researchers: Authorship Trends from 3,295 Abstracts in the <i>Journal of Neurological Surgery Part B: Skull Base</i>.","authors":"Rosemary T Behmer Hansen, Samantha D Palma, William A Blocher Iii, Ryan A Behmer Hansen, Justin L Gold, Stephen J Susman, Sai Batchu, Nicole A Silva, Angela M Richardson","doi":"10.1055/a-2008-2884","DOIUrl":"10.1055/a-2008-2884","url":null,"abstract":"<p><p><b>Objective</b>  The North American Skull Base Society (NASBS) multidisciplinary annual conference hosts skull base researchers from across the globe. We hypothesized that the work presented at the NASBS annual conference would reveal diverse authorship teams in terms of specialty and geography. <b>Methods</b>  In this retrospective review, abstracts presented at the NASBS annual meeting and subsequently published in the <i>Journal of Neurological Surgery Part B: Skull Base</i> between 01/01/2011 and 12/31/2020 were collected. Variables extracted included year, type of presentation, and author names and affiliations. Statistical analyses were performed with SPSS V23.0 with <i>p</i> -values less than 0.05 considered significant. Geographic heat maps were created to assess author distribution, and a network analysis was performed to display authorship collaboration between geographic regions. <b>Results</b>  Of 3,312 published abstracts, 731 (22.1%) had an author with an affiliation outside of the United States. Fifty-seven distinct countries were represented. Three-hundred twenty-four abstracts (9.8%) had authorship teams representing at least 2 different countries. The top five US states by abstract representation were Pennsylvania, California, New York, Ohio, and Minnesota. A majority of authors reported neurosurgery affiliations (56.7% first authors, 53.2% last authors), closely followed by otolaryngology (39.1% first authors, 41.5% last authors). No solo authors and very few (3.3%) of the first authors reported a departmental affiliation outside of otolaryngology or neurosurgery. <b>Conclusions</b>  Authors from many countries disseminate their work through poster and oral presentations at the NASBS annual meeting. Ten percent of abstracts were the product of international collaboration. Most authors were affiliated with a neurosurgery or otolaryngology department.</p>","PeriodicalId":16513,"journal":{"name":"Journal of Neurological Surgery Part B: Skull Base","volume":"1 1","pages":"44-56"},"PeriodicalIF":0.9,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10807966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86973593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}