Journal of neurosurgical sciences最新文献

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Visualization of volume of tissue activated modeling in a clinical planning system for deep brain stimulation. 脑深部刺激临床规划系统中组织激活建模体积的可视化。
IF 1.9 4区 医学
Journal of neurosurgical sciences Pub Date : 2024-02-01 Epub Date: 2020-02-04 DOI: 10.23736/S0390-5616.19.04827-6
Barbara Carl, Miriam Bopp, Benjamin SAß, Josefine Waldthaler, Lars Timmermann, Christopher Nimsky
{"title":"Visualization of volume of tissue activated modeling in a clinical planning system for deep brain stimulation.","authors":"Barbara Carl, Miriam Bopp, Benjamin SAß, Josefine Waldthaler, Lars Timmermann, Christopher Nimsky","doi":"10.23736/S0390-5616.19.04827-6","DOIUrl":"10.23736/S0390-5616.19.04827-6","url":null,"abstract":"<p><strong>Background: </strong>Pathway activating models try to describe stimulation spread in deep brain stimulation (DBS). Volume of tissue activated (VTA) models are simplified model variants allowing faster and easier computation. Our study aimed to investigate, how VTA visualization can be integrated into a clinical workflow applying directional electrodes using a standard clinical DBS planning system.</p><p><strong>Methods: </strong>Twelve patients underwent DBS, using directional electrodes for bilateral subthalamic nucleus (STN) stimulation in Parkinson's disease. Preoperative 3T magnetic resonance imaging was used for automatic visualization of the STN outline, as well as for fiber tractography. Intraoperative computed tomography was used for automatic lead detection. The Guide XT software, closely integrated into the DBS planning software environment, was used for VTA calculation and visualization.</p><p><strong>Results: </strong>VTA visualization was possible in all cases. The percentage of VTA covering the STN volume ranged from 25% to 100% (mean: 60±25%) on the left side and from 0% to 98% (51±30%) on the right side. The mean coordinate of all VTA centers was: 12.6±1.2 mm lateral, 2.1±1.2 mm posterior, and 2.3±1.4 mm inferior in relation to the midcommissural point. Stimulation effects can be compared to the VTA visualization in relation to surrounding structures, potentially facilitating programming, which might be especially beneficial in case of suboptimal lead placement.</p><p><strong>Conclusions: </strong>VTA visualization in a clinical planning system allows an intuitive adjustment of the stimulation parameters, supports programming, and enhances understanding of effects and side effects of DBS.</p>","PeriodicalId":16504,"journal":{"name":"Journal of neurosurgical sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37619994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant calcified thoracic disk herniations: ossification of PLL or autonomous entity? 巨型钙化胸椎椎间盘突出症:PLL 的骨化还是独立实体?
IF 1.9 4区 医学
Journal of neurosurgical sciences Pub Date : 2024-02-01 Epub Date: 2020-07-29 DOI: 10.23736/S0390-5616.20.04938-3
Giuseppe D'Aliberti, Fabio Villa, Pietro Giorgi, Francesco M Crisà, Giulia Gribaudi, Lara Mastino, Anna M Auricchio, Marco Cenzato, Giuseppe Talamonti
{"title":"Giant calcified thoracic disk herniations: ossification of PLL or autonomous entity?","authors":"Giuseppe D'Aliberti, Fabio Villa, Pietro Giorgi, Francesco M Crisà, Giulia Gribaudi, Lara Mastino, Anna M Auricchio, Marco Cenzato, Giuseppe Talamonti","doi":"10.23736/S0390-5616.20.04938-3","DOIUrl":"10.23736/S0390-5616.20.04938-3","url":null,"abstract":"<p><strong>Background: </strong>Giant calcified thoracic disk herniation (GCTD) is an uncommon event, which requires surgical treatment in less than 1% of patients. GCDTs are a specific subgroup of herniated thoracic disks occupying more than 40% of the spinal canal showing calcifications associated with a certain degree of ossification. In this paper, we are reporting our whole experience in the surgical management of GCTDs through anterior approaches. We believe that they present characteristics that associate them to the circumscribed type of ossified posterior longitudinal ligament (OPLL) with a possible common pathophysiology consisting in the dural violation.</p><p><strong>Methods: </strong>Twenty-three consecutive patients with GCDTs were managed through anterior approaches during the period 1996-2019 at the Niguarda Hospital, Milan, Italy. Clinical data, radiological features, surgical reports, histological findings, and outcomes were reviewed.</p><p><strong>Results: </strong>There was no mortality, whereas permanent morbidity consisted of 1 case of worsened paraparesis due to accidental spinal cord contusion. One patient required reoperation to repair a postoperative cerebrospinal fluid (CSF) leakage. All patients underwent postoperative MRI which showed excellent decompression of cord and dural sac in all cases. Histological study of en-bloc removed GCTD showed typical calcification patterns of the PLL.</p><p><strong>Conclusions: </strong>GCDTs may be assimilated to the so-called \"circumscribed type\" of OPLL. The GCDTs may show the same radiological CT and MRI pattern of OPLL. The anterior accesses now represent the standard of care for GCTDs. The use of operative microscope and intraoperative monitoring is mandatory. The risk of CSF leakage can be markedly reduced by meticulous reconstruction of the dura and the placement of spinal drainage. Adequate exposition may sometimes require one or two levels of corpectomy with consequent vertebral body reconstruction and fixation of anterior column of the spine.</p>","PeriodicalId":16504,"journal":{"name":"Journal of neurosurgical sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38211574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term efficacy of spinal cord stimulation for chronic primary neuropathic pain in the contemporary era: a systematic review and meta-analysis. 当代脊髓刺激治疗慢性原发性神经病理性疼痛的长期疗效:系统回顾和荟萃分析。
IF 1.9 4区 医学
Journal of neurosurgical sciences Pub Date : 2024-02-01 Epub Date: 2023-03-21 DOI: 10.23736/S0390-5616.23.05930-1
Kaneez Fatima, Syed O Javed, Aqsa Saleem, Shayan Marsia, Ramsha Zafar, Komal Noorani, Sahlish Kumar, Sara M Ali, Iqra Ismail, Insiya Hashim, Fatima A Ganatra
{"title":"Long-term efficacy of spinal cord stimulation for chronic primary neuropathic pain in the contemporary era: a systematic review and meta-analysis.","authors":"Kaneez Fatima, Syed O Javed, Aqsa Saleem, Shayan Marsia, Ramsha Zafar, Komal Noorani, Sahlish Kumar, Sara M Ali, Iqra Ismail, Insiya Hashim, Fatima A Ganatra","doi":"10.23736/S0390-5616.23.05930-1","DOIUrl":"10.23736/S0390-5616.23.05930-1","url":null,"abstract":"<p><strong>Introduction: </strong>Spinal cord stimulation (SCS) is a modern neuromodulation technique extensively proven to be an effective modality for treatment of chronic neuropathic pain. It has been mainly studied for complex regional pain syndrome (CRPS) and failed back surgery syndrome (FBSS) and recent data almost uniformly establishes its statistically significant positive therapeutic results. It has also been compared with other available treatment modalities across various studies. However, long term data on maintenance of its efficacious potential remains less explored. Few studies have reported data on long follow-up times (>= 12 months) and have compared its efficacy with other treatment options for chronic pain, respectively. Our study pools and analyzes the available data and compares SCS with other treatment options. It also analyzes the efficacy of SCS in long term management of patients with chronic pain.</p><p><strong>Evidence acquisition: </strong>We reviewed all the data available on MEDLINE, Embase and Cochrane CENTRAL using a search strategy designed to fit our pre-set inclusion and exclusion criteria. Both single-arm and double-arm studies were included. The primary outcome was defined as decrease of visual analogue scale (VAS) by >50% at 6, 12 and/or 24 months after SCS.</p><p><strong>Evidence synthesis: </strong>According to the pooled data of double-arm studies, SCS has unanimously proven its superiority over other treatment options at 6 months follow-up; however it fails to prove statistically significant difference in results at longer treatment intervals. Dorsal root ganglion stimulation, a relatively recent technique with the same underlying physiologic mechanisms as SCS, showed far more promising results than SCS. Single-arm studies show around 70% patients experiencing greater than 50% reduction in their VAS scores at 6 and 12 months.</p><p><strong>Conclusions: </strong>SCS is a viable option for management of chronic neuropathic pain secondary to FBSS and CRPS. However, data available for its long term efficacy remains scarce and show no further statistically significant results.</p>","PeriodicalId":16504,"journal":{"name":"Journal of neurosurgical sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9154039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhalational anesthesia during intraoperative monitoring of visual evoked potentials: taboo or option? 术中监测视觉诱发电位时的吸入麻醉:禁忌还是选择?
IF 1.9 4区 医学
Journal of neurosurgical sciences Pub Date : 2024-02-01 Epub Date: 2023-09-13 DOI: 10.23736/S0390-5616.23.06112-X
Evgeny A Levin, Anna G Vasyatkina, Ilya S Zykov, Roman S Kiselev
{"title":"Inhalational anesthesia during intraoperative monitoring of visual evoked potentials: taboo or option?","authors":"Evgeny A Levin, Anna G Vasyatkina, Ilya S Zykov, Roman S Kiselev","doi":"10.23736/S0390-5616.23.06112-X","DOIUrl":"10.23736/S0390-5616.23.06112-X","url":null,"abstract":"","PeriodicalId":16504,"journal":{"name":"Journal of neurosurgical sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10580378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative stereotactic radiosurgery and hypofractionated radiotherapy for brain metastases using Gamma Knife and CyberKnife: a dual-center analysis. 使用伽玛刀和CyberKnife治疗脑转移瘤的术后立体定向放射手术和低分次放射治疗:双中心分析。
IF 1.9 4区 医学
Journal of neurosurgical sciences Pub Date : 2024-02-01 Epub Date: 2020-02-04 DOI: 10.23736/S0390-5616.20.04830-4
Jens Kübler, Michael Wester-Ebbinghaus, Frederik Wenz, Florian Stieler, Bastian Bathen, Sabine K Mai, Robert Wolff, Daniel Hänggi, Oliver Blanck, Frank A Giordano
{"title":"Postoperative stereotactic radiosurgery and hypofractionated radiotherapy for brain metastases using Gamma Knife and CyberKnife: a dual-center analysis.","authors":"Jens Kübler, Michael Wester-Ebbinghaus, Frederik Wenz, Florian Stieler, Bastian Bathen, Sabine K Mai, Robert Wolff, Daniel Hänggi, Oliver Blanck, Frank A Giordano","doi":"10.23736/S0390-5616.20.04830-4","DOIUrl":"10.23736/S0390-5616.20.04830-4","url":null,"abstract":"<p><strong>Background: </strong>Postoperative stereotactic radiosurgery (SRS) and hypofractionated stereotactic radiotherapy (hFSRT) to tumor cavities is emerging as a new standard of care after resection of brain metastases. Both Gamma Knife (GK) and CyberKnife (CK) are modalities commonly used for stereotactic radiotherapy, but fractional schemes are not consistent. The objective of this study was to evaluate outcomes in patients receiving postoperative stereotactic radiotherapy of resected brain metastases (BM) using different fractionation schedules and modalities in two large centers.</p><p><strong>Methods: </strong>Patients with newly diagnosed BM who underwent postoperative SRS or hFSRT with either GK or CK at two large cancer centers were retrospectively evaluated. We analyzed local control (LC), regional control (RC) and overall survival (OS).</p><p><strong>Results: </strong>From April 14<sup>th</sup> to May 18<sup>th</sup>, 2020, 79 patients with 81 resection cavities were treated. Forty-seven patients (59.5%) received GK and 32 patients (40.5%) received CK treatment. Fifty-four cavities (66.7%) were treated with hFSRT and 27 (33.3%) with SRS. The most common hFSRT and SRS scheme was 3x10 Gy and 1x16 Gy, respectively. Median OS was 11.7 months with survival rates of 44.7% at 1 year and 18.5% at 2 years. LC was 83.3% after 1 year. Median time to regional progression was 12.0 months with RC rates of 61.1% at 6 months and 41.0% at 12 months. There was no difference in OS, LC or RC between GK and CK treatments or SRS and hFSRT.</p><p><strong>Conclusions: </strong>Both SRS and hFSRT provide high local control rates in resected BM regardless of the applied modality.</p>","PeriodicalId":16504,"journal":{"name":"Journal of neurosurgical sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37619995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of diabetes insipidus occurrence after endoscopic endonasal removal of sellar lesions using MRI-based radiomics and machine learning. 利用基于核磁共振成像的放射组学和机器学习预测蝶窦病变内窥镜鼻内切除术后的糖尿病发生率。
IF 1.9 4区 医学
Journal of neurosurgical sciences Pub Date : 2024-01-29 DOI: 10.23736/S0390-5616.23.06162-3
Ciro Mastantuoni, Lorenzo Ugga, Domenico Solari, Serena D'Aniello, Gaia Spadarella, Renato Cuocolo, Filippo F Angileri, Luigi M Cavallo
{"title":"Prediction of diabetes insipidus occurrence after endoscopic endonasal removal of sellar lesions using MRI-based radiomics and machine learning.","authors":"Ciro Mastantuoni, Lorenzo Ugga, Domenico Solari, Serena D'Aniello, Gaia Spadarella, Renato Cuocolo, Filippo F Angileri, Luigi M Cavallo","doi":"10.23736/S0390-5616.23.06162-3","DOIUrl":"https://doi.org/10.23736/S0390-5616.23.06162-3","url":null,"abstract":"<p><strong>Background: </strong>Pituitary adenomas and craniopharyngiomas are the most common lesions of the sellar region. These tumors are responsible for invasion or compression of crucial neurovascular structures. The involvement of the pituitary stalk warrants high rates of both pre- and post- operative diabetes insipidus. The aim of our study was to assess the accuracy of machine learning analysis from preoperative MRI of pituitary adenomas and craniopharyngiomas for the prediction of DI occurrence.</p><p><strong>Methods: </strong>All patients underwent MRI exams either on a 1.5- or 3-T MR scanner from two Institutions, including coronal T2-weighted (T2-w) and contrast-enhanced T1-weighted (CE T1-w) Turbo Spin Echo sequences. Feature selection was carried out as a multi-step process, with a threshold of 0.75 to identify robust features. Further feature selection steps included filtering based on feature variance (threshold >0.01) and pairwise correlation (threshold <0.80). A Bayesian Network model was trained with 10-fold cross validation employing SMOTE to balance classes exclusively within the training folds.</p><p><strong>Results: </strong>Thirty patients were included in this study. In total 2394 features were extracted and 1791 (75%) resulted stable after ICC analysis. The number of variant features was 1351 and of non-colinear features was 125. Finally, 10 features were selected by oneR ranking. The Bayesian Network model showed an accuracy of 63% with a precision of 77% for DI prediction (0.68 area under the precision-recall curve).</p><p><strong>Conclusions: </strong>We assessed the accuracy of machine learning analysis of texture-derived parameters from preoperative MRI of pituitary adenomas and craniopharyngiomas for the prediction of DI occurrence.</p>","PeriodicalId":16504,"journal":{"name":"Journal of neurosurgical sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monocentric experience of transforaminal endoscopic lumbar discectomy and foraminotomy outcomes: pushing the indications and avoiding failure. Report of 200 cases. 经椎间孔内窥镜腰椎间盘切除术和椎板切除术的单中心经验:突破适应症,避免失败。200 例病例报告。
IF 1.9 4区 医学
Journal of neurosurgical sciences Pub Date : 2024-01-23 DOI: 10.23736/S0390-5616.23.06105-2
Alessandro Grieco, Letizia Dell'aglio, Jacopo Del Verme, Domenico Billeci, Roberto Zanata, Giuseppe Canova, Enrico Giordan
{"title":"Monocentric experience of transforaminal endoscopic lumbar discectomy and foraminotomy outcomes: pushing the indications and avoiding failure. Report of 200 cases.","authors":"Alessandro Grieco, Letizia Dell'aglio, Jacopo Del Verme, Domenico Billeci, Roberto Zanata, Giuseppe Canova, Enrico Giordan","doi":"10.23736/S0390-5616.23.06105-2","DOIUrl":"https://doi.org/10.23736/S0390-5616.23.06105-2","url":null,"abstract":"<p><strong>Background: </strong>This paper reports the results of the treatment of our first 200 cases of lumbar disc herniation and foraminal stenosis using full-endoscopic transforaminal lumbar discectomy (FETLD). We analyzed outcomes and radiological parameters to overcome failure and inappropriate indications and also highlighted the red flags for surgeons coming to this field as well as the pathways to success.</p><p><strong>Methods: </strong>Data on endoscopic procedures were retrospectively analyzed between October 2018 and March 2023. We abstracted sex, age, leg pain by NPRS, postoperative satisfaction according to the MacNaab score, postoperative surgical complications/adverse events (≤30 days), and history of any previous surgery. Furthermore, we measured different radiological parameters to determine the grade of stenosis or discopathy.</p><p><strong>Results: </strong>Once the learning curve was completed, patients' satisfaction increased to 94%, with only a small percentage (6%) of patients unsatisfied 30 days after the operation. Perioperatively, 33.5% of the patients experienced mild to moderate transitory paresthesia. Univariate analysis showed a tendency toward a higher risk of failure in those patients with degenerative listhesis (odds ratio [OR] 4.8, 95% CI 0.97-23.9, P=0.055) as well as those with severely degenerated discs (OR 8.7, 95% CI 0.96-79.4, P=0.054). Conversely, the chances of failure seemed to be lower in patients with severe foraminal stenosis.</p><p><strong>Conclusions: </strong>FETLD proved its efficacy in treating several degenerative spine conditions or was useful for avoiding previous scarring in patients already operated on to the same extent. Therefore, FETLD can be safely used in patients with comorbidities, the elderly, and when the invasiveness of an open technique is not suitable.</p>","PeriodicalId":16504,"journal":{"name":"Journal of neurosurgical sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139521128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-year clinical and radiologic outcomes of Surpass Evolve flow diverter for large unruptured intracranial aneurysms. Surpass Evolve 分流器治疗大型未破裂颅内动脉瘤的一年临床和放射学疗效。
IF 1.9 4区 医学
Journal of neurosurgical sciences Pub Date : 2023-12-21 DOI: 10.23736/S0390-5616.23.06161-1
Hyun J Han, Joonho Chung, Chang K Jang, Jung-Jae Kim, Keun Y Park, Yong B Kim
{"title":"One-year clinical and radiologic outcomes of Surpass Evolve flow diverter for large unruptured intracranial aneurysms.","authors":"Hyun J Han, Joonho Chung, Chang K Jang, Jung-Jae Kim, Keun Y Park, Yong B Kim","doi":"10.23736/S0390-5616.23.06161-1","DOIUrl":"https://doi.org/10.23736/S0390-5616.23.06161-1","url":null,"abstract":"<p><strong>Background: </strong>Surpass Evolve Flow Diverter (SE-FD; Stryker Neurovascular, Kalamazoo, MI, USA) was launched in 2019 as a new generation FD of Surpass Streamline. The aim of this study was to report the effectiveness and safety of SE-FD insertion for unruptured intracranial aneurysm at one-year follow-up.</p><p><strong>Methods: </strong>Between November 2019 and October 2021, a total of 106 patients with 108 aneurysms were treated with FD in single institution. Of these, SE-FD insertion was performed in 40 patients with 41 aneurysms. At one-year follow-up, clinical and angiographic outcomes were retrospectively evaluated from electronic medical record and aneurysm database.</p><p><strong>Results: </strong>There were 12 male and 28 female patients (mean age 59.1 years, 95% CI: 55.3-62.9). Fusiform aneurysm dissection was 46.3% (19/41). Mean maximum aneurysm diameter was 13.2 mm (SD 5.53), and 34.1% (14/41) of aneurysms were 15 mm or bigger. Among 41 aneurysms, complex aneurysm (recurred, thrombosed, or branch artery-incorporated) was accounted for 41.5% (17/41). All procedures were successfully conducted with 7.3% (3/41) of procedure-related complications. At one-year follow-up (N.=40), neurologic morbidity was noted in 2 cases (5.0%; both with modified Rankin Scale [mRS] 1) without any mortality. At one-year follow-up (N.=41), radiologic outcomes were adequate occlusion in 33 (80.5%) and complete occlusion in 29 (70.7%). There was no retreatment in our cohort.</p><p><strong>Conclusions: </strong>Surpass Evolve Flow Diverter seemed to be safe and effective for the treatment of dissecting/fusiform or complex aneurysms at one-year follow-up. However, further study is needed to evaluate long term results.</p>","PeriodicalId":16504,"journal":{"name":"Journal of neurosurgical sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) PET as a potential selection tool for second surgery in glioblastoma patients. O-(2-18F-氟乙基)-L-酪氨酸(18F-FET)PET作为胶质母细胞瘤患者二次手术的潜在选择工具。
IF 1.9 4区 医学
Journal of neurosurgical sciences Pub Date : 2023-12-21 DOI: 10.23736/S0390-5616.23.06019-8
Orazio S Santonocito, Gianluca Grimod, Anna L DI Stefano, Francesco Pieri, Mariagrazia Nizzola, Nicola Mazzuca, Francesco Pasqualetti, Riccardo Morganti, Vanna Zucchi, Carlo Gambacciani
{"title":"O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) PET as a potential selection tool for second surgery in glioblastoma patients.","authors":"Orazio S Santonocito, Gianluca Grimod, Anna L DI Stefano, Francesco Pieri, Mariagrazia Nizzola, Nicola Mazzuca, Francesco Pasqualetti, Riccardo Morganti, Vanna Zucchi, Carlo Gambacciani","doi":"10.23736/S0390-5616.23.06019-8","DOIUrl":"https://doi.org/10.23736/S0390-5616.23.06019-8","url":null,"abstract":"<p><strong>Background: </strong>Treatment-related changes still represent a diagnostic challenge in the management of patients with suspect of recurrent glioblastoma. The specificity of conventional MRI in detecting recurrence remains limited. Brain PET imaging provides information on tumor metabolism and can contribute to improving the diagnostic accuracy of cerebral neoplasms. We performed a retrospective analysis to evaluate the clinical value of O-(2-<sup>18</sup>F-fluoroethyl)-L-tyrosine (<sup>18</sup>F-FET) PET in the diagnosis of glioblastoma recurrence.</p><p><strong>Methods: </strong>A retrospective analysis on patients considered suitable for salvage surgery for recurrence glioblastoma was performed. <sup>18</sup>F-FET-PET was performed to investigate gadolinium enhancement suspected for recurrence. Static and kinetic <sup>18</sup>F-FET parameters were analyzed and related to O-6-methylguanine-DNA methyltransferase (MGMT) status.</p><p><strong>Results: </strong>Forty-two of the 51 patients who underwent <sup>18</sup>F-FET-PET were re-operated. In each case, neuropathological diagnosis of tumor recurrence was confirmed. pMGMT hypermethylation was detected in 21 patients. Mean tumor-to-brain ratios (TBR) max was 3.87 (range 2.6-6.0). Static and kinetic <sup>18</sup>F-FET parameters were similar according to MGMT status.</p><p><strong>Conclusions: </strong><sup>18</sup>FET-PET can be a reliable tool to improve the selection of patients suitable for salvage surgery for glioblastoma recurrence.</p>","PeriodicalId":16504,"journal":{"name":"Journal of neurosurgical sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Geographic trends in the utilization of frailty as a preoperative decision-making tool in neurosurgery. 利用衰弱作为神经外科术前决策工具的地理趋势。
IF 1.9 4区 医学
Journal of neurosurgical sciences Pub Date : 2023-12-01 Epub Date: 2023-07-10 DOI: 10.23736/S0390-5616.23.06104-0
Joanna M Roy, Syed F Kazim, Kavelin Rumalla, Meic H Schmidt, Christian A Bowers
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