Journal of Neurodegenerative Diseases最新文献_第4页

Death Receptors in the Selective Degeneration of Motoneurons in Amyotrophic Lateral Sclerosis. 肌萎缩性侧索硬化症运动神经元选择性变性中的死亡受体。

Journal of Neurodegenerative Diseases Pub Date : 2013-01-01 Epub Date: 2013-07-16 DOI: 10.1155/2013/746845

Julianne Aebischer, Nathalie Bernard-Marissal, Brigitte Pettmann, Cédric Raoul

引用次数: 15

Immunolocalization of Kisspeptin Associated with Amyloid-β Deposits in the Pons of an Alzheimer's Disease Patient. 与阿尔茨海默病患者脑桥淀粉样蛋白-β沉积相关的Kisspeptin免疫定位

Journal of Neurodegenerative Diseases Pub Date : 2013-01-01 Epub Date: 2013-05-16 DOI: 10.1155/2013/879710

Amrutha Chilumuri, Maria Ashioti, Amanda N Nercessian, Nathaniel G N Milton

{"title":"Immunolocalization of Kisspeptin Associated with Amyloid-β Deposits in the Pons of an Alzheimer's Disease Patient.","authors":"Amrutha Chilumuri, Maria Ashioti, Amanda N Nercessian, Nathaniel G N Milton","doi":"10.1155/2013/879710","DOIUrl":"https://doi.org/10.1155/2013/879710","url":null,"abstract":"The pons region of the Alzheimer's disease (AD) brain is one of the last to show amyloid-β (Aβ) deposits and has been suggested to contain neuroprotective compounds. Kisspeptin (KP) is a hormone that activates the hypothalamic-pituitary-gonadal axis and has been suggested to be neuroprotective against Aβ toxicity. The localization of KP, plus the established endogenous neuroprotective compounds corticotropin releasing hormone (CRH) and catalase, in tissue sections from the pons region of a male AD subject has been determined in relation to Aβ deposits. Results showed Aβ deposits also stained with KP, CRH, and catalase antibodies. At high magnification the staining of deposits was either KP or catalase positive, and there was only a limited area of the deposits with KP-catalase colocalization. The CRH does not bind Aβ, whilst both KP and catalase can bind Aβ, suggesting that colocalization in Aβ deposits is not restricted to compounds that directly bind Aβ. The neuroprotective actions of KP, CRH, and catalase were confirmed in vitro, and fibrillar Aβ preparations were shown to stimulate the release of KP in vitro. In conclusion, neuroprotective KP, CRH, and catalase all colocalize with Aβ plaque-like deposits in the pons region from a male AD subject. ","PeriodicalId":16405,"journal":{"name":"Journal of Neurodegenerative Diseases","volume":"2013 ","pages":"879710"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/879710","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34129118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

P-Glycoprotein Altered Expression in Alzheimer's Disease: Regional Anatomic Variability. 阿尔茨海默病中 P 糖蛋白表达的改变：区域解剖差异。

Journal of Neurodegenerative Diseases Pub Date : 2013-01-01 Epub Date: 2013-04-03 DOI: 10.1155/2013/257953

Brian Jeynes, John Provias

{"title":"P-Glycoprotein Altered Expression in Alzheimer's Disease: Regional Anatomic Variability.","authors":"Brian Jeynes, John Provias","doi":"10.1155/2013/257953","DOIUrl":"10.1155/2013/257953","url":null,"abstract":"We investigated the expression of P-glycoprotein (P-gp) in brain samples of Alzheimer disease (AD) and normative brains (NM). Superior temporal cortex hippocampal and brainstem samples from 15 AD and NM brains were selected from comparable sites. P-gp positive capillaries and β-amyloid (Aβ) senile plaques (SP) were counted. Statistical analysis of the data was performed using nonparametric data analysis with Mann-Whitney, Kruskal-Wallis, and Spearman's tests. There were no significant differences in P-gp expression between superior temporal and hippocampus samples. However, there were significant differences in P-gp expression, when comparing brainstem with both hippocampal and superior temporal samples in both conditions (P < 0.012; P < 0.002 in NM cases and P < 0.001; <0.001 in AD cases); the brainstem has greater P-gp expression in each case and condition. In addition, there was a notable inverse negative correlation (P < 0.01) between P-gp expression and the presence of SPs in the AD condition superior temporal cortex. The results of this study suggest that there were significant site-dependent differences in the expression of P-gp. There may be an increased protective role for P-gp expression against amyloid deposition in the brainstem and in the superior temporal cortex of AD brains. ","PeriodicalId":16405,"journal":{"name":"Journal of Neurodegenerative Diseases","volume":"2013 ","pages":"257953"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33957295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of a Peer Support Program in Multiple Sclerosis in an Australian Community Cohort: A Prospective Study. 澳大利亚社区队列中多发性硬化症同伴支持项目的结果:一项前瞻性研究。

Journal of Neurodegenerative Diseases Pub Date : 2013-01-01 Epub Date: 2013-12-05 DOI: 10.1155/2013/429171

Louisa Ng, Bhasker Amatya, Fary Khan

{"title":"Outcomes of a Peer Support Program in Multiple Sclerosis in an Australian Community Cohort: A Prospective Study.","authors":"Louisa Ng, Bhasker Amatya, Fary Khan","doi":"10.1155/2013/429171","DOIUrl":"https://doi.org/10.1155/2013/429171","url":null,"abstract":"Background/Objectives. This pilot study evaluated the impact of a peer support program on improving multiple sclerosis (MS) related psychological functions (depression, anxiety, and stress) and enhancing quality of life. Methodology. Participants (n = 33) were recruited prospectively and received an 8-week group face-to-face peer support program. Assessments were at baseline (T1), 6 weeks after program (T2), and 12 months after program (T3), using validated questionnaires: Depression Anxiety Stress Scale (DASS), McGill Quality of Life (MQOL), and Brief COPE. Results. Participants' mean age was 52; the majority were female (64%) and married (64%). Median time since MS diagnosis was 16 years. At T2, participants reported improved psychological functioning (DASS \"depression,\" \"anxiety,\" and \"stress\" subscales, z values -2.36, -2.22, and -2.54, moderate effect sizes (r) 0.29, 0.28, and 0.32, resp.) and quality of life (MQOL SIS z score -2.07, r = 0.26) and were less likely to use \"self-blame\" as a coping mechanism (Brief COPE z score -2.37, r = 0.29). At T3, the positive improvements in stress (DASS stress subscale z score -2.41, r = 0.31) and quality of life were maintained (MQOL SIS, z score -2.30, r = 0.29). There were no adverse effects reported. ","PeriodicalId":16405,"journal":{"name":"Journal of Neurodegenerative Diseases","volume":"2013 ","pages":"429171"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/429171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33957299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21