Journal of Infectiology最新文献_第2页

Commentary: Differential Humoral and Cellular Immunity Induced by Vaccination using Plasmid DNA and Protein Recombinant Expressing the NS3 Protein of Dengue Virus type 3 评论:用表达登革热病毒3型NS3蛋白的质粒DNA和蛋白重组疫苗接种诱导的差异体液和细胞免疫

Journal of Infectiology Pub Date : 2019-07-01 DOI: 10.29245/2689-9981/2019/4.1148

Á. Ramos-Ligonio, A. López-Monteon

引用次数: 0

With a Little Help from Good Friends – Boosters for the Prevention of Undesired Enzymatic Degradation of Anti-infective Drugs 从好朋友的一点帮助-助推器防止不希望的酶降解抗感染药物

Journal of Infectiology Pub Date : 2019-07-01 DOI: 10.29245/2689-9981/2019/4.1150

F. Bracher

{"title":"With a Little Help from Good Friends – Boosters for the Prevention of Undesired Enzymatic Degradation of Anti-infective Drugs","authors":"F. Bracher","doi":"10.29245/2689-9981/2019/4.1150","DOIUrl":"https://doi.org/10.29245/2689-9981/2019/4.1150","url":null,"abstract":"The development of anti-infective drugs has been one of the most impressive progresses in drug therapy in the past century. However, some of the promising antibacterial and antiviral drugs lost activity after being used in therapy for some time. Typically, this is due to the development of resistance phenomena, among which the expression of drug-degrading enzymes is one major aspect. In other cases, enzymatic degradation of anti-infective drugs by mammalian enzymes in the liver (or kidney) can limit the efficacy of the drugs. In all of these cases, selection of a drug from a different class is a therapeutic opportunity. Alternatively, the original drug can be used further in combination with other compounds named boosters, pharmacokinetic enhancers or antibiotic adjuvants. These compounds are used in combination with the primary anti-infective agent, but not for their direct effects on the infection itself, but since they enhance or restore the activity of the drug. This mini-review gives an overview on the therapeutically most important classes of boosters/antibiotic enhancers, like β-lactamase inhibitors, inhibitors of CYP enzymes in HIV therapy and hepatitis C. Inhibitors of efflux pumps in pathogenic bacteria and fungi will be addressed shortly.","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79299529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mini Review on the Impact of Mobile Parts' Exchange During the DAIR Procedure (Debridement, Antibiotics, Irrigation, Retention) for Infected Total Joint Arthroplasties 感染全关节置换术DAIR(清创、抗生素、冲洗、保留)过程中活动部件交换影响的综述

Journal of Infectiology Pub Date : 2019-07-01 DOI: 10.29245/2689-9981/2019/4.1144

Pascal Bezel, S. Fucentese, J. Burkhard, D. Holy, Arend Nieuwland, M. Burkhard, I. Uçkay

引用次数: 1

Rifamycin SV Anti-inflammatory and Immunomodulatory Activities for Treatment of Mucosal and Liver Inflammation 利福霉素SV治疗粘膜和肝脏炎症的抗炎和免疫调节活性

Journal of Infectiology Pub Date : 2019-07-01 DOI: 10.29245/2689-9981/2019/4.1145

C. Rosette, A. Mazzetti, R. Camerini, L. Moro, M. Gerloni

{"title":"Rifamycin SV Anti-inflammatory and Immunomodulatory Activities for Treatment of Mucosal and Liver Inflammation","authors":"C. Rosette, A. Mazzetti, R. Camerini, L. Moro, M. Gerloni","doi":"10.29245/2689-9981/2019/4.1145","DOIUrl":"https://doi.org/10.29245/2689-9981/2019/4.1145","url":null,"abstract":"Rifamycin SV (rifamycin), is a member of the ansamycin family of antimicrobial compounds which kills bacteria commonly associated with infectious diarrhea and other enteric infections. For colonic diseases like diverticulitis, inflammatory bowel syndrome (IBS) or inflammatory bowel disease (IBD), bacterial proliferation or microbial dysbiosis is associated with a strong inflammatory component. This inflammation has a profound influence on the liver via the gut-liver axis. This review summarizes the anti-inflammatory activities of rifamycin based on analyses of its impact on two key regulators of inflammation: PXR and NFκB. Rifamycin was found to activate PXR and two of its downstream targets, CYP3A4 and PgP, in liver and intestinal cell lines. Rifamycin also directly inhibited NFκB in a cell line which lacks PXR expression. These dual activities likely explain the inhibition of pro-inflammatory cytokine secretion from human colonic cells lines and activated CD4+ T cells. These experimental data define the immune regulatory characteristics of rifamycin and an emerging role in the treatment of both gastrointestinal (GI) and liver disorders.","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73288306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasion of Human Nails by Microsporum canis 犬小孢子虫对人指甲的侵袭

Journal of Infectiology Pub Date : 2019-07-01 DOI: 10.29245/2689-9981/2019/4.1151

D. F. D. Lana, P. Reginatto, W. Lopes, M. Vainstein, A. Fuentefria

引用次数: 0

Genetic Mutations Conferring Resistance to Candida albicans to Antifungal drugs: A Global Perspective and Regional Implications 赋予白色念珠菌抗真菌药物耐药性的基因突变:全球视角和区域意义

Journal of Infectiology Pub Date : 2019-07-01 DOI: 10.29245/2689-9981/2019/4.1143

P. M. Sawadogo, A. Zida, I. Sangare, T. Guiguemdé, A. Sanfo, M. Idani, H. Nacanabo, S. Bamba, R. Ouedraogo, Traoré, T. R. Guiguemdé

引用次数: 2

Atypical Herpetic Viral Posterior Uveitis: Non-necrotising Retinitis and Focal Retinitis 非典型疱疹病毒性后葡萄膜炎:非坏死性视网膜炎和局灶性视网膜炎

Journal of Infectiology Pub Date : 2019-05-01 DOI: 10.29245/2689-9981/2019/3.1138

D. Hazırolan, G. Sungur

引用次数: 3

Commentary: "Candidemia in tertiary hospitals in northeastern Brazil" 评论:“巴西东北部三级医院的念珠菌”

Journal of Infectiology Pub Date : 2019-05-01 DOI: 10.29245/2689-9981/2019/3.1136

S. Hinrichsen

引用次数: 0

Electro-Filtering Paper Spray Ionization Method 电滤纸喷雾电离法

Journal of Infectiology Pub Date : 2019-05-01 DOI: 10.29245/2689-9981/2019/3.1140

Fangling Wu, Chuan-Fan Ding

引用次数: 0

Commentary: "The Development of an Ideal Antibiotic Compound: A Fairy Tale or a Possible Reality?" 评论:“理想抗生素化合物的发展:童话还是可能的现实?”

Journal of Infectiology Pub Date : 2019-03-01 DOI: 10.29245/2689-9981/2019/2.1139

M. Gajdács

{"title":"Commentary: \"The Development of an Ideal Antibiotic Compound: A Fairy Tale or a Possible Reality?\"","authors":"M. Gajdács","doi":"10.29245/2689-9981/2019/2.1139","DOIUrl":"https://doi.org/10.29245/2689-9981/2019/2.1139","url":null,"abstract":"Original article citation: “The concept of an ideal antibiotic: implications for drug design” by Márió Gajdács. Molecules 2019, 24(5), 892; doi: 10.3390/molecules24050892 After the discovery of penicillin by Alexander Flemming in 1928, the landscape of healthcare has changed drastically, and previously lethal infections have become treatable1. However, the emergence and spread of multidrug-resistant bacteria is currently a major public health issue affecting patients, healthcare professionals, scientists, drug development companies and government officials alike2. Various bacterial resistance mechanisms have been described, allowing pathogens to evade lethal effects of antibiotics, the most important mechanisms being enzymatic degradation (e.g., β‐lactamases, aminoglycoside‐degrading enzymes), target alteration (e.g., penicillin-binding proteins, bacterial topoisomerases), decreased uptake (porin‐deficient mutants) and overexpression of energy‐dependent efflux pump proteins (e.g., AcrAB-TolC in Enterobacteriaceae)3. Multidrug‐resistant (MDR) bacteria can withstand potentially lethal doses of antibiotics with various chemical structures and mechanisms of action. The World Health Organization (WHO), the European Center for Disease Prevention and Control (ECDC), and the Centers for Disease Control and Prevention in the US (CDC) have all published reports on the significance of MDR bacteria4. All of these reports concluded that antibiotic resistance is a global issue that may become the major cause of mortality by 2050. So‐called “ESKAPE” bacteria have been described as the most important problem, including E: Enterococcus faecium, S: Staphylococcus aureus or recently Stenotrophomonas maltophilia, K: Klebsiella pneumoniae or recently C: Clostridioides difficile, A: Acinetobacter baumannii, P: Pseudomonas aeruginosa, E: Enterobacter spp., or recently Enterobacteriaceae5.","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85781283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2