Journal of Liver最新文献_第5页

Possible role of estrogen receptors in gender susceptibility in the development of chronic infections and liver cancers 雌激素受体在慢性感染和肝癌发展中性别易感性的可能作用

Journal of Liver Pub Date : 2016-11-08 DOI: 10.4172/2167-0889.C1.007

A. Kaul

引用次数: 0

The Histological Assessment of Hepatitis B Viral Activity in Patients with Heavy Alcohol Consumption 重度饮酒患者乙型肝炎病毒活性的组织学评估

Journal of Liver Pub Date : 2016-11-04 DOI: 10.4172/2167-0889.1000204

Chih‐Wen Lin, Chia-Chang Hsu, D. Perng, M. Yeh, Sien‐Sing Yang

{"title":"The Histological Assessment of Hepatitis B Viral Activity in Patients with Heavy Alcohol Consumption","authors":"Chih‐Wen Lin, Chia-Chang Hsu, D. Perng, M. Yeh, Sien‐Sing Yang","doi":"10.4172/2167-0889.1000204","DOIUrl":"https://doi.org/10.4172/2167-0889.1000204","url":null,"abstract":"Objectives: Taiwan has a high prevalence of hepatitis B viral (HBV) infection with rising alcoholic liver disease. We investigated the histological assessment of viral hepatitis B activity in patients with concomitant HBV infection and alcoholism. \u0000Methods: 229 patients (33 with concomitant heavy alcoholism and HBV infection, 114 with HBV infection alone, and 82 with heavy alcoholism alone) were enrolled between 2009 and 2012 at Cathy General hospital and E-Da hospital. \u0000Results: Patients with concomitant alcoholism and HBV infection are male predominant and younger. 97.4% and 91.4% patients have detectable HBV DNA in patients with HBV infection without or with alcoholism, respectively. Patients with concomitant HBV infection and alcoholism have much piecemeal necrosis, confluent necrosis, focal necrosis, portal inflammation, necroinflammatory grading, and cirrhosis with Ishak stage 5-6 fibrosis. Moreover, patients with concomitant HBV infection and alcoholism also have much pericelluar fibrosis, sclerosing hyaline necrosis, non-alcoholic fatty liver disease (NAFLD) ballooning, NAFLD activity score (NAS) and NAFLD Stage 4 fibrosis (P<0.001). However, patients with alcoholism alone have much more steatosis than those with HBV infection with and without alcoholism. \u0000Conclusions: Patients having concomitant alcoholism and HBV infection develop the histological features of both alcoholic liver disease and viral hepatitis B. The assessment of hepatitis B viral activity in alcoholic liver disease depends on detectable viral load and histological features of viral hepatitis B in patients with concomitant HBV infection and alcoholism.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"20 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82568727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Acute B Hepatitis after Hepatitis C Virus Therapy with Direct Acting Antivirals in a Co-infected Patient with HIV 直接抗病毒药物治疗丙型肝炎合并HIV感染患者后急性乙型肝炎

Journal of Liver Pub Date : 2016-11-01 DOI: 10.4172/2167-0889.1000203

María García, I. Hernández, F. Cuenca, Maria Villegas

引用次数: 1

Hepatic Functions and its Disorders 肝功能及其紊乱

Journal of Liver Pub Date : 2016-10-31 DOI: 10.4172/2167-0889.1000E111

Xia Xuefeng, J. Park

引用次数: 0

Global Analysis of Proteomics for Discovery of Biomarkers in Hepatocellular Carcinoma 蛋白质组学在肝细胞癌生物标志物发现中的全局分析

Journal of Liver Pub Date : 2016-10-27 DOI: 10.4172/2167-0889.1000202

Hong Li, Jiangbei Yuan, Fangbing Zhai, Jianqiang Zhang, Hua He, Xuefeng Xia

引用次数: 1

Comparative Effects of Scorpion Venom and Aqueous Basil ( Ocimum basilicum ) Leaves Extracts on Ccl4-induced Toxicity in Albino Rats 天蝎毒液与罗勒叶水提取物对ccl4致白化大鼠毒性的比较研究

Journal of Liver Pub Date : 2016-09-27 DOI: 10.4172/2167-0889.1000201

Muhammad Salman, N. Kasem, N. Saleh

{"title":"Comparative Effects of Scorpion Venom and Aqueous Basil ( Ocimum basilicum ) Leaves Extracts on Ccl4-induced Toxicity in Albino Rats","authors":"Muhammad Salman, N. Kasem, N. Saleh","doi":"10.4172/2167-0889.1000201","DOIUrl":"https://doi.org/10.4172/2167-0889.1000201","url":null,"abstract":"The present study aims to compare the therapeutic effects between to extract scorpion venom (bradykinin potentiating factor; BPF) and aqueous extract of Sweet basil (Ocimum basilicum) on CCl4-induced toxicity of liver and kidney in albino rats. Rats were divided into 8 groups. Group (1) was served as normal group; Group (2) was injected intraperitoneal (i.p.) once a week for 3 weeks with BPF at a dose (1 μgm/g). Group (3) was received orally O. basilicum extract, twice a week for 6 weeks at dose (20 ml/kg). Group 4 was treated with the same doses of BPF and O. basilicum. Group (5) was injected i.p. with CCl4 (1 ml/kg), 3 times weekly, for 2 weeks and served as control group. Groups 6, 7 and 8 were injected i.p. with CCl4 then treated i.p. with BPF, orally with O. basilicum and BPF plus O. basilicum respectively. The results of the present study cleared that normal group (1) and groups (2, 3 and 4) showed no significant difference in all liver and kidney functions, besides antioxidant enzymes except creatinine and GSH, were highly significant increase in group (4). CCl4 caused a highly significant decrease in serum albumin, uric acid, besides Catalase, GSH, SOD activities in liver tissue, while there are an elevation in serum AST, ALT, ALP, γ-GT, creatinine and Urea, besides MDA and NO levels in liver tissue. While, groups (6, 7 and 8) revealed reverse effect in all parameters and recorded a remarkable improvement, comparing with normal group. It can be concluded that the treatment with the extract from the scorpion venom Buthus occitanus (BPF) is more effective than those of extract from the plant (O. basilicum) against the toxicity of liver and kidney-induced by CCl4 in albino rats. In addition, the hepato-ameliorating and antioxidant effects of two extracts were found to be better than those of extract of BPF or O. basilicum indepently.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"21 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88162528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Patho-physiological studies on the Reverse Effect of Curcumin (Curcuma longa, Zingiberaceae) and Ursofalk (Ursodeoxycholic acid) against the Toxicity of Carbon Tetrachloride on Albino Rats 姜黄素(Curcuma longa，姜科)和熊去氧胆酸(Ursodeoxycholic acid)对四氯化碳对白化大鼠毒性逆转作用的病理生理研究

Journal of Liver Pub Date : 2016-08-19 DOI: 10.4172/2167-0889.1000200

Muhammad Salman, Abdel-rahman

{"title":"Patho-physiological studies on the Reverse Effect of Curcumin (Curcuma longa, Zingiberaceae) and Ursofalk (Ursodeoxycholic acid) against the Toxicity of Carbon Tetrachloride on Albino Rats","authors":"Muhammad Salman, Abdel-rahman","doi":"10.4172/2167-0889.1000200","DOIUrl":"https://doi.org/10.4172/2167-0889.1000200","url":null,"abstract":"This study, was established five groups of albino rats to determine the therapeutic effect of Curcuma longa and ursofalk against the toxicity of CC14 in liver and kidney. Group (1) was received orally NaCl 0.9% and used as a normal group. Group (2) was injected intraperitoneal (i.p.) with CCl4 (1 ml/kg), 3 times weekly, for 2 weeks. Group (3) was given orally Ursofalk (100 mg/kg per body weight), group (4) was given orally Curcuma longa (100 mg/kg body weight) and group (5) was given the same doses of Ursofalk plus Curcuma longa for 30 days respectively, post-injected intraperitoneal (i.p.) with CCl4 (1 ml/kg) 3 times weekly, for 2 weeks. Two blood samples were collected, for hematological and biochemical parameters. Specimens from liver and kidney were collected for histopathological examination. Group (2) revealed a highly significant decrease in total RBCs, platelets, Hb and PCV, serum uric acid, albumin, glucose, HDL-cholesterol, besides catalase, GSH, SOD activities in liver tissue, while WBCs, serum ALT, AST, ALP, γ-GT, creatinine, urea, cholesterol, triglycerides and LDL-cholesterol levels, besides Malondialdehyde and Nitric Oxide levels in liver tissue showed a highly significant increase. Meanwhile, groups (3, 4 and 5) displayed reverse effect in all parameters and return to normal. The histological results displayed inflammation with necrosis and degenerative changes in group (2), while remain groups showed mild changes particularly in group (5). It could be concluded that CCl4 induced destruction in liver and kidney, which showed a clear improvement by using of Ursofalk and Curcuma longa as treatment.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"41 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77843604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Watershed Hepatocellular Carcinoma Ã¢ÂÂ Utility of Cone Beam CT forTranscatheter Therapy and Case Report 流域肝癌ÃⅱÂÂ锥形束CT在经导管治疗中的应用及病例报告

Journal of Liver Pub Date : 2016-08-10 DOI: 10.4172/2167-0889.1000198

S. McCabe, M. Lim, S. Maddineni, G. Rozenblit

引用次数: 0

Relationship between the Status of Blood Supply in the Non-hypervascular Hepatocellular Nodules among Chronic Liver Diseases and the Hypervascular Change 慢性肝病非高血管性肝细胞结节血供状况与高血管性改变的关系

Journal of Liver Pub Date : 2016-07-28 DOI: 10.4172/2167-0889.1000197

Junichi Taira, Y. Imai, Takatomo Sano, K. Sugimoto, Yoshihiro Furuichi, I. Nakamura, F. Moriyasu

{"title":"Relationship between the Status of Blood Supply in the Non-hypervascular Hepatocellular Nodules among Chronic Liver Diseases and the Hypervascular Change","authors":"Junichi Taira, Y. Imai, Takatomo Sano, K. Sugimoto, Yoshihiro Furuichi, I. Nakamura, F. Moriyasu","doi":"10.4172/2167-0889.1000197","DOIUrl":"https://doi.org/10.4172/2167-0889.1000197","url":null,"abstract":"Objectives: We observed the time-course changes of blood flow in non-hypervascular hepatocellular nodules that showed hypointensity in the hepatobiliary phase on Gd-EOB-DTPA-enhanced magnetic resonance imaging (EOB-MRI), and evaluated the relationship between hypervascular change and the status of blood supply in the nodules. Methods: The study included 69 hepatocellular nodules in 33 patients demonstrating hypointensity in the hepatobiliary phase on EOB-MRI and showing non-hypervascular features on CT during hepatic arteriography (CTHA) performed during the same period. Results: In relation to blood flow on CTHA/ CT during arterial portography (CTAP), the cumulative rate of hypervascular change at 52 weeks was 0.0% for iso/iso, 29.7% for hypo/iso, 61.5% for iso/hypo, and 55.0% for hypo/hypo. Multivariate analysis using COX proportional hazards regression showed that CTAP findings (hypodensity) and CTHA findings (hypo-density) were significant variables for hypervascular change. Conclusions: In cases of non-hypervascular hepatocellular tumors, nodules with decreased arterial or portal blood flow that show hypointensity in the hepatobiliary phase on EOB-MRI are likely to develop into typical hepatocellular carcinoma in a shorter time.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"82 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74088938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Endoscopic Treatment for Anastomotic Varices after Choledochojejunostomy 胆总管空肠吻合术后吻合口静脉曲张的内镜治疗

Journal of Liver Pub Date : 2016-07-07 DOI: 10.4172/2167-0889.1000I103

Takahiro Sato

引用次数: 1