Journal of Nephropharmacology最新文献_第10页

New hope for treatment of respiratory involvement following COVID-19 by bromhexine 溴己新治疗新冠肺炎后呼吸道感染的新希望

Journal of Nephropharmacology Pub Date : 2020-08-12 DOI: 10.34172/npj.2021.11

Abdolrazagh Barzegar, M. Ghadipasha, N. Rezaei, M. Forouzesh, R. Valizadeh

引用次数: 20

The effects of sevelamer carbonate on blood glucose and inflammatory factors in patients with diabetic kidney disease; a controlled clinical trial 碳酸西维拉姆对糖尿病肾病患者血糖及炎症因子的影响对照临床试验

Journal of Nephropharmacology Pub Date : 2020-08-01 DOI: 10.34172/NPJ.2021.10

Shadi Botshekan, Leila Mahmoodnia, A. Momeni, T. Jafari, A. Hasanpour Dehkordi, Mohammadsaleh Ghafari Goosheh

{"title":"The effects of sevelamer carbonate on blood glucose and inflammatory factors in patients with diabetic kidney disease; a controlled clinical trial","authors":"Shadi Botshekan, Leila Mahmoodnia, A. Momeni, T. Jafari, A. Hasanpour Dehkordi, Mohammadsaleh Ghafari Goosheh","doi":"10.34172/NPJ.2021.10","DOIUrl":"https://doi.org/10.34172/NPJ.2021.10","url":null,"abstract":"\u0000 Introduction: Diabetic nephropathy (diabetic kidney disease) is a complication of diabetes that begins and progresses with several factors, including hyperglycemia, inflammation and oxidative stress. Objective: This study demonstrates the effect of sevelamer carbonate administration on hemoglobin A1c levels, blood sugar and inflammatory factors in diabetic nephropathy patients. Patients and Methods: In this clinical trial, 48 diabetic patients under treatment of least one drug who have proteinuria (urinary protein to creatinine ratio greater than 0.5) ≥ 2 times during the past 18 months, received sevelamer carbonate or placebo for two months. Patients’ blood samples were taken before and after the intervention. Data were analyzed by SPSS software. Results: According to the results, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) showed no significant difference between the study groups before and after the intervention (P>0.05). The mean ICAM-1(intercellular adhesion molecule-1) and VCAM-1 (vascular cell adhesion molecule1) showed no significant difference between the study groups before the intervention (P>0.05). However we found a meaningful difference after the intervention, which was significantly lower in the intervention group (P<0.05). Conclusion: Sevelamer carbonate administration in patients with diabetic nephropathy has a significant effect on decreasing ICAM-1 and VCAM-1 levels. Trial registration: The trial protocol was approved in the Iranian Registry of Clinical Trial (identifier: IRCT20191111045401N1; https://en.irct.ir/trial/43662, ethical code; IR.SKUMS. REC.1397.181).","PeriodicalId":16388,"journal":{"name":"Journal of Nephropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44229039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucoherb versus metformin on glycemic markers and glycosylated hemoglobin in prediabetes patients; a clinical trial study 葡糖和二甲双胍对糖尿病前期患者血糖标志物和糖化血红蛋白的影响；临床试验研究

Journal of Nephropharmacology Pub Date : 2020-07-24 DOI: 10.34172/npj.2021.08

Iman Izadi, Rahil Riahi Samani, Afsaneh Malekpour Tehrani, Marziyeh Dehghani, A. Jafari

引用次数: 1

The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial 远程缺血预处理对冠状动脉造影患者血清胱抑素C型急性肾损伤的疗效；随机对照试验

Journal of Nephropharmacology Pub Date : 2020-07-24 DOI: 10.34172/npj.2021.09

Azadeh Moradkhani, H. Samimagham, Mohammad Tamaddondar, Hossein Farshidi, M. Khayatian, Sanaz Soleimani

{"title":"The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial","authors":"Azadeh Moradkhani, H. Samimagham, Mohammad Tamaddondar, Hossein Farshidi, M. Khayatian, Sanaz Soleimani","doi":"10.34172/npj.2021.09","DOIUrl":"https://doi.org/10.34172/npj.2021.09","url":null,"abstract":"Introduction: Contrast-induced acute kidney injury (CI-AKI) is a known complication of cardiac interventions. Remote ischemic preconditioning (RIPC) is a non-pharmacological method which has a nephroprotective effect. Serum cystatin C (CysC) is a suitable biomarker for the early diagnosis of AKI. Objectives: This study aimed to evaluate the incidence of CI-AKI after RIPC in patients undergoing coronary angiography, through assessment of CysC. Patients and Methods: Around 140 patients with stable coronary artery disease undergoing angiography were randomly allocated to two groups of RIPC and control groups. In each group, the following biomarkers were assessed: serum creatinine (Cr) and CysC at baseline, 24-hour and 48-hour serum Cr and 24-hour CysC. The endpoint was the development of AKI based on either the KDIGO criteria or a 15% increase in serum CysC. Results: No significant difference was observed between two groups regarding the incidence of AKI according to either KIDIGO criteria or by the increase of serum CysC (P =0.116 and P =0.392, respectively). Moreover, a 46.99% increase in CysC level was observed among patients with AKI during the first 24 hours after the procedure, while at the same interval, it increased only 16.01% in patients without AKI. Conclusion: RIPC with three cycles of 5-minute ischemia and 5-minute reperfusion, did not decrease serum CysC based CI-AKI or alter renal biomarkers course in patients with low risk, who underwent coronary angiography.","PeriodicalId":16388,"journal":{"name":"Journal of Nephropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47602707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons of mortality following COVID-19 epidemic in the United States especially in the geriatrics COVID-19在美国流行后死亡率的教训，特别是在老年病学

Journal of Nephropharmacology Pub Date : 2020-07-24 DOI: 10.34172/npj.2021.06

M. Daneshfar, N. Dadashzadeh, M. Ahmadpour, H. Haghi, Rahmani Vahid, M. Forouzesh, R. Valizadeh

{"title":"Lessons of mortality following COVID-19 epidemic in the United States especially in the geriatrics","authors":"M. Daneshfar, N. Dadashzadeh, M. Ahmadpour, H. Haghi, Rahmani Vahid, M. Forouzesh, R. Valizadeh","doi":"10.34172/npj.2021.06","DOIUrl":"https://doi.org/10.34172/npj.2021.06","url":null,"abstract":"COVID-19 is spreading all around the world, and is considered as the most widespread infectious disease of the century Coronavirus transmits through respiratory droplets when in close contact with the infected person Therefore, populous places are more likely to be the source of the novel coronavirus that is threatening the health of everyone especially the geriatric population This study aimed to compare the transmission of coronavirus between metropolitan and non-metropolitan counties as lessons of mortality (especially in geriatric) following COVID-19 epidemic The USAFact org public website (https://usafacts org/visualizations) was used to determine the transmission between metro and non-metropolitan counties In this study, four different time periods were considered for the COVID-19 incremental trend (April 1, May 1, June 1, and July 1, 2020) The number of cases was determined per each 10,000 population Yellow color means no case in the metropolitan county (metro) Orange color means less than 10 cases/10,000 of the population in metro Figure and maps were used to show the objectives of the study In metropolitan counties, the spread of COVID-19 is very fast, which is significantly different from the non-metro counties (P 0 001) The results show the sharp increasing trend of infected people in metropolitan counties In metropolitan counties the number of infected people reached 2 420 316 cases per 10 000 populations but the number of infected people reached 231 459 cases per 10 000 populations Over the four months period, the frequency of the light colors was decreased According to the results, susceptible people especially the elderly should move to non-metropolitan counties during the COVID-19 pandemic to be less likely at risk © 2021 The Author(s)","PeriodicalId":16388,"journal":{"name":"Journal of Nephropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46423091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Glomerulonephritis associated with SARS-CoV-2 infection 与严重急性呼吸系统综合征冠状病毒2型感染相关的肾小球肾炎

Journal of Nephropharmacology Pub Date : 2020-07-24 DOI: 10.34172/npj.2021.07

M. Akhavan Sepahi, B. Lakkakula, B. Roshan, Banafsheh Yalameha

引用次数: 0

An overview of complications associated with deferoxamine therapy in thalassemia 地中海贫血中去铁胺治疗相关并发症的综述

Journal of Nephropharmacology Pub Date : 2020-07-17 DOI: 10.34172/npj.2021.05

B. Keikhaei, Neda Farmani-Anooshe, M. Bahadoram, M. Mahmoudian-sani, K. Alikhani, A. Helalinasab

引用次数: 3

Comparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery 冠状动脉搭桥术患者尿KIM-1、NGAL及血浆肌酐的比较

Journal of Nephropharmacology Pub Date : 2020-06-25 DOI: 10.34172/npj.2021.04

Maryam Saeedi Ghaheh, Saeed Mardani, A. Malekpour, Farzaneh Kadkhodaei Elyaderani, Fatemeh Salehi Choliche, Nayereh Mortazavi, Shadi Botshekan

{"title":"Comparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery","authors":"Maryam Saeedi Ghaheh, Saeed Mardani, A. Malekpour, Farzaneh Kadkhodaei Elyaderani, Fatemeh Salehi Choliche, Nayereh Mortazavi, Shadi Botshekan","doi":"10.34172/npj.2021.04","DOIUrl":"https://doi.org/10.34172/npj.2021.04","url":null,"abstract":"Introduction: Serum creatinine level is currently being used as an indicator to detect acute kidney injury (AKI) after cardiac surgery, which is delayed and unreliable. Objectives: This study was conducted to determine the AKI in patients undergoing coronary artery bypass graft (CABG) surgery by measurement of urinary creatinine and plasma kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Patients and Methods: In this cross-sectional study, 96 patients undergoing CABG were divided based on their serum creatinine level of the fourth day after procedure into two groups of AKI (an increase of creatinine more than 0.3 mg/dl or more than 150 % of its baseline level) and non-AKI. In both groups urinary KIM-1 and urinary NGAL were measured on the first day of surgery (first 24 h). Results: No significant difference was observed in baseline creatinine between the two groups (P>0.05). However postoperative serum creatinine, creatinine changes, urinary NGAL and KIM1 showed significant difference between the groups (P<0.05). Serum creatinine was positively correlated with KIM-1 (r = 0.666, P<0.001) and NGAL (r = 0.660, P<0.001). KIM-1 and NGAL had high ability to detect AKI [area under the ROC (receiver operating characteristic) curve of 0.929 and 0.838, respectively]. The NGAL at cut-off point of 97.4 had 86% sensitivity and 80% specificity and KIM-1 at cut-off point of 14.8 had 84% sensitivity and 89% specificity. Conclusion: KIM-1 and NGAL had high ability to detect AKI. However, KIM-1 had higher detection ability than that of NGAL.","PeriodicalId":16388,"journal":{"name":"Journal of Nephropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42723519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Herbal antioxidants and renal ischemic-reperfusion injury; an updated review 中药抗氧化剂与肾缺血再灌注损伤的关系最新的评论

Journal of Nephropharmacology Pub Date : 2020-05-28 DOI: 10.34172/npj.2021.03

Masoumeh Asgharpour, Audrey Tolouian, L. Bhaskar, R. Tolouian, Nilofar Massoudi

引用次数: 8

The impact of metformin in chronic kidney disease-mineral and bone disorder 二甲双胍对慢性肾脏疾病矿物质和骨骼障碍的影响

Journal of Nephropharmacology Pub Date : 2020-05-27 DOI: 10.34172/npj.2021.02

Rohollah Masumi, R. Tolouian, Audrey Tolouian, Leila Mohmoodnia

{"title":"The impact of metformin in chronic kidney disease-mineral and bone disorder","authors":"Rohollah Masumi, R. Tolouian, Audrey Tolouian, Leila Mohmoodnia","doi":"10.34172/npj.2021.02","DOIUrl":"https://doi.org/10.34172/npj.2021.02","url":null,"abstract":"Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a disorder of mineral and bone metabolism due to chronic kidney disease (CKD). Bone disease and mortality are more common in patients with CKD. In addition of antidiabetic properties of metformin (MET), it possesses anti-inflammatory, anti-fibrotic properties and increases the markers of osteogenic effects. Therefore, it improves bone quality and decreases the risk of fractures in patients with type 2 diabetes. Metformin can also inhibit arterial calcification, maintain calcium-phosphorus balance, decrease cellular infiltration, fibrosis, and inflammation in kidney. Based on evidence, the prevalence of lactic acidosis due to metformin in patients with type 2 diabetes (T2D) and renal dysfunction is lower compared to other oral antidiabetic agents. Metformin decreases all-cause mortality in patients with diabetic nephropathy. The administration of metformin showed no difference in the prevalence of lactic acidosis in patients with T2D who had normal, mild, moderate, or severe renal dysfunction. Therefore, metformin can be used in patients with significant CKD to inhibit CKD-MBD due to its osteogenic effects.","PeriodicalId":16388,"journal":{"name":"Journal of Nephropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47267975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0