Journal of Human Lactation最新文献

{"title":"Secretory IgA in Colostrum and Neonatal Feces is Not Associated With Maternal Nutrient Intake in Newborns From Healthy Mothers.","authors":"G Barbosa-Sabanero, A Reyes-Dominguez, C Luevano-Contreras, H M Gomez-Zapata, M I Cardona-Alvarado, M J Palomino-Perez, M L Lazo-de-la-Vega-Monroy","doi":"10.1177/08903344251369415","DOIUrl":"https://doi.org/10.1177/08903344251369415","url":null,"abstract":"<p><strong>Background: </strong>Human milk shapes neonatal immunity through antibodies, transferring passive immunity to the infant, mainly by secretory IgA (sIgA). sIgA provides antimicrobial defense in the infant's gastrointestinal tract, protecting the newborn against infections and mediating much of the potential of human milk to decrease disease risk. Although maternal nutrition may influence some human milk characteristics, the influence of specific maternal macro and micronutrient intake on sIgA concentrations in colostrum is unknown.</p><p><strong>Research aim: </strong>To evaluate the association of maternal nutrient intake with sIgA in colostrum and neonatal feces of full-term newborns from healthy mothers.</p><p><strong>Method: </strong>We used a cross-sectional design to study the colostrum of healthy mothers with uncomplicated pregnancies (<i>N</i> = 17) and the neonatal feces of their term infants. Maternal intake at term was assessed, and the concentration of sIgA was measured by ELISA.</p><p><strong>Results: </strong>The mean (<i>SD</i>) concentration of sIgA in colostrum was 3.42 (6.0) mg/ml, and 8.5 (1.93) mg/g in neonatal feces. The concentration of sIgA in colostrum did not correlate with fecal sIgA concentrations (<i>r</i> = -0.166 <i>p</i> = 0.606). sIgA concentrations in colostrum or feces were similar by sex and delivery method (<i>p</i> = 0.880 and <i>p</i> = 0.0946 respectively). Maternal macro and micronutrient intake was not associated with colostrum or fecal sIgA. Concentrations of sIgA in colostrum and feces were not correlated with maternal age, pregestational BMI, or gestational weight gain. Also, no correlations between colostrum sIgA concentrations and neonatal anthropometry were found. Interestingly, fecal sIgA was negatively associated with birth weight (<i>R</i>² = 0.433, <i>p</i> = 0.032), independent of gestational age.</p><p><strong>Conclusions: </strong>These results suggest that colostrum maintains its immunological properties, independently of maternal nutritional intake at term, and that the presence of sIgA in the newborn's intestine may be related to the newborn's weight. These findings can encourage women to establish lactation as early as possible and continue with it, confident that their dietary habits prior to birth do not affect their colostrum's immune potential.</p>","PeriodicalId":15948,"journal":{"name":"Journal of Human Lactation","volume":" ","pages":"8903344251369415"},"PeriodicalIF":1.8,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"About Research: Writing Case Studies for the Journal of Human Lactation: A Step-by-Step Guide for Lactation Support Providers.","authors":"Gayle Subramaniam, Ellen Chetwynd","doi":"10.1177/08903344251367073","DOIUrl":"https://doi.org/10.1177/08903344251367073","url":null,"abstract":"","PeriodicalId":15948,"journal":{"name":"Journal of Human Lactation","volume":" ","pages":"8903344251367073"},"PeriodicalIF":1.8,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Impacts of Donor Human Milk to Formula Supplementation on the Gut Microbiome of Full-Term Infants Born Via Cesarean Section: Protocol for a Pilot Randomized Controlled Trial.","authors":"Meredith Merilee Brockway, Maria Khalid, Yasmeen Khalil, Heather C Rusi, Michelle R Asbury, Marie-Claire Arrieta, Elizabeth Keys, Christine Ou, Jannette Festival","doi":"10.1177/08903344251369442","DOIUrl":"https://doi.org/10.1177/08903344251369442","url":null,"abstract":"<p><strong>Background: </strong>A disrupted gut microbiome during an infant's first 1000 days of life can lead to long-lasting negative effects on child health. Cesarean delivery and formula feeding are two factors that can detrimentally impact infant microbiome development as well as maternal mental health. Donor human milk may be a superior supplementation alternative to formula.</p><p><strong>Research aim: </strong>To examine donor human milk supplementation compared to formula supplementation in full-term infants born via Cesarean section and the impact on the infant gut microbiome, infant health outcomes, breastfeeding outcomes, and maternal mental health.Methods and Planned Analyses:We are conducting a pilot clinical randomized controlled trial, comparing donor human milk to formula supplementation for 187 full-term infants born via Cesarean section who are breastfeeding and require supplementation in the first postnatal week of life. Infant stool samples, breastfeeding outcomes, maternal mental health, and child health outcomes will be measured at 1-week, 3-, 6-, and 12-months postpartum. Additionally, child health and maternal mental health are being assessed at 18- and 36-months postpartum.</p><p><strong>Discussion: </strong>This study will generate essential data on the association between supplementation types and the full-term infant microbiome, breastfeeding exclusivity and duration, and infant health. It will also provide preliminary data to inform a multi-site, longitudinal mixed-methods randomized controlled trial that will assess longer term child health outcomes. This evidence may be used to inform guidelines and policies that will increase accessibility to and raise awareness of donor human milk as a supplementation option in this population.</p>","PeriodicalId":15948,"journal":{"name":"Journal of Human Lactation","volume":" ","pages":"8903344251369442"},"PeriodicalIF":1.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the Delphi Method to Develop Breastfeeding Quality Indicators for Very Preterm Infants.","authors":"Anfeng Lu, Li Zhu, Peilu Huang, Lei Bi, Jinjie Huang, Zhangbin Yu, Benqing Wu, Guosheng Huang, Lu Ding, Ruirui Xing","doi":"10.1177/08903344251365634","DOIUrl":"https://doi.org/10.1177/08903344251365634","url":null,"abstract":"<p><strong>Background: </strong>Human milk protects very preterm infants from many complications. While quality indicators are crucial for evaluating and improving breastfeeding practices, those specifically tailored for very preterm infants are lacking.</p><p><strong>Research aim: </strong>To develop a set of practical and reliable indicators for evaluating and improving the quality of breastfeeding for very preterm infants.</p><p><strong>Methods: </strong>This study employed a longitudinal, prospective survey design utilizing a two-round Delphi method employing the RAND Corporation/University of California Los Angeles Appropriateness Method. A systematic search of the literature was performed across multiple databases, including PubMed, Cochrane, Embase, and Wanfang, to identify potential quality indicators for breastfeeding in very preterm infants. A multidisciplinary expert panel then evaluated these through two Delphi rounds to establish relevance and feasibility.</p><p><strong>Results: </strong>Twenty-two candidate quality indicators of breastfeeding were extracted for the Delphi process. The experts' authority coefficients for the two rounds were 0.84 and 0.83, respectively. Eleven indicators, encompassing breastfeeding outcome indicators (<i>n</i> = 1), mother's lactation status indicators (<i>n</i> = 3), the breastfeeding process indicators (<i>n</i> = 3), and balancing indicators (<i>n</i> = 4), were considered relevant and feasible and were incorporated into the set of quality indicators for breastfeeding.</p><p><strong>Conclusions: </strong>This study developed a set of practical and reliable indicators for evaluating and improving the quality of breastfeeding for very preterm infants, based on the collective opinion of content experts. These quality indicators may facilitate an objective and quantitative assessment of breastfeeding quality for this vulnerable population.</p>","PeriodicalId":15948,"journal":{"name":"Journal of Human Lactation","volume":" ","pages":"8903344251365634"},"PeriodicalIF":1.8,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-Day-Old Neonate Cocaine Exposure and Human Milk: A Case Report.","authors":"Leonardo Corrêa Cardoso, Karol Andriely de Vargas Paier, Fernanda Ziegler Reginato, Karla Nunes Pereira, Ana Carolina Kieling, Naiara Maeli Michels, André Valle de Bairros","doi":"10.1177/08903344251373052","DOIUrl":"https://doi.org/10.1177/08903344251373052","url":null,"abstract":"<p><strong>Introduction: </strong>The World Health Organization recommends exclusive breastfeeding in the first 6 months of life. Substances used by the nursing mother may be transported through human milk (HM) and absorbed through the infant's gastrointestinal tract; thus, a mother's exposure to illicit drugs such as cocaine (COC) may pose a risk to the breastfeeding child's health.</p><p><strong>Main issue: </strong>On January 19, a 10-day-old newborn girl was admitted at 9 am to the municipal emergency room with cyanosis, abundant sialorrhea (drooling or salivation), and without clinical response even after being stimulated. The mother reported offering the baby supplementary feeding with formula at 4 am and breast milk at 5:30 am The mother admitted dependence on COC and reported that she had inhaled six lines of COC hydrochloride powder between 6 pm on January 18 and midnight on January 19.</p><p><strong>Conclusion: </strong>Case reports of lactational intoxications are frequent, especially with drugs, like COC, which can build up in acidic body fluids, like human milk, without the ability to disperse. Development of new biomarkers for early diagnosis of intoxication are needed for substances with toxic potential, such as COC. An increase in activated Partial Thromboplastin Time (aTTP) time may be associated with lactational COC intoxication and may serve as an early biomarker for liver damage. Furthermore, immunochromatography assays serve as alternative screening tools, particularly well-suited for emergency scenarios involving suspected drug exposure, employing biological samples to enable rapid assessment. More studies are needed to assess the influence of COC exposure on coagulation parameters.</p>","PeriodicalId":15948,"journal":{"name":"Journal of Human Lactation","volume":" ","pages":"8903344251373052"},"PeriodicalIF":1.8,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibility of Microwave Thawing of Human Milk: Effects on Milk Composition and Temperature Distribution.","authors":"Mizuho Ito, Miori Tanaka, Midori Date, Kumiko Miura, Katsumi Mizuno","doi":"10.1177/08903344251365640","DOIUrl":"https://doi.org/10.1177/08903344251365640","url":null,"abstract":"<p><strong>Background: </strong>Freezing is commonly used to preserve human milk; however, microwave thawing is not recommended due to nutritional loss and creation of hotspots in the milk. Data on compositional changes after microwave thawing and uneven temperature distribution are scarce.</p><p><strong>Research aim: </strong>To investigate the association between microwave heating and the composition and temperature distribution of human milk.</p><p><strong>Methods: </strong>In this laboratory-based cross-sectional experimental study, 35 milk samples were divided into six groups based on preheating operations and milk bag material (35 samples each). After thawing at 600 watts for 30 seconds, temperature was immediately measured using thermography. Uneven temperature distribution was evaluated by the difference between maximum and minimum temperatures. Subsequently, it was mixed by inverting, and the temperature was measured again. The secretory Immunoglobulin A and lactoferrin concentrations were analyzed using enzyme-linked immunosorbent assays. Macronutrients were analyzed using mid-infrared transmission spectroscopy. Results were compared with thawing in running water to explore the feasibility of microwave thawing.</p><p><strong>Results: </strong>The median temperature in the sonicated group (33.6 °C) was significantly decreased compared to that in the untreated group (54.9 °C). The median temperature in the polyethylene bag group (42.0 °C) was also significantly decreased compared to that in the polypropylene bag group (53.2 °C). The temperature after inversion mixing was close to the recommended temperature for feeding. The median concentration significantly decreased for secretory Immunoglobulin A (0.9-16.6%) and lactoferrin (21.3-29.1%) after microwaving.</p><p><strong>Conclusion: </strong>Component losses caused by microwave thawing were not clinically problematic compared to the standard value and could be minimized. Microwave heating may be an option for thawing human milk.</p>","PeriodicalId":15948,"journal":{"name":"Journal of Human Lactation","volume":" ","pages":"8903344251365640"},"PeriodicalIF":1.8,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"About Research: Positionality and Reflexivity in Breastfeeding Research.","authors":"Lauren M Dinour, Karen Mendez Camacho","doi":"10.1177/08903344251369433","DOIUrl":"https://doi.org/10.1177/08903344251369433","url":null,"abstract":"<p><p>Positionality and reflexivity are increasingly recognized as essential practices that enhance the rigor, transparency, and ethical integrity of research. Although these concepts are often associated with qualitative studies, they are equally relevant in quantitative and mixed methods approaches. In this article, we define positionality and reflexivity and describe the relationship between these concepts. We also provide three strategies for understanding one's positionality and practicing reflexivity-identity mapping, reflexive journaling, and bracketing-and consider how each method can be applied across different research designs and throughout the research process. We conclude with practical guidance and examples for how to communicate these practices through positionality statements. By explicitly acknowledging positionality and adopting reflexive practices, researchers can better manage assumptions and biases, strengthen credibility and trustworthiness, and promote equity and inclusivity in knowledge production.</p>","PeriodicalId":15948,"journal":{"name":"Journal of Human Lactation","volume":" ","pages":"8903344251369433"},"PeriodicalIF":1.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women's Breastfeeding Support Experiences in Ireland: A Qualitative Framework Analysis.","authors":"Niamh Mc Evoy, Elaine Lehane, Patricia Leahy-Warren, Rhona O'Connell, Liz Cogan, Michelle O'Driscoll, Helen Mulcahy","doi":"10.1177/08903344251363597","DOIUrl":"https://doi.org/10.1177/08903344251363597","url":null,"abstract":"<p><strong>Background: </strong>Breastfeeding rates in Ireland are among the lowest in the world. Social support networks influence initiation and duration.</p><p><strong>Research aim: </strong>To describe pregnant and postpartum women's encounters and experiences with health care professionals, family, or friends around breastfeeding in Ireland.</p><p><strong>Method: </strong>Using a qualitative framework design, data were collected as part of a wider study. Online diary entries were collected between October 2021 and May 2022. Participants reflected on their breastfeeding encounters, focusing on timing, context, and feelings evoked about breastfeeding support. These a priori categories were the starting point for analysis.</p><p><strong>Results: </strong>Participants (<i>N</i> = 27) produced a total of 91 diary entries entered while participants were from 13 weeks pregnant to 30 weeks postpartum. Most interactions recorded were with family members, friends, and lactation support providers. Three themes were identified: (1) Family Circle of Influence, (2) It Takes a Village, and (3) Maternity Service Providers. \"Family Circle of Influence\" included reflections on the influence of those closest to participants on their breastfeeding journey. Partners and female relatives were generally supportive and provided emotional support, despite having concerns about the decision to breastfeed. \"It Takes a Village\" covered troubleshooting feeding issues with friends and support groups. Experiences within this wider community group were influential, positively and negatively. \"Maternity Service Providers\" captured information sources, skills provision, and conflicting advice, which sometimes undermined maternal confidence.</p><p><strong>Conclusion: </strong>Participants' breastfeeding journeys included encounters with family, social networks, and wider health services. Cumulative diary entries provided reflections on the emotional impact of supportive or undermining interactions on breastfeeding decisions.</p>","PeriodicalId":15948,"journal":{"name":"Journal of Human Lactation","volume":" ","pages":"8903344251363597"},"PeriodicalIF":1.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactation Newsmakers: Helen Ball Research That Makes a Difference: Connecting Applied Anthropology, Infant Sleep, Breastfeeding, and Parenting.","authors":"Tanya M Cassidy, Helen Ball","doi":"10.1177/08903344251365939","DOIUrl":"https://doi.org/10.1177/08903344251365939","url":null,"abstract":"<p><p>Helen Ball is professor of anthropology and Director of the Durham Infancy & Sleep Centre. She obtained her PhD in anthropology from the University of Massachusetts, Amherst, in 1992. Her new book <i>How babies sleep: A factful guide to the first 365 days and nights</i> was published by Penguin Random House in May 2025. Helen studies infant sleep and the parent-infant sleep relationship from a biosocial perspective, focusing on the sleep ecology of infants, young children, and their parents. She pioneers the translation of academic research on infant sleep into evidence for use by parents and healthcare staff via Basis-the Baby Sleep Information Source website. She serves on the Lullaby Trust Scientific Advisory Group, and the United Nations Children's Fund (UNICEF) UK Baby Friendly Initiative Qualifications Board, and was recently appointed as a National Mentor (United States) for the Betty Irene Moore Fellowship in Leadership and Innovation Program. She has previously served as an associate editor for the journal <i>Sleep Health</i>, and as an editorial board member for the <i>Journal of Human Lactation</i>. From 2016 to 2025, she was Chair of the Lullaby Trust Research & Grants Committee, and from 2018 to 2024, she was elected as a board member of the International Society for the Study and Prevention of Infant Deaths (ISPID). In 2013, Helen received an award for Outstanding Impact in Society from the Economic and Social Research Council, and in 2018, Durham University received the Queen's Anniversary Prize for her research and outreach on parent-infant sleep.</p>","PeriodicalId":15948,"journal":{"name":"Journal of Human Lactation","volume":" ","pages":"8903344251365939"},"PeriodicalIF":1.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: Flange Fit in the Real World: A NICU Clinician's Perspective on Pumping Research.","authors":"Lisa A Anders","doi":"10.1177/08903344251367072","DOIUrl":"https://doi.org/10.1177/08903344251367072","url":null,"abstract":"","PeriodicalId":15948,"journal":{"name":"Journal of Human Lactation","volume":" ","pages":"8903344251367072"},"PeriodicalIF":1.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}