Journal of Magnesium and Alloys最新文献

{"title":"Achieving the strength and ductility synergy in the AlN/ZK60 Mg matrix composite with the bimodal structure","authors":"Sinuo Xu, Chaoyang Sun, Hongxiang Li, Boyu Liu, Yinghao Feng, Chunhui Wang, Jingchen Liu","doi":"10.1016/j.jma.2025.01.020","DOIUrl":"https://doi.org/10.1016/j.jma.2025.01.020","url":null,"abstract":"Overcoming the strength and ductility trade-off is conducive to expanding the application prospects of the Mg matrix composites. A new approach of using the master alloy containing particulate reinforcements to achieve the strength and ductility synergy in the Mg matrix composites was proposed, which can induce the grain size bimodal structure by regulating the dynamic recrystallization (DRX). Specifically, a novel AlN-Al master alloy was prepared via powder metallurgy to fabricate the AlN/ZK60 composite, and the effects of adding the AlN-Al master alloy on microstructure evolution related to the strength and ductility synergy in the composite were thoughtfully investigated, involving precipitation, grain size, and DRX behavior. The reaction between the Al in the master alloy and the Zr in the ZK60 Mg alloy suppressed the grain refinement, and the coarse grains were further formed after the solution treatment on the as-cast composite. Subsequently, deformation heterogeneity between the AlN and Mg matrix during the hot extrusion induced discontinuous dynamic recrystallization (DDRX) and promoted fine grain fraction. The combination formed the bimodal structure in the AlN/ZK60 composite, and coarse and fine grains acted as hard and soft zones, respectively, during the room temperature deformation. The hard zone was enhanced by the basal texture strengthening, and the ductility was improved due to the promotion of the basal 〈a〉 slipping in the soft zone, jointly leading to the strength and ductility synergy in the AlN/ZK60 composite for the ultimate tensile strength increased by ∼7.4 % while maintaining the same elongation compared with the ZK60 Mg alloy.","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":"105 1","pages":""},"PeriodicalIF":17.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying the adverse effect of secondary phase on the tribological property of Mg alloy","authors":"Jie Li, Ting Zou, Junjie Yang, Helong Yu, Peng Zhang, Xiaochao Ji, Xin Zhao, Zhiyong Yan, Wei Li","doi":"10.1016/j.jma.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.jma.2025.02.003","url":null,"abstract":"Introduction of hard particles is considered an effective approach to improve alloy wear resistances. However, the wear resistances of Mg alloys could be deteriorated by increasing the hard particle content in many researches. To reveal the underlying negative effect of precipitate on the wear resistance, the wear behaviors of three AZ-Mg alloys (precipitate contents: AZ31: 2.1 %, AZ61: 3.8 %, AZ91: 5.0 %) at the axial loads of 3 and 15 N were investigated. The results indicated that although wear volume of the AZ-Mg alloys decreased with the increasing Mg₁₇Al₁₂ content at 3 N (0.30→0.24→0.20 µm³) and 15 N (1.04→0.88→0.85 µm³), the relative wear resistances of AZ61 and AZ91 to AZ31 decreased with increasing load (AZ61: 1.25→1.17, AZ91: 1.50→1.22) and the reduction was proportional to the precipitates content (AZ61:7 %, AZ91:28 %). That is because the wear volume of AZ-Mg was mainly attributed to micro-cutting, which was negatively correlated with the precipitate content and tribolayer hardness. However, the wear hardening ability of AZ-Mg alloys was weakened by precipitate for its inhibition on the formation of mechanical twins that the precursors for the tribolayer. Moreover, the inhibition of the precipitate on tribolayer could be amplified by the load, resulting in an increase in tribolayer hardness at 3 N (AZ31: 0.94, AZ61: 1.03, AZ91: 1.10 GPa) but a decrease at 15 N (AZ31: 1.77, AZ61: 1.73, AZ91: 1.62 GPa). Therefore, the formation of twin was inhibited by precipitates, which is detrimental to the wear resistance of Mg alloys. That means the wear resistance could be enhanced by promoting twin formation, which provides a new concept for the design of wear-resistant Mg alloys.","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":"45 1","pages":""},"PeriodicalIF":17.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical behavior of SiC reinforced ZA63 Mg matrix composites: Experiments and 3D finite element modelling","authors":"Chong Wang ,&nbsp;Zelong Du ,&nbsp;Enyu Guo ,&nbsp;Shuying Bai ,&nbsp;Zongning Chen ,&nbsp;Huijun Kang ,&nbsp;Guohao Du ,&nbsp;Yanling Xue ,&nbsp;Tongmin Wang","doi":"10.1016/j.jma.2024.03.027","DOIUrl":"10.1016/j.jma.2024.03.027","url":null,"abstract":"<div><div>In this work, the microstructure evolution and mechanical behavior of extruded SiC/ZA63 Mg matrix composites are investigated via combined experimental study and three-dimensional finite element modelling (3D FEM) based on the actual 3D microstructure achieved by synchrotron tomography. The results show that the average grain size of composite increases from 0.57 µm of 8 µm-SiC/ZA63 to 8.73 µm of 50 µm-SiC/ZA63. The type of texture transforms from the typical fiber texture in 8 µm-SiC/ZA63 to intense basal texture in 50 µm-SiC/ZA63 composite and the intensity of texture increases sharply with increase of SiC particle size. The dynamic recrystallization (DRX) mechanism is also changed with increasing SiC particle size. Experimental and simulation results verify that the strength and elongation both decrease with increase of SiC particle size. The 8 µm-SiC/ZA63 composite possesses the optimal mechanical property with yield strength (YS) of 383 MPa, ultimate tensile strength (UTS) of 424 MPa and elongation of 6.3%. The outstanding mechanical property is attributed to the ultrafine grain size, high-density precipitates and dislocation, good loading transfer effect and the interface bonding between SiC and matrix, as well as the weakened basal texture. The simulation results reveal that the micro-cracks tend to initiate at the interface between SiC and matrix, and then propagate along the interface between particle and Mg matrix or at the high strain and stress regions, and further connect with other micro-cracks. The main fracture mechanism in 8 µm-SiC/ZA63 composite is ductile damage of matrix and interfacial debonding. With the increase of particle size, interface strength and particle strength decrease, and interface debonding and particle rupture become the main fracture mechanism in the 30 µm- and 50 µm-SiC/ZA63 composites.</div></div>","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":"13 3","pages":"Pages 1294-1309"},"PeriodicalIF":15.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140769221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The growth behavior and performance of microarc oxidation coating on AZ91/Ti composite: Influence of Ti-reinforcement phase and electrolyte","authors":"Jinchao Jiao ,&nbsp;Yongrui Gu ,&nbsp;Jin Zhang ,&nbsp;Yong Lian ,&nbsp;Xintao Li ,&nbsp;Kaihong Zheng ,&nbsp;Fusheng Pan","doi":"10.1016/j.jma.2024.04.023","DOIUrl":"10.1016/j.jma.2024.04.023","url":null,"abstract":"<div><div>Magnesium matrix composites with both high strength and ductility have been achieved by introducing pure Ti particles. However, the properties of the surfaces of the composites need to be improved by surface technology, such as micro-arc oxidation (MAO). In this study, we investigated the influence of the Ti-reinforcement phase on coating growth and evolution by subjecting both AZ91 alloy and AZ91/Ti composite to MAO treatment using silicate-based and phosphate-based electrolytes. Results revealed that the Ti-reinforcement phase influenced the MAO process, altering discharge behavior, and leading to a decreased cell voltage. The vigorous discharge of the Ti-reinforcement phase induced the formation of coating discharge channels, concurrently dissolving and oxidizing Ti-reinforcement to produce a composite ceramic coating with TiO₂. The MAO coating on the AZ91/Ti composite exhibited a dark blue macromorphology and distinctive local micromorphological anomalies. In silicate electrolyte, a “volcano-like” localized morphology centered on the discharge channel emerged. In contrast, treatment in phosphate-based electrolyte resulted in a coating morphology similar to typical porous ceramic coatings, with visible radial discharge micropores at the reinforcement phase location. Compared to the AZ91 alloy, the coating on the AZ91/Ti composite exhibited lower thickness and higher porosity. MAO treatment reduced the self-corrosion current density of the AZ91/Ti surface by two orders of magnitude. The silicate coating demonstrated better corrosion resistance than the phosphate coating, attributed to its lower porosity. The formation mechanism of MAO coatings on AZ91/Ti composites in phosphate-based and silicate-based electrolytes was proposed.</div></div>","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":"13 3","pages":"Pages 1160-1175"},"PeriodicalIF":15.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141047673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding pyramidal slip-induced deformation bands and dynamic recrystallization in AZWX3100 magnesium alloy","authors":"Risheng Pei,&nbsp;Fatim-Zahra Mouhib,&nbsp;Mattis Seehaus,&nbsp;Simon Arnoldi,&nbsp;Pei-Ling Sun,&nbsp;Talal Al-Samman","doi":"10.1016/j.jma.2025.02.013","DOIUrl":"10.1016/j.jma.2025.02.013","url":null,"abstract":"<div><div>Dynamic recrystallization (DRX) in inhomogeneous deformation zones, such as grain boundaries, shear bands, and deformation bands, is critical for texture modification in magnesium alloys during deformation at elevated temperatures. This study investigates the DRX mechanisms in AZWX3100 magnesium alloy under plane strain compression at 200 °C. Microstructural analysis revealed necklace-type DRX accompanied by evidence of local grain boundary bulging. Additionally, ribbons of recrystallized grains were observed within fine deformation bands, aligned with theoretical pyramidal I and II slip traces derived from the matrix. The distribution of local misorientation within the deformed microstructure demonstrated a clear association between deformation bands and localized strain. Dislocation analysis of lamellar specimens extracted from two pyramidal slip bands revealed &lt;<em>c</em> + <em>a</em>&gt; dislocations, indicating a connection between &lt;<em>c</em> + <em>a</em>&gt; slip activation and the formation of deformation bands. Crystal plasticity simulations suggest that the orientation of deformation bands is responsible for the unique recrystallization texture of the DRX grains within these bands. The texture characteristics imply a progressive, glide-induced DRX mechanism. A fundamental understanding of the role of deformation bands in texture modification can facilitate future alloy and process design.</div></div>","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":"13 3","pages":"Pages 1088-1098"},"PeriodicalIF":15.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-phase synergistically enhancing mechanical properties and thermal conductivity of hot-extruded Mg-8Gd-1Er-8Zn-1Mn alloy","authors":"Xudong Li,&nbsp;Wenbo Du,&nbsp;Feng Lou,&nbsp;Ning Ding,&nbsp;Xian Du,&nbsp;Shubo Li","doi":"10.1016/j.jma.2024.03.026","DOIUrl":"10.1016/j.jma.2024.03.026","url":null,"abstract":"<div><div>The contradiction between mechanical properties and thermal conductivity of magnesium alloys is a roadblock for their widespread applications. In this study, we developed a hot-extruded Mg-8Gd-1Er-8Zn-1Mn alloy with high-strength and high-thermal-conductivity via dual-phase, W-phase and α-Mn, synergistically strengthening. The alloy extruded at 300 °C exhibited the yield strength and elongation of 372 MPa and 12%, respectively, it simultaneously demonstrated a high thermal conductivity of 134.3W/(m·K). After extrusion, the original coarse W-phase in the alloy was broken into near-spheroidal particles, which reduced the probability of electron scattering. In addition, a large number of solute atoms dynamically precipitated in the form of nanoscale rod-like W-phase and α-Mn, making α-Mg matrix revert to a nearly periodic arrangement state. The high yield strength of the alloy is predominantly determined by grain boundary strengthening as well as W-phase and α-Mn dual-phase strengthening. Notably, the strategy of dual-phase strengthening provides a valuable approach for developing structure-function integrated Mg alloys.</div></div>","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":"13 3","pages":"Pages 1176-1186"},"PeriodicalIF":15.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140795325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected texture transition induced by grain growth during static annealing of a dilute Mg-1Al alloy","authors":"Meng-Na Zhang ,&nbsp;Hai-Long Jia ,&nbsp;Xiao Ma ,&nbsp;Lei Zhao ,&nbsp;Zhi-Gang Li ,&nbsp;Min Zha","doi":"10.1016/j.jma.2024.04.013","DOIUrl":"10.1016/j.jma.2024.04.013","url":null,"abstract":"<div><div>Conventional rolled Mg-Al alloy sheets typically exhibit strong basal textures that remain and may even strengthen after recrystallization annealing due to the preferential growth of basal-oriented grains, resulting in poor formability at room temperature. Therefore, the knowledge of recrystallization and grain growth is critical for modifying textures of Mg-Al alloy sheets. The static recrystallization and texture evolution in a cold-rolled dilute Mg-1Al (wt.%) alloy during various annealed temperatures ranging from 300 °C to 450 °C, have been investigated using the quasi in-situ electron backscatter diffraction (EBSD) method. The as-rolled Mg-1Al alloy shows a dominant basal texture, which weakens and broadens in the rolling direction (RD) during the subsequent annealing, accompanied by the formation of <span><math><mrow><mo>〈</mo><mrow><mn>1</mn><mspace></mspace></mrow><mn>0</mn><mspace></mspace><mover><mn>1</mn><mo>¯</mo></mover><mspace></mspace><mn>0</mn><mo>〉</mo></mrow></math></span> texture component. Particularly, the <span><math><mrow><mo>〈</mo><mrow><mn>1</mn><mspace></mspace></mrow><mn>0</mn><mspace></mspace><mover><mn>1</mn><mo>¯</mo></mover><mrow><mspace></mspace><mn>0</mn></mrow><mo>〉</mo></mrow></math></span> texture component is more pronounced after annealing at high temperatures. The quasi in-situ EBSD results show that recrystallized grains are mainly induced by shear bands, which exhibit a wide spectrum of orientations with c-axis tilt angles ranging 20°-45° from the normal direction (ND). Orientations of shear band-induced recrystallized grains are retained during the entire recrystallization process, resulting in a reduction in the texture intensity. Moreover, recrystallized grains belonging to the <span><math><mrow><mo>〈</mo><mrow><mn>1</mn><mspace></mspace></mrow><mn>0</mn><mspace></mspace><mover><mn>1</mn><mo>¯</mo></mover><mrow><mspace></mspace><mn>0</mn></mrow><mo>〉</mo></mrow></math></span> texture component grow preferentially compared to those with other orientations, which is attributed to low energy grain boundaries, especially grain boundaries with ∼30° misorientation angles. Furthermore, the high temperature annealing facilitates the rapid growth of grain boundaries having a 30° misorientation angle, leading to the occurrence of distinct <span><math><mrow><mo>〈</mo><mrow><mn>1</mn><mspace></mspace></mrow><mn>0</mn><mspace></mspace><mover><mn>1</mn><mo>¯</mo></mover><mrow><mspace></mspace><mn>0</mn></mrow><mo>〉</mo></mrow></math></span> texture after annealing at 450 °C for 1 h. The results provide insights for texture modification of rare earth-free low-alloyed Mg alloys by controlling annealing parameters.</div></div>","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":"13 3","pages":"Pages 1133-1148"},"PeriodicalIF":15.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141047055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoration of CoFe-LDH/porous MgO composite with ZrO2 nanoparticles for efficient photocatalytic removal of indigo carmine","authors":"Tehseen Zehra ,&nbsp;Ananda Repycha Safira ,&nbsp;Arash Fattah-alhosseini ,&nbsp;Mohammad Alkaseem ,&nbsp;Mosab Kaseem","doi":"10.1016/j.jma.2025.02.001","DOIUrl":"10.1016/j.jma.2025.02.001","url":null,"abstract":"<div><div>This study presents a novel photocatalytic system exploiting the unique properties of ZrO₂ and its integration with layered double hydroxide (LDH) films on porous coatings produced via plasma electrolytic oxidation (PEO). Herein, CoFe-LDH films were created on the porous surface of PEO-coated AZ31 Mg alloy using a hydrothermal treatment in cobalt and iron nitrate solutions, followed by a secondary hydrothermal process in a ZrO₂ solution for 10 h at 70 °C. The impact of ZrO₂ on the morphological, compositional, and photocatalytic performance was then compared to the case where ZrO₂ nanoparticles were electrophoretically incorporated into the porous PEO coating. Characterization results revealed that the ZrO₂-modified LDH coatings exhibited a dispersed flake-like structure with an increased surface area, a reduced band gap energy of 3.14 eV, and enhanced electron-hole separation. Experimental results demonstrated an outstanding 99.8% degradation of indigo carmine within 15 mins, with remarkable multi-cycle stability over five consecutive cycles without significant performance decline. This system demonstrates faster degradation rates and greater durability compared to previously reported catalysts, underscoring its potential for effective and sustainable environmental remediation. The synergistic integration of ZrO₂, LDH, and PEO highlights a promising strategy for wastewater treatment, particularly for the removal of persistent organic dyes like indigo carmine.</div></div>","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":"13 3","pages":"Pages 1203-1217"},"PeriodicalIF":15.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the limits of laser energy density: A study of the combined effects of process parameters on melt pool and microstructure in WE43 magnesium alloys","authors":"Chee Ying Tan ,&nbsp;Cuie Wen ,&nbsp;Edwin Mayes ,&nbsp;Dechuang Zhang ,&nbsp;Hua Qian Ang","doi":"10.1016/j.jma.2025.01.019","DOIUrl":"10.1016/j.jma.2025.01.019","url":null,"abstract":"<div><div>Additive manufacturing (AM) has revolutionized modern manufacturing, but the application of magnesium (Mg) alloys in laser-based AM remains underexplored due to challenges such as oxidation, low boiling point, and thermal expansion, which lead to defects like porosity and cracking. This study provides a comprehensive analysis of microstructure changes in WE43 magnesium (Mg) alloy after laser surface melting (LSM), examining grain morphology, orientation, size, microsegregation, and defects under various combinations of laser power, scan speed, and spot size. Our findings reveal that variations in laser power and spot size exert a more significant influence on the depth and aspect ratio of the keyhole melt pool compared to laser scan speed. Critically, we demonstrate that laser energy density, while widely used as a quantitative metric to describe the combined effects of process parameters, exhibits significant limitations. Notable variations in melt pool depth, normalized width, and microstructure with laser energy density were observed, as reflected by low R² values. Additionally, we underscore the importance of assessing the temperature gradient across the width of the melt pool, which determines whether conduction or keyhole melting modes dominate. These modes exhibit distinct heat flow mechanisms and yield fundamentally different microstructural outcomes. Furthermore, we show that the microstructure and grain size in conduction mode exhibit a good correlation with the temperature gradient (G) and solidification rate (R). This research provides a framework for achieving localized microstructural control in LSM, providing insights to optimize process parameters for laser-based 3D printing of Mg alloys, and advancing the integration of Mg alloys into AM technologies.</div></div>","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":"13 3","pages":"Pages 1034-1049"},"PeriodicalIF":15.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism and application prospect of magnesium-based materials in cancer treatment","authors":"Yutong Ma ,&nbsp;Yi Wang ,&nbsp;Siwei Song ,&nbsp;Xinyue Yu ,&nbsp;Can Xu ,&nbsp;Long Wan ,&nbsp;Fan Yao ,&nbsp;Ke Yang ,&nbsp;Frank Witte ,&nbsp;Shude Yang","doi":"10.1016/j.jma.2025.02.010","DOIUrl":"10.1016/j.jma.2025.02.010","url":null,"abstract":"<div><div>Magnesium-based materials, including magnesium alloys, have emerged as a promising class of biodegradable materials with potential applications in cancer therapy due to their unique properties, including biocompatibility, biodegradability, and the ability to modulate the tumor microenvironment. The main degradation products of magnesium alloys are magnesium ions (Mg²⁺), hydrogen (H₂), and magnesium hydroxide (Mg(OH)₂). Magnesium ions can regulate tumor growth and metastasis by mediating the inflammatory response and oxidative stress, maintaining genomic stability, and affecting the tumor microenvironment. Similarly, hydrogen can inhibit tumorigenesis through antioxidant and anti-inflammatory properties. Moreover, Mg(OH)₂ can alter the pH of the microenvironment, impacting tumorigenesis. Biodegradable magnesium alloys serve various functions in clinical applications, including, but not limited to, bone fixation, coronary stents, and drug carriers. Nonetheless, the anti-tumor mechanism associated with magnesium-based materials has not been thoroughly investigated. This review provides a comprehensive overview of the current state of magnesium-based therapies for cancer. It highlights the mechanisms of action, identifies the challenges that must be addressed, and discusses prospects for oncological applications.</div></div>","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":"13 3","pages":"Pages 982-1011"},"PeriodicalIF":15.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}