Journal of Neuro-Oncology最新文献

{"title":"Correction to: Connectome-guided resection of deep-seated brain tumors using tubular retractors: matched cohort outcomes and exploratory quantitative tractometry.","authors":"Laura Mittelman, Iñigo L Sistiaga, Nitish Seenarine, Shoaib A Syed, Harshal Shah, John Chen, James Duehr, Luis O Vargas, Samuel Latzman, Justin Silverstein, Daniel G Eichberg, Michael Schulder, Randy S D'Amico","doi":"10.1007/s11060-026-05592-6","DOIUrl":"https://doi.org/10.1007/s11060-026-05592-6","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"177 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of early versus late radiotherapy in grade 2 meningiomas: a National retrospective analysis from the TROD neuro-oncology group.","authors":"Volkan Demircan, Ertuğrul Şentürk, Evrim Tezcanlı, Petek Erpolat, Züleyha Akgün, Serra Kamer, Necla Gürdal, Beyhan Ceylaner Bıçakçı, Burak Erdemci, Nuri Kaydıhan, Banu Atalar","doi":"10.1007/s11060-026-05590-8","DOIUrl":"https://doi.org/10.1007/s11060-026-05590-8","url":null,"abstract":"<p><strong>Purpose: </strong>The optimal timing of radiotherapy (RT) in patients with WHO grade 2 meningiomas remains controversial, particularly following gross total resection (GTR). This multicenter study compared long-term outcomes of early RT versus late RT, focusing on progression-free survival (PFS), overall survival (OS), and tumor-related mortality.</p><p><strong>Methods and materials: </strong>This retrospective multicenter cohort study included 263 adult patients with histopathologically confirmed WHO grade 2 meningiomas treated between 2005 and 2023. Patients were stratified by RT timing: early adjuvant RT after initial surgery versus late RT administered after radiologic or clinical progression. Outcomes were analyzed in the overall cohort and in a prespecified GTR subgroup. PFS and OS were estimated using the Kaplan-Meier method. Tumor-related mortality was assessed using cause-specific Cox and Fine-Gray competing-risk models.</p><p><strong>Results: </strong>With a median follow-up exceeding 7 years, early RT was associated with a significant improvement in PFS compared with late RT. In the overall cohort, 10-year PFS was 84.8% with early RT versus 18.6% with late RT (p < 0.001). Among patients undergoing GTR, 10-year PFS remained high with early RT (89.3%) but declined markedly after late RT (18.8%; p < 0.001). RT timing was the strongest independent predictor of PFS in multivariable models, although its effect attenuated over time. Tumor-related mortality was approximately sixfold higher in the late RT group (16.7% vs 2.7%; p = 0.011), whereas all-cause mortality did not differ significantly (24.2% vs 14.7%; p = 0.198). Mitotic count and Ki-67 index were independently associated with early and long-term PFS, whereas male sex, older age, and subtotal resection predicted tumor-related mortality.</p><p><strong>Conclusions: </strong>Early RT provides a durable and clinically meaningful PFS benefit over late RT in WHO grade 2 meningiomas, including after GTR, without conferring an OS advantage. These findings emphasize the importance of RT timing and tumor biology in postoperative risk stratification and support consideration of early RT in selected patients, pending results from randomized trials.</p>","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"177 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unsupervised clustering analysis reveals distinct postoperative cortisol trajectories following pituitary adenoma resection in Cushing's disease.","authors":"Rushmin Khazanchi, Sachin Govind, Rishi Jain, Joshua Vignolles-Jeong, Vikas Munjal, Rahul Chaliparambil, Mark Damante, James P Chandler, Luma Ghalib, Wenyu Huang, Stephen T Magill, Daniel M Prevedello","doi":"10.1007/s11060-026-05532-4","DOIUrl":"10.1007/s11060-026-05532-4","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"177 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glioblastoma region-specific metabolic signatures reflect patient survival duration.","authors":"Dylan A Goodin, Joseph Chen, Brian J Williams, Hermann B Frieboes","doi":"10.1007/s11060-026-05588-2","DOIUrl":"https://doi.org/10.1007/s11060-026-05588-2","url":null,"abstract":"<p><strong>Purpose: </strong>Spatial metabolic differences found in glioblastoma (GBM) tumor core (contrast enhancing) and peritumoral (T2/FLAIR hyperintense) edge tissue regions have recently enabled stratification of patient overall survival. However, the association between metabolic dysregulation and survival duration remains poorly understood. To gain further insight into the biological characteristics underlying longer vs. shorter survival, this study employed an interdisciplinary approach to analyze GBM region-specific metabolic signatures predictive of patient overall survival.</p><p><strong>Methods: </strong>Patient survival data were paired with core and edge biopsy tumor metabolomic data (n = 37 pairs) obtained by 2D liquid chromatography-mass spectrometry/mass spectrometry. Metabolite expression was compared between patients with short (≤ median) and long (> median) overall survival using relative abundance analysis. Metabolic signatures predictive of patient survival were identified via a comprehensive machine learning (ML) workflow, including repeated nested cross validation and test (holdout) set evaluation. Pathways associated with key metabolites were identified from the KEGG database.</p><p><strong>Results: </strong>Core metabolite levels generally were increased and edge metabolite levels were decreased in patients with longer survival, Edge tissue metabolic signatures reflected survival duration better than signatures from core tissue. Metabolites differentiating short vs. long survival were associated with metabolic pathway dysfunction related to fatty acid and amino acid metabolism, glycolysis and gluconeogenesis, and ATP synthesis.</p><p><strong>Conclusion: </strong>Interdisciplinary analysis of GBM region-specific metabolic signatures predictive of patient short vs. long survival can yield insight into the local and global metabolic dysfunction associated with survival duration.</p>","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"177 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal remodeling of brain metastasis resection cavities after adjuvant gamma knife radiosurgery.","authors":"Victor Goulenko, Sarthak Sinha, Babar Gulzar, Venkatesh Shankar Madhugiri, Neil D Almeida, Lindsay Lipinski, Andrew J Fabiano, Kenneth V Snyder, Robert A Fenstermaker, Robert J Plunkett, Dheerendra Prasad","doi":"10.1007/s11060-026-05567-7","DOIUrl":"10.1007/s11060-026-05567-7","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"177 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular schwannoma microsurgery in the era of multimodal treatment: advances in technique and patient selection.","authors":"Ibrahem Albalkhi, Basel Musmar, Nimer Adeeb, Hussam Abou-Al-Shaar, Jacques J Morcos","doi":"10.1007/s11060-026-05589-1","DOIUrl":"10.1007/s11060-026-05589-1","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"177 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-fraction stereotactic body radiotherapy for spinal metastases.","authors":"Suchet Taori, Samuel Adida, Akshath Rajan, James C Bayley, Pascal O Zinn, John C Flickinger, Roberta K Sefcik, Peter C Gerszten","doi":"10.1007/s11060-026-05579-3","DOIUrl":"https://doi.org/10.1007/s11060-026-05579-3","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"177 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of multidimensional cognitive training in the early postoperative period for glioma patients with cognitive impairment.","authors":"Yuanyuan Ma, Rong Zhou, Yingping Ma, Chenghua Mou, Bingyang He, Dengjuan Sun, Xing Wu, Yaxin Dai, Peifen Ma","doi":"10.1007/s11060-026-05575-7","DOIUrl":"https://doi.org/10.1007/s11060-026-05575-7","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"177 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, molecular, and immunologic determinants of survival in WHO-defined IDH-wildtype glioblastoma treated with radiotherapy: a large real-world cohort study.","authors":"Cole Friedes, Melanie Berger, Lauren Linkowski, Casey Hollawell, Harper Hubbeling, Daniel Alexander, Goldie Kurtz, Robert A Lustig, Jay F Dorsey, Arati S Desai, Richard E Phillips, Steven Brem, Christos Davatzikos, MacLean Nasrallah, Donald M O'Rourke, Christina Jackson, Nduka M Amankulor, Michelle Alonso-Basanta, Suyash Mohan, Stephen J Bagley, Emily S Lebow","doi":"10.1007/s11060-026-05572-w","DOIUrl":"https://doi.org/10.1007/s11060-026-05572-w","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"177 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in rates of post-operative oncological treatment for patients with glioblastoma in England: a comprehensive multi-year National cohort study from the GlioCova project.","authors":"Radvile Mauricaite, Kerlann Le Calvez, Stephen David Robinson, Sophie Camp, Andrew Brodbelt, Thomas C Booth, Matt Williams","doi":"10.1007/s11060-026-05440-7","DOIUrl":"https://doi.org/10.1007/s11060-026-05440-7","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"177 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}