Journal of Gastrointestinal & Digestive System最新文献

Rate and Predictors of Endoscopic Mucosal Healing in Biologic Naive Patients with Inflammatory Bowel Disease by Azathioprine Treatment: A Real World, 10 Years' Experience from a Single Centre in Turkey. 经硫唑嘌呤治疗的炎症性肠病生物学初发患者的内镜下粘膜愈合率和预测因素:来自土耳其单一中心的真实世界10年经验。

Journal of Gastrointestinal & Digestive System Pub Date : 2016-08-01 Epub Date: 2016-08-31 DOI: 10.4172/2161-069X.1000467

Metin Basaranoglu, Atilla Ertan, Sanju Mathew, Sonia Michael Najjar, Aftab Ala, Ali Eba Demirbag, Hakan Senturk

{"title":"Rate and Predictors of Endoscopic Mucosal Healing in Biologic Naive Patients with Inflammatory Bowel Disease by Azathioprine Treatment: A Real World, 10 Years' Experience from a Single Centre in Turkey.","authors":"Metin Basaranoglu, Atilla Ertan, Sanju Mathew, Sonia Michael Najjar, Aftab Ala, Ali Eba Demirbag, Hakan Senturk","doi":"10.4172/2161-069X.1000467","DOIUrl":"https://doi.org/10.4172/2161-069X.1000467","url":null,"abstract":"Background: There is increasing evidence that endoscopic mucosal healing (EMH) is a key target in inflammatory bowel disease (IBD) therapy. However, there is limited evidence of EMH rates with conventional IBD therapy outside of Western population groups.Ai̇m: To evaluate the role of azathioprine (AZA) in inducing EMH in IBD patients.Methods: Patients with inflammatory bowel disease were evaluated in terms of endoscopic mucosal healing and the incidence of surgical interventions during the azathioprine treatment between 1995 to 2014.Results: A total of 120 inflammatory bowel disease patients were enrolled. Endoscopic mucosal healing was found in 37% patients with inflammatory bowel disease (42% in chronic ulcerative colitis and 33% in Crohn's disease). Male gender had a negative impact on the efficacy of azathioprine (P<0.05). Responder inflammatory bowel disease patients were older (age at the IBD diagnose) than the nonresponder (P<0.05). Azathioprine therapy reduced the number of the surgical interventions (P<0.05).Conclusi̇on: We showed that azathioprine therapy significantly induced endoscopic mucosal healing in biologic naïve patients with active inflammatory bowel disease as well as decreasing the surgical interventions, with negative predictive factors identified by a younger age at IBD presentation and male gender.","PeriodicalId":15869,"journal":{"name":"Journal of Gastrointestinal & Digestive System","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2161-069X.1000467","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35630522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Transjugular Liver Biopsy in a Multiple Myeloma Patient with Hepatomegaly, Portal Hypertension and "Miliary" Liver Lesions: A Case Report. 经颈静脉肝活检合并肝肿大、门静脉高压及“军事性”肝脏病变1例。

Journal of Gastrointestinal & Digestive System Pub Date : 2016-02-01 Epub Date: 2016-02-10 DOI: 10.4172/2161-069X.1000390

Adrian J Gonzalez-Aguirre, Oscar Lin, Christina Cho, Alexander M Lesokhin, Majid Maybody

引用次数: 7

Increased Incidence of Early Onset Colorectal Cancer in Arizona: A Comprehensive 15-year Analysis of the Arizona Cancer Registry. 亚利桑那州早发性结直肠癌发病率增加:对亚利桑那州癌症登记的15年综合分析

Journal of Gastrointestinal & Digestive System Pub Date : 2015-10-01 Epub Date: 2015-10-05 DOI: 10.4172/2161-069X.1000345

Hassan Aziz, Viraj Pandit, Ryan M DiGiovanni, Eric Ohlson, Angelika C Gruessner, Jana Jandova, Valentine N Nfonsam

{"title":"Increased Incidence of Early Onset Colorectal Cancer in Arizona: A Comprehensive 15-year Analysis of the Arizona Cancer Registry.","authors":"Hassan Aziz, Viraj Pandit, Ryan M DiGiovanni, Eric Ohlson, Angelika C Gruessner, Jana Jandova, Valentine N Nfonsam","doi":"10.4172/2161-069X.1000345","DOIUrl":"https://doi.org/10.4172/2161-069X.1000345","url":null,"abstract":"Introduction: The aim of this study was to investigate and analyze the incidence of early-onset colorectal cancer in Arizona, using the Arizona Cancer Registry.Methods: We performed a retrospective analysis of patients with colorectal cancer reported in the Arizona Cancer Registry from 1995-2010. Outcome measure: incidence of CRC in patients younger than 50 years.Results: 39,623 cases of colorectal cancer were reported to the Arizona Cancer Registry during a period of 15 years. Overall, there was a 17% decrease in the incidence of CRC. However, there was a 23% increase in incidence among patients in the age group 10-50. During the same time period, 15% and 41% increase in the incidence of colon and rectal cancer was observed, respectively. The most significant increase (102%) in overall CRC incidence was seen in the age group 10-29. The highest increase (110%) in incidence of colon cancer was observed in the same age group, while the most significant increase in incidence rates (225%) of rectal cancer was seen in the age group 30-34.Conclusion: Although there is an overall decrease in incidence of colorectal cancer in Arizona, alarming increase in incidence of early-onset CRC was observed; mirroring the national trends.","PeriodicalId":15869,"journal":{"name":"Journal of Gastrointestinal & Digestive System","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2161-069X.1000345","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34389313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Patients Diagnosed with Colorectal Cancer in Rural Areas in Arizona Typically Present with Higher Stage Disease. 在亚利桑那州农村地区被诊断为结直肠癌的患者通常表现为更高阶段的疾病。

Journal of Gastrointestinal & Digestive System Pub Date : 2015-10-01 Epub Date: 2015-10-06 DOI: 10.4172/2161-069X.1000346

Valentine N Nfonsam, Aparna Vijayasekaran, Viraj Pandit, Vera E, Hassan Aziz, Sumediah Nzuonkwelle, Eric Ohlson, Ryan M DiGiovanni, Jana Jandova

{"title":"Patients Diagnosed with Colorectal Cancer in Rural Areas in Arizona Typically Present with Higher Stage Disease.","authors":"Valentine N Nfonsam, Aparna Vijayasekaran, Viraj Pandit, Vera E, Hassan Aziz, Sumediah Nzuonkwelle, Eric Ohlson, Ryan M DiGiovanni, Jana Jandova","doi":"10.4172/2161-069X.1000346","DOIUrl":"https://doi.org/10.4172/2161-069X.1000346","url":null,"abstract":"Background: Despite the decreasing incidence of colorectal cancer (CRC) over the past three decades disparities remain in its incidence, stage at presentation, and efficiency of staging and treatment between different communities, particularly when comparing urban and rural areas. The aim of the study was to assess disparities that exist in CRC outcomes among urban, international border counties, and non-border counties in Arizona.Methods: A retrospective analysis of CRC data from the Arizona Cancer Registry was performed. Data obtained included age, sex, ethnicity, tumor grade, and tumor stage. The data was then categorized into three sections: international border counties, urban counties, and rural counties. The outcome measure was stage of CRC at diagnosis.Results: There were a total of 39, 958 reported incident cases of colorectal cancer from 1995-2010. Of the total incident cases, 53.1% were male and the average age at diagnosis was 69.5. 86.6% were white non-Hispanic, 8.37% Hispanic, 2.4% African American, 1.7% Native American and 1% Asian. There was a significant decrease in the incidence of CRC in all counties, 24.08% in border, 22.5% in urban, and 12.3% in rural. Rural counties showed a higher number of observed cases than expected cases of stage 4 CRC and more unknown diagnosis of grade, stage and lymph node assessment as determined by the adjusted residual.Conclusion: Patients in rural counties are more likely to present with a higher stage of CRC and are less likely to have their cancer adequately staged. This is likely due to lack of better access to healthcare, lack of awareness and poor education and also inadequate specialists.","PeriodicalId":15869,"journal":{"name":"Journal of Gastrointestinal & Digestive System","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2161-069X.1000346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34389312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PhytobezoarInduced Small Bowel Obstruction in a Young Male with Virgin Abdomen. 植物牛黄致年轻男性处女腹部小肠梗阻一例。

Journal of Gastrointestinal & Digestive System Pub Date : 2015-01-01 Epub Date: 2015-03-25 DOI: 10.4172/2161-069X.1000266

Edward P Manning, Vikram Vattipallly, Masooma Niazi, Ajay Shah

引用次数: 3

Rationale for Using Social Media to Collect Patient-Reported Outcomes in Patients with Celiac Disease. 使用社交媒体收集乳糜泻患者报告结果的理由

Journal of Gastrointestinal & Digestive System Pub Date : 2014-02-01 DOI: 10.4172/2161-069X.1000166

Kt Park, Merissa Harris, Nasim Khavari, Chaitan Khosla

引用次数: 10

Asbestos-Induced Gastrointestinal Cancer: An Update. 石棉诱发的胃肠道癌:最新进展。

Journal of Gastrointestinal & Digestive System Pub Date : 2013-10-01 Epub Date: 2013-09-10 DOI: 10.4172/2161-069X.1000135

Seok Jo Kim, David Williams, Paul Cheresh, David W Kamp

{"title":"Asbestos-Induced Gastrointestinal Cancer: An Update.","authors":"Seok Jo Kim, David Williams, Paul Cheresh, David W Kamp","doi":"10.4172/2161-069X.1000135","DOIUrl":"https://doi.org/10.4172/2161-069X.1000135","url":null,"abstract":"Asbestos-related diseases, such as malignancies and asbestosis, remain a significant occupational and public health concern. Asbestos is still widely used in many developing countries despite being a recognized carcinogen that has been banned over 50 countries. The prevalence and mortality from asbestos-related diseases continue to pose challenges worldwide. Many countries are now experiencing an epidemic of asbestos-related disease that is the legacy of occupational exposure during the 20th century because of the long latency period (up to 40 years) between initial asbestos exposure and exhibition of disease. However, the gastrointestinal (GI) cancers resulting from asbestos exposure are not as clearly defined. In this review, we summarize some of the recent epidemiology of asbestos-related diseases and then focus on the evidence implicating asbestos in causing GI malignancies. We also briefly review the important new pathogenic information that has emerged over the past several years that may account for asbestos-related gastrointestinal cancers. All types of asbestos fibers have been implicated in the mortality and morbidity from GI malignancies but the collective evidence to date is mixed. Although the molecular basis of GI cancers arising from asbestos exposure is unclear, there have been significant advances in our understanding of mesothelioma and asbestosis that may contribute to the pathophysiology underlying asbestos-induced GI cancers. The emerging new evidence into the pathogenesis of asbestos toxicity is providing insights into the molecular basis for developing novel therapeutic strategies for asbestos-related diseases in future management.","PeriodicalId":15869,"journal":{"name":"Journal of Gastrointestinal & Digestive System","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856305/pdf/nihms736729.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34465380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Mucins in Gastric Cancer - An Update. 胃癌中的黏蛋白--最新进展。

Journal of Gastrointestinal & Digestive System Pub Date : 2013-07-03 DOI: 10.4172/2161-069X.1000123

Doron Boltin, Yaron Niv

引用次数: 0

Phenotypic Categorization and Profiles of Small and Large Hepatocellular Carcinomas. 小、大肝细胞癌的表型分类和概况。

Journal of Gastrointestinal & Digestive System Pub Date : 2013-03-02 DOI: 10.4172/2161-069X.S12-001

Petr Pancoska, Sheng-Nan Lu, Brian I Carr

{"title":"Phenotypic Categorization and Profiles of Small and Large Hepatocellular Carcinomas.","authors":"Petr Pancoska, Sheng-Nan Lu, Brian I Carr","doi":"10.4172/2161-069X.S12-001","DOIUrl":"https://doi.org/10.4172/2161-069X.S12-001","url":null,"abstract":"We used a database of 4139 Taiwanese HCC patients to take a new approach (Network Phenotyping Strategy) to HCC subset identification. Individual parameters for liver function tests, complete blood count, portal vein thrombosis, AFP levels and clinical demographics of age, gender, hepatitis or alcohol consumption, were considered within the whole context of complete relationships, being networked with all other parameter levels in the entire cohort. We identified 4 multi-parameter patterns for one tumor phenotype of patients and a separate 5 multi-parameter patterns to characterize another tumor phenotype of patterns. The 2 subgroups were quite different in their clinical profiles. The means of the tumor mass distributions in these phenotype subgroups were significantly different, one being associated with larger (L) and the other with smaller (S) tumor masses. These significant differences were seen systematically throughout the tumor mass distributions. Essential and common clinical components of L-phenotype patterns included simultaneously high blood levels of AFP and platelets plus presence of portal vein thrombosis. S included higher levels of liver inflammatory parameters. The 2 different parameter patterns of L and S subgroups suggest different mechanisms; L, possibly involving tumor-driven processes and S more associated with liver inflammatory processes.","PeriodicalId":15869,"journal":{"name":"Journal of Gastrointestinal & Digestive System","volume":"Suppl 12 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745219/pdf/nihms463988.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31667662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Polyamines and Gut Mucosal Homeostasis. 多胺与肠道黏膜稳态。

Journal of Gastrointestinal & Digestive System Pub Date : 2012-02-20

Jennifer Timmons, Elizabeth T Chang, Jian-Ying Wang, Jaladanki N Rao

{"title":"Polyamines and Gut Mucosal Homeostasis.","authors":"Jennifer Timmons, Elizabeth T Chang, Jian-Ying Wang, Jaladanki N Rao","doi":"","DOIUrl":"","url":null,"abstract":"The epithelium of gastrointestinal (GI) mucosa has the most rapid turnover rate of any tissue in the body and its integrity is preserved through the dynamic balance between cell migration, proliferation, growth arrest and apoptosis. To maintain tissue homeostasis of the GI mucosa, the rates of epithelial cell division and apoptosis must be highly regulated by various extracellular and intracellular factors including cellular polyamines. Natural polyamines spermidine, spermine and their precursor putrescine, are organic cations in eukaryotic cells and are implicated in the control of multiple signaling pathways and distinct cellular functions. Normal intestinal epithelial growth depends on the available supply of polyamines to the dividing cells in the crypts, and polyamines also regulate intestinal epithelial cell (IEC) apoptosis. Although the specific molecular processes controlled by polyamines remains to be fully defined, increasing evidence indicates that polyamines regulate intestinal epithelial integrity by modulating the expression of various growth-related genes. In this review, we will extrapolate the current state of scientific knowledge regarding the roles of polyamines in gut mucosal homeostasis and highlight progress in cellular and molecular mechanisms of polyamines and their potential clinical applications.","PeriodicalId":15869,"journal":{"name":"Journal of Gastrointestinal & Digestive System","volume":"2 Suppl 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165078/pdf/nihms-358717.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32681117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0