Journal of Medical pharmaceutical and allied sciences最新文献_第3页

The synthetic approach of benzimidazole derivatives as anti-inflammatory agents 抗炎药苯并咪唑衍生物的合成方法

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-10-31 DOI: 10.55522/jmpas.v12i5.4826

Jugnu Jahan, Satyajit Barik, Bharath Kumar Chagaleti, Muthu Kumaradoss Kathiravan, Priya Deivasigamani

引用次数: 0

Formulation and optimization of Ambrisentan self-micro emulsifying drug delivery system (SMEDDS) tablet by wet granulation 湿造粒法制备氨布里森坦自微乳化给药系统(SMEDDS)片的工艺及优化

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-10-31 DOI: 10.55522/jmpas.v12i5.5673.

Nisarg Bhatt, Hitesh Patel

{"title":"Formulation and optimization of Ambrisentan self-micro emulsifying drug delivery system (SMEDDS) tablet by wet granulation","authors":"Nisarg Bhatt, Hitesh Patel","doi":"10.55522/jmpas.v12i5.5673.","DOIUrl":"https://doi.org/10.55522/jmpas.v12i5.5673.","url":null,"abstract":"Ambrisentan is an orally administered endothelin receptor antagonists used for the treatment of pulmonary hypertension. As it is fall under BCS class 2 medicine, its solubility, stability and oral bio availability are poor. Here, a self-micro-emulsifying drug delivery system (SMEDDS) was developed to improve its solubility and drug dissolution. The objective of our investigation was to formulate a self-micro-emulsifying drug delivery system (SMEDDS) of Ambrisentan using minimized quantity of oil, surfactant and co-surfactant that could improve its solubility, stability, and dissolution. The composition of optimized formulation consists of Maisine CC as oil, Acrysol EL 135 as surfactant and Capryol PGMC as cosurfactant, containing 200 mg of Ambrisentan showing mean droplet size (155.12 nm), rate of self-emulsification (56 sec) and Polydispersibility index (0.331). This optimized liquid SMEDDS is used as a liquid component in wet granulation and prepare tablet of Ambrisentan having 5 mg strength. A prepared tablet is evaluated further for tablet evaluation tests and dissolution. This research results in good dissolution and stability.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135871986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and biological activities of flavonoid sulfamates as steroid sulfatase inhibitors 类黄酮磺胺酸酯类类固醇磺胺酶抑制剂的合成及生物活性研究

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-10-31 DOI: 10.55522/jmpas.v12i5.5576

Hatem A Hejaz, Atul Purohit, Barry V L Potter

{"title":"Synthesis and biological activities of flavonoid sulfamates as steroid sulfatase inhibitors","authors":"Hatem A Hejaz, Atul Purohit, Barry V L Potter","doi":"10.55522/jmpas.v12i5.5576","DOIUrl":"https://doi.org/10.55522/jmpas.v12i5.5576","url":null,"abstract":"Synthesis of potent flavonoid sulfamate inhibitors of the enzyme steroid sulfatase (STS), a topical target in treating postmenopausal women with hormone-dependent breast cancer, is described in the current article. Novel compounds were examined for estrone sulfatase (E1-STS) inhibition in intact MCF-7 breast cells. The strategies adopted to develop STS inhibitors which, while active in vivo, are devoid of any estrogenicity that would limit their use for breast cancer therapy (e.g. estrone 3-O-sulfamate, EMATE), were broadly successful. Several molecules of flavonoid sulfamates were synthesized that potentially possess both aromatase and steroid sulfatase inhibitory properties. The isoflavane-4',7-O,O-bis-sulfamate (equol bis-sulfamate) and flavone-6,4'-O,O-bis-sulfamate were found to be the most potent inhibitors of all the flavonoid sulfamate analogs in vitro, inhibiting STS by about 99% at 0.1μM in MCF-7 cells. Some of these flavonoid sulfamates were also found to be active against both enzymes’ STS and aromatase (e.g., 5-hydroxy-7-methoxyflavone-4'-O-sulfamate, 5-hydroxy-flavone-4',7-O,O-bis-sulfamate, and 5,7-dihydroxy flavanone-4'-O-sulfamate), thus demonstrating the novel concept of a dual inhibitor. The availability of flavonoid sulfamates as STS inhibitors may enable to use of them as a therapy in the treatment of breast cancer.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135872355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PCR- A Paradigm Shift with A Robust Quantum Jump 聚合酶链反应-具有稳健量子跃迁的范式转变

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-10-31 DOI: 10.55522/jmpas.v12i5.5828

Anamitra Goswami, Nabanita Mukherjee, Moumita Sil, Arunava Goswami, Prashant Ratnaparkhi

引用次数: 0

Novel gastroprotective activity of basella alba mucilage-based hydrogel beads on diclofenac sodium induced gastric ulcer 基于白底藻粘液的水凝胶珠对双氯芬酸钠诱发的胃溃疡的新型胃保护作用

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-10-31 DOI: 10.55522/jmpas.v12i5.5648

Moumita Chowdhury, Pintu Kumar De

{"title":"Novel gastroprotective activity of basella alba mucilage-based hydrogel beads on diclofenac sodium induced gastric ulcer","authors":"Moumita Chowdhury, Pintu Kumar De","doi":"10.55522/jmpas.v12i5.5648","DOIUrl":"https://doi.org/10.55522/jmpas.v12i5.5648","url":null,"abstract":"Natural polysaccharides are emerging gastro-protective agents that need extensive characterization and subsequent commercialization. Diclofenac sodium, a non-steroidal anti-inflammatory drug, is generally used as a model drug to induce gastric ulcers experimentally. Therefore, in the present study, Basella alba mucilage is modified to form hydrogel beads, and its gastro-protective potential is judged by incorporating Diclofenac sodium in it and administered orally to Swiss albino rats at an equivalent weight of 50mg Diclofenac sodium/ kg bw for ten days. The results were compared with the rats administered Diclofenac sodium (50 mg/kg bw) and with the group of rats administered Diclofenac sodium (50mg/kg bw) and Pantoprazole (10mg/kg bw). Another group of rats were administered blank hydrogel beads, and another group served as control. The gastro-protective property was evaluated from the gastric secretory parameters, ulcer index, biochemical tests, and histopathology studies. The administration of Basella alba mucilage-based hydrogel beads in rats decreased the ulcer index, total and free acidity, lipid peroxidation, hydrogen peroxide level, and myeloperoxidase activity. It elevated the level of enzymic antioxidants and increased gastric juice's pH significantly compared to the Diclofenac-treated rats. All the evaluated parameters showed similar results for the rats treated with Diclofenac sodium-loaded Basella alba mucilage beads and those treated with Diclofenac sodium and Pantoprazole, with no significant differences. The histopathology analysis also supports the gastro-protective property of the beads. Thus, Basella alba mucilage-based hydrogel beads can be a promising gastro-protective agent against Diclofenac sodium-induced gastric ulcers.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135871513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appraisal, recent advancement, and impacts of nanomedicine in cardiac asthma 纳米药物在心脏性哮喘中的评价、最新进展及影响

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-10-31 DOI: 10.55522/jmpas.v12i5.5214

Jeetendra Kumar Gupta, Abdul Razak Mohamed Sikkander, Faizan ul Haque Nagrami, Krishan Kumar, Nitin Wahi

{"title":"Appraisal, recent advancement, and impacts of nanomedicine in cardiac asthma","authors":"Jeetendra Kumar Gupta, Abdul Razak Mohamed Sikkander, Faizan ul Haque Nagrami, Krishan Kumar, Nitin Wahi","doi":"10.55522/jmpas.v12i5.5214","DOIUrl":"https://doi.org/10.55522/jmpas.v12i5.5214","url":null,"abstract":"Cardiopulmonary asthma is a type of coughing, not an external appearance of asthma. Depending on persistent symptoms, this full-to-the-brim situation can be used to survive a therapeutic emergency. Liquid composition in the lungs and the area around the airways may result from heart failure. This demonstrates how the direction causes symptoms such as shortness of breath, coughing, and bursting at the seams which are likecipher and asthma symptoms. The common condition known as asthma is brought on by airway sensitivity, which can lead to constrictions, most noticeably leading to breathing difficulty. Heart failure treatment is trained to ease the effects of cardiac asthma and heart failure symptoms. Current developments in nano science and nanotechnology point towards a wealth of novel ideas for understanding and treating cardiovascular, pulmonary, and hematological conditions. Asthma is a common complaint that provokes the airways through various causes. Additionally, these instances consistently run into issues with their management schedule pertinent to the collection of the complaints. Asthma quantifiable treatment currently relies primarily on glucocorticoid medication therapy; however, the development of more effective treatments is hampered by glucocorticoid conflict as well as numerous elevated possessions due to deprived drug delivery. Our fundamental understanding of cardiac asthma nano medicine therapy is updated in this review.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"132 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135977328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perception of plagiarism factors among students from the health careers training institute 卫生职业培训学院学生对抄袭因素的认知

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-10-31 DOI: 10.55522/jmpas.v12i5.5120

Lahcen Bandadi, Nadia Chamkal

{"title":"Perception of plagiarism factors among students from the health careers training institute","authors":"Lahcen Bandadi, Nadia Chamkal","doi":"10.55522/jmpas.v12i5.5120","DOIUrl":"https://doi.org/10.55522/jmpas.v12i5.5120","url":null,"abstract":"Plagiarism is an act that negatively affects the quality of students training and the professional skills development. The aim of this study is to examine the perception of plagiarism factors among students from the health careers training institute. To carry out this quantitative study, seventy students were recruited. To collect the data, we used a questionnaire that included participants' socio-demographic characteristics and plagiarism factors. The results highlighted factors attributed to the students, factors relating to the teacher and factors relating to the training institution. Thus, the inability to manage time was raised by 61.3% of participants, ignorance of the rules for citing references (57%), easy access to information (46.8%), lack of awareness (51.6%), insufficient training (52%) and lack of disciplinary measures (76%). Minimizing plagiarism as much as possible requires the involvement of all actors in the teaching-learning process. An approach based on prevention, detection and sanction is proposed. Penalty should only be applied as a last resort, and need be accompanied by an in-depth analysis of the causes of plagiarism.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"8 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135977327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Frequency of Topically Applied Corticosteroid Abuse Among Outpatients with Dermatology-Related Conditions 皮肤相关疾病门诊患者局部应用皮质类固醇滥用的频率

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-10-31 DOI: 10.55522/jmpas.v12i5.5702.

Ning Bo

引用次数: 0

Effects of baclofen administered to reduce muscle spasm on balance maintenance, gait ability and quality of life in stroke patients 巴氯芬减轻肌肉痉挛对脑卒中患者平衡维持、步态能力和生活质量的影响

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-10-31 DOI: 10.55522/jmpas.v12i5.5615

Yong-Jin Jeon

{"title":"Effects of baclofen administered to reduce muscle spasm on balance maintenance, gait ability and quality of life in stroke patients","authors":"Yong-Jin Jeon","doi":"10.55522/jmpas.v12i5.5615","DOIUrl":"https://doi.org/10.55522/jmpas.v12i5.5615","url":null,"abstract":"This study aimed to investigate the impact of Baclofen on balance, gait, functional independence, and quality of life in ischemic stroke patients. Thirty patients diagnosed with ischemic stroke by a rehabilitation medicine specialist were randomly assigned to either an experimental group that underwent exercise therapy in conjunction with Baclofen or a control group that received conventional exercise therapy without Baclofen. In this study, Berg Balance Scale, Timed Up and Go, and 10-Meter Walk Test were used to evaluate balance and walking ability. Functional Independence Measure was employed to assess functional independence, and Stroke-Specific Quality of Life was used to evaluate the quality of life. The experimental results revealed statistically significant improvements in all evaluation measures for both groups when comparing post-test to pre-test. However, in comparisons between groups, all test items in the experimental group that combined Baclofen with exercise therapy were significantly higher than those in the control group. In conclusion, these results suggest that integrating Baclofen into exercise therapy rehabilitation programs could be a promising approach to enhance recovery outcomes for patients recovering from ischemic stroke.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135870992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and pharmacological characterization of new curcumin ester pro-drugs with enhanced anti-inflammatory, anti-ulcerogenic and improved tissue distribution 增强抗炎、抗溃疡和改善组织分布的新型姜黄素酯前药的合成及药理研究

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-10-31 DOI: 10.55522/jmpas.v12i5.5264

Nidhi Agrawal, Meenakshi Jaiswal

引用次数: 0