Journal of Mahatma Gandhi University of Medical Sciences and Technology最新文献

{"title":"Breast Cancer Tumor Biology Characteristics and Its Correlation in a Tertiary Care Center","authors":"J. Sharma, Tapan Kapoor, Guman Singh, A. Loyal, D. Singh","doi":"10.5005/jp-journals-10057-0143","DOIUrl":"https://doi.org/10.5005/jp-journals-10057-0143","url":null,"abstract":"Ab s t r Ac t Aims/Objectives: The study aims to evaluate and correlate the relationship between hormone receptor status—estrogen, progesterone receptor (ER and PR), and Herceptin receptor (Her-2/neu) with tumor characteristics in breast cancer patients. Materials and methods: The current study included 101 breast cancer patients of various age-groups from the period 2016–2020. The tumors were evaluated for hormone expression, size, histologic grade, lymphovascular invasion, and axillary node status. The excised breast tissue specimen was evaluated for hormone status by immunohistochemistry (IHC) testing on paraffin blocks and was further analyzed using the fluorescence in situ hybridization (FISH) technique as per requirement. Stratification based on hormone receptor status was done in four categories—ER+PR+Her-2neu−, ER−PR−Her-2neu+, ER+PR+Her-2neu+, and ER−PR−Her-2neu−. Results: In this study, 37.6% of tumors were ER+PR+Her-2neu−, 13.8% ER−PR−Her-2neu+, 13.8% ER+PR+Her-2neu+, and 34.6% ER−PR−Her2neu−. Among high-grade tumors, more than half (52%) patients were hormone receptor-negative, whereas among low-grade tumors 55% of patients were hormone receptor-positive. Sixteen percent of patients presented with a younger age-group (<35 years) and in these patients, nearly 38% were Her-2/neu positive and most of the Her-2/neu receptor-positive patients (80%) had lymphovascular space invasion. Primary tumor size at time of presentation was <2 cm (T1) in only 11% of cases and 2–5 cm (T2) in 72% of cases. Lymph node positivity did not correlate with hormone receptor status. Conclusion: The incidence of Her2-neu positive breast cancer patients was higher in the Indian population as compared to the Western world. The current study depicts the distinct shift in terms of tumor stage and biology, higher rate of Her-2/neu-positivity, younger age at diagnosis, larger tumor size, advanced tumor grade, and more positive lymph node involvement in contrast to the Western population.","PeriodicalId":16223,"journal":{"name":"Journal of Mahatma Gandhi University of Medical Sciences and Technology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86354628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Beta, Yen, and W Angle in Assessment of Anteroposterior Jaw Relationship in North Indian Population: A Cephalometric Study","authors":"Gurinderbir Singh, A. Choudhary, Sangeeta Sunda, P. H. Mehta, Naveen Bansal, Alisha Chuchra","doi":"10.5005/jp-journals-10057-0153","DOIUrl":"https://doi.org/10.5005/jp-journals-10057-0153","url":null,"abstract":"Aim and objective: To establish the mean value, standard deviation, and to determine statistically significant differences of Beta, Yen, and W angle for skeletal class I, skeletal class II, and skeletal class III malocclusion in North India population. Materials and methods: The study will be carried on 90 pretreatment lateral cephalograms randomly taken from records of the Department of Orthodontics and Dentofacial Orthopedics, Genesis Institute of Dental Sciences and Research, Ferozepur. All the cephalograms will be traced using a sharp 0.5 mm pencil on 0.003-inch acetate tracing paper using an X-ray viewer. Mean values of measurements such as ANB angle and Wits appraisal will be calculated and will be divided into 3 groups of 30 samples each. Then, Beta, Yen, and W angle will be measured for all three groups. The data will then be summarized and standard statistical methods will be applied. Results: Beta angle had a value of 31.23 ± 3.2.99° for skeletal class I group, 25.33 ± 2.64° for skeletal class II group, 40.03 ± 3 0.05° for skeletal class III group, YEN angle had a value of 122.57 ± 6.53 for skeletal class I group, 115.20 ± 2.49 for skeletal class II group, and 132.60 ± 3.56 for skeletal class III group, and W angle had a value of 54.90 ± 2.39 for skeletal class I group, 51.17 ± 3.21 for skeletal class II group, and 59.40 ± 1.95 for skeletal class III group. Conclusion: A significant difference was present between the mean value of Beta, Yen, and W angle for class I, class II, and class III malocclusion. Clinical significance: Beta, Yen, and W angle are new parameters to diagnose the skeletal relationship of both the arches and are important clinically in diagnosis and treatment planning of the patient for orthodontic","PeriodicalId":16223,"journal":{"name":"Journal of Mahatma Gandhi University of Medical Sciences and Technology","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79824651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natal Teeth in Association with Sublingual Ulceration: A Case Report","authors":"Shantanu Jain, Renuka P Chinchalkar, Shavan K Yadav, P. Yadav, P. Lekhwani, N. Gupta","doi":"10.5005/jp-journals-10057-0150","DOIUrl":"https://doi.org/10.5005/jp-journals-10057-0150","url":null,"abstract":"Natal teeth are a rare sight in a newborn child’s oral cavity. The presence of teeth natal teeth can cause a series of damage to the child including difficulty in feeding, ulceration on the tongue. A 31-day-old baby reported to the Department of Pediatric and Preventive Dentistry with a chief complaint of ulceration on the tongue and difficulty in breastfeeding. On further examination, a diagnosis of natal teeth was narrowed down. Due to the presence of mobility of the present teeth and ulceration on the tongue, the teeth were extracted.","PeriodicalId":16223,"journal":{"name":"Journal of Mahatma Gandhi University of Medical Sciences and Technology","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77909411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of OHVIRA Syndrome with Urethral Stenosis","authors":"Ketul R Patel, N. Sadasukhi, T. Sadasukhi, M. Gupta, H. Gupta, Ashish Sharma, Sandeep Malik","doi":"10.5005/jp-journals-10057-0158","DOIUrl":"https://doi.org/10.5005/jp-journals-10057-0158","url":null,"abstract":"A bstrAct Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) is a rare anomaly of the urogenital system. The characteristic triad of this syndrome, which was initially reported in 1950, is didelphys uterus, obstructed hemivagina, and ipsilateral renal agenesis (Embrey 1 ). The prevalence of congenital Müllerian duct anomalies is reported to be 1%. 2 A 24-year-old girl got admission to MGH on 15.3.2019 with lower abdominal pain and difficulty in the passing of urine. Her menarche was established 6 months back with a regular cycle and associated with dysmenorrhea. Magnetic resonance imaging (MRI) established the diagnosis of OHVIRA. She underwent surgery for drainage of the hematocolpos and excision of the vaginal septum and urethral dilatation with cystoscopy followed by an uncomplicated recovery and the patient had normal menstrual cycles after surgery.","PeriodicalId":16223,"journal":{"name":"Journal of Mahatma Gandhi University of Medical Sciences and Technology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81072184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Study the Prevalence of Vitamin B12 Deficiency among Patients with Hypothyroidism","authors":"D. Gupta, G. Saxena, O. Choudhary, Anchin Kalia, R. Jat, Manjeet Lnu","doi":"10.5005/jp-journals-10057-0154","DOIUrl":"https://doi.org/10.5005/jp-journals-10057-0154","url":null,"abstract":"","PeriodicalId":16223,"journal":{"name":"Journal of Mahatma Gandhi University of Medical Sciences and Technology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84060891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes Mellitus as a Bad Prognostic Marker in COVID-19 Patients and Its Relationship with Inflammatory Markers (CRP, D-dimer, LDH, and Ferritin)","authors":"Mukesh Jain, P. Rijhwani, Kishore Moolrajani, Aviral Gupta, Anchin Kalia, C. Mittal, S. Choudhary, Aakriti Vij","doi":"10.5005/jp-journals-10057-0156","DOIUrl":"https://doi.org/10.5005/jp-journals-10057-0156","url":null,"abstract":"Ab s t r Ac t Background: Coronavirus disease 2019 (COVID-19) is a newly recognized illness that is spreading rapidly around the world, causing many disabilities and deaths. Some diseases, for instance, diabetes, are continuously suggested as a risk factor, which contribute to the severity and mortality of COVID-19. However, to date, there are no comprehensive studies done that are aimed at explaining the exact relationship between diabetes mellitus and COVID-19. Thus, this study aims to evaluate the relationship between diabetes and COVID-19 and its relationship with inflammatory markers. Materials and methods: This single-center retrospective observational study was conducted on 187 patients diagnosed with COVID-19. The data were collected on admission or during hospitalization by the attending physicians and was documented in the form of electronic medical records. The need for informed consent from patients was waived due to the time constraints during the COVID-19 emergency. Results: Of the 187 hospitalized patients with COVID-19, 50 patients had diabetes. The median age was 59 years and 35 (70.00%) were male. Common symptoms among all patients included fever (57.21%) and cough (48.13%). Patients with diabetes had a non-significantly higher LDH, ferritin, CRP, and D-dimer when compared with those without diabetes. Coronavirus disease 2019 patients with diabetes were significantly more likely to develop severe disease or suffer mortality, indicating a poorer prognosis among COVID-19 patients. Conclusion: We concluded that diabetes mellitus is associated with greater disease severity and poor outcome (mortality) in COVID-19, and a higher but statistically non-significant inflammatory burden.","PeriodicalId":16223,"journal":{"name":"Journal of Mahatma Gandhi University of Medical Sciences and Technology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74467370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Triaging for COVID-19 Patients in a Tertiary Care Hospital in West India: A Retrospective Analysis of a Case Series","authors":"Ashish Jain, P. Rijhwani, S. Jain, Ravi Jain, Anchin Kalia, Pallaavi Goel, Nimish Mathur, Anand B. Jain, Divyansh Gupta","doi":"10.5005/jp-journals-10057-0145","DOIUrl":"https://doi.org/10.5005/jp-journals-10057-0145","url":null,"abstract":"Ab s t r Ac t Introduction: Assessing the clinical severity of coronavirus disease-2019 (COVID-19) and triaging to appropriate levels of care is certainly one of the key elements in the success of managing COVID-19 patients. During the concluded wave of the pandemic, cases were categorized and cared for with set criteria prescribed by authorities. Other triaging criteria were included in contemporary international guidelines, but this hypothesis was never tested if anyone set is ever better than the other. Materials and methods: This is a case series of 165 deceased patients of COVID-19. All patients were categorized as per clinical disease severity and admitted to the designated care area after confirmation of SARS-CoV-2 infection as decided by the admitting doctors. We collected retrospective data from patient medical records and analyzed for medical history, comorbidity profiles, hematology investigations, organ function tests, computed tomography of the thorax, and point-of-care biomarker test (D-dimer, procalcitonin, NT-proBNP, Trop-T). These data were analyzed to compare the differences between the variables of ward and ICU patients by using XLstat software. Results: In this analysis of deceased patients’ case series, we found that there was no significant difference among the patients admitted to ward and ICU for initial demographic and biomarker variables and risk factors. Diabetes was the most commonly found comorbidity. The mortality rate among the ward and ICU (5.89 vs 6.67%, p value: 0.44) was also similar among both the cohorts. Conclusion: In this case series, we could conclude that both the cohorts were comparable at admission on demographic and laboratory parameter profile. Clinical significance: This analysis led us to the conclusion that our existing “triage criteria” for COVID-19 patients will need appropriate modification before the second wave sets in the region.","PeriodicalId":16223,"journal":{"name":"Journal of Mahatma Gandhi University of Medical Sciences and Technology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84344921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Awareness of School Teachers of Jaipur in Emergency Management of Traumatic Dental Injuries","authors":"Mili R Meghpara, Yashi Sharma, Bharathi Padiyar","doi":"10.5005/jp-journals-10057-0186","DOIUrl":"https://doi.org/10.5005/jp-journals-10057-0186","url":null,"abstract":"","PeriodicalId":16223,"journal":{"name":"Journal of Mahatma Gandhi University of Medical Sciences and Technology","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78104223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive Radiotherapy in Locally Advanced Head and Neck Cancers: Impact on Target Volume Shrinkage and Organ at Risk and its Clinical Outcome","authors":"Sukhveer Tanwar, Shikha Dhal, S. Goyal","doi":"10.5005/jp-journals-10057-0185","DOIUrl":"https://doi.org/10.5005/jp-journals-10057-0185","url":null,"abstract":"","PeriodicalId":16223,"journal":{"name":"Journal of Mahatma Gandhi University of Medical Sciences and Technology","volume":"69 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83427910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paget's Disease of Breast: One-year Experience of a Superspecialty Cancer Hospital","authors":"N. Sethi, Sangeeta Hudda, M. Vijay, Chetna Mehrol, M. Yadav, M. Raghava, Aashish K Gupta","doi":"10.5005/jp-journals-10057-0187","DOIUrl":"https://doi.org/10.5005/jp-journals-10057-0187","url":null,"abstract":"","PeriodicalId":16223,"journal":{"name":"Journal of Mahatma Gandhi University of Medical Sciences and Technology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80419999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}