Neonatology, surgery and perinatal medicine最新文献

{"title":"PECULIARITIES OF THE COURSE OF THE DISEASE IN WOMEN WITH COVID-19","authors":"V. Moskaliuk, O. Yuzko, L. Dubyk, N. Chernetska","doi":"10.24061/2413-4260.xiii.2.48.2023.16","DOIUrl":"https://doi.org/10.24061/2413-4260.xiii.2.48.2023.16","url":null,"abstract":"One of the most crucial topics at the moment is the viral infection caused by the SARS-CoV-2 coronavirus, which has acquired not only medical, but also, of course, social significance. The COVID-19 pandemic has challenged healthcare systems around the world.Pregnant women are the most vulnerable category of people, along with the elderly. Due to low immune reactivity, they are more susceptible to severe complications than others, which makes the problem of pregnancy in patients with COVID-19 a pressing issue.A successful pregnancy requires changes in the immune system of the pregnant woman to tolerate a genetically foreign fetus. These changes in the immune system, as well as in the cardiac, pulmonary, and other systems, can lead to increased susceptibility or increased morbidity and mortality due to infection during pregnancy. Considering the physiological adaptations associated with pregnancy, we found that the high metabolic demand to maintain normal intrauterine development increases the burden of oxidative stress during pregnancy. Intracellular redox changes associated with acute phase reactions at the maternal-fetal interface may be enhanced during pregnancy. Notably, mother-to-fetal transmission of SARS-CoV-2 has not been detected in most COVID-19 pregnancies. This relative absence of vertical transmission may be due to the presence of lactoferrin in the placenta, amniotic fluid, and breast secretions. However, the cytokine storm induced during COVID-19-associated pregnancies can cause severe inflammatory damage to the fetus and, if left uncontrolled, can subsequently lead to autism spectrum disorders and brain developmental abnormalities in newborns. Given this serious health threat to a child's growth and development, preventing COVID-19 during pregnancy should be a priority.We aimed to study risk factors and assess the course of pregnancy in women with COVID-19.The study was carried out within the framework of the research work \"Clinical and pathogenetic substantiation of differentiated treatment of combined pathology of internal organs\" (№0122U002209).","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124826790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECT OF MELATONIN ON THE LEVEL OF CYTOKINES IN PREECLAMPSIA","authors":"R. Savka, A. Berbets, S. Pryimak, O. Yuzko, D. Berbets","doi":"10.24061/2413-4260.xiii.2.48.2023.14","DOIUrl":"https://doi.org/10.24061/2413-4260.xiii.2.48.2023.14","url":null,"abstract":"Introduction. The literature reports a decrease in melatonin levels in preeclampsia, when the degree of decrease correlates with the severity of the process, as well as a decrease in the expression of melatonin receptors in the placental tissue in case of fetal growth restriction.Regarding changes in the cytokine profile in PE: there is evidence that the levels of proinflammatory cytokines, namely TNF-α and IL-6, increase in preeclampsia, while the concentrations of anti-inflammatory cytokines, namely IL-4 and IL-10, decrease. Melatonin, on the contrary, reduces the secretion of proinflammatory cytokines, in particular TNF-α, and increases the production of anti-inflammatory cytokines, namely IL-10. Therefore, normalization of melatonin levels may be a promising direction in the treatment of PE in pregnant women.Objective of the study. Assess the pathogenetic mechanisms of complications arising from a decrease in melatonin, and, in particular, find out more about the changes in melatonin, IL-6 and IL-10, determine the correlation between them.Material and research methodsThe study conducted at the Department of Pregnancy Pathology of the Chernivtsi Regional Perinatal Center, involved 32 women whose pregnancy was complicated by preeclampsia. The control group consisted of 33 women with uncomplicated pregnancies observed in the antenatal clinic of the Chernivtsi Regional Perinatal Center.The patient's informed consent form and the patient's examination card were approved by the Biomedical Ethics Committee of Bukovinian State Medical University (BSMU) of the Ministry of Health of Ukraine (Chernivtsi). The work was guided by the general provisions of the Declaration of Helsinki \"Recommendations for Physicians for Biomedical Research Involving Human Subjects\" (1964), the World Medical Association on Ethical Principles for Scientific Medical Research Involving Human Subjects (1964-2000), considering the requirements of Directive 2001/20/EC of the European Parliament and of the Council, ICH GCP, the Council of Europe Convention on Human Rights and Biomedicine (04.04.1997), Order of the Ministry of Health of Ukraine No. 690 of 23.09.2009.Statistical data were calculated using MedCalc software developed by MedCalc Software (Ostend, Belgium). The results were evaluated using the Mann-Whitney U-test for small groups. The P value of <0.05 was considered valid. Correlation and regression statistical evaluations were also performed using the aforementioned software.R&D «Preservation and restoration of reproductive health of women and girls in obstetric and gynecological pathology». State registration number: 0121U110020. Terms of execution: 01.2021–12.2025 yy.Research results. The level of melatonin in venous blood taken from women with diagnosed PE was significantly lower (p=0.029), as well as levels of placental growth factor PlGF (p<0.0001), compared to healthy women. In our study we also found that the concentrations of both proinflammatory IL-6 and anti-i","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122645305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UKRAINIAN ACADEMY OF PEDIATRIC SPECIALTIES (UAPS) EUROPEAN SLEEP MEDICINE AND NEUROPHYSIOLOGY ASSOCIATION (ESMANA) STATEMENT OF THE ON SAFE SLEEP AS A PRIORITY ISSUE IN THE PREVENTION OF SUDDEN INFANT DEATH SYNDROME","authors":"L. Rakovska, D. Kostyukova, N. Domres, L. Barska","doi":"10.24061/2413-4260.xiii.2.48.2023.17","DOIUrl":"https://doi.org/10.24061/2413-4260.xiii.2.48.2023.17","url":null,"abstract":"Sudden infant death syndrome (SIDS) remains a pressing issue worldwide, with a significant number of cases occurring within the first six months of life. Many of these tragedies can be prevented by adhering to safe sleep guidelines. The effectiveness of large-scale educational programs focusing on these guidelines has been well-documented in developed countries, resulting in the saving of thousands of children's lives.In Ukraine, there are currently no national guidelines for the prevention of SIDS. To address this gap, we have compiled modern guidelines from other countries such as the USA, Great Britain, and Germany, along with the latest research data, to develop recommendations for safe sleep practices for children under one year of age. These recommendations cover various aspects, including the recommended sleep position (on the back), requirements for the sleeping surface and crib, suggestions for safe co-sleeping, and guidelines for maintaining an appropriate temperature. We also provide information on the beneficial effects of breastfeeding and vaccination in preventing SIDS, as well as the increased risks associated with overheating, the presence of soft objects near a sleeping child, and parental smoking and alcohol consumption.These recommendations should be disseminated to both parents and healthcare professionals involved in infant care.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116765666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRAJECTORIES OF SERUM 25(OH)D IN CHILDREN WITH PARALYTIC SYNDROMES WHEN USING VITAMIN D FROM DIFFERENT MANUFACTURERS AND IN DIFFERENT DOSES","authors":"O. Riga, O. Mikhaylova","doi":"10.24061/2413-4260.xiii.2.48.2023.4","DOIUrl":"https://doi.org/10.24061/2413-4260.xiii.2.48.2023.4","url":null,"abstract":"The prevalence of vitamin D deficiency and insufficiency varies significantly in different subpopulations of children depending on age and diseases, and recommendations for their correction in children with paralytic syndromes are limited.Aim. Empirical determination of blood 25(OH)D trajectory in children with paralytic syndromes when using vitamin D from different manufacturers and in different doses.Material and methods. The 25(OH)D (ng/ml) of blood serum was analyzed by immune-enzymatic method \"Labline-90\" (Austria) with the test system \"Monobind Inc.\" (ELISA, USA) in 77 children with paralytic syndromes aged 1-18 years, a repeat study after vitamin D3 supplementation was conducted in 36 children. The rate of increase in 25(OH)D concentration per month was calculated. Methods of descriptive statistics, non-parametric correlation analysis and Kaplan-Meier survival analysis were used with MedCalc Statistical Software (Belgium).This study was approved by the Ethics Committee (protocol No. 5, October 2021), which was conducted with the involvement of minor patients and did not contain measures that could harm their health.The research was carried out within the framework of the Department of Pediatrics of Kharkiv National Medical University \"Medical and social aspects of adaptation of children with somatic pathology in modern conditions\" (state registration number 0120U102471, 2020).Results. Vitamin D insufficiency was diagnosed in 17% of children with paralytic syndromes, and vitamin D deficiency in 73%, so daily doses of 2000-4000 IU of vitamin D3 from different manufacturers were recommended at the discretion of the parents for 6 months. In reality, children received doses from 500 to 5000 IU randomly, from 2 to 7 months. Doses were stratified as greater than 2000 IU and less than 2000 IU. If the child received a dose of 2000 IU or more, the rate of increase of 25(OH)D in the blood in children was 3.6 ng/ml per month, if the dose was less than 2000 IU - 1.6 ng/ml per month.Conclusions. Children with paralytic syndromes should be screened and monitored for serum 25(OH)D levels. With a serum 25(OH)D level of less than 20 ng/ml, daily administration of vitamin D3 in a dose of at least 2000 IU for at least 6 months allows reaching a 25(OH)D level of 30 ng/ml in most of them. Further large-scale studies are needed to supplement current recommendations for vitamin D3 supplementation in children with paralytic syndromes.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127521490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVENTION OF HYPERALGESIA IN CHILDREN WHEN USING VARIOUS ANESTHESIA TECHNIQUES","authors":"Y. Semkovych, D. Dmytriiev","doi":"10.24061/2413-4260.xiii.2.48.2023.10","DOIUrl":"https://doi.org/10.24061/2413-4260.xiii.2.48.2023.10","url":null,"abstract":"Introduction. Opioid-induced hyperalgesia is characterized by a paradoxical response whereby a patient receiving opioids for pain management could actually become more sensitive to certain painful stimuli. Regional anesthesia can also impact central sensitization and reduce hyperalgesia after surgery.The objective of the study was to determine the method of preventing hyperalgesia in the early postoperative period when using different analgesic regimens in children after anterior abdominal wall surgery.Materials and Methods. The study included 87 children at the age of 7-18 years who underwent anterior abdominal wall surgery using different analgesic techniques. Group I included 33 children who underwent anterior abdominal wall surgery under general anesthesia using fentanyl. Group II comprised 27 children who underwent anterior abdominal wall surgery under general anesthesia using the transversalis fascia plane block (TFPB). Group III involved 27 children who underwent anterior abdominal wall surgery under general anesthesia using the TFPB, combined with the quadratus lumborum block 4 (QLB-4) via a single injection.All clinical and laboratory studies were conducted in accordance with the World Medical Association Declaration of Helsinki “Ethical Principles for Medical Research Involving Human Subjects”. According to the Law, prior to a subject’s participation in the study, a written informed consent form was signed by each subject (parents/adult guardians). The manuscript was approved by the Ethics Committee of the Communal Non-Profit Enterprise “Ivano-Frankivsk Regional Children’s Clinical Hospital of Ivano-Frankivsk Regional Council”, as evidenced by an Excerpt from the Minute of the Committee Meeting No. 2 dated February 24, 2022.The results obtained were statistically processed using statistical measures of variation, correlation analysis, Student’s t-test. Differences were considered statistically significant at p<0.05. The proportions were statistically compared by a z-test.The study is a fragment of the research project of the Department of Children Diseases of Postgraduate Medical Education Faculty, Ivano-Frankivsk National Medical University “Health Status and Adaption of Children from the Pre-Сarpathian Region with Somatic Diseases, Their Prevention” 2021-2026, state registration number 0121U111129; the author is a co-researcher.Results. In most (48.5 %) patients of Group I, the response to stimulation occurred only when applying pressure forces of 8 and 10 g, while the motor response was observed to stimulation with a pressure force of 8 g, with the FLACC scale score of 5.1±0.3, indicating insufficient pain threshold and potential development of opioid-induced hyperalgesia in the early postoperative period. In patients of Group II and Group III, the response to stimulation occurred when applying a pressure force of 8 g and the FLACC scale scores were 2.9±0.27 and 2.4±0.32, respectively (p<0.05).Conclusions. The results obtained confir","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129986767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DISTANCE LEARNING OF MEDICAL PHDS IN UKRAINE UNDER COVID19 AND WAR WITH RUSSIA: A NEW REALITIES","authors":"I. Kuchyn, L. Lymar","doi":"10.24061/2413-4260.xiii.2.48.2023.1","DOIUrl":"https://doi.org/10.24061/2413-4260.xiii.2.48.2023.1","url":null,"abstract":"Introduction. Distance learning during the COVID-19 outbreak in 2020-2021, and the Russian war actions whichstarted in 2022, which we refer to as \"training under and after attacks,\" has had a significant impact on medicalundergraduate and postgraduate training in Ukraine. Despite the challenges posed by these events, the implementationof distance learning for medical PhD students proved to be beneficial for their academic performance, and regarded it asadvantageous.The aim of the research is to explore the peculiarities of distance learning for medical PhD medical students, includingits organization, main advantages, disadvantages, and challenges. The research focused on the experience of distancelearning of medical PhD students, particularly at Bogomolets National Medical University in Ukraine, and some others.Material and methods. To determine the effectiveness of distance learning for future medical PhDs, we analyzed theperformance in the course \"Academic and Medical English for Medical PhD Students\" of 247 medical PhD students, aged21 to 59, who were enrolled in the course at Kyiv Medical University, Bukovinian State Medical University, ZaporizhzhiaState Medical University, Kharkiv Medical Academy of Postgraduate Education, during 2021-2022, and BogomoletsNational Medical University, during 2018-2023, as well as the subjective perception of distance learning by medicalPhDs. The scope of the multi-center research was chosen to neutralize factors that may hinder objective research. Theparticipation was voluntary, upon oral consent of the respondents. The results were treated by the Statistica 19.0., and thesignificance was determined using the Wilcoxon and Student's t-tests.The study was conducted within the doctoral research framework of L. Lymar, “Developing English academic competenceof Healthcare PhD students through distance communication”, approved by the Scientific Council of Bogomolets NationalMedical University on 25.11.2021, protocol № 4.Results. The English language communicative competence characteristics of the medical PhD students were analyzed,and it was statistically determined that after distance learning, the overall level of the competence improved by 0.3-0.5points on a 5-point scale. Additionally, medical PhD students expressed positive attitude towards distance learning.The advantages of distance learning of the medical PhD students, based on a 4-year experience, include: time savingsin commuting, absence of classroom space issues, transparency in the implementation of electronic assessment, andincreased opportunities for creativity and collaboration. Under the realities of Ukraine, distance learning limited possibilityof COVID19 infection, and since 2022, mitigated military threats, with the opportunity to study in safe locations, suchas bomb shelters, in a flexible mode. Disadvantages of distance learning for Ukrainian medical PhD students includedependence on the internet connection and electricity supply, and the psycho","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133277363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 IN NEWBORNS: OWN EXPERIENCE ON THE EXAMPLE OF CLINICAL CASES","authors":"N. Drutsul-Melnyk, L. Ivanova, M. Garas, I. Savka, S. Savka","doi":"10.24061/2413-4260.xiii.2.48.2023.18","DOIUrl":"https://doi.org/10.24061/2413-4260.xiii.2.48.2023.18","url":null,"abstract":"Introduction. Currently, there is controversial information regarding the epidemiologic characteristics and severity of COVID-19 in pregnant women and newborns. Most researchers report the same severity of disease in pregnant and non-pregnant women, and a milder course of disease in the neonatal period, with the possibility of critical illness in some infants. Ideas about the possibility of transmission of SARS-CoV-2 to a newborn have changed. Since intrauterine transmission of the novel coronavirus is currently considered rare, COVID-19 in newborns is usually associated with postnatal transmission of the virus.The aim of the work was to analyze the epidemiologic and clinical features of the COVID-19 in newborns based on the analysis of clinical cases.Material and methods. On 2020, at the beginning of the COVID-19 pandemic, 11 newborns were admitted to the infectious diseases departments of Chernivtsi Regional Children's Clinical Hospital, 9 children were referred from home by a family physician, and 2 children were transferred from maternity care facilities. Diagnosis was confirmed by PCR-RT detection of SARS-CoV-2 RNA in nasal/oropharyngeal swabs.The research was conducted in accordance with the principles of bioethics, the conclusion of the Commission on Biomedical Ethics of the Bukovinian State Medical University on the observance of moral and legal rules for conducting medical-scientific research, Protocol No. 6 dated March 16, 2023.The research was carried out within the framework of scientific and research activity of the Department of Pediatrics and Infectious Diseases of Children of the Bukovinian State Medical University \"Modern epidemiological, clinical-paraclinical and diagnostic features of the most common inflammatory infectious and non-infectious diseases in children\", state registration number: 0122U002208.Results. The analysis of the epidemiologic data allowed to identify an intrafamilial source of infection in all identified cases (in one case the source of infection could not be identified), in most cases it was the mother, in one case the source of infection was the father and the grandmother. In most families there are older siblings who could serve as a potential additional source of infection, but respiratory symptoms in siblings were identified in one third of the families.In the late neonatal period, cases of horizontal virus transmission were characterized by mild symptoms of upper respiratory tract infection as acute nasopharyngitis, one case - as a mixture with secretory diarrhea. COVID-19 in another child was accompanied by acute gastroenteritis and moderate dehydration. The clinical picture of coronavirus infection in the remaining third of cases was characterized by lower respiratory tract infection as acute tracheobronchitis, acute obstructive bronchitis and bronchiolitis.Two infants were transferred from the maternity hospital after delivery because of COVID-19 maternal symptoms and SARS-CoV-2 RNA detection in the","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130000690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPERIENCE OF THE BUKOVINIAN STATE MEDICAL UNIVERSITY IN CONTINUOUS PROFESSIONAL DEVELOPMENT FOR MEDICAL PERSONNEL PERFORMING NEONATAL AND PEDIATRIC CARE IN UKRAINE","authors":"A. Babintseva, Y. Hodovanets","doi":"10.24061/2413-4260.xiii.2.48.2023.2","DOIUrl":"https://doi.org/10.24061/2413-4260.xiii.2.48.2023.2","url":null,"abstract":"Continuous professional development of doctors and nurses using modern learning tools is the key to the quality andeffectiveness of neonatal and pediatric care in Ukraine, especially given the extremely difficult challenges of wartime. The basicprinciples of continuing professional development (CPD) of Ukrainian medical and pharmaceutical practitioners were approvedby the Resolution of the Cabinet of Ministers of Ukraine No. 725 \"Regulations on the System of Continuing ProfessionalDevelopment of Medical and Pharmaceutical Workers\" dated July 14, 2021.The article presents the experience of the Department of Pediatrics, Neonatology and Perinatal Medicine of Bukovinian State Medical University (BSMU) (Head - Doctor of Medicine, Professor Nechytailo Y. M.) in conducting CPD activities for medical staff providing neonatal and pediatric care in Ukraine. The Department hosts specialization and internship cycles in Neonatology and Pediatric Anesthesiology, as well as all kinds of professional seminars, workshops, simulation trainings and professional schools. The target group of the CPD activities is neonatologists, pediatric anesthesiologists, pediatricians, pediatric neurologists, family medicine doctors, emergency medicine doctors, etc.The educational activity is carried out on the basis of the Training Center for Modern Technologies of Perinatal Medicine(headed by Doctor of Medicine, Professor Yulija Godovanets), the Center for Simulation Medicine and Innovative TechnologiesCOSMIT of BSMU and clinical bases of the department. The training process involves the use of full-time and distance learning.Based on the current educational requirements and the Order of the Ministry of Health of Ukraine No. 2016 dated10.11.2022, the Department of Pediatrics, Neonatology and Perinatal Medicine of BSMU has launched CPD cycles for medicaland pharmaceutical staff with higher, entry-level (short cycle) and first (bachelor's) level of higher medical and pharmaceuticaleducation and Masters in Nursing.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"329 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122743077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MICROCIRCULATORY PREDICTORS OF THE FORMATION OF PRIMARY ARTERIAL HYPERTENSION IN CHILDHOOD","authors":"D. Nechytaylo, T. M. Mikheeva, O. G. Buryak, O. Godovanets","doi":"10.24061/2413-4260.xiii.2.48.2023.8","DOIUrl":"https://doi.org/10.24061/2413-4260.xiii.2.48.2023.8","url":null,"abstract":"Introduction. The problem of early diagnosis of arterial hypertension in children is extremely urgent. According to some foreign scientists, the prevalence of this disease among school-age children in the world has been increasing over the past ten years. Children of prepubertal and pubertal age are most prone to the development of arterial hypertension, which is largely determined by vegetative dysfunctions and microcirculation disorders characteristic of these periods of childhood.It has been proven that changes in microcirculation are determined by the variant of arterial hypertension and are a fairly early marker of the degree of damage to target organs.The aim of the study is to study microcirculatory predictors of the formation of primary arterial hypertension in childhood.Material and methods.113 school-age children from the residents of Chernivtsi region and Chernivtsi were examined. The examined children were divided into two groups: the main group consisted of 30 children with arterial hypertension and the control group - 83 children with a normal level of blood pressure.Blood pressure was measured with automatic pressure gauge with removable cuffs, in the morning on both arms, three times with an interval of 2 minutes. Results were evaluated according to percentile tables for age, sex, and height.The recommendations of the American Academy of Pediatrics (AAR) were used to diagnose hypertension in children.Capillaroscopic examination of the nail bed was used to assess the state of peripheral microcirculation in the examined children. Quantitative and qualitative parameters of microcirculation were evaluated.The research was carried out in compliance with the \"Rules of Ethical Principles of Conducting Scientific Medical Research with Human Participation\" approved by the Declaration of Helsinki (1964-2013), ICH GCP (1996), EU Directive No. 609 (from 24.11.1986), orders of the Ministry of Health of Ukraine No. 690 from 23.09.2009, No. 944 from 14.12.2009, No. 616 from 03.08.2012.Statistical processing of the data was performed using nonparametric methods of evaluation. Mathematical processing of the data was performed using Microsoft Office Excel and Statistica 10.0.The work was performed within the framework of the planned research work of the Department of Pediatrics, Neonatology and Perinatal Medicine of Bukovinian State Medical University: Chronobiological and adaptation aspects and features of autonomic regulation in pathological conditions in children of different age groups, (№ 0122U002245, term of execution 2022 - 2026).Results. When comparing the quantitative capillaroscopic indicators of the nail bed between the groups, it was found that the children from the main group showed probable differences in individual indicators (reduced linear density, greater distance between capillaries, 2 times less number of anastomoses, change in the shape of capillaries) compared to the control group, which indicates on changes in peripheral micr","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126220100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RISK FACTORS ASSOCIATED WITH PROLONGED MECHANICAL VENTILATION IN VERY LOW BIRTH WEIGHT INFANTS","authors":"A. Menshykova, D. Dobryanskyy","doi":"10.24061/2413-4260.xiii.2.48.2023.6","DOIUrl":"https://doi.org/10.24061/2413-4260.xiii.2.48.2023.6","url":null,"abstract":"Introduction. Mechanical ventilation (MV) remains a life-saving intervention for the sickest very low birth weight (VLBW) neonates. Despite the widespread use of non-invasive respiratory support, many VLBW neonates require some duration of MV during their initial hospitalization. As prolonged exposure to MV is associated with adverse outcomes in VLBW infants, it is important to identify the factors that influence the duration of this intervention.The study aimed to determine the factors affecting the duration of MV in VLBW infants.Material and methods. Data from a prospectively created computerized database were used in a retrospective cohort study. The database included information on 1086 VLBW infants < 32 weeks' gestation who were ventilated at any time during their hospitalization at the tertiary care hospital between January 2010 and December 2020. Factors that potentially influenced the duration of MV were examined.The research was carried out in compliance with the requirements of bioethics as part of the planned scientific work of the department (state registration number 0117U001083).The data obtained were analyzed using descriptive and comparative statistics, as well as Spearman's rank correlation coefficient and one-way analysis of covariance (ANCOVA). Measurements with normal distribution are presented as mean (standard deviation). Non-parametric continuous data are presented as median (interquartile range). All values were considered significant when p <0.05.The study was carried out as a part of the planned scientific work of the department \"Clinical-laboratory and instrumental substantiation of differential approaches to diagnosis, treatment and prevention of childhood diseases\" (state registration number 0122U000164) without external sources of funding.Results. According to univariant analysis, bronchopulmonary dysplasia (BPD) (rS=0.32, p<0.05), severe BPD (rS=0.418, p<0.05), pneumothorax (rS=0.06, p=0.05), severe intraventricular hemorrhages (IVH) (rS=0.255, p<0.05), periventricular leukomalacia (PVL) (rS=0.15, p<0.05), sepsis (rS=0.087, p<0.05), necrotizing enterocolitis (rS=0.088, p<0.05), longer duration of antibiotic therapy (rS=0.168, p<0.05), and a lower gestational age (rS=-0.118, p<0.05) were associated with longer duration of MV in VLBW infants. At the same time, BPD (F=18.544, p<0.0001), severe BPD (F=109.810, p<0.0001), severe IVH (F=23.859, p<0.0001), PVL (F=15.031, p<0.0001), and more days of antibiotic therapy (F=13.173, p<0.0001) significantly and independently affected the duration of MV based on the results of one-way ANCOVA.Conclusion. Severe lung and brain injury and prolonged antibiotic exposure were the main risk factors that significantly and independently prolonged MV in VLBW infants.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126389159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}