肌动蛋白调节中性粒细胞在健康和疾病中的作用机制。

IF 3.1 3区医学 Q3 CELL BIOLOGY

Journal of Leukocyte Biology Pub Date : 2025-10-09 DOI:10.1093/jleuko/qiaf142

Noelle Pisacano, Rebecca A Evans, Abigail S Nutley, Katharine M Lodge, Maria Prendecki

{"title":"肌动蛋白调节中性粒细胞在健康和疾病中的作用机制。","authors":"Noelle Pisacano, Rebecca A Evans, Abigail S Nutley, Katharine M Lodge, Maria Prendecki","doi":"10.1093/jleuko/qiaf142","DOIUrl":null,"url":null,"abstract":"Neutrophils are central to immune responses in health and disease, and their ability to deform correlates with their functional responses. In health, reorganisation of the neutrophil cytoskeleton allows neutrophils to carry out their effector mechanisms. However, in the disease state, dysregulation of neutrophil cytoskeletal properties results in disruption of neutrophil structural integrity, in turn altering their immune response capabilities. We outline how actin and actin polymerisation are essential for cell processes, the role of actin in neutrophil function, and how disruption of actin can lead and contribute to a range of disease pathogeneses.","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Actin regulation of neutrophil effector mechanisms in health and disease.\",\"authors\":\"Noelle Pisacano, Rebecca A Evans, Abigail S Nutley, Katharine M Lodge, Maria Prendecki\",\"doi\":\"10.1093/jleuko/qiaf142\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Neutrophils are central to immune responses in health and disease, and their ability to deform correlates with their functional responses. In health, reorganisation of the neutrophil cytoskeleton allows neutrophils to carry out their effector mechanisms. However, in the disease state, dysregulation of neutrophil cytoskeletal properties results in disruption of neutrophil structural integrity, in turn altering their immune response capabilities. We outline how actin and actin polymerisation are essential for cell processes, the role of actin in neutrophil function, and how disruption of actin can lead and contribute to a range of disease pathogeneses.\",\"PeriodicalId\":16186,\"journal\":{\"name\":\"Journal of Leukocyte Biology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Leukocyte Biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/jleuko/qiaf142\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Leukocyte Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jleuko/qiaf142","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

中性粒细胞是健康和疾病免疫反应的核心，它们的变形能力与其功能反应相关。在健康状态下，中性粒细胞骨架的重组允许中性粒细胞发挥其作用机制。然而，在疾病状态下，中性粒细胞细胞骨架特性的失调导致中性粒细胞结构完整性的破坏，进而改变其免疫反应能力。我们概述了肌动蛋白和肌动蛋白聚合如何对细胞过程至关重要，肌动蛋白在中性粒细胞功能中的作用，以及肌动蛋白的破坏如何导致和促进一系列疾病的发病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Actin regulation of neutrophil effector mechanisms in health and disease.

Neutrophils are central to immune responses in health and disease, and their ability to deform correlates with their functional responses. In health, reorganisation of the neutrophil cytoskeleton allows neutrophils to carry out their effector mechanisms. However, in the disease state, dysregulation of neutrophil cytoskeletal properties results in disruption of neutrophil structural integrity, in turn altering their immune response capabilities. We outline how actin and actin polymerisation are essential for cell processes, the role of actin in neutrophil function, and how disruption of actin can lead and contribute to a range of disease pathogeneses.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Leukocyte Biology 医学-免疫学

CiteScore

11.50

自引率

0.00%

发文量

358

审稿时长

2 months

期刊介绍： JLB is a peer-reviewed, academic journal published by the Society for Leukocyte Biology for its members and the community of immunobiologists. The journal publishes papers devoted to the exploration of the cellular and molecular biology of granulocytes, mononuclear phagocytes, lymphocytes, NK cells, and other cells involved in host physiology and defense/resistance against disease. Since all cells in the body can directly or indirectly contribute to the maintenance of the integrity of the organism and restoration of homeostasis through repair, JLB also considers articles involving epithelial, endothelial, fibroblastic, neural, and other somatic cell types participating in host defense. Studies covering pathophysiology, cell development, differentiation and trafficking; fundamental, translational and clinical immunology, inflammation, extracellular mediators and effector molecules; receptors, signal transduction and genes are considered relevant. Research articles and reviews that provide a novel understanding in any of these fields are given priority as well as technical advances related to leukocyte research methods.