Journal of Natural Science, Biology, and Medicine最新文献_第3页

Retention and caries preventive effect of GC fuji VII sealant on the first permanent molars among high-risk residential school children - A three year follow up study GC富士7型密封胶对高危寄宿学校儿童第一恒磨牙固位及龋预防效果的三年随访研究

Journal of Natural Science, Biology, and Medicine Pub Date : 2021-07-01 DOI: 10.4103/jnsbm.JNSBM_154_20

B. Godhi, R. Shanbhog, B. Nandlal, S. Rashmi, A. Gopi

{"title":"Retention and caries preventive effect of GC fuji VII sealant on the first permanent molars among high-risk residential school children - A three year follow up study","authors":"B. Godhi, R. Shanbhog, B. Nandlal, S. Rashmi, A. Gopi","doi":"10.4103/jnsbm.JNSBM_154_20","DOIUrl":"https://doi.org/10.4103/jnsbm.JNSBM_154_20","url":null,"abstract":"Objective: The objective of the study is to seal the permanent first molars in high-risk children aged 7–8 years with GC Fuji VII and evaluate its retention and caries preventive effect over 3 years. Methodology: The present study was a longitudinal, randomized, interventional trial with a sealant and control group. 538 residential schoolchildren with high caries risk received sealants. 495 day scholars did not receive sealant formed the control group. Children of both the groups were evaluated annually for sealant retention and development of caries for 3 years. Independent sample t-test and Chi-square test were used to compare the sealant retention and caries incidence rates. Kaplan–Meier survival analysis and log-rank test were performed to compare the cumulative molar survival and sealant retention rates over 3 years. Results: Comparison of baseline oral health characteristics between sealant and control group revealed no statistically significant variation (P > 0.05). At the end of 3 years, total retention was 43.4% (n = 178), 45.9% (n = 188), 44.9% (n = 184), and 44.4% (n = 182), respectively. Cumulative mean incidence of dental caries at the end of 3 years showed statistically significant higher caries incidence among control 2.15 ± 3.33 as compared to sealant 0.25 ± 0.85 with mean difference of 1.90 (P = 0.001). Conclusion: School-based sealant program targeting low socioeconomic, high caries risk population can form comprehensive approach for caries-free generation. GC Fuji VII may be a better choice for preventing dental caries in school-based sealant program.","PeriodicalId":16373,"journal":{"name":"Journal of Natural Science, Biology, and Medicine","volume":"72 1","pages":"155 - 160"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80444925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Lipoprotein(a) as a risk factor for atherosclerotic peripheral arterial occlusive disease 脂蛋白(a)作为动脉粥样硬化性外周动脉闭塞性疾病的危险因素

Journal of Natural Science, Biology, and Medicine Pub Date : 2021-07-01 DOI: 10.4103/jnsbm.JNSBM_139_20

B. Kothari, Kallale Bhagavan, L. Lobo, Nawin Kumar, A. Shetty, Kalikivayi Naresh

{"title":"Lipoprotein(a) as a risk factor for atherosclerotic peripheral arterial occlusive disease","authors":"B. Kothari, Kallale Bhagavan, L. Lobo, Nawin Kumar, A. Shetty, Kalikivayi Naresh","doi":"10.4103/jnsbm.JNSBM_139_20","DOIUrl":"https://doi.org/10.4103/jnsbm.JNSBM_139_20","url":null,"abstract":"Background and Aim: Peripheral arterial occlusive disease (PAOD) commonly results from progressive narrowing of arteries in the lower extremities due to atherosclerosis. The objective of this study was to measure plasma levels of Lipoprotein (a) (Lp[a]) in patients with and without clinical evidence of PAOD and find an association (risk ratio) between Lp(a) and PAOD. Materials and Methods: This study was conducted in the Department of General Surgery at Justice K. S. Hegde Charitable Hospital, Mangalore. The age and sex of the patients, clinical symptoms were noted. The study included a total of 100 patients further divided into two groups: Fifty symptomatic patients with clinical evidence and 50 age and sex-matched asymptomatic patients without clinical evidence of PAOD. History of hypertension, diabetes mellitus, and ischemic heart disease were recorded. The diagnosis basically was made by clinical symptoms and signs. Arterial Doppler/computed tomography angiogram was done only if symptoms or signs of PAOD were present. Two ml of overnight fasting blood sample was collected, serum separated, and was analyzed for Lp(a) by immune turbidometry method. Results: In patients with PAOD, Lp(a) value was 90.06 ± 23.4 mg/dl, whereas among patients without PAOD, Lp(a) values was 48.02 ± 24.1 mg/dl and was statistically significant (P < 0.001). Patients with elevated Lp(a) levels were found to have 13.50 times higher risk of developing PAOD as compared to patients with normal Lp(a) levels. As per the ROC curve analysis, with area under the curve of 0.895 th cutoff value was considered to be 69.8 mg/dl with sensitivity of 88% and specificity of 76%. Conclusion: Males are at a higher risk of developing PAOD as compared to females. Patients within the age group of 51–60 years are more prone to develop PAOD as per this study. From the study results, it was found that there is a high association of patients with PAOD and elevated Lp(a) as compared to other risk factors.","PeriodicalId":16373,"journal":{"name":"Journal of Natural Science, Biology, and Medicine","volume":"10 1","pages":"218 - 223"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82075837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using biodentine for non-surgical endodontic re-treatment of maxillary central incisor associated with severe external apical root: A case report with 2-years follow-up 生物牙本质汀用于上颌中切牙合并严重外根根的非手术根管再治疗1例，随访2年

Journal of Natural Science, Biology, and Medicine Pub Date : 2021-07-01 DOI: 10.4103/jnsbm.jnsbm_47_21

P. Gehlot, Brinda Murali, B. Annapoorna, Krishna Prasada

引用次数: 0

Clinical evaluation of acute respiratory distress and chest wheezing in infants 婴幼儿急性呼吸窘迫及胸哮的临床评价

Journal of Natural Science, Biology, and Medicine Pub Date : 2021-07-01 DOI: 10.4103/jnsbm.JNSBM_98_20

G. Joag, Megha Rustagi

{"title":"Clinical evaluation of acute respiratory distress and chest wheezing in infants","authors":"G. Joag, Megha Rustagi","doi":"10.4103/jnsbm.JNSBM_98_20","DOIUrl":"https://doi.org/10.4103/jnsbm.JNSBM_98_20","url":null,"abstract":"Background: Differentiating acute respiratory distress and wheezing in infants is difficult due to similar clinical presentations. Therefore, it is of utmost importance to diagnose and differentiate bronchopneumonia, bronchiolitis, and bronchial asthma on the basis of clinical parameters in infants. Materials and Methods: One hundred infants with fever, cough, and increased respiratory distress with wheezing were included, and detailed clinical history, allergic disorder, immunization status were collected. Study cases were diagnosed as bronchopneumonia, bronchiolitis, or bronchial asthma based on clinical criteria, and a suitable treatment regimen was provided. Chi-square test, Fisher's exact test, and two-sample proportion test were used to analyze the data. Results: Among 100 cases, 50% of cases were of bronchopneumonia, whereas 36% and 14% of cases were of bronchiolitis and bronchial asthma. A significant difference was observed among them for the history of wheezing (P = 2.839e-12), presentation of various signs and symptoms (P = 0.00), and treatment regimens. The odds of occurrence of bronchopneumonia was more with the signs of flaring of alae nasi and palpable liver (OR=[0.62–4.32]; and [0.63–4.14]). For bronchiolitis also, it was higher if they showed signs of tachycardia, pallor, and reduced breathing sounds (OR = [0.96–6.8679]; [0.44–2.76]; and [0.70–5.44]). Furthermore, for bronchial asthma, it was higher if it presented the signs of tachycardia, cyanosis, reduced breathing sounds, palpable spleen, etc., (OR = [0.90–16.18]; [1.93–36.50]; [0.43–6.92]; and [0.17–11.52]). Ampicillin and gentamicin treatment regimen for bronchopneumonia; salbutamol and intravenous fluids for bronchiolitis; and steroids and salbutamol for bronchial asthma were the choice of treatment. Conclusion: The study demonstrated the differential diagnosis of bronchopneumonia, bronchiolitis, and bronchial asthma based on clinical features and will be useful in the rational management of these conditions.","PeriodicalId":16373,"journal":{"name":"Journal of Natural Science, Biology, and Medicine","volume":"51 8 1","pages":"165 - 169"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91020048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of functional outcome of management of scaphoid waist fractures with herbert screw fixation 赫伯特螺钉内固定治疗舟状骨腰骨折的功能效果分析

Journal of Natural Science, Biology, and Medicine Pub Date : 2021-07-01 DOI: 10.4103/jnsbm.JNSBM_152_20

V. Thirunarayanan, T. Sivabalan, S. Cheralathan, M. Ravi, S. Shankar

{"title":"Analysis of functional outcome of management of scaphoid waist fractures with herbert screw fixation","authors":"V. Thirunarayanan, T. Sivabalan, S. Cheralathan, M. Ravi, S. Shankar","doi":"10.4103/jnsbm.JNSBM_152_20","DOIUrl":"https://doi.org/10.4103/jnsbm.JNSBM_152_20","url":null,"abstract":"Introduction: Fractures of the scaphoid bone mainly occur in young adults and constitute 70%–80% of all carpal bone fractures. The aim of our study was to assess the functional outcome of undisplaced and minimally displaced scaphoid fractures with percutaneous Herbert screw fixation. Materials and Methods: We conducted a prospective study from 2016 to 2018 including patients of more than 18 years of both sexes with waist fractures of scaphoid excluding avulsion fractures and compound injuries. The functional outcome of patients was assessed with the Modified Mayo Wrist Score (MMWS) at a minimum of 1-year follow-up. Results: Fifteen patients (M: F = 12:3) with a mean age of 39.4 years were enrolled in the study. The mean time to surgery after trauma was 5.75 days. Union was achieved in all the cases at a mean duration of 7.2 weeks; 93.3% (n = 14) of patients showed an excellent outcome, while the other 6.7% (n = 1) showed a good outcome with an average MMWS score of 92.6. Patients were able to reach this functional status as early as 3 months. The average duration of follow-up was 15 months. No major complications were encountered. Conclusion: Percutaneous Herbert screw fixation of scaphoid waist fractures provides excellent functional results enabling the patients to return to the preinjury status as early as 4 months without major complications.","PeriodicalId":16373,"journal":{"name":"Journal of Natural Science, Biology, and Medicine","volume":"1 1","pages":"193 - 197"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79616485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Merit of gait patterns for early detection of risk of falls among elderly participants: A comparative analysis from India 步态模式对早期检测老年人跌倒风险的价值:来自印度的比较分析

Journal of Natural Science, Biology, and Medicine Pub Date : 2021-07-01 DOI: 10.4103/jnsbm.jnsbm_38_21

V. Sengodan, Hisham Abubeker, A. Pillai

{"title":"Merit of gait patterns for early detection of risk of falls among elderly participants: A comparative analysis from India","authors":"V. Sengodan, Hisham Abubeker, A. Pillai","doi":"10.4103/jnsbm.jnsbm_38_21","DOIUrl":"https://doi.org/10.4103/jnsbm.jnsbm_38_21","url":null,"abstract":"Background: The aim of this study was to compare the gait patterns among Indian elderly participants with younger adults and to assess if altered gait patterns can predispose to trivial falls among the elderly. Materials and Methods: Three hundred and twenty healthy volunteers were recruited for this study, out of which 160 individuals were young (aged 15–30 years) and 160 individuals were elderly (aged 50–65 years) participants. The following three important gait characteristics, i.e. the stride length, foot clearance, and stride velocity were assessed at our 3D motion analysis laboratory. Results: The elderly participants had a significantly reduced stride length/velocity and foot clearance when compared to the young. Stride velocity although reduced among the elderly participants was however within the normal lower range. Conclusion: Significant reduction in foot clearance is likely to contribute to the higher incidence of falls among the elderly participants. A routine practice to assess these gait parameters in outpatient clinics can be helpful in early detection of the risk of fall among the elderly participants.","PeriodicalId":16373,"journal":{"name":"Journal of Natural Science, Biology, and Medicine","volume":"20 1","pages":"203 - 206"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76342022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Biochemical role of zinc in dengue fever 锌在登革热中的生化作用

Journal of Natural Science, Biology, and Medicine Pub Date : 2021-07-01 DOI: 10.4103/jnsbm.jnsbm_5_21

T. Poojary, K. Sudha, K. Sowndarya, Reshma Kumarachandra, Y. Durgarao

{"title":"Biochemical role of zinc in dengue fever","authors":"T. Poojary, K. Sudha, K. Sowndarya, Reshma Kumarachandra, Y. Durgarao","doi":"10.4103/jnsbm.jnsbm_5_21","DOIUrl":"https://doi.org/10.4103/jnsbm.jnsbm_5_21","url":null,"abstract":"Background: Zinc is an essential trace element that has been shown to play a crucial role in viral infections. As a part of RNA polymerases, zinc helps in the replication of many viruses. Cholinesterases are low-grade inflammatory markers that have zinc-dependent carboxypeptidase activity. Plasma butyrylcholine esterase is an indicator of dietary zinc level. Matrix metalloproteinases (MMP) that participate in inflammatory processes and contribute to tissue remodeling and repair are zinc containing endopeptidases. The present study attempts to establish the association of zinc with these enzymes in dengue. Materials and Methods: Plasma zinc, butyrylcholinesterase (BChE), and erythrocyte acetylcholinesterase (AChE) were estimated spectrophotometrically in 100 dengue patients and 50 healthy controls. MMP9 was determined using ELISA. Results: Plasma zinc was markedly lower in dengue fever patients compared to healthy controls (P < 0.05). Both BChE and AChE decreased significantly in these patients (P < 0.001) compared to healthy controls. There was an elevation of MMP9 in dengue, although the increase was statistically insignificant. Cholinesterases and MMP9 correlated positively with zinc in controls and dengue, although the correlation was statistically insignificant. Conclusion: The study highlights the role of zinc in the pathology of dengue, as it is essential for the maintenance of activities of cholinesterases and MMP9 that are involved in anti-inflammatory and tissue remodeling processes. Further, prompt administration of micronutrients like zinc may reduce the adverse manifestations and morbidity in dengue.","PeriodicalId":16373,"journal":{"name":"Journal of Natural Science, Biology, and Medicine","volume":"57 22","pages":"131 - 134"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72366942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The impact of tumor necrosis factor-α (-308 G/A) and transforming growth factor beta 1 (-509C/T) gene polymorphism in Egyptian children with primary nephrotic syndrome 肿瘤坏死因子-α (-308 G/A)和转化生长因子- 1 (-509C/T)基因多态性对埃及原发性肾病综合征患儿的影响

Journal of Natural Science, Biology, and Medicine Pub Date : 2021-07-01 DOI: 10.4103/jnsbm.JNSBM_187_20

Rehab Elmougy, A. Elsaid, N. Salah

{"title":"The impact of tumor necrosis factor-α (-308 G/A) and transforming growth factor beta 1 (-509C/T) gene polymorphism in Egyptian children with primary nephrotic syndrome","authors":"Rehab Elmougy, A. Elsaid, N. Salah","doi":"10.4103/jnsbm.JNSBM_187_20","DOIUrl":"https://doi.org/10.4103/jnsbm.JNSBM_187_20","url":null,"abstract":"Background: Nephrotic syndrome (NS) is a disease affecting both children and adults. Cytokines act as inflammatory mediators in childhood NS. Excretion of too much protein in patients' urine as well as reduction in albumin levels in their blood are the most common symptoms of NS. Aim of the Study: The aim is to assess the potential relationship of tumor necrosis factor (TNF)-α (−308 G/A) and transforming growth factor beta 1 (TGF-β1) (−509C/T) genes with the incidence of NS. Subjects and Methods: In this study, 99 healthy children and 98 children with NS have been included. Polymerase chain reaction was used to detect the gene polymorphism of both TNF-α-G308A and TGF-β1 (−509C/T). Results: The TNF-α G308A showed a significant different genotype distribution among children with NS compared with the healthy volunteers (GG vs. AA, P = 0.0009; [odds ratio [OR] 95% CI = 25.2 [2.45–259.23]); GG vs. GA, P = 0.001; (OR 95% CI = 4.84 [1.74–13.5]); as well as alleles distribution of G vs. A, P = 0.022; (OR 95% CI = 1.06 [1.068–2.42]). However, there is a non-significant variation in the frequency of TGF-β1 (-509C/T) genotypes (CC, CT and TT) respectively (11.4%, 78.5% and 10.1) in NS patients, compared with their corresponding levels in healthy control subjects (15.5%, 68% and 16.5). Conclusion: TNF-α-G308A polymorphism may help to early predict the incidence of NS in children, while TGF-β1 showed no effect on the disease incidence.","PeriodicalId":16373,"journal":{"name":"Journal of Natural Science, Biology, and Medicine","volume":"13 1","pages":"180 - 184"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84496779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation, identification, and cytotoxic study of secondary metabolites from Pyxine Coccifera lichen 球藻地衣次生代谢产物的分离、鉴定及细胞毒性研究

Journal of Natural Science, Biology, and Medicine Pub Date : 2021-07-01 DOI: 10.4103/jnsbm.jnsbm_50_21

R. Rajesh, M. Lal Prasanth

{"title":"Isolation, identification, and cytotoxic study of secondary metabolites from Pyxine Coccifera lichen","authors":"R. Rajesh, M. Lal Prasanth","doi":"10.4103/jnsbm.jnsbm_50_21","DOIUrl":"https://doi.org/10.4103/jnsbm.jnsbm_50_21","url":null,"abstract":"Background: Lichens are renowned organisms with slow growth rate and are competent to extreme habitats with their bioactive secondary metabolites getting enormous attention owing to their dominant contribution in therapeutics. The present work focuses on the ethanolic extraction of a novel secondary metabolite, 5, 7-dihydroxy-3-(1-oxo-1H-inden-7-yl)-4H-chromen-4-one from Pyxine coccifera lichen. Materials and Methods: The secondary metabolite is isolated using column chromatographic technique. A comprehensive phytochemical analysis of the extract is carried out using various characterization techniques. Results: Using ultraviolet, Fourier transform infrared, Thin-layer chromatography High-performance liquid chromatography, nuclear magnetic resonance, and Liquid chromatography-Mass spectrometry, a detailed phytochemical study of P. coccifera ethanolic extract was performed. The results led to the identification and characterization of 5,7-dihydroxy-3-(1-oxo-1H-inden-7-yl)-4H-chromen-4-one based on their precise molecular masses and molecular formula. After dose-dependent treatment with lichen ethanol extract, cell viability analysis measured after 48 h revealed that the morphology of A549 human lung cancer cells had changed. In comparison to monitor cell viability, P. coccifera ethanolic extract (17.50 μg) significantly reduced the spread of A549 human lung cancer cells. Conclusions: The isolated bioactive secondary metabolite has excellent antiproliferative activity against A-549 lung cancer cells.","PeriodicalId":16373,"journal":{"name":"Journal of Natural Science, Biology, and Medicine","volume":"16 1","pages":"242 - 248"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81485119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparison of equations for the calculation of low-density lipoprotein cholesterol in thai population 泰国人群低密度脂蛋白胆固醇计算公式的比较

Journal of Natural Science, Biology, and Medicine Pub Date : 2021-07-01 DOI: 10.4103/jnsbm.jnsbm_53_21

L. Rerksuppaphol, S. Rerksuppaphol

{"title":"Comparison of equations for the calculation of low-density lipoprotein cholesterol in thai population","authors":"L. Rerksuppaphol, S. Rerksuppaphol","doi":"10.4103/jnsbm.jnsbm_53_21","DOIUrl":"https://doi.org/10.4103/jnsbm.jnsbm_53_21","url":null,"abstract":"Background: Low-density lipoprotein cholesterol (LDL-C) has been established as a major risk factor for cardiovascular diseases. Various equations have been proposed for LDL-C calculation; however, the accuracy of these equations varies among different ethnicities. This study aimed to assess the accuracy and concordance of LDL-C equations for dyslipidemia classifications in Thai adults. Materials and Methods: The lipid profiles of 1091 healthy Thai adults were measured using a homogenous enzymatic assay. The estimated LDL-C equations by Friedewald, Ahmadi, Anandaraja, Chen, Cordova, Densethakul, Hattori, Martin, Puavillai, Sampson, and Vujovic were compared to directly measured LDL-C using Pearson's correlation test. Cohen's kappa statistic was also used to test the concordance of the LDL-C equations with directly measured LDL-C levels, according to the standard guidelines for blood cholesterol management. Results: The LDL-C values calculated by Friedewald, Sampson, and Chen equations showed a high degree of correlation and values close to directly measured LDL-C levels with mean differences ranging from − 0.04 to 0.07 mmol/L. All these three equations had a high degree of concordances with directly measured LDL-C levels for classifying the degree of dyslipidemia. Conclusion: Friedewald, Sampson, and Chen equations showed better estimations of LDL-C levels and had higher accuracy in classifying the degree of LDL-C strata than other equations in the Thai population.","PeriodicalId":16373,"journal":{"name":"Journal of Natural Science, Biology, and Medicine","volume":"12 1","pages":"224 - 229"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84495799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11