Journal of Medicinal and Chemical Sciences最新文献_第4页

Decoding Stress of Doctors and Nursing Staff during Covid-19 in Leading Social Entrepreneur Sponsored Hospitals in Odisha 奥里萨邦领先的社会企业家赞助医院在Covid-19期间解码医生和护理人员的压力

Journal of Medicinal and Chemical Sciences Pub Date : 2021-10-04 DOI: 10.26655/jmchemsci.2021.6.9

Pragyan Ranjan Gharai, B. Das

引用次数: 0

Survey Rheumatic Diseases in ILAM Province, Iran (2018-2019) 伊朗ILAM省2018-2019年风湿病调查

Journal of Medicinal and Chemical Sciences Pub Date : 2021-10-03 DOI: 10.26655/jmchemsci.2021.6.7

Nasrin Bazgir, M. Bonyadi, E. Shafiei

引用次数: 1

Evaluation of the Effect of Gummy Candy on Postoperative Ileus and Its Complications 软糖治疗术后肠梗阻及其并发症的疗效评价

Journal of Medicinal and Chemical Sciences Pub Date : 2021-10-03 DOI: 10.26655/jmchemsci.2021.6.6

M. Dousti, H. Otaghvar, A. Jafarian, Ideh Rokhzadi, Najva Mazhari, S. Moghaddam

{"title":"Evaluation of the Effect of Gummy Candy on Postoperative Ileus and Its Complications","authors":"M. Dousti, H. Otaghvar, A. Jafarian, Ideh Rokhzadi, Najva Mazhari, S. Moghaddam","doi":"10.26655/jmchemsci.2021.6.6","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.6.6","url":null,"abstract":"Prolonged postoperative ileus can delay hospital discharge. According to the reports, diet and in particular gummy candy may strengthen bowel movements and hence eliminate ileus. A total of 149 patients within the age range of 7-60 years who underwent laparotomy were randomly divided into the experimental group that were treated with gummy candy and the control group which included 73 patients. The experimental group chewed gummy candy four times a day, hours after operation until the first flatulence. The patients in the both groups were checked for bowel movement and flatulence every two hours and it was recorded precisely. Both groups were also divided into 3 subgroups based on surgical incision. On average, the first recorded bowel sound was 10.78 ± 7.66 hours after the surgery. In addition, the first flatulence was recorded on average 2.51 ± 14.32 hours after the surgery. The mean time of hospitalization in both groups was 104.21±7 57.85 hours. The mean duration between the surgical end time, the first recorded bowel sound and the time to first flatulence was significantly lower in the experimental group compared with the control group.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88660244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development of Digital Competence of Portable Telemedicine Complex Operators for Optimizing the Provision of Medical Care 为优化医疗服务提供便携式远程医疗复合运营商的数字能力发展

Journal of Medicinal and Chemical Sciences Pub Date : 2021-10-03 DOI: 10.26655/jmchemsci.2021.6.8

S. Sayganov, V. Mazurov, Aleksey V. Silin, A. Shmatko, I. V. Gaivoronsky

{"title":"Development of Digital Competence of Portable Telemedicine Complex Operators for Optimizing the Provision of Medical Care","authors":"S. Sayganov, V. Mazurov, Aleksey V. Silin, A. Shmatko, I. V. Gaivoronsky","doi":"10.26655/jmchemsci.2021.6.8","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.6.8","url":null,"abstract":"A complex of six advanced training programs for the management of a portable telemedicine complex was developed on the basis of Federal State Budgetary Educational Institution of Higher Education \"North-Western State Medical University named after I.I. Mechnikov\", the Ministry of Health of the Russian Federation. A pilot training program \"Operator of a portable telemedicine complex\" was implemented for persons with a full-time graduate degree. 17 trainees took part in the program. According to the results of the program, all the trainees had passed certification testing successfully and demonstrated sufficient development of the digital competence of portable telemedicine complex operators to optimizing the provision of medical care. The results of the program allowed to identify positive aspects of its implementation, namely training in a comfortable and familiar environment by 85.7%; the opportunity to combine work and studies by 57.1%; and the opportunity for repetitive self-assessment by 28.6%. The article presents the results of the study under the additional agreement dated September 24, 2020 No. 075-15-2019-1346/1 to the agreement dated June 13, 2019 No. 075-15-2019-1346 with the Ministry of Science and Higher Education of the Russian Federation as a part of implementing the federal target program \"Research and development in priority areas of development of the scientific and technological complex of Russia for 2014-2020\", event 1.2, stage 01 Code: 2018-14-000-0001) on the topic \"Development of a portable telemedicine complex for optimizing the provision of medical care\"(UIP of the project: No. УИП RFMEFI60418X0201).","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"152 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83526179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthesis and SAR of Imidazo[1,2-a] Pyridinyl-Phenylacrylonitrile Derivatives as Potent Anticandidosis Agents 咪唑[1,2-a]吡啶基苯基丙烯腈衍生物的合成及抗结核活性研究

Journal of Medicinal and Chemical Sciences Pub Date : 2021-09-27 DOI: 10.26655/jmchemsci.2021.6.3

Deto N'guessan, S. Coulibaly, F. Kassi, Pierre‐Olivier Delaye, M. Pénichon, C. Enguehard-Gueiffier, H. Allouchi, M. Ouattara

{"title":"Synthesis and SAR of Imidazo[1,2-a] Pyridinyl-Phenylacrylonitrile Derivatives as Potent Anticandidosis Agents","authors":"Deto N'guessan, S. Coulibaly, F. Kassi, Pierre‐Olivier Delaye, M. Pénichon, C. Enguehard-Gueiffier, H. Allouchi, M. Ouattara","doi":"10.26655/jmchemsci.2021.6.3","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.6.3","url":null,"abstract":"The increase of immunodeficiency situations such as HIV and cancer is stemmed from the expansion of fungal infections due to the genus Candida. Although Candida albicans remains the most widespread species in pathogenic isolates, its epidemiological impact in human infectiology has declined in favor of new emerging species of Candida refractory to conventional treatment. Faced with this situation, we decided to contribute to the development of some imidazo [1,2-a] pyridinyl-arylacrylonitriles, as potential new anticandidosics. We proposed the design by molecular hybridization and the synthesis of some imidazo [1,2-a]pyridinyl-arylacrylonitriles following a Knoevenagel condensation reaction between aldehydes and various arylacetonitriles. Furthermore, we carried out the evaluation of the antifungal activities of these hybrid derivatives against Candida albicans, Candida tropicalis and Candida glabrata using the microplate dilution methodology. In the end, imidazo[1,2-a]pyridinyl-arylacrylonitriles turned out to be molecules with strong antifungal activities. The best anticandidosis profile on the three Candida species tested was obtained with the 3-chlorinated compound (5), the MICs of which varied between 357.5 - 0.52 µM. Likewise, the doubly modulated derivative (3c), was particularly illustrated by its good efficacy against Candida tropicalis. These two best compounds can be proposed as the \"hit molecules\" for further pharmacomodulations in order to have a drug candidate for anticandidosis purpose.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83729375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interdisciplinary Approach in Remedial Work on Speech Development for Students with Disabilities 残疾学生言语发展辅导工作的跨学科方法

Journal of Medicinal and Chemical Sciences Pub Date : 2021-09-21 DOI: 10.26655/jmchemsci.2021.6.2

Dmitry A. Melnikov, Larisa A. Panteleeva, M. Zhigoreva, A. Y. Prokopenko

{"title":"Interdisciplinary Approach in Remedial Work on Speech Development for Students with Disabilities","authors":"Dmitry A. Melnikov, Larisa A. Panteleeva, M. Zhigoreva, A. Y. Prokopenko","doi":"10.26655/jmchemsci.2021.6.2","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.6.2","url":null,"abstract":"The success of socialization of children with disabilities is determined by a sufficient level of formation of speech activity. Ideas about difficulties in mastering the language and speech abilities of children with developmental disabilities that hinder their successful socialization serve as the basis for optimizing the learning and upbringing process. The purpose of the article is to consider the features of speech development of students with disabilities and determine the main directions of correctional work based on an interdisciplinary approach. The methodological basis of the study was interdisciplinary, systematic, activity-based, complex and individually differentiated, aiming at the development and improvement of speech among students with disabilities. The data obtained from the study of the speech capabilities of children with disabilities of different nosological groups indicated that they had violations of the formation of various components of the language system that affected the process of speech communication necessary for adaptation, integration and socialization. There was the need to create a correctional speech therapy work with an interdisciplinary nature, containing technologies, methods and techniques aimed at developing the speech of students with disabilities. Based on the results of this study, the directions of correctional speech therapy work, i.e., diagnostic and prognostic, software design, organizational and procedural, advisory and educational, were proposed, revealing the specifics of an interdisciplinary approach that allows optimizing the process of speech development of students with sensory, speech disorders, and mental retardation.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74358922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socialization-Individualization of Preschool Children with Speech Disorders in Motor Activity 学龄前运动言语障碍儿童的社会化-个体化研究

Journal of Medicinal and Chemical Sciences Pub Date : 2021-09-06 DOI: 10.26655/jmchemsci.2021.6.1

Кarina Е. Panasenko, L. N. Voloshina, L. Shinkareva, Оlga G. Galimskaya

{"title":"Socialization-Individualization of Preschool Children with Speech Disorders in Motor Activity","authors":"Кarina Е. Panasenko, L. N. Voloshina, L. Shinkareva, Оlga G. Galimskaya","doi":"10.26655/jmchemsci.2021.6.1","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.6.1","url":null,"abstract":"Urgency of the research is driven by the need to solve the problems of integral socialization-individualization of children with speech disorders in the theory and practice of pre-primary education. The purpose of the present research was to deal with the problems of integral socialization-individualization of preschoolers of over five years old with speech disorders in motor activity. The study engaged 100 older preschoolers with a normal level of speech development and 100 over-five group with speech disorders attending compensatory and combined groups of preschool educational organizations in Belgorod. The assessment of the results of testing motor abilities has shown that children with speech disorders have an insufficient level of their development. Low indices have been obtained for motor-coordinating abilities (accuracy – nonsufficient level in 100% of girls and boys; dexterity – in 68.2% of boys and 71.4% of girls), involving strength abilities (in 70.5% of boys and in 72, 3% of girls), tolerance (77.3% of boys and 75% of girls). Qualitative and quantitative analyses of the results of self-assessment of motor abilities of preschoolers with speech disorders revealed inadequately exaggerated self-assessment and overestimation of their abilities in motor activity with peers in 30% of children. 21% of children with speech disorders had inadequately negative self-feeling, lack of self-confidence, showed shyness and timidity.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83460969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Modeling of Hospital Length of Stay in COVID-19 Patients Using Machine Learning Algorithms 基于机器学习算法的COVID-19患者住院时间预测建模

Journal of Medicinal and Chemical Sciences Pub Date : 2021-09-01 DOI: 10.26655/JMCHEMSCI.2021.5.15

M. Afrash, H. Kazemi-Arpanahi, Parvaneh Ranjbar, Raoof Noupor, M. Saki, M. Amraei, M. Shanbehzadeh

{"title":"Predictive Modeling of Hospital Length of Stay in COVID-19 Patients Using Machine Learning Algorithms","authors":"M. Afrash, H. Kazemi-Arpanahi, Parvaneh Ranjbar, Raoof Noupor, M. Saki, M. Amraei, M. Shanbehzadeh","doi":"10.26655/JMCHEMSCI.2021.5.15","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2021.5.15","url":null,"abstract":"The rapid worldwide outbreak of COVID-19 has posed serious and unprecedented challenges to healthcare systems in predicting disease behavior, consequences and resource utilization. Therefore, predicting the Length of Stay (LOS) is necessary to ensure optimal allocate of scarce hospital resources. The purpose of this research was to construct a model for predicting COVID-19 patients' hospital LOS by multiple Machine Learning (ML) algorithms. Using a single-center registry, we studied the records of 1225 laboratory-confirmed COVID-19 hospitalized patients from February 9, 2020, to December 20, 2020. The most important clinical parameters in the COVID-19 LOS prediction were identified with a correlation coefficient at the P-value< 0.2. Then, the prediction models were developed based on seven ML techniques according to selected variables. Finally, to evaluate the performances of those models several standard quantitative measures includes accuracy, sensitivity, specificity and ROC curve were used to evaluate the proposed predictive models. After implementing feature selection, a total of 20 variables was identified as the most relevant predictors to build the prediction models. The results indicated that the best performance belonged to the Support Vector Machine (SVM) algorithm with the mean accuracy of 99.5%, mean specificity of 99.7%, mean sensitivity of 99.4%, and the standard deviation of 1.2. The SVM provided a reasonable level of accuracy and certainty in predicting the LOS in COVID-19 patients and potentially facilitates hospital bed management, turnover and optimized resource allocation.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75013904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Covid-19 Vs Challenge to a New Health Care Reform Covid-19 Vs新医疗改革的挑战

Journal of Medicinal and Chemical Sciences Pub Date : 2021-09-01 DOI: 10.26655/jmchemsci.2021.5.12

E. Snarskaya, Ekaterina Yurievna Shammazova, L. Mukharyamova, A. R. Zalyaev

{"title":"Covid-19 Vs Challenge to a New Health Care Reform","authors":"E. Snarskaya, Ekaterina Yurievna Shammazova, L. Mukharyamova, A. R. Zalyaev","doi":"10.26655/jmchemsci.2021.5.12","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.5.12","url":null,"abstract":"The absence of signs of legitimacy of power structures, and disagreement with the health policy lead to dissatisfaction, condemnation and protest moods among the population. This disagreement is manifested both at the level of consumers of services - ordinary citizens, and at the level of producers of services - the medical (professional) community. If until recently episodes with a low degree of public satisfaction with the quality of medical services were widely discussed in the media, recent years would have indicated protest moods in the professional group, portending the failure of health care reform. Today, one can hear the conventional wisdom everywhere that it is the medical community that must take full responsibility for solving the pandemic problem fully. However, the analysis of the transitional state of the modern public health system presented in the article, including in the context of the COVID-19 pandemic, shows the ability of this “state” to such challenges as political destabilization, public outcry, professional protests and much more. In fact, today we are witnessing a process of expanding the functions of the health care system from traditional, in particular, the provision of medical care to citizens, pharmaceutical activities, the development of state policy in the field of health care and social development, etc., to the area of non-specific and until recently marginal - we mean the ideological component, accumulating in wide layers of society, turns out to be capable of direct political action.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86611690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac Conduction Disorders in Children with Community-Acquired Pneumonia 社区获得性肺炎儿童的心传导障碍

Journal of Medicinal and Chemical Sciences Pub Date : 2021-09-01 DOI: 10.26655/jmchemsci.2021.5.14

E. Ivanova, L. Gerasimova, О. V. Sharapova, O. N. Bragina, E. V. Bushueva, A. G. Petrov, Mikhail Yurievich Mikhaylov

{"title":"Cardiac Conduction Disorders in Children with Community-Acquired Pneumonia","authors":"E. Ivanova, L. Gerasimova, О. V. Sharapova, O. N. Bragina, E. V. Bushueva, A. G. Petrov, Mikhail Yurievich Mikhaylov","doi":"10.26655/jmchemsci.2021.5.14","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.5.14","url":null,"abstract":"The purpose of this study was to evaluate the cardiac conduction in children with non-severe community-acquired pneumonia during inpatient treatment and period of convalescence by electrocardiographic examination. The study involved 166 children aged 1 to 17 years, patients with non-severe community-acquired pneumonia, undergoing inpatient treatment in Pediatric Hospital. On the second day of treatment, each child underwent a heart ECG. The control sample consisted of 271 healthy children. Then, after dispensary observation, children with abnormalities in cardiac conduction had another ECG. The study found that 76% of children with non-severe pneumonia had ECG changes. The majority of children had conduction disorders of different localization and degree. Intraventricular conduction disorder in pneumonia occurred in 38% of cases, 2.5 times more often than in the control sample. Considering pathology of heart excitability, 3.96% of children had signs of right atrium overload, and 2.85 % - of left ventricle. 70 % of children with conduction disorders still had these changes after the ECG study in dynamics. This study showed that children with pneumonia had significant changes in the electrophysiological activity of the heart, which may have persisted after the convalescence period. This group of patients requires special management tactics at the stage of therapy and rehabilitation.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83059492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0