Journal of interferon research最新文献_第10页

Obituary Shigeyasu Kobayashi 小林茂康的讣告

Journal of interferon research Pub Date : 1993-10-01 DOI: 10.1089/JIR.1993.13.311

M. Azuma

引用次数: 2

The effect of interferon-gamma on rejection and neutrophil function following transplantation. 干扰素对移植后排斥反应和中性粒细胞功能的影响。

Journal of interferon research Pub Date : 1993-10-01 DOI: 10.1089/jir.1993.13.359

A D Slater, J B Klein, C W Czarniecki, G Sonnenfeld

引用次数: 3

Effects of cytokines on the pituitary-adrenal axis in cancer patients. 细胞因子对肿瘤患者垂体-肾上腺轴的影响。

Journal of interferon research Pub Date : 1993-10-01 DOI: 10.1089/jir.1993.13.349

W E Nolten, D Goldstein, M Lindstrom, M V McKenna, I H Carlson, D L Trump, J Schiller, E C Borden, E N Ehrlich

{"title":"Effects of cytokines on the pituitary-adrenal axis in cancer patients.","authors":"W E Nolten, D Goldstein, M Lindstrom, M V McKenna, I H Carlson, D L Trump, J Schiller, E C Borden, E N Ehrlich","doi":"10.1089/jir.1993.13.349","DOIUrl":"https://doi.org/10.1089/jir.1993.13.349","url":null,"abstract":"Cytokines, which include interferons (IFNs), interleukins (ILs), and tumor necrosis factor (TNF), are immunoregulatory proteins produced by lymphocytes and inflammatory cells. Several cytokines, most noteworthy IFNs and ILs, stimulate glucocorticoid secretion. In this study, the effects of variable doses and repetitive administration of IFNs and TNF on secretion of pituitary hormones and cortisol were measured. Patients were given for a period of 15 days on alternating days injections of IFN-beta (IFN-beta ser), 90 or 450 x 10(6) IU, IFN-gamma, 0.1-100 x 10(6) IU, or TNF 125-275 micrograms/m2. Sixty to 120 min after IFN-beta ser injection median levels of cortisol, adrenocorticotropin (ACTH), prolactin (PRL), and growth hormone (GH) rose two-fold. Urinary free cortisol excretion increased significantly during the day following IFN-beta ser administration. IFN-gamma > or = 30 x 10(6) IU caused a comparable rise in plasma cortisol. TNF induced two- to four-fold increases in ACTH and cortisol. The fact that increased cortisol secretion was associated with a rise in the level of ACTH as well as PRL and GH suggests that the cytokines increased cortisol by stimulating the anterior pituitary. The hormonal response induced by cytokines was unrelated to their pyrogenic effect, undiminished with repetitive treatment, and not dose-dependent above a threshold level. These observations reinforce the concept of a physiologic link between the immune system and the hypothalamic-pituitary-adrenal (HPA) axis.","PeriodicalId":16268,"journal":{"name":"Journal of interferon research","volume":"13 5","pages":"349-57"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jir.1993.13.349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19287912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

Interferon-resistant Daudi cells are deficient in interferon-alpha-induced ISGF3 alpha activation, but remain sensitive to the interferon-alpha-induced increase in ISGF3 gamma content. 抗干扰素的Daudi细胞缺乏干扰素α诱导的ISGF3 α激活，但对干扰素α诱导的ISGF3 γ含量的增加仍然敏感。

Journal of interferon research Pub Date : 1993-10-01 DOI: 10.1089/jir.1993.13.377

M Dron, M G Tovey

{"title":"Interferon-resistant Daudi cells are deficient in interferon-alpha-induced ISGF3 alpha activation, but remain sensitive to the interferon-alpha-induced increase in ISGF3 gamma content.","authors":"M Dron, M G Tovey","doi":"10.1089/jir.1993.13.377","DOIUrl":"https://doi.org/10.1089/jir.1993.13.377","url":null,"abstract":"Low levels of the transcription factor ISGF3 alpha were detected in the cytoplasm and nucleus of untreated Daudi cells, which increased markedly following interferon (IFN) treatment. In contrast no ISGF3 alpha was detected in an IFN-resistant clone of Daudi cells, DIF8, and only low levels were detected in these cells after IFN-alpha treatment. High levels of ISGF3 were produced in vitro, however, by the addition of ISGF3 alpha to extracts of IFN-treated DIF8 cells, indicating that IFN is unable to produce substantial amounts of functional ISGF3 alpha in DIF8 cells. A second clone of IFN-resistant Daudi cells, DIF3, also exhibited defective ISGF3 alpha production, which was restored to normal in the subclone DIF3REV5 that had reverted to high IFN sensitivity. Thus, the antiproliferative effect of IFN on Daudi cells and derived clones is closely related to the level of ISGF3 present in the nucleus of these cells. IFN-alpha, however, also enhances the content of ISGF3 gamma in IFN-resistant cells as well as certain proteins of unknown function, raising the possibility that a second pathway of IFN-alpha signal transduction, distinct from the ISGF3 pathway, remains functional in both DIF8 and DIF3 cells.","PeriodicalId":16268,"journal":{"name":"Journal of interferon research","volume":"13 5","pages":"377-83"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jir.1993.13.377","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19288526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Transcription termination/polyadenylation occurs at multiple sites in the human type I interferon receptor gene. 人类I型干扰素受体基因的转录终止/多聚腺苷化发生在多个位点。

Journal of interferon research Pub Date : 1993-10-01 DOI: 10.1089/jir.1993.13.329

L L Hensley, P J Vojta, V K Han, D C Lee, H Ozer

{"title":"Transcription termination/polyadenylation occurs at multiple sites in the human type I interferon receptor gene.","authors":"L L Hensley, P J Vojta, V K Han, D C Lee, H Ozer","doi":"10.1089/jir.1993.13.329","DOIUrl":"https://doi.org/10.1089/jir.1993.13.329","url":null,"abstract":"Based on the previously reported sequence, we isolated an independent cDNA clone encoding a binding component of the human type I interferon receptor (IFN-R). This cDNA is identical to the published sequence except that it lacks 62 bases of 5' untranslated sequence and terminates at the first of two potential polyadenylation sites. In Northern blot analyses of poly(A)+RNAs from both IFN-sensitive and IFN-resistant Daudi cells, this cloned cDNA hybridized to a predominant mRNA of 2.4 kb, as well as to mRNAs of 1.8, 4.8, and 5.6 kb, and occasionally 6.9 kb. These various transcripts, which were also observed at similar levels in Raji B cells and two T-cell lines, Jurkat and MOLT-4, were detected after high-stringency washes, and by alternate probes corresponding to subfragments of the cDNA. In contrast, only the 4.8- and 5.6-kb transcripts hybridized to a polymerase chain reaction (PCR)-derived probe that corresponded to genomic sequences immediately down-stream from the second polyadenylation site. These results indicate that the latter transcripts arise from the same gene as the predominant 2.4-kb mRNA due to incomplete transcription termination at either of the known polyadenylation sites. Finally, Northern blot analysis of total RNAs revealed the presence of the predominant 2.4-kb type I IFN-R transcript in numerous tissues from second trimester human fetuses, suggesting that the type I IFN-R gene is constitutively expressed in multiple cell types.","PeriodicalId":16268,"journal":{"name":"Journal of interferon research","volume":"13 5","pages":"329-32"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jir.1993.13.329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19287909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

ISICR 93. Annual Meeting of the International Society for Interferon and Cytokine Research. Tokyo, Japan, October 24-28, 1993. Abstracts. ISICR 93。国际干扰素和细胞因子研究学会年会。1993年10月24日至28日，日本东京。摘要。

Journal of interferon research Pub Date : 1993-10-01

引用次数: 0

Cloning and structural analysis of four genes encoding interferon-omega in rabbit. 兔干扰素编码基因的克隆及结构分析。

Journal of interferon research Pub Date : 1993-10-01 DOI: 10.1089/jir.1993.13.313

M Charlier, R L'Haridon, M Boisnard, J Martal, P Gaye

{"title":"Cloning and structural analysis of four genes encoding interferon-omega in rabbit.","authors":"M Charlier, R L'Haridon, M Boisnard, J Martal, P Gaye","doi":"10.1089/jir.1993.13.313","DOIUrl":"https://doi.org/10.1089/jir.1993.13.313","url":null,"abstract":"By using an ovine interferon-tau (IFN-tau) cDNA probe, four recombinant phages were isolated from a rabbit genomic library and sequenced from nucleotides -450 to 1,300 relative to the CAP site. Each of the four rabbit genes contains an open reading frame of 595 nucleotides and code for proteins that exhibit structural characteristics of the interferon-omega (IFN-omega) family. They display more than 98% identity in their coding regions. The deduced amino acid sequences share > 96% sequence similarity. In contrast, the 5' and 3' noncoding regions have diverged considerably (approximately 50% identity). Amino acid comparisons of rabbit IFN-omega with IFN-omega of other species reveal the highest degree of identity with human (72%), followed by porcine (68%) IFN-omega. Rabbit IFN-omega displays only 57% sequence similarity with ovine IFN-tau. The coding regions of the four genes subcloned in a cytomegalovirus eukaryotic expression vector and transfected in monkey COS-7 cells direct the production of proteins that protect bovine and rabbit cells against vesicular stomatitis virus infection, thus demonstrating that these genes encode fully active IFN proteins. The expression of these genes was studied in Sendai-induced rabbit leukocytes. A single band of poly(A)+RNA hybridized with a rabbit IFN-omega probe under stringent conditions, whereas no IFN-omega transcript was detected with RNA isolated from uninduced leukocytes. Southern blot analysis suggest the existence of at least eight IFN-omega genes or pseudogenes in the rabbit genome.","PeriodicalId":16268,"journal":{"name":"Journal of interferon research","volume":"13 5","pages":"313-22"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jir.1993.13.313","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19287908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Reversal of an interferon-gamma-resistant phenotype by poly(I:C): possible role of double-stranded RNA-activated kinase in interferon-gamma signaling. 通过poly(I:C)逆转干扰素- γ抗性表型:双链rna激活激酶在干扰素- γ信号传导中的可能作用。

Journal of interferon research Pub Date : 1993-08-01 DOI: 10.1089/jir.1993.13.283

O N Ozes, M W Taylor

{"title":"Reversal of an interferon-gamma-resistant phenotype by poly(I:C): possible role of double-stranded RNA-activated kinase in interferon-gamma signaling.","authors":"O N Ozes, M W Taylor","doi":"10.1089/jir.1993.13.283","DOIUrl":"https://doi.org/10.1089/jir.1993.13.283","url":null,"abstract":"Indoleamine 2,3-dioxygenase (IDO) is induced in neoplastic cell lines by interferon-gamma (IFN-gamma) treatment. In ME180 cervical carcinoma cells, there is a rapid increase in IDO mRNA accumulation beginning at 4 h after IFN-gamma treatment and continuing for at least 24 h. The IFN-gamma-resistant mutant of ME180, IR3B6B, expresses very low levels of IDO message after IFN-gamma treatment. However, pretreatment of this mutant with poly(I:C) restores normal levels of IDO mRNAs and IDO enzyme activity. Poly(I:C) mediated reversal of the IFN-gamma-resistant phenotype and induction of IDO mRNA are inhibited by 2-aminopurine. In vitro phosphorylation of calf thymus histone using the immunoprecipitated p68 kinase prepared from IFN-gamma-treated ME180 and IR3B6B cells revealed the deficiency of activation of this kinase in IR3B6B cells after IFN-gamma treatment, and treatment of this mutant cells with poly(I:C) restores p68 kinase activity. From these results, we conclude that a double-stranded RNA-dependent kinase is activated by IFN-gamma treatment and its activation correlates with IFN-gamma-mediated induction of the IDO gene.","PeriodicalId":16268,"journal":{"name":"Journal of interferon research","volume":"13 4","pages":"283-8"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jir.1993.13.283","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18897703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Effect of carbohydrates on the pharmacokinetics of human interferon-gamma. 碳水化合物对人干扰素- γ药代动力学的影响。

Journal of interferon research Pub Date : 1993-08-01 DOI: 10.1089/jir.1993.13.267

T Sareneva, K Cantell, L Pyhälä, J Pirhonen, I Julkunen

{"title":"Effect of carbohydrates on the pharmacokinetics of human interferon-gamma.","authors":"T Sareneva, K Cantell, L Pyhälä, J Pirhonen, I Julkunen","doi":"10.1089/jir.1993.13.267","DOIUrl":"https://doi.org/10.1089/jir.1993.13.267","url":null,"abstract":"Human interferon-gamma (IFN-gamma) has two N-linked glycosylation sites at positions 25 and 97 of the 143-amino-acid-long secretory form. To study the role of glycan residues in the pharmacokinetics of IFN-gamma, we produced recombinant IFN-gamma molecules lacking either one or both of the glycosylation sites (Asn mutated to Gln) by baculovirus expression in insect cells. In addition, we produced the fully glycosylated forms both in insect cells and in human leukocyte cultures. Two million units of each IFN were injected intravenously or intramuscularly into rabbits. The glycosylated IFN-gamma molecules from the insect cells were rapidly eliminated from the blood. This is probably due to the fact that their oligosaccharides are of a high mannose type that are rapidly taken up by the liver. The unglycosylated IFN-gamma persisted longer in the blood than the glycosylated recombinant forms. However, the natural IFN-gamma exhibited the longest survival in the blood. The results emphasize the importance of the carbohydrate groups in human IFN-gamma to its pharmacokinetic properties.","PeriodicalId":16268,"journal":{"name":"Journal of interferon research","volume":"13 4","pages":"267-9"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jir.1993.13.267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19217569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Interferon-gamma, but not interferon-alpha beta, synergizes with tumor necrosis factor-alpha and lipid A in the induction of nitric oxide production by murine L929 cells. 干扰素- γ，而非干扰素- α - β，与肿瘤坏死因子- α和脂质A协同诱导小鼠L929细胞产生一氧化氮。

Journal of interferon research Pub Date : 1993-08-01 DOI: 10.1089/jir.1993.13.271

D J Fast, R C Lynch, R W Leu

{"title":"Interferon-gamma, but not interferon-alpha beta, synergizes with tumor necrosis factor-alpha and lipid A in the induction of nitric oxide production by murine L929 cells.","authors":"D J Fast, R C Lynch, R W Leu","doi":"10.1089/jir.1993.13.271","DOIUrl":"https://doi.org/10.1089/jir.1993.13.271","url":null,"abstract":"Recently, we have demonstrated that tumor necrosis factor (TNF)-sensitive tumor cells produce nitric oxide (NO) in response to TNF whereas TNF-resistant cells do not. Because the addition of interferon-gamma (IFN-gamma) augmented NO production, we were interested in investigating this phenomenon further and comparing the effects of IFN-gamma with those of IFN-alpha beta. We found that cell lines that are sensitive to TNF-mediated cytotoxicity (TMC) produced NO in response to TNF and IFN-gamma, but not in response to IFN-alpha beta. The effect of IFN-gamma on NO production was dose dependent, but IFN-gamma by itself did not induce NO production. A TNF-resistant cell line (MCA) did not produce NO under any of the conditions tested. Different results were obtained when the effect of IFNs on TMC was assayed. TNF-sensitive L929 cells were rendered less sensitive to TNF after treatment with both types of IFN. In contrast, another TNF-sensitive cell, WEHI 164, was rendered more sensitive to TMC after treatment with both types of IFN. The effect of IFNs on WEHI cells was dose dependent. Neither IFN had any effect on TNF sensitivity of TNF-resistant MCA cells. The addition of lipid A (LA) had no effect on TMC under any condition. However, L929 cells treated with LA, TNF, and IFN-gamma produced twice as much NO as cells treated with TNF and IFN-gamma only. Northern analysis for cytokine-inducible NO synthase (NOS) mRNA steady-state levels indicated that TNF synergized with IFN-gamma to induce increased accumulation of NOS mRNA.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":16268,"journal":{"name":"Journal of interferon research","volume":"13 4","pages":"271-7"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jir.1993.13.271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18698101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14