Journal of Medical Toxicology最新文献_第2页

Multisystemic Consequences Following Oclacitinib Maleate (Apoquel^®) Overdose Ingestion in Cats and Dogs. 猫和狗过量摄入马来酸奥拉西替尼（阿波奎尔®）后的多系统后果。

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2025-07-01 Epub Date: 2025-04-21 DOI: 10.1007/s13181-025-01076-7

Leah D Swanson, Holly A Hommerding, Renee D Schmid, Lynn R Hovda

{"title":"Multisystemic Consequences Following Oclacitinib Maleate (Apoquel®) Overdose Ingestion in Cats and Dogs.","authors":"Leah D Swanson, Holly A Hommerding, Renee D Schmid, Lynn R Hovda","doi":"10.1007/s13181-025-01076-7","DOIUrl":"10.1007/s13181-025-01076-7","url":null,"abstract":"Introduction: Pet Poison Helpline® (PPH), a 24/7 international animal poison control center has observed a significant and rising number of exposures detailing multisystemic signs and adverse outcomes associated with oclacitinib maleate (Apoquel®) overdoses.Methods: Pet Poison Helpline® utilizes a proprietary electronic database which was retrospectively reviewed for oclacitinib maleate exposure information from January 2022 to November 2024 through their toxicology consultation service.Results: Market entry and distribution of chewable oclacitinib maleate occurred in October 2023. In the year following, there was a 299% increase in calls to PPH from inadvertent exposure. Of the 417 symptomatic cases reviewed, 63 cases were symptomatic cats, and 354 cases were symptomatic dogs. Multi-system organ involvement, including neurological, gastrointestinal, cardiovascular, renal, hepatic, and ocular signs, as well as laboratory abnormalities were observed.Discussion: Introduction of a chewable formulation in October 2023 likely attributed to a marked increase in exposures. Accompanying this rise in overdose exposures, a notable escalation in multisystemic effects was seen, including neurological, gastrointestinal signs, cardiovascular disturbances, ocular irregularities, renal and hepatic injury, and complete blood count (CBC) hematological abnormalities. Treatment is largely symptomatic and supportive therapy.Conclusion: The increased occurrence of exposures to oclacitinib maleate underscores necessity for additional research of JAK inhibitors in animals to better understand and address oclacitinib maleate toxicosis.","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"360-365"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Angiotensin II Utilization for Refractory Shock in a Polysubstance Overdose. 血管紧张素II用于治疗多种药物过量的难治性休克一例。

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2025-07-01 Epub Date: 2025-05-30 DOI: 10.1007/s13181-025-01080-x

Brian W Gilbert, Charles S Wilson, Nicholas Kim, Tessa R Cox, Melissa V Ortiz

{"title":"A Case of Angiotensin II Utilization for Refractory Shock in a Polysubstance Overdose.","authors":"Brian W Gilbert, Charles S Wilson, Nicholas Kim, Tessa R Cox, Melissa V Ortiz","doi":"10.1007/s13181-025-01080-x","DOIUrl":"10.1007/s13181-025-01080-x","url":null,"abstract":"Amlodipine and quetiapine are widely utilized medications that are generally well-tolerated at therapeutic doses. However, overdoses can lead to severe, life-threatening cardiovascular effects, leading to refractory vasoplegia. The management of poly-ingestion overdoses is challenging and often requires aggressive, multimodal treatment strategies especially when the causative agent is unknown. In this case report, a 38-year-old male intentionally ingested a large amount of amlodipine and quetiapine resulting in refractory shock despite high doses of vasopressors, calcium, and insulin therapy. After conventional therapies failed, the administration of exogenous angiotensin II (Ang II), a vasoconstrictor traditionally used for septic shock, led to a marked improvement in the patient's blood pressure and stabilization of hemodynamics. Sixty minutes after initiation of Ang II, the patient's mean arterial pressure (MAP) improved, allowing for the weaning of other vasopressors and a gradual reduction in insulin therapy. This case highlights the potential role of Ang II as a salvage therapy in polysubstance ingestions when other therapies fail.","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"350-354"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Pharmacokinetics and Toxicokinetics: Is a New Diagnostic and Therapeutic Framework Needed? 胰高血糖素样肽-1受体激动剂对药代动力学和毒代动力学的影响：需要一个新的诊断和治疗框架吗？

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2025-07-01 Epub Date: 2025-04-11 DOI: 10.1007/s13181-025-01075-8

James D Whitledge, Joseph Kennedy, C James Watson, Carin Malley, Karen Simone, Mark Neavyn

引用次数: 0

Response to "Comment on Naloxone Dosing and Hospitalization for Nitazene Overdose: A Scoping Review". 对《纳洛酮给药和尼塔尼过量住院的评论：一项范围综述》的回应。

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2025-07-01 Epub Date: 2025-04-16 DOI: 10.1007/s13181-025-01071-y

Jonathan Berger, Mohamed Jalloh, Alec Severe, Alex Manini

引用次数: 0

The Value of Medical Toxicologists. 医学毒理学家的价值

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2025-07-01 Epub Date: 2025-06-19 DOI: 10.1007/s13181-025-01082-9

Paul M Wax, Tracy M Kolian, Anthony F Pizon

{"title":"The Value of Medical Toxicologists.","authors":"Paul M Wax, Tracy M Kolian, Anthony F Pizon","doi":"10.1007/s13181-025-01082-9","DOIUrl":"10.1007/s13181-025-01082-9","url":null,"abstract":"Poisoning is a major public health issue and one of the leading causes of injury related death in the US. Poisonings result from intentional or unintentional use of prescription drugs or illicit overdose including opioids, inhalation of toxic fumes, ingestion of contaminated food or drinking water, and envenomations. The cost of poisonings to US health care is large, especially when considering the costs of addiction and illicit opioids. As specially trained physicians, medical toxicologists play a major role in the treatment and care of poisoned patients while improving patient care, population health, and health care systems related to chemical exposures and poisonings including prevention. They also play a major role in the opioid epidemic and in caring for patients with opioid use disorder and substance use disorders more broadly. Regardless of these important roles, the recognition and knowledge of the value that medical toxicologists provide to health and the health care system is limited. As reimbursement becomes linked to outcome in a value-based care (VBC) market, medical toxicologists must continue to demonstrate their value to stakeholders. The American College of Medical Toxicology (ACMT) has long recognized the need for medical toxicologists to articulate their value and to advocate for themselves, the profession, and for the patients they serve. To that end, modeling infectious disease (ID) efforts in establishing value for their specialty, this paper outlines the 'value' of medical toxicologists in improving patient outcomes, and their positive impact on population health and health care systems.","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"336-342"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Tianeptine Exposures Reported to United States Poison Centers, 2015-2023". 评论“2015-2023年向美国中毒中心报告的天奈肽暴露”。

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2025-07-01 Epub Date: 2025-04-10 DOI: 10.1007/s13181-025-01073-w

James B Leonard, Perry E Rosen, Christopher J Counts

引用次数: 0

Biostatistics and Epidemiology for the Toxicologist: Miscellaneous Bias - Confirmation, Non-Response, Survivorship, and Selection. 毒理学家的生物统计学和流行病学：杂项偏倚——确认、无反应、存活和选择。

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2025-07-01 Epub Date: 2025-06-18 DOI: 10.1007/s13181-025-01083-8

Alexandra Ortego, Sanjay Mohan, Mark K Su

引用次数: 0

Articles You Might Have Missed. 你可能错过的文章。

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2025-05-22 DOI: 10.1007/s13181-025-01079-4

Allison R Font, Michael O Khoury, Christopher D Riviello, Michael F Singer

引用次数: 0

Welcome to the 2025 ACMT Annual Scientific Meeting. 欢迎参加2025年ACMT年度科学会议。

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.1007/s13181-025-01064-x

Charlotte E Goldfine, Joseph E Carpenter, Maryann Mazer-Amirshahi, Adrienne Dunavin, Stephanie Abston

引用次数: 0

ACMT Position Statement: Sterile Solution Shortage. ACMT 立场声明：无菌溶液短缺。

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2025-04-01 Epub Date: 2025-02-05 DOI: 10.1007/s13181-025-01060-1

Maryann Mazer-Amirshahi, Erin R Fox, Andrew Stolbach

引用次数: 0