Journal of Intensive Care Medicine最新文献

{"title":"In-hospital Mortality is Lower in Brain-Injured Patients After Admission to a Neuroscience Intensive Care Unit: A Multi-Center Cohort Study.","authors":"Angel J Cadena-Tejada, Shaista Alam, Varoon Thavapalan, Sara Habib, Fred Rincon","doi":"10.1177/08850666251325778","DOIUrl":"10.1177/08850666251325778","url":null,"abstract":"<p><p>ObjectiveTo study the impact of dedicated Neuroscience Intensive Care Units (NSU) on clinical outcomes in patients with acute brain injury.DesignRetrospective, multicenter cohort study.Setting172 intensive care units within the United States.PatientsProspectively compiled and maintained a registry of a total of 32,047 brain-injured patients (stroke = AIS, aneurysmal-bleed = SAH, intra-cerebral-hemorrhage = ICH, and traumatic brain injury = TBI) from 2008-2013.MeasurementsExposure of interest was the type of intensive care unit (ICU), divided into NSU and non-NSU (medical = MICU, non-neurosurgical = SICU, trauma = TICU, cardiac = CCU, or mixed). Outcomes of interest were the actual and predicted in-hospital mortality, ICU mortality, ICU length of stay, and ventilator-free days. We calculated the actual and predicted in-hospital mortality using the Cerner Corporation Acute Physiology and Chronic Health Evaluation IV (APACHE Clinical Information System, CIS). We then compared the actual in-hospital mortality against the mortality prediction of the APACHE-IV model based on ICU designation (NSU v. non-NSU). The multivariable model was adjusted for within-hospital effects and known predictors of poor outcomes after brain injury.Main ResultsNational APACHE-IV predicted that in-hospital mortality was higher for NSU admissions than non-NSU admissions (21% v. 19%, p < .0001). However, the actual ICU mortality (10% vs 11%, p < 0.01) and in-hospital mortality (15% vs 16%, p = 0.06) were lower in patients admitted to a NSU as compared to non-NSU. We observed lower ventilator-free days (22 vs 24, p < 0.001) in NSU v. non-NSU. In the multivariable regression analysis adjusted for within-hospital effects, known variables of poor outcome, and the severity of illness APACHE-III score, the in-hospital mortality was lower for NSU admissions (OR, 0.8; 95%CI, 0.7-0.9, p = 0.02) as compared to non-NSU.ConclusionAdmission of critically ill brain-injured patients to dedicated NSUs is associated with lower actual in-hospital mortality. Future iterations of APACHE-IV modeling may need to incorporate NSU designations for calculations of expected mortality among brain-injured patients.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"902-906"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare-associated infections in Iranian pediatric and adult intensive care units: A comprehensive review of risk factors, etiology, molecular epidemiology, antimicrobial sensitivity, and prevention strategies during the COVID-19 pandemic.","authors":"Mehdi Safarabadi, Tahereh Motallebirad, Davood Azadi, Ali Jadidi","doi":"10.1177/08850666241249162","DOIUrl":"10.1177/08850666241249162","url":null,"abstract":"<p><p>The current review article provides a comprehensive analysis of nosocomial infections in pediatric and adult intensive care units (ICUs) in Iran. We examine the risk factors and etiology of nosocomial infections, with a particular focus on molecular epidemiology and antimicrobial sensitivity. In this article, we explore a range of prevention strategies, including hand hygiene, personal protective equipment, environmental cleaning, antibiotic stewardship, education, and training. Moreover, we discuss the impact of the COVID-19 pandemic on infection control measures in ICUs and provide valuable insights for healthcare professionals and policymakers seeking to address this critical public health issue. In conclusion, this review article can serve as a valuable resource for those interested in understanding and improving infection control in ICUs and beyond.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"839-848"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sepsis as a Potential Risk Factor for Upper Gastrointestinal Bleeding in Critically Ill Patients: A Systematic Review and Meta-analysis.","authors":"Yanfen Yao, Tejin Ba, Bagenna Bao, Shuanglin Zhang, Li Kong","doi":"10.1177/08850666241252048","DOIUrl":"10.1177/08850666241252048","url":null,"abstract":"<p><p><b>Purpose:</b> Sepsis is a common and critical condition in intensive care units (ICUs) known to complicate patient outcomes. Previous studies have indicated an association between sepsis and various ICU morbidities, including upper gastrointestinal bleeding (UGIB). However, the extent of this relationship and its implications in ICU settings remain inadequately quantified. This study aims to elucidate the association between sepsis and the risk of UGIB in ICU patients. <b>Methods:</b> A comprehensive meta-analysis was conducted, encompassing nine studies with a total of nearly 9000 participants. These studies reported events for both sepsis and nonsepsis patients separately. Pooled odds ratios (ORs) were calculated to assess the risk of UGIB in septic versus nonseptic ICU patients. Subgroup analyses were conducted based on age and study design, and both unadjusted and adjusted ORs were examined. <b>Results:</b> The pooled OR indicated a significant association between sepsis and UGIB (OR = 3.276, 95% CI: 1.931 to 5.557). Moderate heterogeneity was observed (I² = 43.9%). The association was significant in adults (pooled OR = 4.083) but not in children. No difference in association was found based on the study design. Unadjusted and adjusted ORs differed slightly, indicating the influence of confounding factors. <b>Conclusion:</b> This meta-analysis reveals a significant association between sepsis and an increased risk of UGIB in ICU patients, particularly in adults. These findings highlight the need for vigilant monitoring and proactive management of septic ICU patients to mitigate the risk of UGIB. Future research should focus on understanding the underlying mechanisms and developing tailored preventive strategies.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"849-859"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cleveland Clinic Post-ICU Recovery Clinic: Early Experience During the COVID-19 Pandemic.","authors":"Kavya Kommaraju, Heather Torbic, Joshua Veith, Xiaofeng Wang, Michelle Biehl","doi":"10.1177/08850666251326551","DOIUrl":"10.1177/08850666251326551","url":null,"abstract":"<p><p>BackgroundOver half of ICU survivors experience post intensive care syndrome (PICS). Few PICS clinics were operational in the United States at the onset of the COVID-19 pandemic. Here we describe early experience of such a clinic at a large academic medical center. Our objective was to describe the (a) model of care (b) clinic interventions (c) short-term cognitive, psychiatric, and functional outcomes (d) one-year outcomes of COVID-19 ICU survivors at the Cleveland Clinic post-ICU recovery clinic (PIRC).MethodsWe conducted a retrospective cohort study through a chart review of all patients seen in PIRC from April 2020 - December 2020. A total of 59 patients completed the visit with 49% being virtual, and 51% being in-person. The cohort was predominantly white (50.8%), and male (57.6%) with a median age of 58.2 years. We screened for cognitive and psychiatric impairments using several different validated questionnaires. Functional impairments were self-reported and detected after assessment by a physical therapist. Quantifiable clinic interventions were referrals, pharmacy medication reconciliation, and vaccine administration. One-year outcomes were health care utilization, and death.ResultsIn our cohort, 36%, 39.6%, and 17% of patients screened positive for cognitive impairment, anxiety and/or depression, and PTSD respectively. 42.3% of patients had lower extremity mobility impairment. 57.6% of patients required at least one referral after clinic. Of the 67.9% of patients who were working and 93.9% driving prior to hospitalization, only 24.6% and 73.2% had returned to those activities, respectively. The most common pharmacy intervention was discontinuation of a medication no longer in use. By one year, 34% of patients had hospital re-admissions with 5% requiring the ICU. There were no deaths.ConclusionsAdult survivors of COVID-19 critical illness have impairments in all PICS domains as well as high health care utilization in the first year after hospital discharge.MeSH TermsPost intensive care syndrome, COVID-19Key Points/SummaryAdult survivors of COVID-19 critical illness have impairments in all PICS domains as well as high health care utilization in the first year after hospital discharge. Post-ICU recovery clinics can help survivors with recovery.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"893-901"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Methylene Blue and Cyanocobalamin for Vasoplegic Syndrome in Liver Transplantation.","authors":"Yaroslava Longhitano, Ezeldeen Albuelkasem, Antonio Voza, Luigi La Via, Christian Zanza, Raymond M Planinsic","doi":"10.1177/08850666251347951","DOIUrl":"10.1177/08850666251347951","url":null,"abstract":"<p><p>Vasoplegic syndrome is a complication that may occur during liver transplantation, most often after donor graft reperfusion. Multiple factors in end-stage liver disease (ESLD) may contribute to this vasodilation which may be exacerbated during reperfusion in liver transplantation. Two cases of vasoplegia during living donor liver transplantation are reported along with a systematic review of current literature. These patients were successfully treated with methylene blue and cyanocobalamin. All publications between January 1992 to september 2024 that assessed the use of methylene blue and/or cyanocobalamin in vasoplegia during liver transplantation in humans were included. Seven case reports and one case series were found and reviewed. These consisted of 4 case reports of vasoplegic syndrome during liver transplantation treated with methylene blue and other four describing the use of cyanocobalamin. A total of twenty-four patients were treated with methylene blue and eight patients with cyanocobalamin in the reviewed articles and all patients had a beneficial impact on blood pressure after administration of the medications. Patients affected by vasoplegia during liver transplantation show encouraging results when treated with methylene blue and cyanocobalamin, but these data have to be confirmed by additional studies.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"907-914"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Cohort Study of the Role of Palliative Care Consultation for Patients on Extracorporeal Membrane Oxygenation.","authors":"Samira Teeri, Pooja Singh, Ritika Gadodia, Shikha Kapil, Maxwell Hockstein, Keki Balsara, Akram M Zaaqoq, Anirudh Rao","doi":"10.1177/08850666251327105","DOIUrl":"10.1177/08850666251327105","url":null,"abstract":"<p><p>BackgroundExtracorporeal membrane oxygenation (ECMO) serves as a critical intervention for patients with severe cardiac and pulmonary dysfunction. Given the high rates of mortality and morbidity, as well as the impact on families, palliative care (PC) integration is recommended. We aimed to examine the indications and outcomes of ECMO patients at a tertiary care hospital and evaluate the impact of PC consultation on patient outcomes.MethodsWe conducted a retrospective cohort study of 306 patients cannulated for venovenous (VV) or venoarterial (VA) ECMO from January 2020 to December 2022. We analyzed demographics, ECMO indications, and outcomes, comparing those who received PC consultations with those who did not.ResultsOf the 306 patients analyzed, 220 were on VA-ECMO and 86 on VV-ECMO. The overall in-hospital mortality rate was 49%. Patients on VV-ECMO had longer ECMO durations (8 vs 4 days) and hospital stays (31 vs 16 days, P < 0.001) than patients on VA-ECMO. PC consultations were associated with increased ECMO duration and hospital stay in both groups (P < 0.001). Mortality among patients who received PC consultations was not statistically different from those who did not (P = 0.68). Notably, patients with obesity on VA-ECMO had 2.3 times higher odds of in-hospital death (P = 0.027).ConclusionPC consultation is integral in managing patients on ECMO, focusing on holistic support for patients and their families. Further prospective studies are warranted to explore the psychosocial benefits of PC for patients on ECMO and their family members.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"885-892"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BRAIN-SIM: Leveraging Simulation for Neurocritical Care Education with an Innovative Multidisciplinary Approach.","authors":"Brett DerGarabedian, Lauren Lacovara, Justin Delic, Swarna Rajagopalan","doi":"10.1177/08850666251327156","DOIUrl":"10.1177/08850666251327156","url":null,"abstract":"<p><p>Background and ObjectivesEarly recognition and response are paramount in the treatment of neurologic emergencies. Due to its complexity, neurocritical care continues to provoke unease for practitioners and trainees. Simulation provides a realistic opportunity for learners to detect an acutely deteriorating neurologic patient and make rapid-fire treatment decisions. A multidisciplinary simulation-based learning environment may improve trainee confidence when caring for the neurocritical care patient population.MethodsNine simulation lab sessions were performed with a multidisciplinary team including medical students, residents, critical care medicine fellows, advanced practice providers (APP), critical care pharmacy residents, and neuroscience unit nurses. High fidelity manikins capable of reproducing acute neurologic and physiologic emergencies were used. After the simulation, participants completed a survey utilizing Likert scale responses regarding simulation logistics, faculty competence, and pre- and post-simulation confidence levels managing specific acute neurologic emergencies and performing neurocritical care procedural skills.ResultsNine simulation lab sessions were conducted, and thirty-eight surveys were completed. Mean learner confidence levels in managing patients improved from pre- to post-simulation in patients with coma [3.18 ± 0.51 versus 4.32 ± 0.25 (<i>P </i>< .001)], status epilepticus [3.23 ± 0.55 versus 4.36 ± 0.29 (<i>P </i>< .001)], acute ischemic stroke [3.75 ± 0.59 versus 4.63 ± 0.43 (<i>P </i>< .001)], intracerebral hemorrhage [3.25 ± 0.74 versus 4.63 ± 0.43 (<i>P </i>< .001)], intracranial hypertension [3.25 ± 0.74 versus 4.63 ± 0.43 (<i>P </i>< .001)], respiratory failure [3.5 ± 0.77 versus 4.63 ± 0.43 (<i>P </i>= .0016)], and procedures such as central lines [2.2 ± 0.56 versus 3.8 ± 0.56 (<i>P </i>= .003)], intubations [2.25 ± 0.39 versus 3.63 ± 0.62 (<i>P </i>< .001)], and bronchoscopies [2 ± 0 versus 3.2 ± 0.56 (<i>P </i>= .004). Consistently, learners strongly agreed that faculty were knowledgeable, well-informed, and thorough. Learners commented that the simulation experiences were realistic and allowed them to identify areas for improvement.DiscussionSimulation training can be an effective method to improve neurocritical care education by increasing clinician confidence in managing neurologic emergencies and procedures while providing opportunities for multidisciplinary collaboration. Further evaluation of the effectiveness of simulation education in this patient care setting is warranted.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"876-884"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and Impact of Sleep Disturbance in Critical Illness: A Review.","authors":"Shanshan Meng, Xiaoqing Li, Yixuan Chen, Jianfeng Xie, Yi Yang, Fengmei Guo","doi":"10.1177/08850666251359203","DOIUrl":"https://doi.org/10.1177/08850666251359203","url":null,"abstract":"<p><p>Sleep disturbances should not be overlooked in the management of critically ill patients. Critically ill patients frequently encounter sleep deprivation and circadian rhythm disruptions due to various factors, such as underlying diseases, environmental influences, frequent medical interventions, immobility, and delirium. This manuscript aims to review the research progress regarding the mechanisms and impact of sleep disturbances in critically ill patients, thereby enhancing sleep quality and stabilizing circadian rhythms. The synaptic homeostasis hypothesis, neural synchronization and desynchronization processes, memory consolidation mechanisms, metabolic and energy dynamics, immune system modulation, organ functional interactions, disruption of the light-dark cycle, and pharmacological agents utilized are all implicated in the pathophysiology of sleep disorders and circadian rhythm disturbances of critically ill patients. These conditions can exacerbate organ dysfunction, delay recovery, prolong hospital stays, and negatively impact both short-term and long-term outcomes. Understanding the pathogenesis of sleep disorders in critically ill patients effectively is of paramount importance.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666251359203"},"PeriodicalIF":3.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Community-Acquired Pneumonia: Impact of HIV on Clinical Presentation, Microbiological and Laboratory Findings, and Outcome.","authors":"J P Venturas, A Titus, G A Richards, C Feldman","doi":"10.1177/08850666251359546","DOIUrl":"https://doi.org/10.1177/08850666251359546","url":null,"abstract":"<p><p>Severe community-acquired pneumonia (SCAP) is associated with significant morbidity and mortality, but there is a paucity of data regarding these infections in sub-Saharan Africa, especially among people living with HIV (PLWH). This study investigated the impact of HIV on clinical presentation, microbial aetiology, laboratory findings, and outcome of SCAP. This was additional analysis of data from a large, single-centre, retrospective, observational study conducted among consecutive adult patients (≥18 years) admitted to the multidisciplinary ICU at the Charlotte Maxeke Johannesburg Academic Hospital, between 1 July 2007 and 31 May 2019, with SCAP. The current study describes 718 PLWH and 131 HIV-negative cases extracted from the initial cohort. The median age was 37 [IQR 30-46] years with PLWH significantly younger than their HIV-negative counterparts (36 years [IQR 29-44] years vs 52 years [IQR 34-65] years; P < .001). PLWH were more commonly female (P = .053), while more of the HIV-negative patients were male. The median CD₄ count of the PLWH was 42 [IQR 14-108] cells/mm³ and only 15.5% were on anti-retroviral therapy (ART) prior to hospitalisation. Differences were noted in clinical, laboratory and radiological features between the groups. Overall, <i>Mycobacterium tuberculosis</i> was the most common microbial aetiology in both groups, followed by <i>Streptococcus pneumoniae,</i> which was associated with a significantly lower mortality, whereas mortality with <i>Pneumocystis jirovecii</i> infection, which occurred only in PLWH, was high. Overall ICU mortality was high (48.9%), and while HIV was an independent risk factor for mortality (OR 0.58, 95% CI 0.37-0.92; p = .02) on univariate analysis, this finding was not true when HIV considered within the multivariable analysis. This study describes one of the largest cohorts of PLWH with SCAP and compares their findings with HIV-negative cases. HIV was not a significant predictor of mortality when considered in the context of other covariables on multivariable analysis.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666251359546"},"PeriodicalIF":3.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Tissue Oximetry Monitoring for Severe Brain Injury.","authors":"Sebastián Vásquez-García, Andrés M Rubiano, Kiwon Lee","doi":"10.1177/08850666251357487","DOIUrl":"https://doi.org/10.1177/08850666251357487","url":null,"abstract":"<p><p>Neurocritical care management for severe brain injuries (SBI) has traditionally focused on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) monitoring and treatment to prevent brain herniation and ischemia. However, the complex pathophysiology of secondary brain injury in SBI patients involves various mechanisms, including oxygen metabolism and transport disturbances, mitochondrial dysfunction, and signaling cascade disruption. Multimodal neuromonitoring (MMN) techniques and modern high-technology resources are being utilized to detect these detrimental phenomena and guide individualized clinical management strategies. Recent and ongoing clinical trials, mainly in traumatic brain injury (TBI), aim to assess the potential benefits, safety, reproducibility, and feasibility of adding cerebral tissue oximetry monitoring (CTOM) to the common practice of ICP monitoring. This state-of-the-art review highlights the essential concepts behind CTOM in patients with SBI, particularly in TBI, and provides practice-oriented analysis and considerations for healthcare providers managing these complex patients.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666251357487"},"PeriodicalIF":3.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}