Journal of Leukocyte Biology最新文献

Pregnancy is associated with a simultaneous but independent increase in circulating CD177pos and immature low-density granulocytes.

IF 3.6 3区医学

Journal of Leukocyte Biology Pub Date : 2024-12-19 DOI: 10.1093/jleuko/qiae255

Agnes Dahlstrand Rudin, Agnes Torell, Jordan Popovic, Marit Stockfelt, Bo Jacobsson, Anna Rudin, Karin Christenson, Anna-Carin Lundell, Johan Bylund

{"title":"Pregnancy is associated with a simultaneous but independent increase in circulating CD177pos and immature low-density granulocytes.","authors":"Agnes Dahlstrand Rudin, Agnes Torell, Jordan Popovic, Marit Stockfelt, Bo Jacobsson, Anna Rudin, Karin Christenson, Anna-Carin Lundell, Johan Bylund","doi":"10.1093/jleuko/qiae255","DOIUrl":"https://doi.org/10.1093/jleuko/qiae255","url":null,"abstract":"The neutrophil marker CD177 (NB1, HNA-2a) is expressed by 0-100% of circulating neutrophils in any given donor, dividing neutrophils into two distinct subpopulations (CD177pos and CD177neg). High proportions of CD177pos blood neutrophils have been linked to both systemic infections and a range of inflammatory pathologies, but whether this is a cause or a consequence of disease is not known. Many conditions displaying elevated CD177pos neutrophil proportions are also accompanied by the presence of circulating low-density granulocytes (LDGs). Accordingly, it is tempting to speculate that these two events are connected, i.e., that proportions of CD177pos neutrophils increase as a result of an enlarged pool of circulating LDGs. A temporary increase in CD177pos neutrophils, in combination with the presence of LDGs has been reported during pregnancy. The present study aimed to investigate whether elevated proportions of CD177pos neutrophils in peripheral blood from pregnant women can be attributed to the presence of LDGs. We found that LDGs were indeed present in pregnancy and included both immature, and activated mature neutrophils. The proportion of CD177pos LDGs increased over time during pregnancy and correlated with a simultaneous increase in immature cells. However, a majority of immature neutrophils were CD177neg, meaning that increased release of immature cells cannot explain the increased proportions of the CD177pos subtype. Therefore, although LDGs and CD177pos neutrophils are expanded simultaneously during pregnancy these events occur independent from each other.","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mertk Signaling and Immune Regulation in T cells.

IF 3.6 3区医学

Journal of Leukocyte Biology Pub Date : 2024-12-17 DOI: 10.1093/jleuko/qiae253

Christopher Varsanyi, Raymond B Birge

引用次数: 0

Unveiling the Role of Resident Memory T Cells in Psoriasis.

IF 3.6 3区医学

Journal of Leukocyte Biology Pub Date : 2024-12-17 DOI: 10.1093/jleuko/qiae254

Juan Saavedra-Almarza, Felipe Malgue, Moira García-Gómez, Solange Gouët, Natalie Edwards, Verónica Palma, Mario Rosemblatt, Daniela Sauma

引用次数: 0

IL-17A/IFN-γ producing γδ T cell functional dichotomy impacts cutaneous leishmaniasis in mice. 产生 IL-17A/IFN-γ 的 γδ T 细胞功能二分法影响小鼠皮肤利什曼病。

IF 3.6 3区医学

Journal of Leukocyte Biology Pub Date : 2024-12-04 DOI: 10.1093/jleuko/qiae251

Júlio Souza Dos-Santos, Luan Firmino-Cruz, Diogo Oliveira-Maciel, Alessandra Marcia da Fonseca-Martins, Tadeu Diniz Ramos, Letícia Nunes-Sousa, Igor Bittencourt Dos Santos, Rodrigo Pedro Soares, Daniel Claudio Oliveira Gomes, José Mengel, Bruno Silva-Santos, Herbert Leonel de Matos Guedes

{"title":"IL-17A/IFN-γ producing γδ T cell functional dichotomy impacts cutaneous leishmaniasis in mice.","authors":"Júlio Souza Dos-Santos, Luan Firmino-Cruz, Diogo Oliveira-Maciel, Alessandra Marcia da Fonseca-Martins, Tadeu Diniz Ramos, Letícia Nunes-Sousa, Igor Bittencourt Dos Santos, Rodrigo Pedro Soares, Daniel Claudio Oliveira Gomes, José Mengel, Bruno Silva-Santos, Herbert Leonel de Matos Guedes","doi":"10.1093/jleuko/qiae251","DOIUrl":"https://doi.org/10.1093/jleuko/qiae251","url":null,"abstract":"γδ T cells play diverse roles in immune responses, producing either IL-17A or IFN-γ. Here we investigated the impact of this functional dichotomy on cutaneous leishmaniasis. We demonstrate that in Sv129 mice susceptible to Leishmania amazonensis, Vγ4+ γδ T cells are the main source of IL-17A. In type 1 interferon receptor-deficient (A129) mice with heightened susceptibility, there is an increased frequency of IL-17A-producing γδ T cells. L. amazonensis's lipophosphoglycan induces these IL-17A-producing γδ T cells. Notably, C57Bl/6 mice deficient in γδ T cells or IL-17 receptor exhibit smaller lesions, indicating a pathogenic role of IL-17A-producing γδ T cells in cutaneous leishmaniasis. Conversely, adoptive transfer of FACS-sorted γδ T cells lead to an accumulation of IFN-γ-producing γδ T cells, associated with control of lesion development. On the other hand, adoptive transfer of FACS-sorted IFN- γ- deficient-γδ T cells abolished the control of lesion development. These data demonstrate a pathophysiological dichotomy where IL-17A-producing γδ T cells promote pathogenesis, while IFN-γ-producing γδ T cells offer therapeutic potential in cutaneous leishmaniasis.","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cxcl10 is protective during mouse-adapted SARS-CoV-2 infection.

IF 3.6 3区医学

Journal of Leukocyte Biology Pub Date : 2024-11-28 DOI: 10.1093/jleuko/qiae252

Shamik Majumdar, Joseph D Weaver, Sergio M Pontejo, Mahnaz Minai, Xinping Lu, Ji-Liang Gao, Gibran Holmes, Reed Johnson, Hongwei Zhang, Brian L Kelsall, Joshua M Farber, Derron A Alves, Philip M Murphy

{"title":"Cxcl10 is protective during mouse-adapted SARS-CoV-2 infection.","authors":"Shamik Majumdar, Joseph D Weaver, Sergio M Pontejo, Mahnaz Minai, Xinping Lu, Ji-Liang Gao, Gibran Holmes, Reed Johnson, Hongwei Zhang, Brian L Kelsall, Joshua M Farber, Derron A Alves, Philip M Murphy","doi":"10.1093/jleuko/qiae252","DOIUrl":"https://doi.org/10.1093/jleuko/qiae252","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic, remains endemic worldwide. Circulating levels of the chemokine CXCL10 are strongly positively associated with poor outcome; however, its precise role in SARS-CoV-2 pathogenesis and its suitability as a therapeutic target have remained undefined. Here, we challenged mice genetically deficient in Cxcl10 with a mouse-adapted strain of SARS-CoV-2. Infected male, but not female, Cxcl10-/- mice displayed increased mortality compared to wild type controls. Histopathological damage, inflammatory gene induction and virus load in the lungs of male mice were not broadly influenced by Cxcl10 deficiency. However, accumulation of B and T lymphocytes in the lung parenchyma of infected mice was reduced in the absence of Cxcl10. Thus, during acute SARS-CoV-2 infection, Cxcl10 regulates lymphocyte infiltration in lung and confers protection against mortality. Our preclinical model results do not support targeting CXCL10 therapeutically in severe COVID-19.","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking secrets: lipid metabolism and lipid droplet crucial roles in SARS-CoV-2 infection and the immune response. 揭开秘密：脂质代谢和脂滴在 SARS-CoV-2 感染和免疫反应中的关键作用。

IF 3.6 3区医学

Journal of Leukocyte Biology Pub Date : 2024-11-27 DOI: 10.1093/jleuko/qiae170

Vinicius Cardoso Soares, Suelen Silva Gomes Dias, Julia Cunha Santos, Patrícia T Bozza

{"title":"Unlocking secrets: lipid metabolism and lipid droplet crucial roles in SARS-CoV-2 infection and the immune response.","authors":"Vinicius Cardoso Soares, Suelen Silva Gomes Dias, Julia Cunha Santos, Patrícia T Bozza","doi":"10.1093/jleuko/qiae170","DOIUrl":"10.1093/jleuko/qiae170","url":null,"abstract":"Lipid droplets (LDs) are crucial for maintaining lipid and energy homeostasis within cells. LDs are highly dynamic organelles that present a phospholipid monolayer rich in neutral lipids. Additionally, LDs are associated with structural and nonstructural proteins, rapidly mobilizing lipids for various biological processes. Lipids play a pivotal role during viral infection, participating during viral membrane fusion, viral replication, and assembly, endocytosis, and exocytosis. SARS-CoV-2 infection often induces LD accumulation, which is used as a source of energy for the replicative process. These findings suggest that LDs are a hallmark of viral infection, including SARS-CoV-2 infection. Moreover, LDs participate in the inflammatory process and cell signaling, activating pathways related to innate immunity and cell death. Accumulating evidence demonstrates that LD induction by SARS-CoV-2 is a highly coordinated process, aiding replication and evading the immune system, and may contribute to the different cell death process observed in various studies. Nevertheless, recent research in the field of LDs suggests these organelles according to the pathogen and infection conditions may also play roles in immune and inflammatory responses, protecting the host against viral infection. Understanding how SARS-CoV-2 influences LD biogenesis is crucial for developing novel drugs or repurposing existing ones. By targeting host lipid metabolic pathways exploited by the virus, it is possible to impact viral replication and inflammatory responses. This review seeks to discuss and analyze the role of LDs during SARS-CoV-2 infection, specifically emphasizing their involvement in viral replication and the inflammatory response.","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":"1254-1268"},"PeriodicalIF":3.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In a sticky situation: pro-coagulant properties expand the importance of neutrophil EVs in driving tissue injury. 陷入困境：促凝血特性扩大了中性粒细胞 EVs 在造成组织损伤方面的重要性。

IF 3.6 3区医学

Journal of Leukocyte Biology Pub Date : 2024-11-27 DOI: 10.1093/jleuko/qiae185

Matthew C Madison, Dakota C Finley, Kristopher R Genschmer

引用次数: 0

Bacterial efflux pump OMPs as vaccine candidates against multidrug-resistant Gram-negative bacteria. 将细菌外排泵 OMPs 作为针对耐多药革兰氏阴性菌的候选疫苗。

IF 3.6 3区医学

Journal of Leukocyte Biology Pub Date : 2024-11-27 DOI: 10.1093/jleuko/qiae154

Thaynara O Silva, Ana Carolina S Bulla, Bárbara A Teixeira, Vinnicius Machado Schelk Gomes, Thiago Raposo, Luiza S Barbosa, Manuela Leal da Silva, Lilian O Moreira, Priscilla C Olsen

{"title":"Bacterial efflux pump OMPs as vaccine candidates against multidrug-resistant Gram-negative bacteria.","authors":"Thaynara O Silva, Ana Carolina S Bulla, Bárbara A Teixeira, Vinnicius Machado Schelk Gomes, Thiago Raposo, Luiza S Barbosa, Manuela Leal da Silva, Lilian O Moreira, Priscilla C Olsen","doi":"10.1093/jleuko/qiae154","DOIUrl":"10.1093/jleuko/qiae154","url":null,"abstract":"The emergence and propagation of bacteria resistant to antimicrobial drugs is a serious public health threat worldwide. The current antibacterial arsenal is becoming obsolete, and the pace of drug development is decreasing, highlighting the importance of investment in alternative approaches to treat or prevent infections caused by antimicrobial-resistant bacteria. A significant mechanism of antimicrobial resistance employed by Gram-negative bacteria is the overexpression of efflux pumps that can extrude several compounds from the bacteria, including antimicrobials. The overexpression of efflux pump proteins has been detected in several multidrug-resistant Gram-negative bacteria, drawing attention to these proteins as potential targets against these pathogens. This review will focus on the role of outer membrane proteins from efflux pumps as potential vaccine candidates against clinically relevant multidrug-resistant Gram-negative bacteria, discussing advantages and pitfalls. Additionally, we will explore the relevance of efflux pump outer membrane protein diversity and the possible impact of vaccination on microbiota.","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":"1237-1253"},"PeriodicalIF":3.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced CCR2 expression by ACKR2-deficient NK cells increases tumoricidal cell therapy efficacy. ACKR2缺陷的NK细胞CCR2表达增强，提高了杀瘤细胞疗法的疗效。

IF 3.6 3区医学

Journal of Leukocyte Biology Pub Date : 2024-11-27 DOI: 10.1093/jleuko/qiae162

Alan J Hayes, Marieke Pingen, Gillian Wilson, Chris Hansell, Samantha Love, Paul Burgoyne, Daniel McElroy, Robin Bartolini, Francesca Vidler, Fabian Schuette, Alistair Gamble, Jordan Campbell, Dimitrios Galatis, John D M Campbell, Gerard J Graham

{"title":"Enhanced CCR2 expression by ACKR2-deficient NK cells increases tumoricidal cell therapy efficacy.","authors":"Alan J Hayes, Marieke Pingen, Gillian Wilson, Chris Hansell, Samantha Love, Paul Burgoyne, Daniel McElroy, Robin Bartolini, Francesca Vidler, Fabian Schuette, Alistair Gamble, Jordan Campbell, Dimitrios Galatis, John D M Campbell, Gerard J Graham","doi":"10.1093/jleuko/qiae162","DOIUrl":"10.1093/jleuko/qiae162","url":null,"abstract":"Chemokines regulate leukocyte navigation to inflamed sites and specific tissue locales and may therefore be useful for ensuring accurate homing of cell therapeutic products. We, and others, have shown that atypical chemokine receptor 2 (ACKR2)-deficient mice (ACKR2-/-) are protected from metastasis development in cell line and spontaneous mouse models. We have shown that this relates to enhanced CCR2 expression on ACKR2-/- natural killer cells, allowing them to home more effectively to CCR2 ligand-expressing metastatic deposits. Here we demonstrate that the metastatic-suppression phenotype in ACKR2-/- mice is not a direct effect of the absence of ACKR2. Instead, enhanced natural killer cell CCR2 expression is caused by passenger mutations that originate from the creation of the ACKR2-/- mouse strain in 129 embryonic stem cells. We further demonstrate that simple selection of CCR2+ natural killer cells enriches for a population of cells with enhanced antimetastatic capabilities. Given the widespread expression of CCR2 ligands by tumors, our study highlights CCR2 as a potentially important contributor to natural killer cell tumoricidal cell therapy.","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":"1544-1553"},"PeriodicalIF":3.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eosinophils as modulators of host defense during parasitic, fungal, bacterial, and viral infections. 嗜酸性粒细胞是寄生虫、真菌、细菌和病毒感染期间宿主防御的调节器

IF 3.6 3区医学

Journal of Leukocyte Biology Pub Date : 2024-11-27 DOI: 10.1093/jleuko/qiae173

Pedro H Gazzinelli-Guimaraes, Shelby M Jones, David Voehringer, Katrin D Mayer-Barber, Amali E Samarasinghe

{"title":"Eosinophils as modulators of host defense during parasitic, fungal, bacterial, and viral infections.","authors":"Pedro H Gazzinelli-Guimaraes, Shelby M Jones, David Voehringer, Katrin D Mayer-Barber, Amali E Samarasinghe","doi":"10.1093/jleuko/qiae173","DOIUrl":"10.1093/jleuko/qiae173","url":null,"abstract":"Eosinophils, traditionally associated as central innate effector cells with type 2 immunity during allergic and helminth parasitic diseases, have recently been revealed to have important roles in tissue homeostasis as well as host defense in a broader variety of infectious diseases. In a dedicated session at the 2023 biennial conference of the International Eosinophil Society titled \"Eosinophils in Host Defense,\" the multifaceted roles eosinophils play against diverse pathogens, ranging from parasites to fungi, bacteria, and viruses, were presented. In this review, the session speakers offer a comprehensive summary of recent discoveries across pathogen classes, positioning eosinophils as pivotal leukocytes in both host defense and pathology. By unraveling the intricacies of eosinophil engagement in host resistance, this exploration may provide valuable insights not only to understand specific underpinnings of eosinophil functions related to each class of pathogens but also to develop novel therapeutics effective against a broad spectrum of infectious diseases.","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":"1301-1323"},"PeriodicalIF":3.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0