Journal of Liver最新文献_第8页

Liver Cell Carcinoma in Poland: Data Reported to the National Health Fundin the Years 2008-2012 波兰的肝细胞癌:2008-2012年向国家卫生基金报告的数据

Journal of Liver Pub Date : 2015-08-05 DOI: 10.4172/2167-0889.1000183

M. Piechota, Anna Piechota, A. Śliwczyński, M. Marczak

{"title":"Liver Cell Carcinoma in Poland: Data Reported to the National Health Fundin the Years 2008-2012","authors":"M. Piechota, Anna Piechota, A. Śliwczyński, M. Marczak","doi":"10.4172/2167-0889.1000183","DOIUrl":"https://doi.org/10.4172/2167-0889.1000183","url":null,"abstract":"Introduction: Liver cell carcinoma includes primary malignant liver neoplasms originating from epithelial cells. Liver cell carcinoma is one of the most common cancers and is the 3rd leading cause of cancer-related mortality worldwide. However, the epidemiology and the various available treatment options have not been sufficiently studied in Poland. The aim of the present study was to assess the frequency of use of various liver cell carcinoma treatments in Poland based on data reported by service providers to the National Health Fund in the years 2008-2012. \u0000Patients and methods: Data concerning patients with liver cell carcinoma were obtained by querying the National Health Fund databases. The data were collected from the databases using SQL tools and a filter in accordance with the accepted scope of ICD-10 diagnoses. The analysis was conducted using Excel and Statistica 10. The demographic data were collected from the Central Statistical Office’s website. \u0000Results: Data on the number of patients and the type of medical services available for patients with a diagnosis of liver cell carcinoma financed by NFZ in the years 2008-2012 are described. \u0000Conclusions: The health care system in Poland does not provide liver cell carcinoma patients with rapid access to required health care services, which decreases patient survival. Treatment of advanced stage liver cell carcinoma with Sorafenib, with public payer financing, represents a real and accessible alternative treatment option for this group of patients.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"41 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2015-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76056037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Prevalence and risk factors of HBV infection among pregnant women in urban and rural Egyptian communities 埃及城市和农村社区孕妇HBV感染的流行率和危险因素

Journal of Liver Pub Date : 2015-08-03 DOI: 10.4172/2167-0889.S1.002

Doaa A Saleh

引用次数: 25

Ligase chain reaction as a modality for the detection of point mutation in the precore region of HBV related HCC cases from Northern India 连接酶链反应作为检测印度北部HBV相关HCC病例前区点突变的一种方式

Journal of Liver Pub Date : 2015-08-03 DOI: 10.4172/2167-0889.S1.003

Abdul Malik

引用次数: 1

Alpha-1-Antitrypsin Deficiency Presenting as Neonatal Cholestasis: Predictors of Outcome and Effect of Ursodeoxycholic Acid α -1-抗胰蛋白酶缺乏表现为新生儿胆汁淤积:熊去氧胆酸的预后和效果的预测因素

Journal of Liver Pub Date : 2015-07-20 DOI: 10.4172/2167-0889.1000185

E. Silva, Helena Moreira Silva, C. Melo, H. Rocha, M. Medina, E. Martins

{"title":"Alpha-1-Antitrypsin Deficiency Presenting as Neonatal Cholestasis: Predictors of Outcome and Effect of Ursodeoxycholic Acid","authors":"E. Silva, Helena Moreira Silva, C. Melo, H. Rocha, M. Medina, E. Martins","doi":"10.4172/2167-0889.1000185","DOIUrl":"https://doi.org/10.4172/2167-0889.1000185","url":null,"abstract":"Background and objective: Alpha-1-antitrypsin deficiency presenting as neonatal cholestasis occurs in a small percentage of affected individuals. The prognosis is variable, from “healing” to liver cirrhosis and/or severe hepatocellular failure, requiring liver transplantation. We researched for predictors of outcome, including the effect of ursodeoxycholic acid. Methods: Retrospective cohort study of 27 cases of neonatal cholestasis due to alpha-1-antitrypsin deficiency, in the period between 1985 and 2013. Inclusion criteria: patients with neonatal cholestasis and ZZ phenotype. Exclusion criteria: presence of other diagnosis or known risk factors for developing neonatal cholestasis. We analyzed several clinical, biochemical, histological and therapeutic variables. Patients were categorized into two groups: favorable outcome (n=18), unfavorable outcome (n=9). We also divided the patients as treated (n=16), and untreated (n=11) with ursodeoxycholic acid. Results: Splenomegaly at admission (P=0.006) and persistent jaundice at 6 months old (P=0.007) were associated with unfavorable outcome. The values of conjugated bilirubin (P=1.000), aspartate aminotransferase (P=1.000), alanine aminotransferase (P=0.371) and gamma-glutamyltransferase (P=0.667) were not significantly different in both groups of outcome. Early treatm e nt with ursodeoxycholic acid was associated with a favorable outcome (P=0.011). Treated patients did not differ significantly from the untreated-ones in biochemical parameters (conjugated bilirubin, aspartate aminotransferase, alanine aminotransferase and gamma-glutamyltransferase), and had significantly lower alpha-1-antitrypsin serum levels (P=0.015). Conclusion: Splenomegaly at admission and persistence of jaundice at 6 months old were predictive for bad prognosis, and early treatment with ursodeoxycholic acid might have interfered positively in the outcome.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"8 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2015-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81877631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Non-Invasive Parameters of Oesophageal Varices Diagnosis: Which Sensitiveand Applicable; A Pilot Study 食管静脉曲张无创参数诊断的敏感性和适用性一项初步研究

Journal of Liver Pub Date : 2015-07-13 DOI: 10.4172/2167-0889.1000182

E. Hassan, A. A. El-Rehim, Z. Sayed, E. Kholef, Mostafa Abdullah Mohammed Hareedy, Refaat Fathi Abd El-Aal

{"title":"Non-Invasive Parameters of Oesophageal Varices Diagnosis: Which Sensitiveand Applicable; A Pilot Study","authors":"E. Hassan, A. A. El-Rehim, Z. Sayed, E. Kholef, Mostafa Abdullah Mohammed Hareedy, Refaat Fathi Abd El-Aal","doi":"10.4172/2167-0889.1000182","DOIUrl":"https://doi.org/10.4172/2167-0889.1000182","url":null,"abstract":"Background: Oesophageal varices (OV) have the greatest clinical impact. Upper endoscopy is the gold standard for OV diagnosis, despite its own limitations. Non-invasive detection of OV promises to decrease the necessity of endoscopic screening. \u0000Objectives: To assess blood ammonia level, spleen longitudinal (SLD), portal vein (PVD), splenic vein (SVD) diameters, platelets count and platelets/SLD ratio to evaluate their predictive accuracy as non-invasive indicators for the presence of OV and their correlation with variceal size. Patients and methods: This was a prospective study. Sixty cirrhotic patients were screened using upper endoscopy (for the presence and size of OV) and abdominal ultrasonography (for measurement of PVD, SVD, SLD). Fasting blood ammonia level, platelets / SLD ratio were measured. \u0000Results: Blood ammonia, PVD, SVD and SLD were significantly higher in patients with OV than those without (P < 0.001 for all). Using area under receiver operating characteristic curve (AUC), these parameters were good predictors for the presence of OV where, PVD had the highest AUC (I.00) followed by blood ammonia (AUC 0.99). Blood ammonia level correlated with variceal size (rho = 0.442, P = 0.002). \u0000Conclusion: Blood ammonia, PVD, SVD and SLD were good non-invasive predictors for OV presence with the superiority of PVD and ammonia. Blood ammonia level could be clinically useful, as it correlated with the size of OV so, pinpoint those patients requiring closer follow-up and endoscopic screening.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"20 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2015-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88418550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Laparoscopic Resection of Hepatic Angiomyolipoma - An Uncommon PrimaryLiver Tumor: A Case Report and Literature Review 腹腔镜下肝血管平滑肌脂肪瘤切除术-一种罕见的原发性肝脏肿瘤:1例报告并文献复习

Journal of Liver Pub Date : 2015-07-13 DOI: 10.4172/2167-0889.1000181

M. Potkonjak, J. Miura, A. Hammad, K. Oshima, T. Gamblin

引用次数: 0

Difficulty in Diagnosis of Leiomyosarcoma of Infrahepatic Inferior Vena Cava 肝下下腔静脉平滑肌肉瘤的诊断难点

Journal of Liver Pub Date : 2015-05-08 DOI: 10.4172/2167-0889.1000180

Ai-Jun Li, Teng Zhao, L. Yin, Xiaoyu Yang, Meng‐chao Wu

{"title":"Difficulty in Diagnosis of Leiomyosarcoma of Infrahepatic Inferior Vena Cava","authors":"Ai-Jun Li, Teng Zhao, L. Yin, Xiaoyu Yang, Meng‐chao Wu","doi":"10.4172/2167-0889.1000180","DOIUrl":"https://doi.org/10.4172/2167-0889.1000180","url":null,"abstract":"Background: Leiomyosarcomas of inferior vena cava (IVC) are rare tumors that mostly are proposed as a primary malignancy of the IVC. The optimal treatment is completely resects the malignant lesion with preservation of venous return. According to the treated experience of one patient in our hospital, we present our opinions as below. \u0000Methods and Results: A 61-year-old woman underwent successful surgical treatment for a leiomyosarcoma with the method of infrahepatic inferior vena cava (IVC). A large tumor that was demonstrated in the Spiegel lobe liver with IVC tumor thrombus was imagined by tomography and magnetic resonance. The tumor was found from IVC, which was performed by suprahepatic and infrahepatic IVC occlusion with Satinskys clamp in the operation. The patient underwent a combined operation which is en bloc resection of the IVC tumor and lobotomy of the left lateral section of liver. Pathological examination confirmed that is primary leiomyosarcoma of the IVC. The patient had a normal live for nearly one year and no recurrence. \u0000Conclusion: It is difficult to distinguish leiomyosarcoma from a hepatic tumor. About two thirds of these patients were confirmed as the diagnosis of leiomyosarcomas only after laparotomy. The misdiagnosis to be considered as tumor arising from segment I of the liver with IVC tumor thrombus was lead to the tumor to predominant intra-luminal growth. Radical surgical en bloc resection is the mainly treatment for IVC leiomyosarcomas. Using suprahepatic IVC and infrahepatic IVC occlusion with Satinsky clamp, surgical management of an infrahepatic IVC leiomyosarcoma is a simple vascular surgical techniques.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"43 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2015-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90157616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Protective Effect of Grape Seed Extract and/or Silymarin Against Thioacetamide-induced Hepatic Fibrosis in Rats 葡萄籽提取物和/或水飞蓟素对硫代乙酰胺诱导大鼠肝纤维化的保护作用

Journal of Liver Pub Date : 2015-04-27 DOI: 10.4172/2167-0889.1000178

S. Nada, Ayah M H Gowifel, E. S. El-Denshary, A. Salama, M. Khalil, K. Ahmed

{"title":"Protective Effect of Grape Seed Extract and/or Silymarin Against Thioacetamide-induced Hepatic Fibrosis in Rats","authors":"S. Nada, Ayah M H Gowifel, E. S. El-Denshary, A. Salama, M. Khalil, K. Ahmed","doi":"10.4172/2167-0889.1000178","DOIUrl":"https://doi.org/10.4172/2167-0889.1000178","url":null,"abstract":"The aim of the present study was designed to evaluate the hepatoprotective and antioxidant potentials of GSE (100 and 200 mg/kg) and/or silymarin against TAA-induced liver fibrosis in rats. This study was designed to investigate the protective effect of grape seed extract (GSE) and/or silymarin against thioacetamide (TAA)-induced hepatic fibrosis in Sprague-Dawley rats. Mature male Sprague-Dawley rats were divided into 7 equal groups (8 rats each) and treated as follows: Group 1, kept as control group and orally given saline; groups 2-7 were injected intraperitoneally (i.p.) with TAA (100 mg/Kg) twice weekly for 6 weeks to induce hepatic fibrosis. Group 2, kept as control positive; groups 3-5 were administered daily oral doses of silymarin (50 mg/kg), GSE (100 mg/kg) and GSE (200 mg/kg), respectively. While groups 6-7 were administered combined treatments of silymarin and GSE (100 mg/kg) or GSE (200 mg/kg), respectively. Our results indicated that TAA caused significant elevation of hydroxyproline (Hyp), malondialdehyde (MDA) and nitric oxide (NO) contents in liver homogenate and increased serum levels of: aminotransferases (AST and ALT), alkaline phosphatase (ALP) and total bilirubin. While, TAA-treatment alone significantly decreased serum total protein and reduced glutathione (GSH) content in liver homogenate. Administration of GSE (100 and 200 mg/kg) and/or silymarin attenuated TAA-induced hepatic fibrosis, improved enzymes and reduced the oxidative stress in dose dependant manner Histopathological study showed disruption of the hepatic architecture and collagen fibers deposition in the portal tract of TAA-injected group. Concomitant treatment with GSE (100 and 200 mg/kg) and/or silymarin significantly improved histopathological structure of liver tissue in variable degrees. In conclusion, the combined effect of GSE (200 mg/kg) with silymarin (50 mg/kg) had powerful hepatoprotective effect than any other studied doses.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"55 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2015-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79433608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Biliary Reconstruction in Pediatric Liver Transplantation: A Case Report of Biliary Complications and Review of the Literature 小儿肝移植中胆道重建:胆道并发症1例报告及文献复习

Journal of Liver Pub Date : 2015-04-07 DOI: 10.4172/2167-0889.1000179

N. ThaoT.Nguyen, Theresa R. Harring, J. Goss, C. O'Mahony

引用次数: 7

Liver Transplantation for Alcoholic Hepatitis: Light at the End of Tunnel 肝移植治疗酒精性肝炎:隧道尽头的光明

Journal of Liver Pub Date : 2015-04-06 DOI: 10.4172/2167-0889.1000E110

Rehan Naseemuddin, A. Singal

引用次数: 8