Journal of Korean Medical Science最新文献

{"title":"Clinical Characteristics and Epidemiology of Cardiovascular Autonomic Neuropathy in Peoples With Long-Standing Diabetes.","authors":"Sook Jung Lee, Chong Hwa Kim, Su Jin Jeong, Jae-Seung Yun, Jong Chul Won, Jae Hyuk Lee, Ie Byung Park, Chang Won Lee, Hyuk-Sang Kwon, Tae Sun Park","doi":"10.3346/jkms.2025.40.e154","DOIUrl":"10.3346/jkms.2025.40.e154","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular autonomic neuropathy (CAN) is a frequently underdiagnosed complication of diabetes mellitus that contributes to increased mortality and morbidity rates. This multicenter study investigated the epidemiology and clinical characteristics of CAN in patients with long-term diabetes.</p><p><strong>Methods: </strong>Retrospective data were collected from 884 individuals with diabetes who were assessed for CAN across eight hospitals in Korea. CAN was diagnosed using electrocardiography and cardiovascular autonomic function tests, including the heart rate-corrected QT interval and Ewing's method. This study evaluated the clinical characteristics, cardiovascular autonomic nerve function test results, and risk factors associated with CAN.</p><p><strong>Results: </strong>Among the 884 patients, 778 (88%) were diagnosed with CAN (DCAN), while 106 (12%) were not (non-DCAN). Individuals with DCAN were older, had a longer duration of diabetes, and had higher creatinine levels. The DCAN group showed decreased time and frequency parameters of heart rate variability (HRV). A multiple logistic regression analysis revealed that a longer diabetes duration, older age, and higher creatinine level were significant risk factors for CAN.</p><p><strong>Conclusion: </strong>CAN was associated with advanced age, a longer duration of diabetes, higher creatinine levels, and lower time and frequency HRV parameters.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 28","pages":"e154"},"PeriodicalIF":2.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outbreak of Severe Obesity and Metabolic Complications in Children and Adolescents Using the Korea National School Health Examination (KNSHE) From 2017 to 2021.","authors":"Kyung Hee Kim, Hye Ah Lee, Jung Eun Choi, Eunji Mun, Rosie Lee, Hyesook Park, Hae Soon Kim","doi":"10.3346/jkms.2025.40.e160","DOIUrl":"10.3346/jkms.2025.40.e160","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to estimate the prevalence of obesity in school children by severity and to assess the coronavirus disease 2019 (COVID-19) pandemic's impact on changes in the prevalence of obesity. In addition, the prevalence of obesity-related metabolic complications was calculated.</p><p><strong>Methods: </strong>We used data from 390,580 school-aged children in the 2017-2021 Korea National School Health Examination to estimate the prevalence of obesity and assess secular trends in prevalence. We estimated the prevalence of metabolic complications in overweight and obese students with serological data and assessed their association with the degree of obesity, which was classified as overweight, obesity, and severe obesity per the criteria of the American Academy of Pediatrics.</p><p><strong>Results: </strong>In 2021, the prevalence of overweight, obesity, and severe obesity among school children was 12.5%, 17.6%, and 4.9%, respectively, for boys and 10.8%, 11.9%, and 2.9%, respectively, for girls, and these values have been increasing significantly since 2017. Compared with the pre-COVID-19 period, the increase in the prevalence of obesity and severe obesity was remarkable, especially in elementary school students. The linear relationship between the prevalence of metabolic complications and the degree of obesity was evident in high school students. In elementary school students, similar relationships were found with nonalcoholic fatty liver disease and high blood pressure.</p><p><strong>Conclusion: </strong>The severity of obesity in school-age children (especially younger children) is worsening, and this may predict an increase in the prevalence of related metabolic complications. To prevent long-term complications, it is essential to expand health screening programs.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 28","pages":"e160"},"PeriodicalIF":2.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical Guide of the Korean Association for Geriatric Psychiatry to Anti-Amyloid Monoclonal Antibody Therapy for Alzheimer's Disease: Focused on Lecanemab.","authors":"So Yeon Jeon, Sheng-Min Wang, Hyun Woong Roh, Keun You Kim, Yoon Young Chang, Eosu Kim, Jae-Nam Bae, Seung-Ho Ryu","doi":"10.3346/jkms.2025.40.e215","DOIUrl":"10.3346/jkms.2025.40.e215","url":null,"abstract":"<p><p>The advent of anti-amyloid monoclonal antibody (mAb) therapies represents a paradigm shift in the treatment of Alzheimer's disease (AD), from symptomatic relief to disease modification. Lecanemab, a humanized mAb targeting soluble Aβ protofibrils and plaque, received regulatory approval in Korea in July 2024, following global randomized controlled trial data demonstrating its efficacy to reduce amyloid burden and slow cognitive decline. However, the introduction of such therapies into routine clinical realm presents several practical and systemic challenges, particularly in the context of Korea's unique healthcare infrastructure and reimbursement environment. In response, the Korean Association for Geriatric Psychiatry has developed the first comprehensive domestic guidance to facilitate the safe, evidence-based, and patient-centered use of anti-amyloid mAb therapies, first focused on lecanemab. This practical guide goes beyond simple eligibility criteria. It provides detailed recommendations on clinical and imaging-based candidate selection, amyloid-related imaging abnormalities (ARIA) risk stratification and monitoring protocols, infusion workflows, adverse event management strategies, and multidisciplinary coordination within hospital systems. It also emphasizes shared decision-making and outlines how to navigate situations where treatment is not appropriate, such as in patients with advanced dementia, high-risk magnetic resonance imaging findings, or poor treatment adherence, reinforcing that non-treatment can also represent a legitimate, evidence-based clinical decision. The guidance further highlights the urgent need to generate real-world data that reflect the treatment experiences of Korean patients. Multicenter collaboration will be essential for collecting data on adherence rates, ARIA incidence, cognitive outcomes, and functional trajectories, which in turn can inform policy decisions, insurance reimbursement models, and future updates to clinical guidelines. This publication represents the first nationwide roadmap in Korea to support clinicians in the appropriate integration of monoclonal antibody therapies for AD. By combining scientific rigor, operational feasibility, and ethical sensitivity, it aims to promote safe and responsible adoption of disease-modifying treatment across various clinical settings.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 28","pages":"e215"},"PeriodicalIF":2.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Correction of Authors and Supplementary Tables in the Article \"Quality of Life in Women With Gestational Diabetes Mellitus and Treatment Satisfaction Upon Intermittently Scanned Continuous Glucose Monitoring\".","authors":"Joon Ho Moon, Hyeon Ji Kim, Jee Yoon Park, Kyung Joon Oh, Sung Hee Choi, Hak Chul Jang","doi":"10.3346/jkms.2025.40.e222","DOIUrl":"10.3346/jkms.2025.40.e222","url":null,"abstract":"<p><p>This corrects the article on p. e46 in vol. 40, PMID: 40259722.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 28","pages":"e222"},"PeriodicalIF":2.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Triple Therapy on the Clinical Course of Non-Eosinophilic COPD Groups B.","authors":"Jin Hwa Song, Shinhee Park, Jong Geol Jang, Youlim Kim, Seung Won Ra, Chang Youl Lee, Deog Kyeom Kim, Hyoung Kyu Yoon, Kwang Ha Yoo, Hee Joung Kim","doi":"10.3346/jkms.2025.40.e147","DOIUrl":"10.3346/jkms.2025.40.e147","url":null,"abstract":"<p><strong>Background: </strong>Although the efficacy of triple therapy in treating chronic obstructive pulmonary disease (COPD) patients with a history of exacerbation is well established in groups with frequent exacerbations, less research has been conducted on its use in group B. Here, we investigated the effects of triple therapy on COPD patients with low eosinophil counts in the context of the current management of group B.</p><p><strong>Methods: </strong>Using data from the Korean COPD Subtype Study (KOCOSS), we selected patients with blood eosinophil count (BEC) less than 300 cells/μL as non-eosinophilic COPD groups. The study evaluated the effect of a triple therapy group (combination of inhaled corticosteroid, a long-acting β2-agonist [LABA] and a long-acting muscarinic antagonist [LAMA]) and a dual therapy group (LABA/LAMA) on moderate-to-severe exacerbations, as well as longitudinal changes in lung function over 3 years in patients categorized as Global Initiative for Chronic Obstructive Lung Disease (GOLD) B.</p><p><strong>Results: </strong>Of the 328 non-eosinophilic COPD group B, 145 (44.2%) patients were in triple therapy and 183 (55.8%) patients were in dual therapy. Triple therapy group showed an increased risk of moderate-to-severe exacerbation in multivariate adjusted model (adjusted incidence rate ratio of annual rate, 2.04; 95% confidence interval, 1.45 to 2.84; <i>P</i> < 0.001). Similarly, restricted cubic spline regression analysis of annual rates of moderate-to-severe exacerbations suggested an increased risk associated with the triple therapy over dual therapy in BEC lower than 300 cells/μL. There was no significant difference in the adjusted rate of forced expiratory volume in 1 second decline between triple therapy group and dual therapy group (-10.0 [-39.8 to -19.7] mL/year vs. 22.3 [-4.4 to -49.0] mL/year, <i>P</i> for interaction = 0.888).</p><p><strong>Conclusion: </strong>In conclusion, our research suggests that triple therapy was associated with a higher risk of moderate-to-severe exacerbations in non-eosinophilic COPD categorized as GOLD B compared with dual therapy.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 28","pages":"e147"},"PeriodicalIF":2.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Safety of Stereotactic Hematoma Aspiration via Supraorbital Keyhole Route in Patients With Basal Ganglia Spontaneous Intracerebral Hemorrhage: A Single Center Retrospective Analysis.","authors":"Jang Hun Kim, Seongwoo Lee, Dong-Hyuk Park, Shin-Hyuk Kang, Kyung-Jae Park","doi":"10.3346/jkms.2025.40.e159","DOIUrl":"10.3346/jkms.2025.40.e159","url":null,"abstract":"<p><strong>Background: </strong>Stereotactic hematoma aspiration surgery was introduced to mitigate the mass effect and subsequent secondary injuries caused by spontaneous intracerebral hemorrhage (sICH) in the basal ganglia. This study posited that the supraorbital keyhole (SOK) route, along with its longer axial trajectory, may achieve improved hematoma aspiration rates and functional outcomes compared with the traditional Kocher's point (KP) route for the evacuation of hematomas in the basal ganglia.</p><p><strong>Methods: </strong>Seventy-six patients were enrolled between January 2010 and December 2021 (KP [n = 41] and SOK [n = 35]). Frameless stereotactic hematoma aspiration was performed under a neurosurgical navigation system. Comparison analyses of radiologic and clinical data and logistic regression analyses for identifying the parameters of \"well-aspirated (> 70%)\" were performed. Additionally, subgroup analyses (KP [n = 22] and SOK [n = 28]) were performed in patients with \"typical\" shape of hematomas.</p><p><strong>Results: </strong>In the comparative analyses, the aspiration rate of the hematoma was lower in the SOK group (50.71% vs. 38.49%) than that in the KP group; however, this difference was not significant (<i>P</i> = 0.077). In the subgroup analysis, the aspiration rate was significantly higher in the SOK group than that in the KP group (52.6% vs. 33.6%, <i>P</i> = 0.039), and good functional outcomes (modified Rankin Scale score, 0-2) were significantly higher in the SOK group (71.4% vs. 28.6%, <i>P</i> = 0.049) than those in the KP group. Univariate and multivariate logistic regression analyses identified \"lesser midline shifting\" and \"SOK approach\" as the significant predictors of better aspiration rates (> 70%), suggesting that these factors are beneficial for achieving optimal surgical outcomes.</p><p><strong>Conclusion: </strong>Considering the unique lentiform shape and deep-seated location of basal ganglia sICH, stereotactic aspiration of the SOK route is recognized for its safety and efficacy in achieving a high rate of hematoma aspiration.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 28","pages":"e159"},"PeriodicalIF":2.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness of Psychosomatic Medicine in Korea: Results From an Online Survey Conducted With Doctors and the General Public.","authors":"Hee Jin Kim, Hong Jun Jeon, Won Sub Kang, Jae-Won Choi, Seung-Ho Jang, Cheolmin Shin, Moon-Soo Lee, Hyungmo Sung, Jeongwan Hong, Sun Mi Kim, Jee Hyun Ha","doi":"10.3346/jkms.2025.40.e138","DOIUrl":"10.3346/jkms.2025.40.e138","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess and compare psychosomatic medicine (PM) awareness, understanding, and related educational needs in doctors and the general public, and discuss how education for these groups should be provided.</p><p><strong>Methods: </strong>The Korean Psychosomatic Society conducted an online survey targeting 101 doctors and 100 general public, aged 20-60 years. Sociodemographic data, PM awareness, understanding, PM-related keyword before and after a brief introduction to PM, and educational needs concerning PM were collected.</p><p><strong>Results: </strong>PM awareness, understanding, and educational needs concerning PM differed significantly between groups. The doctor group reported a significantly higher PM awareness and understanding, and there were significant differences between the groups regarding the frequently-selected PM-related keywords. In the doctor group, they were \"digestion,\" \"functional,\" \"irritable bowel syndrome,\" \"pain,\" \"psychogenic,\" and \"somatic symptom disorder\" in the general public group, they were \"brain,\" \"cause,\" \"influence,\" \"mind,\" \"panic disorder,\" \"problem,\" \"psychology,\" \"response,\" and \"treatment.\" Additionally, the brief introduction to PM improved PM awareness in both groups. There was a significant difference in the frequently-selected PM-related keywords after the brief introduction. In the doctor group, the words significantly more selected were \"association,\" \"concept,\" \"connection,\" and \"influence\" and the word significantly less selected was \"mind.\" In the general public group, the words significantly more selected were \"association,\" \"connection,\" \"irritable bowel syndrome,\" and \"somatic symptom disorder,\" and the words significantly less selected were \"autonomic nervous system,\" \"brain,\" \"menopause,\" \"panic disorder.\" The two groups also diverged in their educational needs concerning PM. The most frequently selected needs in the doctor group were \"stress and chronic pain,\" \"mental health issues in cancer patients,\" and \"stress and gastrointestinal disorders\" in the general public, they were \"how to self-manage stress,\" \"stress and chronic pain,\" and \"medical treatments for stress.\"</p><p><strong>Conclusion: </strong>Doctors identified more PM-specific terms, whereas the general public had a vaguer understanding of PM. Even a brief education intervention significantly helped align the perceptions of both groups with current PM theory, highlighting the impact of education. Regarding PM educational content recommendations, the focus should be on stress education for the general public and on practical assessment and management of psychosomatic disorders for doctors.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 27","pages":"e138"},"PeriodicalIF":3.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Limitations of the MMSE in the Diagnosis and Staging of Dementia: A Commentary.","authors":"Josef Finsterer","doi":"10.3346/jkms.2025.40.e218","DOIUrl":"10.3346/jkms.2025.40.e218","url":null,"abstract":"","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 27","pages":"e218"},"PeriodicalIF":3.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Gaps in Research on Infectious Diseases Among Migrants in Korea: Implications for Future Studies.","authors":"Junseo Oh, Dongwook Kim, Chiara Achangwa, Sheikh Taslim Ali, Sukhyun Ryu","doi":"10.3346/jkms.2025.40.e142","DOIUrl":"10.3346/jkms.2025.40.e142","url":null,"abstract":"<p><strong>Background: </strong>The public health impact of infectious diseases among migrants is a growing concern. In this study, we aimed to examine Korean studies focused on infectious diseases among the migrant population in South Korea.</p><p><strong>Methods: </strong>We searched PubMed, Medline, Embase, Cochrane Library, and Web of Science for studies published between 2000 and 2024 that reported and provided quantitative data on infectious diseases in migrants in Korea.</p><p><strong>Results: </strong>Five studies met the inclusion criteria, focusing on measles, hepatitis A, hepatitis B, and tuberculosis (TB). The seroprevalence among migrants was 75.3% for measles, 70.1% for hepatitis A, and 60.4% for hepatitis B which were similar to that of the Korean population. However, migrants showed a higher burden of TB, with 28.1% testing positive for latent TB compared to 19.0% for the Korean population.</p><p><strong>Conclusion: </strong>Migrants in Korea exhibited a significantly higher prevalence of latent TB compared to the native population, while their seropositivity rates for measles, hepatitis A, and hepatitis B are comparable to those of Koreans. These findings highlight the urgent need for targeted screening and enhanced surveillance programs to monitor TB and other infectious diseases within this growing migrant population.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 27","pages":"e142"},"PeriodicalIF":3.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>SLC5A8</i> Missense Variants on Its Tumor-Suppressive Function.","authors":"Seung Yeon Ha, Hyo Sook Song, Jin-Young Kim, Youn-Hee Choi, Ji Ha Choi","doi":"10.3346/jkms.2025.40.e146","DOIUrl":"10.3346/jkms.2025.40.e146","url":null,"abstract":"<p><strong>Background: </strong>Solute carrier family-5 member-8 (SLC5A8) serves as a plasma membrane transporter for monocarboxylates, such as lactate, butyrate, pyruvate, acetate, propionate, nicotinate, and β-hydroxybutyrate. SLC5A8 can suppress colorectal cancer (CRC), and its tumor-suppressive function is mainly associated with butyrate, propionate, and pyruvate, which inhibit histone deacetylase. Although SLC5A8 is an important tumor suppressor, the impact of <i>SLC5A8</i> variants on its tumor-suppressive function have not been reported. In this study, we investigated the effects of <i>SLC5A8</i> missense variants on the expression and tumor-suppressive function of the transporter using various in vitro assays.</p><p><strong>Methods: </strong>Common <i>SLC5A8</i> missense variations were identified using data from the Database of Single-Nucleotide Polymorphisms of the National Center for Biotechnology Information. We generated HCT116 and DLD-1 cell lines stably overexpressing wild-type <i>SLC5A8</i> or <i>SLC5A8</i> variants. The effect of each variant on SLC5A8 expression was examined via immunoblotting. Finally, using colony-formation, wound-healing, and invasion assays, we investigated whether the decrease in SLC5A8 expression resulting from its variants could affect the tumor-suppressive function of the transporter.</p><p><strong>Results: </strong>We identified two common missense single-nucleotide polymorphisms of <i>SLC5A8</i>, Val193Ile (rs1709189) and Met490Ile (rs164365), and assembled two major haplotypes of <i>SLC5A8</i>. Among these haplotypes, haplotype 1 contained wild-type <i>SLC5A8</i> mRNA sequences and H2 contained two variants: Val193Ile and Met490Ile. Val193Ile and H2 significantly decreased SLC5A8 expression. These variants significantly increased the proliferation, migration, and invasion abilities of CRC cells.</p><p><strong>Conclusion: </strong>Decreased SLC5A8 expression caused by missense <i>SLC5A8</i> variants appeared to significant impair the tumor-suppressive function of the transporter.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 27","pages":"e146"},"PeriodicalIF":3.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}