Journal of multiple sclerosis最新文献_第9页

Non-Linear Techniques Reveal Adaptive and Maladaptive Postural Control Dynamics in Persons with Multiple Sclerosis 非线性技术揭示了多发性硬化症患者的自适应和非自适应姿势控制动力学

Journal of multiple sclerosis Pub Date : 2016-05-30 DOI: 10.4172/2376-0389.1000177

Michael Ab, Scott Wd, Van Emmerik Rea

引用次数: 5

Recent Advances in Essential Tremor 特发性震颤的最新进展

Journal of multiple sclerosis Pub Date : 2016-05-27 DOI: 10.4172/2376-0389.1000176

A. Goksemin

引用次数: 1

Demyelination in Peripheral Nerves: Much to Learn from Leprosy Neuropathy 周围神经脱髓鞘:从麻风病神经病学到了很多

Journal of multiple sclerosis Pub Date : 2016-05-24 DOI: 10.4172/2376-0389.1000174

B. S. Mietto, P. Andrade, M. Jardim, S. Antunes, E. Sarno

{"title":"Demyelination in Peripheral Nerves: Much to Learn from Leprosy Neuropathy","authors":"B. S. Mietto, P. Andrade, M. Jardim, S. Antunes, E. Sarno","doi":"10.4172/2376-0389.1000174","DOIUrl":"https://doi.org/10.4172/2376-0389.1000174","url":null,"abstract":"Copyright: © 2016 Mietto BS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Leprosy is a chronic infectious disorder of the peripheral nervous system (PNS) caused by the infection of non-neuronal nerve cells, preferentially Schwann cells and resident macrophages, by Mycobacyerium leprae (ML) [1]. There is growing evidence suggesting that damage to the myelin sheath is due to a disturbed Schwann cell response in conjunction with immune cell participation [2-4]. Although demyelination is not easily found in neuropathic leprosy nerve biopsies (Figure 1), nerve conduction studies routinely used in leprosy referral centers indicate that demyelination occurs during most leprosy reactional episodes [5]. Moreover, nerve conduction analyses show that part of these patients recover from previous lesions after 6-month corticosteroid treatment (Jardim MR personal communication). Other drugs that favor re-myelination are worth being investigated (Figure 1).","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"22 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77438037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Demyelination in Organotypic Slice Cultures is Attenuated by BAF312 (Siponimod) BAF312 (Siponimod)对器官型切片培养细胞脱髓鞘的抑制作用

Journal of multiple sclerosis Pub Date : 2016-05-24 DOI: 10.4172/2376-0389.1000175

C. O’Sullivan

{"title":"Demyelination in Organotypic Slice Cultures is Attenuated by BAF312 (Siponimod)","authors":"C. O’Sullivan","doi":"10.4172/2376-0389.1000175","DOIUrl":"https://doi.org/10.4172/2376-0389.1000175","url":null,"abstract":"Copyright: © 2016 O’Sullivan C. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The therapeutic value of sphingosine-1 phosphate receptor (S1PR) modulation was highlighted by the success of fingolimod (pFTY720) in the clinical management of relapsing remitting multiple sclerosis (MS). Great effort was then made to generate high selectivity agonists towards certain S1PR subtypes. Of particular interest were agonists with selectivity towards the S1PR1 subtype with little or no activity at the S1PR3. This was in large part due to preclinical studies in mice that suggested the transitory bradycardia that occurred after the introductory dose of pFTY720 may be attributable to the S1PR3 subtype [1,2]. Furthermore, favourable properties associated with the S1PR1 and S1PR5 subtypes, such as the key role S1PR1 plays in lymphocyte migration and the reported role of S1PR5 on oligodendrocyte function and myelination, made these attractive receptor subtypes to target [3,4]. This resulted in the synthesis of BAF312 (Siponimod), a second generation S1PR modulator selective towards the S1PR1/S1PR5 subtypes [1].","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"167 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2016-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91022702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Time Domain and Spectral Domain Optical CoherenceTomograph to Evaluate Eyes with And Without Optic Neuritis in MultipleSclerosi Patients 时域和谱域光学相干成像评价多发性硬化患者有无视神经炎的有效性

Journal of multiple sclerosis Pub Date : 2016-05-17 DOI: 10.4172/2376-0389.1000173

M. Iester, C. Cordano, A. Costa, E. D’Alessandro, A. Panizzi, F. Bisio, A. Masala, L. Landi, Traverso Ce, A. Ferreras, G. Mancardi, A. Uccelli

{"title":"Effectiveness of Time Domain and Spectral Domain Optical CoherenceTomograph to Evaluate Eyes with And Without Optic Neuritis in MultipleSclerosi Patients","authors":"M. Iester, C. Cordano, A. Costa, E. D’Alessandro, A. Panizzi, F. Bisio, A. Masala, L. Landi, Traverso Ce, A. Ferreras, G. Mancardi, A. Uccelli","doi":"10.4172/2376-0389.1000173","DOIUrl":"https://doi.org/10.4172/2376-0389.1000173","url":null,"abstract":"Abstract \u0000Purpose: To compare the macular assessment and retinal nerve fiber layer (RNFL) thickness by using two different optical coherence tomographies (OCTs): a time domain (TD) and a spectral domain (SD) OCT, in multiple sclerosis (MS) patients with and without unilateral optic neuritis (ON). \u0000Methods: We enrolled 34 patients (13 males and 21 females): 18 without previous episodes of ON and16 with a previous monolateral episode of ON occurred at least 3 months prior to examination. Patients underwent ophthalmological examination, TD OCT and SD OCT scans. We compared the outcomes of eyes with and without ON by using Student’s t test. \u0000Results: In the affected eye group a reduction of the average RNFL was found using TD OCT (reduction of 22.8%) with the difference between the two groups being statistically significant (p<0.05) in almost all the investigated retina areas. Similar results were found when eyes were analysed with SD OCT, also when the ganglion cell layer (GCC) was considered: a reduction of 18.1% of GCC average thickness was found. No significant difference was found when the outer retina was considered. \u0000Conclusions: In MS patients both OCT systems were able to detect a difference between eyes with an outcome of optic neuritis and those without optic neuritis.","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"23 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82759010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

TNF Blockade, CNS Autoimmunity, Sex, and the Microbiome TNF阻断，中枢神经系统自身免疫，性别和微生物组

Journal of multiple sclerosis Pub Date : 2016-05-10 DOI: 10.4172/2376-0389.1000172

Susan Cm, Francesca Em

引用次数: 1

Could Metabolomics Clarify the Multiple Sclerosis–Vitamin D Metabolites Relationship? 代谢组学能阐明多发性硬化症与维生素D代谢物的关系吗?

Journal of multiple sclerosis Pub Date : 2016-04-26 DOI: 10.4172/2376-0389.1000171

L. Castro

{"title":"Could Metabolomics Clarify the Multiple Sclerosis–Vitamin D Metabolites Relationship?","authors":"L. Castro","doi":"10.4172/2376-0389.1000171","DOIUrl":"https://doi.org/10.4172/2376-0389.1000171","url":null,"abstract":"Copyright: © 2016 Luque de Castro MD. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. It has been accepted for more than 30 years that multiple sclerosis (MS) is determined by a combination of genetic and environmental factors. Among the latter, Epstein–Barr virus infection, cigarette smoking and concentration of vitamin D are the most remarkable [1,2]. The deficiency of vitamin D as a risk factor for multiple sclerosis (MS) was proposed, in principle, to explain a latitude gradient in MS prevalence that correlates with ultraviolet radiation duration and intensity as the main source of vitamin D in most populations [3]. More than 30 years later and after huge amounts of research and publications on the vitamin D–MS relationship the opinion of scientists working in this field is that further work is needed to determine the optimal vitamin D dose for MS prevention or treatment [4-8]. When high doses of vitamin D have been used the treatment has never proved effective or safe. Attracted by the option of a “natural” and “curative” treatment for MS, even neurological or systemic complications were observed while high doses of vitamin D were being used [9,10].","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"5 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85067884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Analysis of 258 Different Lesions of the Central Nervous System for RealTime Histopathological Diagnosis Using Confocal Laser Endomicroscopy 258种不同中枢神经系统病变的共聚焦激光内镜实时病理诊断分析

Journal of multiple sclerosis Pub Date : 2016-04-07 DOI: 10.4172/2376-0389.1000169

D. Samira, J. Mehreen, A. Ann-Kristin, I. Alhadi, L. Maximilian, B. Richard, S. Juergen, C. Patra

{"title":"Analysis of 258 Different Lesions of the Central Nervous System for RealTime Histopathological Diagnosis Using Confocal Laser Endomicroscopy","authors":"D. Samira, J. Mehreen, A. Ann-Kristin, I. Alhadi, L. Maximilian, B. Richard, S. Juergen, C. Patra","doi":"10.4172/2376-0389.1000169","DOIUrl":"https://doi.org/10.4172/2376-0389.1000169","url":null,"abstract":"Abstract \u0000Objective: \u0000The safe removal of central nervous system tumors in or near eloquent tissue remains extremely challenging due to its complex anatomy. The injury of eloquent tissue can have serious consequences for both mental and physical health while an insufficiently resected tumor bears a high risk of tumor recurrence decreasing the patient’s life quality and quantity. The novel method, confocal laser endomicroscopy (CLE), promises safe tumor resection as it permits intraoperative histological imaging of tissues in real-time. Thus, aim of the current study was to evaluate CLE for a fast diagnosis of brain and spinal cord lesions in neurosurgery. \u0000Methods: CLE was used for an ex vivo assessment of tumor samples from 258 diverse central nervous system lesions. Additionally, traditional histology was performed on the same examined tissue as the gold standard. Nonneoplastic brain tissue served as a control. \u0000Results: The examination of brain and spinal biopsies using CLE allowed the identification of healthy tissue, primary brain and spinal tumors, metastases, abscesses and vascular malformations with a high accuracy of 88.64%. Confocal imaging provided precise cellular and sub-cellular details such as psammoma bodies in meningiomas, perivascular pseudorosettes in ependymomas, microvascular proliferation in glioblastomas and mitotic activity in highgrade tumors. \u0000Conclusion: CLE is a promising method for distinguishing tumor from the surrounding healthy tissue, as well as for the immediate diagnosis of biopsies. Our studies have the potential to establish a faster preliminary diagnosis in an ongoing surgery as compared to current available methods. Moreover, the presented characteristic cellular and subcellular confocal features of examined tumors and non-neoplastic tissues could be used to guide future tumor surgeries to enable a more precise and safe resection.","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"1 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2016-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91111343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clinical Commentary: About Acupuncture and Electroacupuncture in Advances in Muscle Weakness 针刺与电针在肌无力治疗中的研究进展

Journal of multiple sclerosis Pub Date : 2016-04-05 DOI: 10.4172/2376-0389.1000168

J. Comachio

引用次数: 3

Optical Coherence Tomography of First-Ever Optic Neuritis Helps Differentiate Neuromyelitis Optica Spectrum Disorder from Multiple Sclerosis 首次视神经炎的光学相干断层扫描有助于区分视神经脊髓炎与多发性硬化症

Journal of multiple sclerosis Pub Date : 2016-01-01 DOI: 10.4172/2376-0389.1000189

Y. Shin

引用次数: 0