B. Kothari, Kallale Bhagavan, L. Lobo, Nawin Kumar, A. Shetty, Kalikivayi Naresh
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History of hypertension, diabetes mellitus, and ischemic heart disease were recorded. The diagnosis basically was made by clinical symptoms and signs. Arterial Doppler/computed tomography angiogram was done only if symptoms or signs of PAOD were present. Two ml of overnight fasting blood sample was collected, serum separated, and was analyzed for Lp(a) by immune turbidometry method. Results: In patients with PAOD, Lp(a) value was 90.06 ± 23.4 mg/dl, whereas among patients without PAOD, Lp(a) values was 48.02 ± 24.1 mg/dl and was statistically significant (P < 0.001). Patients with elevated Lp(a) levels were found to have 13.50 times higher risk of developing PAOD as compared to patients with normal Lp(a) levels. As per the ROC curve analysis, with area under the curve of 0.895 th cutoff value was considered to be 69.8 mg/dl with sensitivity of 88% and specificity of 76%. Conclusion: Males are at a higher risk of developing PAOD as compared to females. Patients within the age group of 51–60 years are more prone to develop PAOD as per this study. From the study results, it was found that there is a high association of patients with PAOD and elevated Lp(a) as compared to other risk factors.","PeriodicalId":16373,"journal":{"name":"Journal of Natural Science, Biology, and Medicine","volume":"10 1","pages":"218 - 223"},"PeriodicalIF":0.0000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lipoprotein(a) as a risk factor for atherosclerotic peripheral arterial occlusive disease\",\"authors\":\"B. Kothari, Kallale Bhagavan, L. Lobo, Nawin Kumar, A. Shetty, Kalikivayi Naresh\",\"doi\":\"10.4103/jnsbm.JNSBM_139_20\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background and Aim: Peripheral arterial occlusive disease (PAOD) commonly results from progressive narrowing of arteries in the lower extremities due to atherosclerosis. The objective of this study was to measure plasma levels of Lipoprotein (a) (Lp[a]) in patients with and without clinical evidence of PAOD and find an association (risk ratio) between Lp(a) and PAOD. Materials and Methods: This study was conducted in the Department of General Surgery at Justice K. S. Hegde Charitable Hospital, Mangalore. The age and sex of the patients, clinical symptoms were noted. The study included a total of 100 patients further divided into two groups: Fifty symptomatic patients with clinical evidence and 50 age and sex-matched asymptomatic patients without clinical evidence of PAOD. History of hypertension, diabetes mellitus, and ischemic heart disease were recorded. The diagnosis basically was made by clinical symptoms and signs. Arterial Doppler/computed tomography angiogram was done only if symptoms or signs of PAOD were present. Two ml of overnight fasting blood sample was collected, serum separated, and was analyzed for Lp(a) by immune turbidometry method. Results: In patients with PAOD, Lp(a) value was 90.06 ± 23.4 mg/dl, whereas among patients without PAOD, Lp(a) values was 48.02 ± 24.1 mg/dl and was statistically significant (P < 0.001). Patients with elevated Lp(a) levels were found to have 13.50 times higher risk of developing PAOD as compared to patients with normal Lp(a) levels. As per the ROC curve analysis, with area under the curve of 0.895 th cutoff value was considered to be 69.8 mg/dl with sensitivity of 88% and specificity of 76%. Conclusion: Males are at a higher risk of developing PAOD as compared to females. Patients within the age group of 51–60 years are more prone to develop PAOD as per this study. From the study results, it was found that there is a high association of patients with PAOD and elevated Lp(a) as compared to other risk factors.\",\"PeriodicalId\":16373,\"journal\":{\"name\":\"Journal of Natural Science, Biology, and Medicine\",\"volume\":\"10 1\",\"pages\":\"218 - 223\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Science, Biology, and Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jnsbm.JNSBM_139_20\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Science, Biology, and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jnsbm.JNSBM_139_20","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
摘要
背景和目的:外周动脉闭塞性疾病(PAOD)通常是由动脉粥样硬化引起的下肢动脉进行性狭窄引起的。本研究的目的是测量有和无临床证据的pad患者血浆脂蛋白(a) (Lp[a])水平,并发现Lp(a)与pad之间的关联(风险比)。材料与方法:本研究在芒格洛尔Justice K. S. Hegde慈善医院普通外科进行。记录患者的年龄、性别、临床症状。该研究共纳入100例患者,进一步分为两组:50例有临床证据的症状患者和50例年龄和性别匹配的无临床证据的无症状患者。记录高血压、糖尿病、缺血性心脏病病史。诊断主要依据临床症状和体征。动脉多普勒/计算机断层血管造影仅在出现pad症状或体征时进行。采集空腹血样2 ml,分离血清,免疫浊度法检测Lp(a)。结果:有PAOD的患者Lp(a)值为90.06±23.4 mg/dl,无PAOD的患者Lp(a)值为48.02±24.1 mg/dl,差异有统计学意义(P < 0.001)。与Lp(a)水平正常的患者相比,Lp(a)水平升高的患者发生pad的风险高出13.50倍。根据ROC曲线分析,曲线下面积为0.895,认为截断值为69.8 mg/dl,敏感性为88%,特异性为76%。结论:与女性相比,男性患pad的风险更高。根据本研究,51-60岁年龄组的患者更容易发生pad。从研究结果来看,与其他危险因素相比,pad患者与Lp(a)升高有较高的相关性。
Lipoprotein(a) as a risk factor for atherosclerotic peripheral arterial occlusive disease
Background and Aim: Peripheral arterial occlusive disease (PAOD) commonly results from progressive narrowing of arteries in the lower extremities due to atherosclerosis. The objective of this study was to measure plasma levels of Lipoprotein (a) (Lp[a]) in patients with and without clinical evidence of PAOD and find an association (risk ratio) between Lp(a) and PAOD. Materials and Methods: This study was conducted in the Department of General Surgery at Justice K. S. Hegde Charitable Hospital, Mangalore. The age and sex of the patients, clinical symptoms were noted. The study included a total of 100 patients further divided into two groups: Fifty symptomatic patients with clinical evidence and 50 age and sex-matched asymptomatic patients without clinical evidence of PAOD. History of hypertension, diabetes mellitus, and ischemic heart disease were recorded. The diagnosis basically was made by clinical symptoms and signs. Arterial Doppler/computed tomography angiogram was done only if symptoms or signs of PAOD were present. Two ml of overnight fasting blood sample was collected, serum separated, and was analyzed for Lp(a) by immune turbidometry method. Results: In patients with PAOD, Lp(a) value was 90.06 ± 23.4 mg/dl, whereas among patients without PAOD, Lp(a) values was 48.02 ± 24.1 mg/dl and was statistically significant (P < 0.001). Patients with elevated Lp(a) levels were found to have 13.50 times higher risk of developing PAOD as compared to patients with normal Lp(a) levels. As per the ROC curve analysis, with area under the curve of 0.895 th cutoff value was considered to be 69.8 mg/dl with sensitivity of 88% and specificity of 76%. Conclusion: Males are at a higher risk of developing PAOD as compared to females. Patients within the age group of 51–60 years are more prone to develop PAOD as per this study. From the study results, it was found that there is a high association of patients with PAOD and elevated Lp(a) as compared to other risk factors.