Journal of neurosurgery最新文献

{"title":"Timing of pharmacological venous thromboembolism prophylaxis after firearm-related penetrating brain injury.","authors":"Jiaqi Liu, Tej D Azad, Foad Kazemi, Kathleen R Ran, Megan Parker, Vikas N Vattipally, Carlos Aguilera, Wuyang Yang, Caitlin W Hicks, Elliott R Haut, Christopher D Witiw, Morgan Schellenberg, Debraj Mukherjee, James P Byrne","doi":"10.3171/2024.12.JNS242004","DOIUrl":"https://doi.org/10.3171/2024.12.JNS242004","url":null,"abstract":"<p><strong>Objective: </strong>Mounting evidence supports early initiation of pharmacological venous thromboembolism (VTE) prophylaxis after traumatic brain injury. However, the effectiveness and safety of VTE prophylaxis after penetrating brain injury (PBI) is unclear. The objective of this study was to evaluate the effectiveness and safety of pharmacological VTE prophylaxis in patients with firearm-related PBI.</p><p><strong>Methods: </strong>This was a retrospective cohort study of patients aged ≥ 16 years with isolated firearm-related PBI treated at level I or II trauma centers participating in the American College of Surgeons Trauma Quality Improvement Program (2017-2019). The exposure was the timing of VTE prophylaxis initiation measured in days from admission (prophylaxis delay). The primary outcome was VTE. Secondary outcomes were the need for late neurosurgical decompression (craniotomy/craniectomy after 48 hours) and in-hospital mortality. Hierarchical logistic regression estimated the association between prophylaxis delay and the outcomes after adjusting for patient baseline and injury characteristics. Effect modification was tested to determine if observed associations varied by type of early neurosurgical intervention: craniotomy/craniectomy, intracranial monitor/drain placement, or no intervention.</p><p><strong>Results: </strong>The authors identified 2012 patients with isolated firearm-related PBI. The median presenting Glasgow Coma Scale score was 8 (IQR 3-14) and 31% had an abnormal pupillary response. Nearly half of the cohort received early neurosurgical intervention (craniotomy/craniectomy, 40%; intracranial monitor/drain, 8%). The median VTE prophylaxis delay was 3 days (IQR 2-5 days). VTE occurred in 6% of patients. Overall, late neurosurgical decompression was required in 9%, and 10% died. After risk adjustment, each additional day of prophylaxis delay was associated with 6% increased odds of VTE (OR 1.06 per day, 95% CI 1.02-1.11). However, the association between timing of prophylaxis and late neurosurgical decompression depended on type of early neurosurgical intervention. Specifically, each day of prophylaxis delay was associated with decreased odds of late decompression among patients who underwent intracranial monitor/drain only (OR 0.51, 95% CI 0.35-0.75) or no intervention (OR 0.85, 95% CI 0.75-0.95). Timing of prophylaxis was not associated with late neurosurgical decompression for patients who underwent early craniotomy/craniectomy. There was no association with in-hospital mortality.</p><p><strong>Conclusions: </strong>Among patients with firearm-related PBI, earlier pharmacological prophylaxis was associated with decreased odds of VTE. However, earlier prophylaxis was also associated with late neurosurgical decompression among patients who underwent intracranial monitor/drain placement or no intervention, an effect not observed for patients who underwent early craniotomy/craniectomy. These findings suggest that","PeriodicalId":16505,"journal":{"name":"Journal of neurosurgery","volume":" ","pages":"1-11"},"PeriodicalIF":3.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction. Preface to the Mayo Clinic Vestibular Schwannoma Quality of Life Index digital supplement.","authors":"Fred G Barker","doi":"10.3171/2024.11.JNS242572","DOIUrl":"https://doi.org/10.3171/2024.11.JNS242572","url":null,"abstract":"","PeriodicalId":16505,"journal":{"name":"Journal of neurosurgery","volume":"142 Suppl","pages":"S1"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spanish translation of the Mayo Clinic Vestibular Schwannoma Quality of Life Index.","authors":"Matthew L Carlson, Christine M Lohse, Benjamin J Arnold, Nicole M Tombers, Devin L McCaslin, Aniket A Saoji, Melanie Hutchins, Kathleen J Yost, Michael J Link","doi":"10.3171/2024.11.JNS242319","DOIUrl":"10.3171/2024.11.JNS242319","url":null,"abstract":"<p><p>The authors developed a new disease-specific patient-reported outcome measure to capture the multifaceted impacts of vestibular schwannoma on daily life, the Vestibular Schwannoma Quality of Life (VSQOL) Index, which contains 40 items grouped into eight categories: hearing problems; dizziness and imbalance; pain, discomfort, and tinnitus; problems with face or eyes; impact on physical, emotional, and social well-being; difficulty with thinking and memory; satisfaction or regret; and impact on employment.1 The VSQOL Index was developed in English, although the availability of this instrument in other languages can improve access to quality of life (QOL) research worldwide with enhanced racial, ethnic, and geographic representation. The authors partnered with FACITtrans, a component of the Functional Assessment of Chronic Illness Therapy (FACIT) group with more than 25 years of experience in translation, cultural adaptation, and linguistic validation of patient-reported outcome measures, to translate the VSQOL Index to Spanish using a rigorous translation methodology.2-5 The translation of the VSQOL Index presented at the end of this article may be used for noncommercial research, clinical, or educational purposes without seeking written permission from the authors. By providing a suite of translations in this digital supplement of the Journal of Neurosurgery, the authors hope to increase the reach and breadth of QOL research and facilitate international collaborations.</p>","PeriodicalId":16505,"journal":{"name":"Journal of neurosurgery","volume":"142 Suppl","pages":"S4"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplified Chinese translation of the Mayo Clinic Vestibular Schwannoma Quality of Life Index.","authors":"Matthew L Carlson, Christine M Lohse, Benjamin J Arnold, Nicole M Tombers, Devin L McCaslin, Aniket A Saoji, Melanie Hutchins, Kathleen J Yost, Michael J Link","doi":"10.3171/2024.11.JNS242318","DOIUrl":"10.3171/2024.11.JNS242318","url":null,"abstract":"<p><p>The authors developed a new disease-specific patient-reported outcome measure to capture the multifaceted impacts of vestibular schwannoma on daily life, the Vestibular Schwannoma Quality of Life (VSQOL) Index, which contains 40 items grouped into eight categories: hearing problems; dizziness and imbalance; pain, discomfort, and tinnitus; problems with face or eyes; impact on physical, emotional, and social well-being; difficulty with thinking and memory; satisfaction or regret; and impact on employment.1 The VSQOL Index was developed in English, although the availability of this instrument in other languages can improve access to quality of life (QOL) research worldwide with enhanced racial, ethnic, and geographic representation. The authors partnered with FACITtrans, a component of the Functional Assessment of Chronic Illness Therapy (FACIT) group with more than 25 years of experience in translation, cultural adaptation, and linguistic validation of patient-reported outcome measures, to translate the VSQOL Index to Simplified Chinese using a rigorous translation methodology.2-5 The translation of the VSQOL Index presented at the end of this article may be used for noncommercial research, clinical, or educational purposes without seeking written permission from the authors. By providing a suite of translations in this digital supplement of the Journal of Neurosurgery, the authors hope to increase the reach and breadth of QOL research and facilitate international collaborations.</p>","PeriodicalId":16505,"journal":{"name":"Journal of neurosurgery","volume":"142 Suppl","pages":"S3"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving access to vestibular schwannoma quality of life research through multilanguage translations of the Mayo Clinic Vestibular Schwannoma Quality of Life Index.","authors":"Matthew L Carlson, Christine M Lohse, Benjamin J Arnold, Nicole M Tombers, Devin L McCaslin, Aniket A Saoji, Melanie Hutchins, Kathleen J Yost, Michael J Link","doi":"10.3171/2024.11.JNS242317","DOIUrl":"10.3171/2024.11.JNS242317","url":null,"abstract":"<p><p>To address the limitations of existing instruments, the authors developed the Vestibular Schwannoma Quality of Life (VSQOL) Index. The Index captures the multifaceted impacts of vestibular schwannoma (VS) on daily life across eight categories: hearing problems; dizziness and imbalance; pain, discomfort, and tinnitus; problems with face or eyes; impact on physical, emotional, and social well-being; difficulty with thinking and memory; satisfaction or regret; and impact on employment. Initially developed in English, this digital supplement of the Journal of Neurosurgery presents translations of the VSQOL Index to Simplified Chinese, Spanish, Japanese, Arabic, French, and Norwegian. These translations aim to improve access to VS quality of life (QOL) research globally with enhanced racial, ethnic, and geographic representation. The goal is to comprehensively evaluate the impact of VS diagnosis and management on well-being and QOL by offering the VSQOL Index in patients' native, or first-learned, languages. The English version and these translations may be used for noncommercial research, clinical, or educational purposes without written permission from the authors. Investigators interested in translating the VSQOL Index to other languages should contact the corresponding author for translation methodology instructions.</p>","PeriodicalId":16505,"journal":{"name":"Journal of neurosurgery","volume":"142 Suppl","pages":"S2"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Norwegian translation of the Mayo Clinic Vestibular Schwannoma Quality of Life Index.","authors":"Matthew L Carlson, Christine M Lohse, Benjamin J Arnold, Nicole M Tombers, Devin L McCaslin, Aniket A Saoji, Melanie Hutchins, Kathleen J Yost, Michael J Link","doi":"10.3171/2024.11.JNS242325","DOIUrl":"10.3171/2024.11.JNS242325","url":null,"abstract":"<p><p>The authors developed a new disease-specific patient-reported outcome measure to capture the multifaceted impacts of vestibular schwannoma on daily life, the Vestibular Schwannoma Quality of Life (VSQOL) Index, which contains 40 items grouped into eight categories: hearing problems; dizziness and imbalance; pain, discomfort, and tinnitus; problems with face or eyes; impact on physical, emotional, and social well-being; difficulty with thinking and memory; satisfaction or regret; and impact on employment.1 The VSQOL Index was developed in English, although the availability of this instrument in other languages can improve access to quality of life (QOL) research worldwide with enhanced racial, ethnic, and geographic representation. The authors partnered with FACITtrans, a component of the Functional Assessment of Chronic Illness Therapy (FACIT) group with more than 25 years of experience in translation, cultural adaptation, and linguistic validation of patient-reported outcome measures, to translate the VSQOL Index to Norwegian using a rigorous translation methodology.2-5 The translation of the VSQOL Index presented at the end of this article may be used for noncommercial research, clinical, or educational purposes without seeking written permission from the authors. By providing a suite of translations in this digital supplement of the Journal of Neurosurgery, the authors hope to increase the reach and breadth of vestibular schwannoma QOL research and facilitate international collaborations.</p>","PeriodicalId":16505,"journal":{"name":"Journal of neurosurgery","volume":"142 Suppl","pages":"S8"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Japanese translation of the Mayo Clinic Vestibular Schwannoma Quality of Life Index.","authors":"Matthew L Carlson, Christine M Lohse, Benjamin J Arnold, Nicole M Tombers, Devin L McCaslin, Aniket A Saoji, Melanie Hutchins, Kathleen J Yost, Michael J Link","doi":"10.3171/2024.11.JNS242322","DOIUrl":"10.3171/2024.11.JNS242322","url":null,"abstract":"<p><p>The authors developed a new disease-specific patient-reported outcome measure to capture the multifaceted impacts of vestibular schwannoma on daily life, the Vestibular Schwannoma Quality of Life (VSQOL) Index, which contains 40 items grouped into eight categories: hearing problems; dizziness and imbalance; pain, discomfort, and tinnitus; problems with face or eyes; impact on physical, emotional, and social well-being; difficulty with thinking and memory; satisfaction or regret; and impact on employment.1 The VSQOL Index was developed in English, although the availability of this instrument in other languages can improve access to quality of life (QOL) research worldwide with enhanced racial, ethnic, and geographic representation. The authors partnered with FACITtrans, a component of the Functional Assessment of Chronic Illness Therapy (FACIT) group with more than 25 years of experience in translation, cultural adaptation, and linguistic validation of patient-reported outcome measures, to translate the VSQOL Index to Japanese using a rigorous translation methodology.2-5 The translation of the VSQOL Index presented at the end of this article may be used for noncommercial research, clinical, or educational purposes without seeking written permission from the authors. By providing a suite of translations in this digital supplement of the Journal of Neurosurgery, the authors hope to increase the reach and breadth of QOL research and facilitate international collaborations.</p>","PeriodicalId":16505,"journal":{"name":"Journal of neurosurgery","volume":"142 Suppl","pages":"S5"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arabic translation of the Mayo Clinic Vestibular Schwannoma Quality of Life Index.","authors":"Matthew L Carlson, Christine M Lohse, Benjamin J Arnold, Nicole M Tombers, Devin L McCaslin, Aniket A Saoji, Melanie Hutchins, Kathleen J Yost, Michael J Link","doi":"10.3171/2024.11.JNS242323","DOIUrl":"10.3171/2024.11.JNS242323","url":null,"abstract":"<p><p>The authors developed a new disease-specific patient-reported outcome measure to capture the multifaceted impacts of vestibular schwannoma on daily life, the Vestibular Schwannoma Quality of Life (VSQOL) Index, which contains 40 items grouped into eight categories: hearing problems; dizziness and imbalance; pain, discomfort, and tinnitus; problems with face or eyes; impact on physical, emotional, and social well-being; difficulty with thinking and memory; satisfaction or regret; and impact on employment.1 The VSQOL Index was developed in English, although the availability of this instrument in other languages can improve access to quality of life (QOL) research worldwide with enhanced racial, ethnic, and geographic representation. The authors partnered with FACITtrans, a component of the Functional Assessment of Chronic Illness Therapy (FACIT) group with more than 25 years of experience in translation, cultural adaptation, and linguistic validation of patient-reported outcome measures, to translate the VSQOL Index to Arabic using a rigorous translation methodology.2-5 The translation of the VSQOL Index presented at the end of this article may be used for noncommercial research, clinical, or educational purposes without seeking written permission from the authors. By providing a suite of translations in this digital supplement of the Journal of Neurosurgery, the authors hope to increase the reach and breadth of QOL research and facilitate international collaborations.</p>","PeriodicalId":16505,"journal":{"name":"Journal of neurosurgery","volume":"142 Suppl","pages":"S6"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"French translation of the Mayo Clinic Vestibular Schwannoma Quality of Life Index.","authors":"Matthew L Carlson, Christine M Lohse, Benjamin J Arnold, Nicole M Tombers, Devin L McCaslin, Aniket A Saoji, Melanie Hutchins, Kathleen J Yost, Michael J Link","doi":"10.3171/2024.11.JNS242324","DOIUrl":"10.3171/2024.11.JNS242324","url":null,"abstract":"<p><p>The authors developed a new disease-specific patient-reported outcome measure to capture the multifaceted impacts of vestibular schwannoma on daily life, the Vestibular Schwannoma Quality of Life (VSQOL) Index, which contains 40 items grouped into eight categories: hearing problems; dizziness and imbalance; pain, discomfort, and tinnitus; problems with face or eyes; impact on physical, emotional, and social well-being; difficulty with thinking and memory; satisfaction or regret; and impact on employment.1 The VSQOL Index was developed in English, although the availability of this instrument in other languages can improve access to quality of life (QOL) research worldwide with enhanced racial, ethnic, and geographic representation. The authors partnered with FACITtrans, a component of the Functional Assessment of Chronic Illness Therapy (FACIT) group with more than 25 years of experience in translation, cultural adaptation, and linguistic validation of patient-reported outcome measures, to translate the VSQOL Index to French using a rigorous translation methodology.2-5 The translation of the VSQOL Index presented at the end of this article may be used for noncommercial research, clinical, or educational purposes without seeking written permission from the authors. By providing a suite of translations in this digital supplement of the Journal of Neurosurgery, the authors hope to increase the reach and breadth of QOL research and facilitate international collaborations.</p>","PeriodicalId":16505,"journal":{"name":"Journal of neurosurgery","volume":"142 Suppl","pages":"S7"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indications and outcomes of the extended endoscopic endonasal approach for the removal of \"unconventional\" suprasellar pituitary neuroendocrine tumors.","authors":"Domenico Solari, Elena d'Avella, Garni Barkhoudarian, Matteo Zoli, Stephanie Cheok, Ilaria Bove, Gianluca Lorenzo Fabozzi, Gabriel Zada, Diego Mazzatenta, Daniel F Kelly, Paolo Cappabianca, Luigi Maria Cavallo","doi":"10.3171/2024.11.JNS242484","DOIUrl":"https://doi.org/10.3171/2024.11.JNS242484","url":null,"abstract":"<p><strong>Objective: </strong>Pituitary neuroendocrine tumors (PitNETs) rarely harbor \"unconventional\" inner features such as wide intracranial extension, fibrous consistency, irregular shape, vessel encasement, and subarachnoid space invasion that increase surgical complexity, as they are not suitable for the standard transsphenoidal route. Among this subset of difficult adenomas, PitNETs harboring an unconventional suprasellar extension present peculiar surgical considerations and challenges. Herein, the authors present an international multicentric study, intending to analyze the indications and outcomes of the endoscopic endonasal transtuberculum-transplanum approach (ETTA) for the removal of these so-called unconventional PitNETs in a large cohort of patients.</p><p><strong>Methods: </strong>PitNETs removed via an endoscopic endonasal approach (EEA) between January 2000 and December 2023 at 4 primary referral centers were retrospectively reviewed. Tumors removed via the ETTA and harboring one or more of the following unconventional suprasellar features, regardless of size and/or cavernous sinus invasion, were included in the study: irregular shape, vessel encasement, subarachnoid invasion at the supradiaphragmatic space, and firm or fibrous consistency. Clinical, radiological, surgical findings, and outcomes were reviewed.</p><p><strong>Results: </strong>Of a total of 5138 patients with PitNETs, 257 patients underwent an ETTA (5%). Nonfunctioning PitNETs were the most common (65.4%). The most common presenting symptoms were visual field restriction (64.6%), decreased visual acuity (51%), anterior pituitary deficiency (44.8%), and endocrine hyperproduction syndromes (20.6%). All PitNETs harbored prominent suprasellar extension: 33.1% were giant and 30.7% were fibrous; the majority were multilobular (43.6%) and Knosp grade ≥ 3 (54.1%). Overall, 51.8% of patients had undergone previous treatment. The gross-total resection (GTR) rate was 49.8%. Visual field and visual acuity improved in 67.5% and 82.4% of cases, respectively. The postoperative complication rate was 19.1%. Previous treatment, vessel encasement, and Knosp grade ≥ 3 were independent risk factors affecting extent of resection. A suprasellar tumor remnant was the only significant risk factor for vascular complications, and tumor GTR the only protecting factor.</p><p><strong>Conclusions: </strong>This is the largest series in the literature describing indications and outcome expectations of the ETTA for the removal of unconventional suprasellar PitNETs. Tumor size, shape, and consistency did not represent a limitation to favorable surgical outcomes. The difficulty in achieving total removal of unconventional PitNETs, especially in the presence of vessel encasement and recurrent lesions, should raise the awareness of the increased risk of suprasellar tumor remnant apoplexy and arterial vasospasm, particularly in tumors with subarachnoid invasion.</p>","PeriodicalId":16505,"journal":{"name":"Journal of neurosurgery","volume":" ","pages":"1-10"},"PeriodicalIF":3.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}