Journal of Neuroimaging最新文献

{"title":"Larger Perfusion Mismatch Volume Is Associated With Longer Hospital Length of Stay in Medium Vessel Occlusion Stroke","authors":"Janet Mei,&nbsp;Hamza Adel Salim,&nbsp;Dhairya A. Lakhani,&nbsp;Aneri Balar,&nbsp;Vaibhav Vagal,&nbsp;Manisha Koneru,&nbsp;Dylan Wolman,&nbsp;Risheng Xu,&nbsp;Victor Urrutia,&nbsp;Elisabeth Breese Marsh,&nbsp;Benjamin Pulli,&nbsp;Meisam Hoseinyazdi,&nbsp;Licia Luna,&nbsp;Francis Deng,&nbsp;Nathan Z. Hyson,&nbsp;Mona Bahouth,&nbsp;Adam A. Dmytriw,&nbsp;Adrien Guenego,&nbsp;Gregory W Albers,&nbsp;Hanzhang Lu,&nbsp;Kambiz Nael,&nbsp;Argye E. Hillis,&nbsp;Raf Llinas,&nbsp;Max Wintermark,&nbsp;Tobias D. Faizy,&nbsp;Jeremy J. Heit,&nbsp;Vivek Yedavalli","doi":"10.1111/jon.70015","DOIUrl":"10.1111/jon.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and purpose</h3>\u0000 \u0000 <p>Prolonged length of stay (LOS) following a stroke is associated with unfavorable clinical outcomes. Factors predicting LOS in medium vessel occlusion (MeVO), impacting up to 40% of acute ischemic stroke (AIS) cases, remain underexplored. This study aims to investigate the predictors of LOS in AIS-MeVO.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective analysis of prospectively maintained stroke databases, comprising AIS cases with MeVO in the anterior circulation, assessed by adequate CT perfusion (CTP). Baseline and clinical data were obtained from electronic health records. Alberta Stroke Program Early CT Scores (ASPECTS) were calculated from non-contrast head CT. The perfusion mismatch volume (time to maximum &gt; 6 s minus relative cerebral blood flow &lt;30%) volume was reported from CTP. Multiple regression was employed to examine the relationship between baseline parameters and hospital LOS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 133 patients (median age 71 [interquartile range 63–80] years, 59.4% females) were included in the study cohort. The perfusion mismatch volume significantly positively correlated with LOS (<i>r</i> = 0.264, <i>p</i> = 0.004). After adjusting for age, sex, hypertension, diabetes, prior stroke or transient ischemic attack, admission NIHSS, ASPECTS, Tan score, intravenous thrombolysis, mechanical thrombectomy (MT), and hemorrhagic transformation, a larger mismatch volume remained independently associated with longer hospital stays (<i>β</i> = 0.209, 95% confidence interval [CI] 0.006–0.412, <i>p</i> = 0.045). Additional significant determinants of longer hospital stay included admission NIHSS (<i>β</i> = 0.250, 95% CI: 0.060–0.440, <i>p</i> = 0.010) and MT (<i>β</i> = 0.208, 95% CI: 0.006–0.410, <i>p</i> = 0.044). Among patients who underwent MT (<i>n</i> = 83), multiple regression analysis incorporating both perfusion mismatch volume and admission NIHSS revealed that perfusion mismatch volume remained independently associated with LOS (<i>β</i> = 0.248, 95% CI: 0.019–0.471, <i>p</i> = 0.033), while admission NIHSS did not retain significance (<i>β</i> = 0.208, 95% CI: 0.019–0.433, <i>p</i> = 0.071).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In our cohort of AIS patients with MeVO in the anterior circulation, and particularly in those who underwent MT, the perfusion mismatch volume serves as an independent predictor of LOS. These findings offer critical valuable insights in clinical assessments and decision-making protocols of MT in AIS-MeVO.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Field-Blinded Assessment of Portable Ultra-Low-Field Brain MRI for Multiple Sclerosis","authors":"Serhat V. Okar,&nbsp;Govind Nair,&nbsp;Karan D. Kawatra,&nbsp;Ashley A. Thommana,&nbsp;Corinne A. Donnay,&nbsp;María I. Gaitán,&nbsp;Joel M. Stein,&nbsp;Daniel S. Reich","doi":"10.1111/jon.70005","DOIUrl":"10.1111/jon.70005","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>MRI is crucial for multiple sclerosis (MS), but the relative value of portable ultra-low field MRI (pULF-MRI), a technology that holds promise for extending access to MRI, is unknown. We assessed white matter lesion (WML) detection on pULF-MRI compared to high-field MRI (HF-MRI), focusing on blinded assessments, assessor self-training, and multiplanar acquisitions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty-five adults with MS underwent pULF-MRI following their HF-MRI. Two neuroradiologists independently assessed pULF-MRI images in an evaluation process, including initial assessment blinded to HF-MRI, self-training with reference to HF-MRI and evaluation of 20 cases with additional T2-fluid-attenuated inversion recovery in an additional plane. A third rater conducted cross-referenced analysis with HF-MRI data to determine true-positive lesions, false-positive areas, and case-level sensitivity and positive predictive value.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age of participants was 50 years (standard deviation: 11; 74% women). Initially, Rater 2 marked more false-positive areas than Rater 1 (<i>p</i> = 0.003). After self-training, both raters embraced a conservative approach, with Rater 2 marking fewer false-positive areas (<i>p</i> = 0.01). Both raters maintained 100% case-level sensitivity and positive predictive value for detecting at least one WML, particularly in periventricular areas. Multiplanar acquisitions reduced both false-positive areas and true-positive lesions. True-positive lesions and false-positive areas had similar contrast-to-noise ratios in the juxtacortical region (<i>p</i> = 0.73) but not in periventricular, deep parenchymal regions (<i>p</i> = 0.004, <i>p</i> = 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>With adequate training, radiological interpretation of pULF-MRI has high sensitivity and positive predictive value for MS lesions but should be approached conservatively. These results suggest utility for patient triage, potentially reducing diagnostic delay, and screening high-risk individuals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Prolonged Venous Transit in Large Vessel Occlusion Acute Ischemic Strokes","authors":"Hamza Adel Salim,&nbsp;Dhairya A. Lakhani,&nbsp;Aneri B. Balar,&nbsp;Janet Mei,&nbsp;Licia Luna,&nbsp;Mona Shahriari,&nbsp;Nathan Z. Hyson,&nbsp;Francis Deng,&nbsp;Adam A. Dmytriw,&nbsp;Adrien Guenego,&nbsp;Victor C. Urrutia,&nbsp;Elisabeth B. Marsh,&nbsp;Hanzhang Lu,&nbsp;Risheng Xu,&nbsp;Rich Leigh,&nbsp;Gaurang Shah,&nbsp;Sijin Wen,&nbsp;Gregory W. Albers,&nbsp;Argye E. Hillis,&nbsp;Rafael Llinas,&nbsp;Kambiz Nael,&nbsp;Max Wintermark,&nbsp;Jeremy J. Heit,&nbsp;Tobias D. Faizy,&nbsp;Vivek S. Yedavalli","doi":"10.1111/jon.70006","DOIUrl":"10.1111/jon.70006","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Prolonged venous transit (PVT), derived from computed tomography perfusion (CTP) time-to-maximum (<i>T</i>_max) maps, reflects compromised venous outflow (VO) in acute ischemic stroke due to large vessel occlusion (AIS-LVO). Poor VO is associated with worse clinical outcomes, but pre-treatment markers predictive of PVT are not well described.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective analysis of 189 patients with anterior circulation AIS-LVO who underwent baseline CT evaluation, including non-contrast CT, CT angiography, and CTP. PVT was assessed on <i>T</i>_max maps; PVT+ was defined as <i>T</i>_max ≥ 10 s within the posterior superior sagittal sinus or torcula. Baseline clinical data were collected. Multivariable logistic regression identified independent associations between pre-treatment markers and PVT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PVT+ was identified in 65 patients (34%). In multivariable analysis, higher admission National Institutes of Health Stroke Scale (NIHSS) scores (adjusted odds ratio [aOR], 1.05 per point; 95% confidence interval [CI], 1.01–1.11; <i>P</i>  =  0.028) and male sex (aOR, 1.98; 95% CI, 1.03–3.89; <i>P</i>  =  0.043) were independently associated with PVT+.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Higher admission NIHSS scores and male sex are independently associated with PVT in anterior circulation AIS-LVO, suggesting that readily available clinical markers may help identify patients with poor VO profiles.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A [123I]-CLINDE-SPECT Study","authors":"Per Jensen,&nbsp;Brice Ozenne,&nbsp;Per Meden,&nbsp;Ling Feng,&nbsp;Gerda Thomsen,&nbsp;Lars Knudsen,&nbsp;Henrik Steglich-Arnholm,&nbsp;Kirsten Møller,&nbsp;Carsten Thomsen,&nbsp;Claus Svarer,&nbsp;Vincent Beliveau,&nbsp;Jens Mikkelsen,&nbsp;Gitte Knudsen,&nbsp;Lars H Pinborg","doi":"10.1111/jon.70002","DOIUrl":"10.1111/jon.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>This study aims to investigate the longitudinal changes in translocator protein (TSPO) following stroke in different brain regions and potential associations with chronic brain infarction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twelve patients underwent SPECT using the TSPO tracer 6-Chloro-2-(4ʹ-123I-Iodophenyl)-3-(<i>N</i>,<i>N</i>-Diethyl)-Imidazo[1,2-a]Pyridine-3-Acetamide, as well as structural MRI, at 10, 41, and 128 days (median) after ischemic infarction in the middle cerebral artery. TSPO expression was measured in lesional (MRI lesion and SPECT lesion), connected (pons and ipsilesional thalamus), and nonconnected (ipsilesional cerebellum and contralesional occipital cortex) regions. Correlations were explored between the volume of chronic infarction and TSPO expression in nonconnected regions of interest (ROIs) at 128 days</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Throughout the study period, TSPO levels decreased by 24%–33% in lesional ROIs, while levels increased in connected ROIs by 35%–69% and in nonconnected ROIs by 53%–77%. At 128 days poststroke, TSPO expression in ipsilesional cerebellum positively correlated with chronic infarction volume (<i>p</i> = 0.001, <i>r</i>² = 0.78).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study expands the current knowledge of spatial and temporal TSPO expression in humans by quantifying TSPO changes in lesional, connected, and nonconnected brain regions at three time points after cerebral infarction as well as correlating late-stage TSPO upregulation and chronic infarction volume.</p>\u0000 \u0000 <p>[Correction added on January 29, 2025, after first online publication: The p and r2 values in the results section of the abstract have been corrected in this version].</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143056051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing Quantitative Analysis of CSF Volume from Clinical T1-Weighted MRI to Predict Thrombectomy Outcomes","authors":"Mohammad I. Kawas,&nbsp;Ahmad Shamulzai,&nbsp;Kyle M. Atcheson,&nbsp;Alex C. Horn,&nbsp;Renate Ma,&nbsp;Carol Kittel,&nbsp;Brian Curry,&nbsp;Megan Lipford,&nbsp;Jeongchul Kim,&nbsp;Kiran K. Solingapuram Sai,&nbsp;Stacey Q. Wolfe,&nbsp;Christopher T. Whitlow","doi":"10.1111/jon.70013","DOIUrl":"10.1111/jon.70013","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Endovascular thrombectomy (EVT) is the standard for acute ischemic stroke from large vessel occlusion, but post-EVT functional independence varies. Brain atrophy, linked to higher cerebrospinal fluid volume (CSFV), may affect outcomes. Baseline CSFV could predict EVT benefit by assessing brain health. We aimed to quantify total CSFV from clinical T1-weighted (w) magnetic resonance imaging (MRI) to assess global brain atrophy and its association with functional outcomes following successful EVT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a retrospective analysis of patients achieving thrombolysis-in-cerebral-infarction ≥2b revascularization via prospectively maintained single-institution stroke thrombectomy registry (<i>n</i> = 432) between 2015 and 2021. We included 214 patients (mean age 67.5 ± 14.6, 49% female) with acceptable quality MRI within 14 days of EVT and available modified Rankin-scale (mRS) at 90 days post EVT. Clinical T1w images were transformed into high-resolution images using the convolutional neural-network SynthSR. FreeSurfer software was then used to estimate total cranial CSFV. To correct for head size, percentage of CSFV to intracranial volume was used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Baseline CSFV% significantly predicted 90-day mRS in an ordinal regression model adjusted for baseline mRS (<i>p </i>&lt; 0.001). Further modeling was performed to account for age, sex, 24-h National-Institutes-Health-Stroke-Scale (NIHSS), smoking history, prior stroke, hypertension, congestive heart failure, hemoglobin-A1c, atrial fibrillation, and Alberta-Stroke-Program-Early-CT-Score (ASPECTS). Total CSFV% remained an independent predictor of 90-day mRS (<i>p</i> = 0.012). CSFV% did not significantly predict the occurrence of any type of hemorrhagic transformation in a logistic regression model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Increased CSFV% correlates with poorer functional outcomes post EVT. Total CSFV% may serve as a useful imaging biomarker for clinicians determining patient prognostication prior to EVT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial Doppler Arterial Pressure Gradient Is Associated With Delayed Infarction After Subarachnoid Hemorrhage","authors":"Yongwoo Kim,&nbsp;Alexander Kim,&nbsp;Josef D. Williams,&nbsp;Charles Withington,&nbsp;Eshetu Tefera,&nbsp;Samrawit Gizaw,&nbsp;Daniel R. Felbaum,&nbsp;Jeffrey C. Mai,&nbsp;Ai-Hsi Liu,&nbsp;Rocco A. Armonda,&nbsp;Jason J. Chang","doi":"10.1111/jon.70010","DOIUrl":"10.1111/jon.70010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>While the pulsatility index (PI) measured by transcranial Doppler (TCD) has broader associations with outcomes in neurocritical care, its use in monitoring delayed cerebral infarction (DCI) in patients with aneurysmal subarachnoid hemorrhage (SAH) is not endorsed by current clinical guidelines. Recognizing that arterial pressure gradient (Δ<i>P</i>) can be estimated using PI, we investigated the potential significance of TCD-estimated Δ<i>P</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this observational study of 186 SAH patients, we recorded the mean cerebral blood flow velocity (mCBFV) and PI values from the middle cerebral artery, along with corresponding blood pressures. Using a previously reported mathematical model, we estimated Δ<i>P</i> by dividing pulse pressure by PI. We investigated the association between Δ<i>P</i> and mCBFV values and two acute phase complications of SAH—DCI and angiographic vasospasm. Additionally, we explored the association between DCI, vasospasm, and 90-day functional outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Elevated Δ<i>P</i> was associated with DCI (odds ratio [OR] 1.021, 95% confidence interval [CI] 1.004–1.039, <i>p</i> = 0.014) but not vasospasm (OR 1.006, 95% CI 0.991–1.022, <i>p</i> = 0.402). Elevated mCBFV was associated with vasospasm (OR 1.037, 95% CI 1.017–1.057, <i>p</i> &lt; 0.001) but not DCI (OR 0.998, 95% CI 0.979–1.018, <i>p</i> = 0.873). DCI (OR 29.380, 95% CI 2.930–294.615, <i>p</i> = 0.004), rather than vasospasm (OR 0.695, 95% CI 0.120–4.043, <i>p</i> = 0.686), was associated with functional outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Increased Δ<i>P</i>, rather than elevated mCBFV, was associated with DCI. While elevated mCBFV was associated with vasospasm, it was not associated with DCI. Hence, TCD-estimated Δ<i>P</i> may serve as a predictor for the DCI in SAH patients, a condition that impacts long-term outcome.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distal Access Catheter Improves Balloon Guide and Stent Retriever Thrombectomy Outcomes in Nonagenarians","authors":"Josep Puig,&nbsp;Mariano Werner,&nbsp;Guillem Dolz,&nbsp;Alejandro Pascagaza,&nbsp;Pepus Daunis-i-Estadella,&nbsp;Marc Comas-Cufí,&nbsp;Eva González,&nbsp;Jon Fondevila,&nbsp;Pedro Vega,&nbsp;Eduardo Murias,&nbsp;Veredas Romero,&nbsp;Carlos Martínez,&nbsp;Fernando Aparici-Robles,&nbsp;Lluis Morales-Caba,&nbsp;Sebastià Remollo,&nbsp;Isabel Rodríguez-Caamaño,&nbsp;Carlos Pérez-García,&nbsp;Santiago Rosati,&nbsp;Saima Bashir,&nbsp;Isabel Vielba-Gomez,&nbsp;Sonia Aixut,&nbsp;Andrés Julian Paipa,&nbsp;Javier Martínez-Fernández,&nbsp;Yeray Aguilar,&nbsp;Eduardo Fandiño,&nbsp;Giorgio Barbieri,&nbsp;Blanca García-Villalba,&nbsp;Víctor Cuba,&nbsp;Miguel Castaño,&nbsp;Jordi Blasco,&nbsp;ROSSETTI Group","doi":"10.1111/jon.70012","DOIUrl":"10.1111/jon.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>The safety and effectiveness of endovascular techniques in elderly patients with large vessel occlusion (LVO) remain controversial. We investigated the angiographic and clinical outcomes of nonagenarians treated with different endovascular techniques using a balloon guide catheter (BGC), distal aspiration catheter (DAC), and/or stent retriever (SR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed the data from the Registry of Combined versus Single Thrombectomy Techniques (ROSSETTI) of consecutive nonagenarian patients with anterior circulation LVO and compared the outcomes of those treated with BGC+noDAC+SR (101-group), BGC+DAC+SR (111-group), and noBGC+DAC+SR (011-group). Demographic, clinical, angiographic, and clinical outcome data (National Institute of Health Stroke Scale score at 24 h [24h-NIHSS] and modified Rankin Scale score at 3 months) were compared. Predictors of the first-pass effect (FPE), defining Modified Treatment In Cerebral Ischemia 2c-3 (mTICI 2c-3) after one pass, were explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 4111 patients from the ROSSETTI registry, 243 nonagenarians (68.7% female) were included in the analysis. The distribution of endovascular techniques was 101-group (61.4%), 111-group (15.6%), and 011-group (23%). The 101-group and 111-group had significantly shorter procedural times than the 011-group. The 111-group had a higher FPE rate, a lower number of passes, and a higher rate of final mTICI ≥2c than the other groups. The 24h-NIHSS score was significantly lower in the 111-group. In multivariate analysis, the only independent predictor for FPE was the BGC+DAC+SR endovascular technique (odds ratio 2.74 [confidence interval 1.16–6.47]; <i>p</i> = 0.021).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The addition of a DAC to a BGC increases the likelihood of FPE in nonagenarians with anterior circulation LVO SR-based thrombectomy for acute stroke.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Serotonergic and Dopaminergic Binding: Impact on Parkinson's Disease Progression and Levodopa Dyskinesia","authors":"Eun Hye Jeong,&nbsp;Jae Yong Lee,&nbsp;Yoo Sung Song","doi":"10.1111/jon.70014","DOIUrl":"10.1111/jon.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>We investigated the relationship between serotonergic and dopaminergic specific binding transporter ratios (SBRs) over 4 years in Parkinson's disease (PD) patients. We assessed serotonergic innervation's potential compensatory role for dopaminergic denervation, association with PD symptoms, and involvement in the development of levodopa-induced dyskinesia (LID).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>SBRs of the midbrain and striatum were evaluated from [I-123] <i>N</i>-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane SPECT images at baseline and after 4 years. Correlations between SBRs and PD symptoms were analyzed, alongside interval changes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Study included 177 PD patients (110 males, 67 females; mean age 61.0 ± 9.0 years). Significant worsening was observed in Hoehn and Yahr staging and Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part II and III scores over 4 years (<i>p</i> &lt; 0.05, <i>p</i> &lt; 0.001, and <i>p</i> &lt; 0.001, respectively). SBRs of the caudate, putamen, and midbrain declined significantly (<i>p</i> &lt; 0.001). Midbrain and striatal SBRs correlated significantly at both baseline and 4-year follow-up (<i>p</i> &lt; 0.0001). Striatal SBRs correlated significantly with MDS-UPDRS II and III scores at both time points, while midbrain SBRs correlated with changes in MDS-UPDRS III scores over the 4 years (<i>p</i> &lt; 0.01). Putamen and midbrain SBRs at 4 years were significantly lower in patients who developed LID compared to those who did not (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study demonstrates correlations between midbrain and putamen SBRs and MDS-UPDRS scores over 4 years in PD patients. Midbrain serotonin dysfunction may contribute to the development of LID.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Pediatric Posterior Fossa Tumor Treatments on Working Memory Tracts Using Resting-State fMRI and Tractography","authors":"Abir Troudi Habibi,&nbsp;Ines Ben Alaya,&nbsp;Fatima Tensaouti,&nbsp;Eloïse Baudou,&nbsp;Germain Arribarat,&nbsp;Lisa Pollidoro,&nbsp;Patrice Péran,&nbsp;Yves Chaix,&nbsp;Salam Labidi,&nbsp;Anne Laprie","doi":"10.1111/jon.70007","DOIUrl":"10.1111/jon.70007","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Working memory, a primary cognitive domain, is often impaired in pediatric brain tumor survivors, affecting their attention and processing speed. This study investigated the long-term effects of treatments, including surgery, radiotherapy (RT), and chemotherapy (CT), on working memory tracts in children with posterior fossa tumors (PFTs) using resting-state functional MRI (rs-fMRI) and diffusion MRI tractography.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 16 medulloblastoma (MB) survivors treated with postoperative RT and CT, 14 pilocytic astrocytoma (PA) survivors treated with surgery alone, and 16 healthy controls from the Imaging Memory after Pediatric Cancer in children, adolescents, and young adults study (NCT04324450). Working memory tracts were identified by combining seed masks from rs-fMRI maps and whole-brain tractography from diffusion MRI. Connectivity alterations were assessed qualitatively and quantitatively, alongside neuropsychological evaluations and correlations with behavioral outcomes and mean supratentorial dose.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to controls, MB survivors exhibited significant impairments in the working memory network, including reductions in tract volume (TV), fiber density, fiber cross-section (FC), mean streamline length (MLS), and fractional anisotropy (FA) (all <i>p</i> = 0.04). Lower working memory scores were correlated with reduced TV and FA in MB survivors. Higher mean supratentorial doses were associated with lower TV, FC, and FA values across multiple tracts, particularly in the arcuate and superior longitudinal fasciculi.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Tractography-derived features highlighted white matter damage as a biomarker of treatment-related neurotoxicity in PFTs survivors. These findings underscore the detrimental impact of RT and CT on working memory networks and emphasize the importance of preserving cognitive function during treatment planning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voxel-Based Morphometry and Subfield Volumetry Analysis Reveal Limbic System Involvement in Tinnitus","authors":"Sekwang Lee,&nbsp;Sung-Bom Pyun,&nbsp;Youngbo Sim,&nbsp;Sangwon Um,&nbsp;Woo-Suk Tae,&nbsp;Eui-Cheol Nam","doi":"10.1111/jon.70008","DOIUrl":"10.1111/jon.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Tinnitus is a condition in which individuals perceive sounds, such as ringing or buzzing, without any external source. Although the exact cause is not fully understood, recent studies have indicated the involvement of nonauditory brain structures, including the limbic system. We aimed to compare the volumes of specific brain structures between patients with tinnitus and controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Voxel-based morphometry and subfield volumetry were applied to analyze the brain structures of 53 patients with tinnitus and 52 age- and sex-matched controls. The volumes of the amygdala, hippocampus, and thalamus were measured and compared between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with tinnitus had larger volumes in the whole amygdala, basal nucleus, right lateral nucleus, and left paralaminar nucleus compared with controls. In addition, the subiculum head, left fimbria, and left presubiculum head in the hippocampus were larger in patients with tinnitus. No differences were found in the total thalamic volume or thalamic subnuclei between groups. The gray matter volumes in the thalamus, amygdala, and hippocampus were significantly high in the tinnitus group. The cortical thicknesses of both of the marginal branches of the cingulate sulcus, the left superior parietal lobule, and the left subparietal sulcus were also high in the tinnitus group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings indicate the involvement of the limbic system in tinnitus, and enhance our understanding of the condition. The subfield volumetry technique used in this study may aid in identifying the structural differences associated with specific neurological and psychiatric conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}