Journal of Natural Remedies最新文献

{"title":"Potency of Clitoria ternatea L. Ethanol Extract Against IFNγ and GLUT4 Protein in Type 2 Diabetes Mellitus Rat Model","authors":"Philips Onggowidjaja, R. Tjokropranoto, Richard Gunawan, Wahyu Widowati, Hanna Sari Widya Kusuma, Faradhina Salfa Nindya","doi":"10.18311/jnr/2024/32205","DOIUrl":"https://doi.org/10.18311/jnr/2024/32205","url":null,"abstract":"Diabetes Mellitus (DM) is a chronic disease caused by genetics, lifestyle, and immunology. Type 2 DM is caused by resistanceto insulin, which causes blood sugar to not be stored in glycogen. Clitoria ternatea L. (Fabaceae) flower contains a lot ofanthocyanins and has long been used in various traditional medicines. They are believed to treat fever, inflammation, anddiabetes. Anthocyanins have antidiabetic, anticancer, anti-inflammatory, and anticancer properties. This study aimed toevaluate anti-DM of Clitoria ternatea L. flower extract (CTE) in DM model rats with parameters such as liver weight ratio,IFNγ, and GLUT4 protein expression in pancreas and femoral muscle. Rats with a streptozotocin-induced (STZ) DM modelwere used to test the effects of oral administration of CTE at doses of 200, 400, and 800 mg/kg BW, glybenclamide (0.45mg/kg BW), and simvastatin (0.9 mg/kg BW). After blood sugar levels were >200 mg/dL, the rats were given various dosesof CTE and tested for protein expression of IFNγ and GLUT4 in femoral muscle by immunohistochemistry (IHC) method.Data analysis used ANOVA and continued with Tukey’s post hoc test. Results showed that CTE could increase liver ratiowhile decreasing IFNγ activation at CTE 400 mg/kg BW and upregulating GLUT4 at 400 mg/kg BW. CTE has an anti-DM activity potential for diabetes mellitus treatment due to its anthocyanin content.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139392399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Tea Made from Cissampelos sympodialis Leaves in the Treatment of Anxiety and Depression: A Controlled Clinical Trial","authors":"Liane Franco Barros Mangueira, Ricardo Andre Medeiros Negreiros, Cícero Flávio Soares Aragão, José Kenio de Sousa, Mayra Ferreira de Freitas Montenegro, João Bosco Guerreiro Da Silva, J. Barbosa-Filho, Margareth de Fátima Formiga Melo Diniz","doi":"10.18311/jnr/2024/34177","DOIUrl":"https://doi.org/10.18311/jnr/2024/34177","url":null,"abstract":"The species Cissampelos sympodialis Eichl. (CsE) is popularly used for its anti-inflammatory, bronchodilator and anti-allergiceffects. In preclinical studies, the plant has shown anxiolytic and antidepressant properties, which necessitated a controlledclinical trial to verify its effects in humans. A quasi-randomized study was developed in which the volunteers were divided intothree groups: CsE leaves tea (n = 21), auriculotherapy (n = 20) and no intervention (n = 19). The participants in the three groupsreceived weekly sachets of powdered dried leaves of CsE for tea preparation or auriculotherapy or did not receive intervention,respectively. At the beginning and end of the 5-week follow-up, the volunteers completed the following questionnaires: STAI-S,STAI-T, BDI and BAI. The phytochemical analysis of the sachet containing the powdered dried CsE leaves showed the presenceof alkaloids, steroids, tannins and flavonoids. In addition, the chromatographic analysis of CsE leaves identified the presence of7 chemical substances, for instance Malic Acid, α-L-Mannofuranose and Myo-Inositol. The STAI-S, STAI-T, BDI and BAI responsesshowed that the groups using tea or auriculotherapy showed significant reductions in mean scores in the two-way repeatedmeasures analysis of variance. In the no-intervention group, no significant differences were found on any scale. Applying the post-hoc test, the influence of the group on the initial or final variances of the STAI-S (p = 0.004), STAI-T (p = 0.005), BDI (p < 0.0005)and BAI (p = 0.011) data were tested, highlighting that the tea and auriculotherapy led to the decrease in the questionnairescores post-treatment. The tea of leaves of CsE proved, in this study, to be effective in decreasing the scores of STAI-S, STAI-T,BDI and BAI and could represent a new perspective of complementary treatment for the symptoms of anxiety and depression.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"344 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Curcumin in Gastric Carcinoma by Modulating the Immune System and its SAR","authors":"Akshay Kumar, C. Majee, R. Mazumder, Ruchi Sharma, Avijit Mazumder, Rashmi Mishra, Pankaj Wadhwa","doi":"10.18311/jnr/2024/34910","DOIUrl":"https://doi.org/10.18311/jnr/2024/34910","url":null,"abstract":"The second most prevalent cancer in the world and the fifth most common malignant tumour is gastric carcinoma. It is thought that several factors, including genetics, epigenetics, and environmental impacts, contribute to the development of gastric cancer. One of the main pathogenic variables associated with stomach cancer risk has been identified as inflammation. There are currently few methods to treat the gastric carcinoma. Therefore, an alternative plan is urgently needed. Explaining the importance of curcumin derived from Curcuma longa Linn. in stomach cancer is the goal of this review. According to recent research, Curcumin (CUR) has a great effect against stomach mucosal injury brought on by non-steroidal anti-inflammatory medicines, gastric mucosal injury in rats, stress haemorrhage, and Helicobacter pylori infection. In this review article, we have discussed the chemistry of CUR, the role of CUR in immunomodulation, and gastric cancer. We have also highlighted the various signalling pathway of gastric cancer where CUR work. By controlling miRNAs on gastric cancer and other relevant signal pathways, CUR exhibits notable anti-inflammatory and anti-cancer properties. In future there are more research work will be done on CUR.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Botanical Odyssey of Ipomoea carnea - A Revelatory Exploration of Taxonomy, Phytochemistry, Medicinal Horizons, and Ecological Reverberations","authors":"Vaishali D. Naphade, Dishant Gupta","doi":"10.18311/jnr/2024/34864","DOIUrl":"https://doi.org/10.18311/jnr/2024/34864","url":null,"abstract":"Ipomoea carnea is a prominent member of the Convolvulaceae family, known for its diverse phytochemical profile and potential therapeutic applications. This review provides a comprehensive analysis of the taxonomy, phytochemistry, medicinal uses, and ecological significance of Ipomoea carnea. The intricate relationship between its chemical constituents and bioactivities, along with its role in traditional medicine and its impact on local ecosystems, are discussed. The wealth of compounds present in this subspecies suggests promising avenues for further research and exploration.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"69 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139396022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Remedial Effects of Solanum nigrum Berries on Alopecia: An In Vivo Study","authors":"Arpan Chakraborty, A. Bhattacharjee, Manas Chakraborty, Goutam Mukhopadhyay, B. Mondal, A. Majumder, Mainak Chakraborty, Nilanjan Sarkar","doi":"10.18311/jnr/2024/34626","DOIUrl":"https://doi.org/10.18311/jnr/2024/34626","url":null,"abstract":"This study aimed to explore the ability of Solanum nigrum (S. nigrum) to stimulate hair growth. In this study, we investigated the effectiveness of two different extracts named methanol and petroleum ether from S. nigrum when applied topically. Hair loss was induced in Swiss albino rats by subcutaneously administering testosterone for 21 days. The extract was applied at the same time to assess its ability to prevent hair loss, and various measures such as follicle density, anagen/telogen (A/T) ratio, and skin section histology were monitored. Finasteride solution was used as a standard for topical application. The group treated with petroleum ether extract of S. nigrum showed noticeable hair regrowth, evidenced by increased (A/T) ratio, follicle density, and positive results in skin sections. The study’s findings suggest that the petroleum ether extract derived from S. nigrum shows potential in treating hair loss induced by testosterone in experimental animals.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":" 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139393027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the Potential of Herbal Therapy for Polycystic Ovarian Disorder","authors":"Kangkana Sharma, Nuri Farzina Rahman, Sahaniyaz Laskar, Sahjahan Ali, Md. A. Ahmed, Wearank Terang, Ningthoujam Dabung Meitei, Haider Khan, Md. Iliyash Ahamad, Akshay Kumar Haloi, Rituraj Bharadwaj","doi":"10.18311/jnr/2024/34761","DOIUrl":"https://doi.org/10.18311/jnr/2024/34761","url":null,"abstract":"Polycystic Ovarian Disorder is among the most well-known hormonal diseases influencing many women overall prompting the development of cysts on the ovaries. Albeit, the specific ground for its improvement isn’t very much revealed till now, however a mix of hereditary, ecological and way of life factors were considered as noticeable contributing variables for its development and advancement. The ongoing treatments for polycystic ovarian disorder incorporate a way of life alteration, utilization of oral contraceptives, anti-androgen therapy and insulin-sensitizing agents, ovulation induction and assisted reproductive technologies. Even though these ongoing treatments are well dependent to some degree in females enduring polycystic ovarian issues, various secondary effects are being accounted for to be related to these treatments. Herbal treatment could be an option for polycystic ovarian problems as it offers compelling recuperation with immaterial aftereffects. Herbal treatment frequently focuses on the main driver of the sickness instead of alleviating symptoms, expecting to re-establish general well-being and prosperity. In this ongoing review, we have compiled the purposes of specific spices for the treatment of polycystic ovarian disorders including cinnamon, fenugreek, gymnema, saw palmetto, spearmint, liquorice, turmeric and berberine - containing plants. These plants were accounted for too effective against polycystic ovarian disorder with their system of activity as portrayed. Escalated research on these plants will clear many new courses towards the advancement of medication disclosure and medication plans for the powerful treatment of polycystic ovarian issues.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":" 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139392484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cocos nucifera Linn.: A Promising Candidate for Drug Development","authors":"Bijesh Vatakkeel, R. Mythreyi, E. N. Siju","doi":"10.18311/jnr/2024/34866","DOIUrl":"https://doi.org/10.18311/jnr/2024/34866","url":null,"abstract":"Cocos nucifera Linn. (Arecaceae) is a common palm found in different parts of the world and is consumed for various purposes, especially food and oil. It is widely used as a nutraceutical globally. Cocos nucifera has a wide range of conventional medical applications in inflammation, protozoal and microbial infection, cancer, hepatic illness, diabetes, mellitus, pain, epilepsy, fungal infection, and depression. Different parts of C. nucifera like leaves, flowers, roots, oil, and cotyledon were explored for scientific authentication in various illnesses. The presence of phytochemicals like amino acids (lauric acid, arginine, caprylic acid, linoleic acid and palmitic acid), vitamin C, saponins, phenols, terpenoids, phenolics, and tannins were reported in C. nucifera and this knowledge further hint for hidden pharmacological activities. This paper presents a review of the phytopharmacological activities of C. nucifera so that it may be used for developing a promising herbal candidate for the drug discovery process.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"24 S52","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139393908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Achyranthes bidentata Root Extract Based Herbal-insecticide","authors":"Nuri Farzina Rahman, Kangkana Sharma, Sahaniyaz Laskar, Sahjahan Ali, Md. Asif Ahmed, Wearank Terang, Ningthoujam Dabung Meitei, Haider Khan, Md. Iliyash Ahamad, Rituraj Bharadwaj","doi":"10.18311/jnr/2024/34759","DOIUrl":"https://doi.org/10.18311/jnr/2024/34759","url":null,"abstract":"Pesticides are the chemicals most commonly used by humans in the production of many foods worldwide. Most of thepesticides are chemical derived which not only causes different diseases in the human population rather affects the environment too. The natural pesticide obtained from plant-based sources can be considered as an alternative. Achyranthes bidentata is chosen for this current study to formulate an effective pesticide based on plant origin. The root extract of A. bidentata has been prepared and it has been subjected to its phytochemical screening. The functional group presentin the extract has been determined by using FTIR and the volatile constituents have been detected by using GCMS. Theinsect-repellent property of the extract has been investigated using weevil and found to be efficacious. FTIR analysisshowed hydroxyl, amine, amide, carbonyl, nitrile, alkanes, alkenes and nitro groups, while GCMS analysis showed benzene,1-phenyl ethyl alcohol, limonene, toluene. In the insect repellent study, it has been found that A 3% to 15% concentration of A. bidentata extract and duration time of 24, 48 and 72 hours caused 88.33% grain weevils after 72 hours at 10% extractconcentration. It can be concluded from the performed studies that, A. bidentata root extract can be effectively used as aninsecticide for agricultural purposes.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"326 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic Management of Bell’s Palsy - A Case Report","authors":"Aiswarya Krishna, Mayur V. Shiralkar, Anand Kale, Pallavi Jagtap, Santosh Rahinj, Shubhangi Kale","doi":"10.18311/jnr/2024/34447","DOIUrl":"https://doi.org/10.18311/jnr/2024/34447","url":null,"abstract":"Background: Bell’s palsy is a sudden and unexplained condition characterized by temporary weakness or paralysis of one side of the face or the areas supplied by the facial nerve, resulting from the paralysis of the peripheral facial nerve. It can be caused by various factors varying from trauma, infection, ischemia, or inflammation that affects the seventh cranial nerve. In Ayurveda, Bell’s palsy can be compared to Ardita Vata, a condition described within the realm of Vatavyadhi Chapter mentioned in various Samhitas and its treatment has also been explained in detail in Samhitas. Aim and Objectives: The effectiveness of different Kriyakalpa techniques, as well as oral medication, was studied and observed in detail in this medical study by investigating a patient with Acute Bell’s palsy. The main goal was to assess the outcomes of these interventions which is a much better option than Allopathic steroids. Settings: A fresh case of Bell’s palsy that had occurred only 24 hours ago was treated at the outpatient Department of Shalakya Tantra OPD at Dr. D. Y. Patil College of Ayurved and Research Centre, Pimpri, Pune. The patient’s condition was evaluated before and after receiving the prescribed treatment. Treatment Plan: The individual received Mukhabhyanga (facial massage) with Mahamasha oil, Nadi Sweda (sweating therapy) with Dashamoola herbal decoction fumigation, Marsha Nasya (intranasal treatment) with Panchendriya vardhana oil, and Netratarpana with Ksheerabala oil for seven days in addition to Shamana medication for one month. Result: Significant progress was noted according to the House-Brackmann scale. Following 15 days of therapy, the scale decreased from IV to III, and subsequently to II and I after the 30th day of monitoring. Conclusion: This study demonstrates encouraging and speedy outcomes of Ayurvedic therapy by taking into account factors of Vatavyadhi, particularly Ardita Vata, without exhibiting any complexities.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":" 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139393298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhalation Therapy with Clerodendrum serratum Linn. Extract: An Experimental Study on Ovalbumin-induced Asthma in Rats","authors":"Lima Patel, Dimal Shah, Hitesh Chandpa, Avani Khristi, Puja Bhavsar","doi":"10.18311/jnr/2024/34453","DOIUrl":"https://doi.org/10.18311/jnr/2024/34453","url":null,"abstract":"Bronchial asthma is a chronic inflammatory condition marked by airway constriction, inflammation, and structural changes known as airway remodeling. Clerodendrum serratum Linn., a plant traditionally used in Ayurvedic medicine, has shown anti-inflammatory and bronchodilatory effects. This research work aims to study the potential anti-asthmatic properties of an inhalable formulation prepared from C. serratum extract in an ovalbumin-induced asthma rat model. The formulation was evaluated for its effects on serum leukocytes and eosinophils, mast cells, total tissue protein, airway inflammation, and histopathological changes in the lungs. The results showed that the inhalable formulation significantly reduced the symptoms of asthma in the rat model. The formulation led to a significant reduction in the levels of serum leukocytes and eosinophils, key indicators of asthma inflammation. It effectively stabilized mast cells, preventing their degranulation, and reducing airway reactivity. A decrease in total tissue protein levels was observed, suggesting reduced tissue damage associated with asthma. The formulation also demonstrated a substantial reduction in airway inflammation, as evidenced by histopathological changes in the lungs and reduced Th2 cytokines namely Tumour necrosis factor α and Interleukin 4, in bronchoalveolar lavage fluid. These effects may be attributed to the anti-inflammatory, mast cell stabilizing, and immunomodulatory properties of the formulation. The study provides scientific evidence supporting the traditional use of C. serratum in the treatment of asthma and demonstrates its potential as a therapeutic alternative for the treatment of respiratory diseases.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"96 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139393734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}